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Comparison of the hemodynamic effects of propofol and ketamine as anesthetic induction agents during high-dose remifentanil administration: a single-center retrospective comparative study

  • Sanuki, Takuro;Mishima, Gaku;Kurata, Shinji;Watanabe, Toshihiro;Kiriishi, Kensuke;Tachi, Mizuki;Ozaki, Yu;Okayasu, Ichiro;Kawai, Mari;Matsushita, Yuki;Miura, Keiichiro;Ayuse, Takao
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.15 no.3
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    • pp.129-134
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    • 2015
  • Background: We hypothesized that ketamine, when administered as the anesthetic induction agent, may prevent cardiovascular depression during high-dose remifentanil administration, unlike propofol. To test our hypothesis, we retrospectively compared the hemodynamic effects of ketamine, during high-dose remifentanil administration, with those of propofol. Methods: Thirty-eight patients who underwent oral surgery at the Nagasaki University Hospital between April 2014 and June 2015 were included in this study. Anesthesia was induced by the following procedure: First, high-dose remifentanil ($0.3-0.5{\mu}g/kg/min$) was administered 2-3 min before anesthesia induction;next, the anesthetic induction agent, either propofol (Group P) or ketamine (Group K), was administered. Mean arterial pressure (MAP) and the heart rate were recorded by the automated anesthesia recording system at four time points: immediately before the administration of high-dose remifentanil (T1);immediately before the administration of propofol or ketamine (T2);2.5 min (T3), and 5 min (T4) after the administration of the anesthetic induction agent. Results: In Group P, the MAP at T3 ($75.7{\pm}15.5mmHg$, P = 0.0015) and T4 ($68.3{\pm}12.5mmHg$, P < 0.001) were significantly lower than those at T1 ($94.0{\pm}12.4mmHg$). However, the MAP values in the K group were very similar (P = 0.133) at all time points. The heart rates in both Groups P (P = 0.254) and K (P = 0.859) remained unchanged over time. Conclusions: We showed that ketamine, when administered as the anesthetic induction agent during high-dose remifentanil administration, prevents cardiovascular depression.

The Influence of Surface Treatments on Shear Bond Strength between Zirconia Core and Heat Press Ceramic Interface (지르코니아 코어의 표면처리방법이 열 가압 세라믹과의 전단결합강도에 미치는 영향)

  • Park, Hang-Min;Chung, In-Sung
    • Journal of Technologic Dentistry
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    • v.31 no.2
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    • pp.23-30
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    • 2009
  • All-ceramic restorations have gained acceptance among clinicians and patients because of their superior esthetics. Most all-ceramic systems have a 2-layer structure, using a weak veneering ceramic over a strong supporting core. often, failure of all-ceramic restorations occurs when the veneering ceramic fractures, exposing the core material. The purpose of this study was to compare the shear bond strength of heat press ceramic system (Zirpress) to zirconia core with various surface treatments. 10 metal cores and 50 zirconia cores were fabricated and divided into six groups according to surface treatment such as Zirliner application, aluminium oxide blasting, and 9.5% HF etching. Sixty specimens were prepared using Zirpress, veneered 8mm height and 3mm in diameter, over the zirconia cores (n=10). The shear bond strength test was performed in a universal testing machine with a crosshead speed of 1/min. Ultimate shear bond strength data were analyzed with One-way ANOVA and the Scheffe's test (p=.05). Within the limits of this study, the following conclusions were drawn: The mean shear bond strengths (MPa) were: 12.93 for $110{\mu}m$ aluminium oxide blasting/Rexillium III/IPS e.Max Zirpress; 14.92 for $50{\mu}m$ aluminium oxide blasting ${\pm}9.5%$ HF etching/Zirconis core/IPS e.Max Zirpress; 16.37 for $110{\mu}$ aluminium oxide blasting + 9.5% HF etching/Zirconis core/IPS e.Max Zirpress; 12.89 for $200{\mu}$ aluminium oxide blasting + 9.5% HF etching/Zirconis core/IPS e.Max Zirpress; 19.30 for 9.5% HF etching/Zirconis core/IPS e.Max Zirpress; 19.55 for Zirliner/Zirconis core/IPS e.Max Zirpress. The mean shear bond strength for ZNTZH (Zirliner/Zirconis core) and ZNTEH (9.5% HF etching/Zirconis core) were significantly superior to MS110H ($110{\mu}$ aluminium oxide blasting/Rexillium III) and ZS200EH ($200{\mu}$ aluminium oxide blasting + 9.5% HF etching/Zirconis core) (p<0.05).

