• Title/Summary/Keyword: forensic science

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Non-Association of IL-16 rs4778889 T/C Polymorphism with Cancer Risk in Asians: a Meta-analysis

  • Xu, Lin-Lin;Song, Zhi-Chun;Shang, Kun;Zhao, Li-Qin;Zhu, Zhan-Sheng
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.2
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    • pp.803-805
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    • 2014
  • The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI:0.55-1.02, $P_h=0.15$; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, $P_h=0.03$; CC vs. TT: OR=0.73, 95%CI: 0.53-1.00, $P_h=0.08$; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, $P_h=0.08$; C vs. T: OR=0.89, 95%CI: 0.74-1.07, $P_h=0.02$). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future.

Cone-beam computed tomography findings of impacted upper canines

  • Da Silva Santos, Ludmilla Mota;Bastos, Luana Costa;Oliveira-Santos, Christiano;Da Silva, Silvio Jose Albergaria;Neves, Frederico Sampaio;Campos, Paulo Sergio Flores
    • Imaging Science in Dentistry
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    • v.44 no.4
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    • pp.287-292
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    • 2014
  • Purpose: To describe the features of impacted upper canines and their relationship with adjacent structures through three-dimensional cone-beam computed tomography (CBCT) images. Materials and Methods: Using the CBCT scans of 79 upper impacted canines, we evaluated the following parameters: gender, unilateral/bilateral occurrence, location, presence and degree of root resorption of adjacent teeth (mild, moderate, or severe), root dilaceration, dental follicle width, and presence of other associated local conditions. Results: Most of the impacted canines were observed in females (56 cases), unilaterally (51 cases), and at a palatine location (53 cases). Root resorption in adjacent teeth and root dilaceration were observed in 55 and 47 impacted canines, respectively. In most of the cases, the width of the dental follicle of the canine was normal; it was abnormally wide in 20 cases. A statistically significant association was observed for all variables, except for root dilaceration (p=0.115) and the side of impaction (p=0.260). Conclusion: Root resorption of adjacent teeth was present in most cases of canine impaction, mostly affecting adjacent lateral incisors to a mild degree. A wide dental follicle of impacted canines was not associated with a higher incidence of external root resorption of adjacent teeth.

Simultaneous Determination of Asperosaponins and Iridoid Glycosides from Dipsaci Radix by Using LC-ESI-MS Spectrometry (속단(Dipsaci Radix) 중 Asperosaponins 및 Iridoid glycosides의 LC-ESI-MS에 의한 동시분석)

  • Cho, Hwang-Eui;Son, In-Seop;Kim, Sun-Cheun;Son, Kun-Ho;Woo, Mi-Hee;Moon, Dong-Cheul
    • Korean Journal of Pharmacognosy
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    • v.43 no.2
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    • pp.137-146
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    • 2012
  • Dipsaci Radix (Dipsacaceae) has been used as a tonic, an analgesic, anti-inflammatory and anti-complement agents in traditional herbal medicine for the therapy of low back pain, knee pain, rheumatic arthritis, traumatic hematoma, and bone fractures. A high-performance liquid chromatography-electrospray ionization-mass spectrometric method (HPLC-ESI-MS) was developed for the simultaneous quantitation method of the five compounds from the herbal drug: asperosaponin VI and asperosaponin XII (terpene glycosides), sweroside, loganin and dipsacus A(iridoid glycosides). HPLC separation of the analytes was achieved on a C18 column ($150{\times}2.0$ mm i.d., 5 ${\mu}m$) using the aqueous methanol containing 5 mM ammonium acetate with gradient flow of the mobile phase. Detection of the analytes was performed by positive ion electrospray ionization, and selected ion monitoring was used for data acquisition using m/z corresponding molecular adduct ion, $[M+NH_4]^+$ and $[M+H]^+$. Calibration graphs showed good linearity ($r^2$=0.9997) over the wide range of the analytes; intra- and inter-day precisions (RSD, %) were within 9.1% and the accuracy between 94.0-111.0%. Recoveries of the analytes through the assay procedure were in the range of 93.7-110.8%. Analytical results of the herbal drugs of Dipsaci Radix (17 samples) show wide distribution of the five marker compounds and clear difference of the species from Phlomidis Radix (4 samples). The developed method would provide a practical guide for the quality control of the herbal drug.

