Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Non-Association of IL-16 rs4778889 T/C Polymorphism with Cancer Risk in Asians: a Meta-analysis

  • Xu, Lin-Lin (Department of Clinical Laboratory, The First People's Hospital of Yancheng) ;
  • Song, Zhi-Chun (Clinical Laboratory of the Sixth Affiliated Hospital of Wenzhou Medical University & Lishui People's Hospital) ;
  • Shang, Kun (Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University) ;
  • Zhao, Li-Qin (Department of Hematology, The First Affiliated Hospital, University of South China) ;
  • Zhu, Zhan-Sheng (Department of Forensic Medicine, Xuzhou Medical College)
  • Published : 2014.01.30
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Abstract

The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI:0.55-1.02, $P_h=0.15$; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, $P_h=0.03$; CC vs. TT: OR=0.73, 95%CI: 0.53-1.00, $P_h=0.08$; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, $P_h=0.08$; C vs. T: OR=0.89, 95%CI: 0.74-1.07, $P_h=0.02$). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future.

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References

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