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Validation of Methods for Isolation and Culture of Alpaca Melanocytes: A Novel Tool for In vitro Studies of Mechanisms Controlling Coat Color

  • Bai, Rui;Sen, Aritro;Yu, Zhihui;Yang, Gang;Wang, Haidong;Fan, Ruiwen;Lv, Lihua;Lee, Kyung-Bon;Smith, George W;Dong, Changsheng
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.4
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    • pp.430-436
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    • 2010
  • The objective of the present studies was to develop and validate a system for isolation, purification and extended culture of pigment-producing cells in alpaca skin (melanocytes) responsible for coat color and to determine the effect of alpha melanocyte stimulating hormone treatment on mRNA expression for the melanocortin 1 receptor, a key gene involved in coat color regulation in other species. Skin punch biopsies were harvested from the dorsal region of 1-3 yr old alpacas and three different enzyme digestion methods were evaluated for effects on yield of viable cells and attachment in vitro. Greatest cell yields and attachment were obtained following dispersion with dispase II relative to trypsin and trypsin-EDTA treatment. Culture of cells in medium supplemented with basic fibroblast growth factor, bovine pituitary extract, hydrocortisone, insulin, 12-O-tetradecanolphorbol-13-acetate and cholera toxin yielded highly pure populations of melanocytes by passage 3 as confirmed by detection of tyrosinase activity and immunocytochemical localization of melanocyte markers including tyrosinase, S-100 and micropthalmia-associated transcription factor. Abundance of mRNA for tyrosinase, a key enzyme in melanocyte pigment production, was maintained through 10 passages showing preservation of melanocyte phenotypic characteristics with extended culture. To determine hormonal responsiveness of cultured melanocytes and investigate regulation of melanocortin 1 receptor expression, cultured melanocytes were treated with increasing concentrations of ${\alpha}$-melanocyte stimulating hormone. Treatment with ${\alpha}$-melanocyte stimulating hormone increased melanocortin receptor 1 mRNA in a dose dependent fashion. The results demonstrated culture of pure populations of alpaca melanocytes to 10 passages and illustrate the potential utility of such cells for studies of intrinsic and extrinsic regulation of genes controlling pigmentation and coat color in fiber-producing species.

A survey of the Types of Burns in Children and Mother's Preventive Attitudes to, and Knowledge of Burns (어린이 화상사고 유형과 어머니의 예방, 태도, 지식에 대한 실태조사)

  • Han Jung Suk;Kim Dong Hee
    • Child Health Nursing Research
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    • v.4 no.1
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    • pp.97-104
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    • 1998
  • Burns in children result in the loss of precious life, or if the child survives, in much suffering from physical, emotional, social, and economic problems. These burn accidents to children happen in the bustle of family life and frequently without any warning. With this background information, this study was designed to identity types of burns in children and mothers' attitudes towards, and knowledge of burn prevention, in order, to not only, in still a safety consciousness regarding the seriousness of burn accidents and the strengthening prevention, but also as basic data towards the development of an educational program aimed at prevention. From May 1 to May 25 in 1997, data were collected from the mothers of children attending five day care centers and kindergartens located in Seoul, which had been selected for the study. The tools used for the study, which were developed by the researchers, surveyed the type of burns suffered by children, mothers' knowledge of burns and attitudes toward burn accidents. The data were analyzed through real numbers percentages and analysis was done using SPSS computer programs. The results of the study show that the most frequent type of burn accidents were those caused by hot water(55.4%) and these were frequently related to everyday habits that easily lead to danger. Further, the first aid treatment following a burn was weak. The majority of the mothers had not instructed their children on who to contact in the case of a fire, first aid for burns, or how to take escape in the case of a fire. This left the children in a defenseless position in case of a fire. The mothers showed a lack knowledge, on what to do when a blaze is discovered, how to put out a fire, first aid for burns, escaping from a fire and appropriate water temperature, in that 50% of the time they answered incorrectly. From this study a prevention program, HIPP (Home Injury Prevention Program) could be developed that includes fire prevention habits and first aid for burns. This program can be used with kindergarten and elementary school children for group education on fire prevention and can be used as a foundation for construction of a system of facilities and equipment to prevent fires and also prevent injury from fires.