Acari Attracted to Carrion of Chicken and Cattle (닭과 소의 사체에 유인되는 진드기류)

  • Lim, Chae-Suck;Lee, Won-Koo
    • The Korean Journal of Soil Zoology
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    • v.10 no.1_2
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    • pp.16-21
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    • 2005
  • This study includes the taxonomy and occurrence of ticks and mites from Jinju, Kyogsangnamdo province, Korea. Materials examined were attraccted to carrions of chicken and cattle flesh from September 2002 to December 2003. As a result, the following seven species were identified. Suborder Ixodida Family Ixodidae 1. Haemaphysalis longicorttis Neumann, 1901 Suborder Mesostigmata Family Machrochelidae 2. Macrocheles muscaedomesticae (Scopoli, 1772) 3. Holostaspella ornata (Berlese, 1904) Family Ascidae 4. Protogamasellus micus (Athias-Henriot, 1961) 5. Lasioseius sugawarai Ehara, 1964 6. Proctolaelaps sp. Suboder Prostigamta Family Erythraeidae 7. Abrolophus sp. Of these, M. muscaedomesticae and Protogamasellus micus are dominant species. Holostaspella ornate(Berlese, 1904) and Protogamasellus mica(Athias-Henriot, 1961) are new to Korean fauna.

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Identification of human blood using Rapid FOB (Fecal Occult Blood) Test Kit (신속 FOB(분변 잠혈) 검사 키트를 이용한 혈흔 검출 및 인혈 검사)

  • Lim, Si Keun;Park, Ki Won;Choi, Sang Kyu
    • Analytical Science and Technology
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    • v.17 no.3
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    • pp.211-216
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    • 2004
  • Commercial one-step rapid fecal occult blood (FOB) kit which was used as a screening test to detect traces of blood in stool samples was evaluated for the feasibility of the forensic identification of human blood. The sensitivity was determined and compared with the conventional Leucomalichite green (LMG) method. In addition, the specificity of the kit and the effects of various chemicals and environmental factors were examined. FOB kit was specific for human hemoglobin and more sensitive than LMG test (approximately 100 times). FOB kit showed positive band using at least 1,000,000-fold diluted human blood. The antigen was very stable regardless of storage temperature and boiling. The positive reaction was not affected by LMG and Luminol, the traditional tests for identification of bloodstain. As a results, FOB test kit could be effectively applied to identification of human blood at crime scene and crime laboratories.

Discriminatory ability of cervical vertebral maturation stages in predicting attainment of the legal age threshold of 14 years: A pilot study using lateral cephalograms

  • Banda, Thirupathi Reddy;Komuravelli, Anil Kumar;Balla, Sudheer B.;Korrai, Bala Raju;Alluri, Kavya;Kondapaneni, Jayasurya;Abhyankar, Sourab
    • Imaging Science in Dentistry
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    • v.50 no.3
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    • pp.209-216
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    • 2020
  • Purpose: In India, the age of 14 years is the legal age threshold for child labour. Therefore, in suspected instances of child labour, age assessment plays a crucial role in determining whether a violation of the law on the employment of children has occurred. The aim of this retrospective cross-sectional study was to assess the discriminatory ability of stages of cervical vertebral maturation (CVM) in predicting the legal age threshold of 14 years. Materials and Methods: Routinely taken lateral cephalograms from 408 subjects aged 10 to 18 years were evaluated retrospectively using the CVM stages described by Baccetti et al. Descriptive statistics, accuracy, sensitivity, specificity, positive and negative predictive values, and likelihood ratios were calculated for stages 2, 3, and 4 of CVM. Results: Real age increased as the CVM stage gradually increased. The results of 2×2 contingency tables showed that CVM stage 4 produced an accuracy of 71% and 73%, a false positive rate of 7% and 18%, and a post-test probability of 59% and 68% for boys and girls, respectively. Conclusion: Based on these findings, it can be concluded that the stages of CVM are of limited use for predicting the attainment of the legal age threshold of 14 years. Future studies should investigate whether combinations of skeletal and dental methods could achieve better accuracy and post-test probability.