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Arch Forms & Dimensions after Orthodontic Treatment by Premolar Extraction (소구치 발치에 의한 교정치료후의 치열궁 형태 및 크기에 관한 연구)

  • Lee, Seung-Mi;Yoon, Young-Jooh;Kim, Kwang-Won
    • The korean journal of orthodontics
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    • v.28 no.5 s.70
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    • pp.717-729
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    • 1998
  • This study was done to estimate arch forms and dimensions at the bracket level where archwire was placed in Angle's Class I first premolars extraction cases. 60 post-treatment dental casts which had attained good orthodontic treatment results were used in this study Many landmarks and linear measurement items to describe arch forms and dimensions were determined and measured. With a computer system and digitizer, arch forms were described and linear measurement items were statistically analysed. The following results were obtained. 1. The average labial and lingual arch forms at the bracket level were obtained. 2. Arch forms were expressed by parabolic equations and coefficients of determination. 3. Arch widths were larger in male than in female. 4. There were statistical significances in upper intercanine width, upper interfirst molar width, upper intersecond molar height, lower intercanine width and lower interfirst molar width between both sexes (p<0.05, p<0.01). 5. Interfirst molar width differences between maxilla and mandible were 6.43mm in male and 6.05mm in female.

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Value-Relevance of R&D and Ad expenditures in the Medical Industry : Medical Precision and Medicine Industry Case (의료관련 산업의 연구개발비와 광고선전비 지출이 기업가치에 미치는 영향 (의료정밀과 의약품 산업을 중심으로))

  • Cho, Duk-Young;Choi, Soo-Hyung
    • Korea Journal of Hospital Management
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    • v.11 no.3
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    • pp.1-18
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    • 2006
  • The purpose of this study is to analyze the relationship between intangible asset items and company value by empirical research in the medical industry, which may enhance usefulness of the results of other empirical research on intangible asset and company value. In order to attain the purpose of this study, the stock price is taken as the independent variable and all of intangible asset items reported to a balance sheet except the development expenditures and other development expenditures, and advertisement expenses, ordinary research & development expenditures reported on the income statement are taken as the dependent variables. In the following, I carried out four meaningful results from the analysis. First, research hypothesis 1; Book value of intangible asset reported in balance sheet bears positive relationship with company value shows that development expenditures 1 variable gives positive association in a significant level while a group of \10,000-above-company shows no relationship with company value, the other group of below-\10,000-company supports a consistently significant association. All this considering, we have to keep in mind that lack of prudence may leads to wrong results when we try to analyze. Second, research hypothesis 2; Intangible asset and other intangible asset expenditures reported on the income statement gives positive effect on company value shows that R&D accounts variables give insignificance in a statistical level to all company, including entire group, \10,000-above and below consistently. These results testify that current accounting system is valid. Third, in the case of other intangible asset, it requires further examination of current KAS because statistical results show negatively significant value or insignificant value in a statistical level. That means the more intangible assets, the less company value or nothing. Last, in the case of advertisement expenditure variables of above-\10,000 and entire company shows insignificances in a statistical level consistently while below-\10,000-company shows significant result coherently. We should regard accounting information on the advertisement expenditures of \10,000-below-company with caution. The results of this study provide controversial points whether intangible asset items reported on B/S, excluding development expenditures, should be regarded as asset. To facilitate the utility of accounting information on intangible asset, it seems necessary to regard advertisement expenditures reported on I/S as asset accounts. There are further arguments on the way of dealing with intangible asset under KAS that might be considered.