Genetic Analysis study of Sasang Constitution Classification by DNA-fingerprinting methods (유전자지문법을 이용한 사상체질의 유전적 분석 연구)

  • Cho, DongWuk;Lee, ChangSoo;Ko, ByungHee;Cho, HwangSung
    • Journal of Sasang Constitutional Medicine
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    • v.8 no.2
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    • pp.151-163
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    • 1996
  • VNTR and STR DNA typing are typical genetic analysis methods which are widely used in DNA-fingerprinting for forensic science and other genetic research purposes. In this study, genomic DNA of different constitutions(Taeun, Soyang and Soum) were analyzed by VNTR and STR DNA typing to provide scientific and objective references for Sasang Medicine. It was found out in this study that VNTR-MCT118 and YNZ22 loci showed too many different variation of allele distribution and numbers for each constitution. Therefore, it is thought that VNTR typing can not used for genetic classification study for Sasang Constitution which classifies human body into 4 groups. However, vWA locus, one of the STR loci investigated in this study, showed slight difference in allele distribution for each different constitution.

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Accuracy of an equation for estimating age from mandibular third molar development in a Thai population

  • Verochana, Karune;Prapayasatok, Sangsom;Janhom, Apirum;Mahasantipiya, Phattaranant May;Korwanich, Narumanas
    • Imaging Science in Dentistry
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    • v.46 no.1
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    • pp.1-7
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    • 2016
  • Purpose: This study assessed the accuracy of age estimates produced by a regression equation derived from lower third molar development in a Thai population. Materials and Methods: The first part of this study relied on measurements taken from panoramic radiographs of 614 Thai patients aged from 9 to 20. The stage of lower left and right third molar development was observed in each radiograph and a modified Gat score was assigned. Linear regression on this data produced the following equation: Y=9.309+1.673 mG+0.303S (Y=age; mG=modified Gat score; S=sex). In the second part of this study, the predictive accuracy of this equation was evaluated using data from a second set of panoramic radiographs (539 Thai subjects, 9 to 24 years old). Each subject's age was estimated using the above equation and compared against age calculated from a provided date of birth. Estimated and known age data were analyzed using the Pearson correlation coefficient and descriptive statistics. Results: Ages estimated from lower left and lower right third molar development stage were significantly correlated with the known ages (r=0.818, 0.808, respectively, $P{\leq}0.01$). 50% of age estimates in the second part of the study fell within a range of error of ${\pm}1year$, while 75% fell within a range of error of ${\pm}2years$. The study found that the equation tends to estimate age accurately when individuals are 9 to 20 years of age. Conclusion: The equation can be used for age estimation for Thai populations when the individuals are 9 to 20 years of age.

Comparing Recoverability of Deleted Data According to Original Source Collection Methods on Microsoft SQL Server (Microsoft SQL Server의 원본 수집 방식에 따른 삭제 데이터의 복구 가능성 비교)

  • Shin, Jiho
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.28 no.4
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    • pp.859-868
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    • 2018
  • Previous research related to recovering deleted data in database has been mainly based on transaction logs or detecting and recovering data using original source files by physical collection method. However there was a limit to apply if the transaction log does not exist in the server or it is not possible to collect the original source file because a database server owner does not permit stopping the database server because of their business loss or infringement at the scene. Therefore it is necessary to examine various collection methods and check the recoverability of the deleted data in order to handling the constraints of evidence collection situation. In this paper we have checked an experiment that the recoverability of deleted data in the original database source according to logical and physical collection methods on digital forensic investigation of Microsoft SQL Server database.

A study on the reproducibility of blood alcohol concentration - time profile of an individual (음주 후의 혈중알코올농도 변화의 재현성에 관한 연구)

  • Hong, Sungwook
    • Analytical Science and Technology
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    • v.26 no.3
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    • pp.199-204
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    • 2013
  • In this study, the reproducibility of blood alcohol concentration (BAC) - time profile for the same individuals were investigated. Five Korean males were made to drink 55.5 g of ethyl alcohol (neglecting body weight) in the form of undiluted Soju (22% v/v), Korean popular liquor, within 30 min and each drinking sessions were performed for five times. Two kind of side dishes, a sliced raw fish and a sweet and sour pork, were served alternately along with alcohol. The peak BAC reaching time, the maximum BAC and the reduction rate of BAC of an individual varied greatly even though the dose and drinking time interval were not changed. Also, the food taken along with alcohol varies the shape of BAC - time profile. From the repetitive drinking sessions we can know that the BAC - time profile of an individual is not a reproducible one even though the dose, kind of liquer, drinking time and food were maintained constantly. It means that any assumption of blood alcohol concentration of an individual at a previous time stage based on the alcohol dose can not be justified because of large fluctuation of BAC-time profile of an individual.