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A Study on the National Competency Standards of Fashion Accessories Production (패션소품생산 분야의 국가직무능력표준(NCS) 개발에 관한 연구)

  • Suh, Seung-Hee;Lee, Shin-Young
    • Journal of the Korean Society of Costume
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    • v.65 no.1
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    • pp.46-60
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    • 2015
  • This study analyzed the process of development and verification of standards through the competency analysis of fashion accessories products in the development of 'National Competency Standards'(NCS), which was carried out in 2013 for the fashion industry. The NCS for fashion accessories production was developed through three Focus Group Interviews (FGIs) and fashion accessories production was defined as "the process of design, development and manufacture intended to produce items that improve the degree of completion of fashion products that are produced from textile fabric, knitted fabric, leather and other materials such as bags, belts, hats, gloves, scarves, neckties and socks with the exception of clothes". The competency unit for fashion accessories production was analyzed in 11 categories: development of design; development of materials; production of prototype samples; calculation of cost; determination of mass production model and price; planning of main manufacture process; ordering of materials; planning for mass production; preparation for mass production; mass production; and inspection of completed products, and the verification was carried out on development outcomes through a survey carried out of on-site personnel. This study recommends the following direction for future improvements based on an analysis of the development process of the NCS for fashion accessories production. First, future development of standards should first provide a rational category system for each area of fashion good production based on the production process, which should be followed by a detailed competency survey. Second, in order to ensure a more efficient verification survey, an expert for each competency unit should be designated for the develop standard to induce a more sincere response. Also the questionnaire should require supplementation in order to collect the various additional opinions of experts of the field. Finally, this study concludes that it is urgent to procure an education infrastructure and specialized professors in order to apply the competency standard for fashion accessories production to the education sector. This study also concludes that the government will be required to provide systematic and consistent support aimed at supplementing development and forming a firm collaborative working environment for the industry and academia in order to improve the current education environment and build a more field-oriented education environment.

A Study on Ancient Korean Clothing and Ornaments Through Official Chinese History - focusing on hat and hair style - (중국정사(中國正史) 조선전(朝鮮傳)의 한국(韓國) 고대복식(古代服飾) - 관(冠)과 수발(修髮)을 중심으로 -)

  • Kim, Jin Seon;Koh, Bou Ja
    • Journal of the Korean Society of Costume
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    • v.64 no.1
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    • pp.106-122
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    • 2014
  • This study is based on the official Chinese history of the ancient Korean(中國正史朝鮮傳) clothing and ornaments, and also tries to discover, study, and adjust the system of the ancient Korean clothing and ornaments. Ancient Korea has very poor official records of its clothing and ornaments. Therefore, this study had no choice but to rely on the official Chinese history to cover for the lack of resources. The official Chinese history documents are not only important for studying ancient Korean history, but also important for studying about the ancient Korean clothing and ornaments. This research selected historical documents about the ancient Korean clothing and ornaments from fifteen different Chinese dynasties' official documents, and then systematically classified the documents in order to compare them. All these processes confirmed the following subjects. In regards to the Kwan(冠: general hat), the hat types included Check, Byun(弁), Jeol-poong(折風), Jowoo-Kwan(鳥羽冠), So-gol(蘇骨), and Na-kwan(羅冠). These Kwan(冠) were influenced from Chinese clothing and ornaments. Gold and silver decorations on the Kwan(冠) were influenced from the Scythai culture. The feather decorations on the hat were residual of the bird worshiping culture or the hunting lifestyle. These things show that the ancient Korean clothing and ornaments originated the clothing and ornaments from the North. But the use of Jo-woo(bird feather) was common around the globe in many ways during the ancient times, regardless of area and period. The official Chinese history describes men's hair style as Choo-gyul (椎結) or sometimes pronounced, Choo-gyul(椎結). These seem to describe the topknot. Women had various types of hair styles such as Yu-byun-bal-su-hu (wear women's hair in a braid). The official Chinese history show that the ancient Korean clothing and ornaments originated the clothing and ornaments from the north. The ancient Korean clothing and ornaments influenced and were influenced by its neighboring countries.

Actual Condition and Sensitivity Analysis of Sexual Harassment in Campus by Gender (성별에 따른 대학 내 성희롱에 관한 실태 및 인지도 분석)

  • 박옥임;김정숙;강희순
    • The Korean Journal of Community Living Science
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    • v.15 no.3
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    • pp.137-148
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    • 2004
  • The purpose of this study is to prevent and review counter-action for the sexual harassment in campus by revealing current state of sexual harassment in campus relatively weak in sexual discrimination with regard to sexual harassment emerged as social problem serious in our nation. The targets of study were students and assistants in three schools located at $Kwangju\cdot{Chonnam}$ area, a questionnaire made by pre-researcher was applied to student vs. assistant with regard to sexual consciousness and recognition, and current state of sexual harassment, with analysis of material processed through statistical analysis using SPSSWIN 10.0 for verification of $$\chi$^2$ for identification of difference vs. family and student vs. assistant. The result of this research with regard to sexual harassment is under following: Firstly, the recognition of concept of sexual harassment was proved to be aware of be more than half a responders above average, lack of recognition showed significant number requiring establishment of concept of sexual harassment, the responders stated that they could do it alone should be treated in the counseling room in school. Secondly, 28.7% of students and assistants answered that they have suffered from sexual harassment now and. before, even a great number of males have experienced such sexual harassment. In case of female assistants, more than half of them suffered from sexual harassment suggesting us significant level of sexual harassment to female assistants. A depth of sexual harassment to assistants should be investigated in a further way by preparing for and establishing concrete preventive actions and researches, mostly suffered by males; In this respect, a preventive training of sexual harassment should be deemed to be provided to males. Thirdly, as a result of investigation of sex education and preventive action against sexual harassment in college, most of elementary, junior, junior high school hardly provide no or inefficient sexual harassment, and they responded that the campus needs its education. As a way to educate campus with sexual harassment efficiently, a special lecture or regular class might be designed for systematic education or sexual harassment through schools counseling room might be effective emphasizing upon role of the room according to opinions of responders. The college is required to install such offices or centers as can exclusively manage and take charge of sex education program operation, legal system of anti-sexual harassment, or personnel arrangement for such activities in school by reflecting such result into school for appropriate and efficient education of or counseling to sex.

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Design Analysis of Hydraulic Excavator since 1990 (1990년대 유압굴삭기 조형 분석에 관한 연구)

  • 윤진필;문무경
    • Archives of design research
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    • v.13 no.4
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    • pp.233-242
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    • 2000
  • The traditional image of hydraulic excavator started to change in two ways since 1990. First, post-heavy equipment's visual image was new waves to traditional image of heavy, strong, and wild. They are the negative aspect that excavators have. Another movement of getting rid of its negative image can be found in late-heavy equipment, which was intended to adapt traditional and positive, but off negative images. In 1990s, the design trend is moving from warm/hard to warm/soft, and KOBELCO can be exceptional example that went even further, gone up to cool-soft image. KOBELCO specially aimed 'post- excavator image' strategy, which has been successful. Image of cabin as a human space changed little bit further than outside image. Each company tried to differentiate the design of cabin focusing on its safety. Following paragraphs show specific trend of image change in form, colour, texture, and the composition. Major visual image change in form tries to follow the image of cars and home appliances which are showing the movement from tough and hard image to soft one. Structural change on local image shows the movement from angular edge to edgeless and the movement of cabin's pillar C placed to back of the equipment with gentle inclination. All of these movements are the result of effort to improve traditional excavator's negative image, that top structure is assembled separately, to positive ones. Today's tendency about its color becomes important to apply two different colour styles. Each style has brightness and tone comparison. As an enormous power convey system, it was in common that its brightness comparison was useful because of the alarm of its damage possibility. However, as its colour control and its design have been emphasized gradually, the tone comparison takes a part in an important role, too. As an example, there is an occasion that these comparisons are compromised simultaneously. In the respect of its image creation, its texture treatments make the tendency of being the same as passenger cars. It is caused from its development of the manufacture techniques of from the fabrication method in small business to the press method in big firm. Further, it is also because of its improvement of painting & coating skills. It may prohibit the reflection effect from solar rays. In the point of view of its visual images, it is recognized the prominent tendency that its composition has been gradually decreased. Lots of windows and the frames tends dark-colour as a whole. It is more preferred to have one colour image, but except KOBELCO and HITACHI. As well, there is another high-tendency to improve its standard treatments, especially for its corner and texture treatments.

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