• 한국지역지리학회지
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• 제14권4호
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• pp.279-289
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• 2008

본 연구에서는 고령군에 산재하는 지형경관자원을 발굴하여, 그 분포를 지도화 함으로써 지형경관자원의 관리에 기반이 되는 자료를 제공하고, 이를 활용하는 방안을 제시하고자 하였다. 분석결과는 다음과 같다. 첫째, 산지지역에 분포하는 지형경관은 고령읍의 미숭산과 주산, 그리고 덕곡면 노리의 상비리 계곡, 개진면 오사리의 고립구릉 등이다. 둘째, 하천 연안에 분포하는 지형경관은 개진면 부리의 진촌늪, 다산면 호촌리의 호촌늪과 달성습지, 우곡면 봉산리의 봉산늪 등의 자연습지, 고령읍 외리와 개진면 반운리의 보 축조에 따른 인공습지, 개진면 반운리의 곡류 절단에 따른 구하도와 곡류 핵, 고령읍 내곡리와 우곡면 월오리의 하식애, 우곡면 야정리의 넓은 모래톱과 망류하도 등이다. 셋째, 개진면 부리의 진촌늪은 전형적인 범람원의 모습을 갖추고 있고 비교적 보존상태가 양호하며 대도시와의 접근성도 양호하므로 생태공원을 조성하기에 적합하다. 그리고 개진면 반운리에는 탐구학습장을 조성하여 감입곡류의 절단과 연관된 환경변화와 보의 생태학적 순기능을 관찰할 수 있는 기회를 확대하여야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1601-1607
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• 2013

A determination of circulating tumor cell (CTC) effectiveness for prediction of progression-free survival (PFS) and overall survival (OS) was conducted as an adjunct to standard treatment of care in breast cancer management. Between November 2008 and March 2009, 22 metastatic and 12 early stage breast carcinoma patients, admitted to Ankara Oncology Training and Research Hospital, were included in this prospective trial. Patients' characteristics, treatment schedules and survival data were evaluated. CTC was detected twice by CellSearch method before and 9-12 weeks after the initiation of chemotherapy. A cut-off value equal or greater than 5 cells per 7.5 ml blood sample was considered positive. All patients were female. Median ages were 48.0 (range: 29-65) and 52.5 (range: 35-66) in early stage and metastatic subgroups, respectively. CTC was positive in 3 (13.6%) patients before chemotherapy and 6 (27.3%) patients during chemotherapy in the metastatic subgroup whereas positive in only one patient in the early stage subgroup before and during chemotherapy. The median follow-up was 22.0 (range: 21-23) and 19.0 (range: 5-23) months in the early stage and metastatic groups, respectively. In the metastatic group, both median PFS and OS were significantly shorter in any time CTC positive patients compared to CTC negative patients (PFS: 4.0 vs 14.0 months, Log-Rank p=0.013; and OS: 8.0 months vs. 20.5 months, Log-Rank p<0.001). OS was affected from multiple visceral metastatic sites (p=0.055) and higher grade (p=0.044) besides CTC positivity (log rank p<0.001). Radiological response of chemotherapy was also correlated with better survival (p<0.001). As a result, CTC positivity was confirmed as a prospective marker even in a small patient population, in this single center study. Measurement of CTC by CellSearch method in metastatic breast carcinoma cases may allow indications of early risk of relapse or death with even as few as two measurements during a chemotherapy program, but this finding should be confirmed with prospective trials in larger study populations.

• 산업융합연구
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• 제21권6호
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• pp.43-51
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• 2023

본 연구는 노인들이 주로 사용하는 야외운동 기구의 특허 현황을 분석하여 노인들의 건강증진을 위한 기초 자료 활용에 목적이 있다. 특허 검색은 특허청 정보 검색 서비스인 키프리스에서 수집하였다. 검색어는 '야외운동기구'이며, 직접적으로 관련된 특허 157건을 최종 선정하여 분석하였다. 분석 결과 첫째, 시대별 특허 경향은 2007년부터 특허 등록이 시작되었으며, 매년 2-3건의 특허가 등록되었다. 둘째, 발전모듈이 작동하여 전기를 생산할 수 있고, 사용자 운동량에 정보를 제공하거나 특성상 중량추 분실 및 도난과 안전사고 방지 등 무선 통신 이용 운동처방 시스템을 제공하는 스포츠융합 관점의 특허가 조사되었다. 마지막으로 사용자 편의성 제공, 운동기구 사용빈도를 증가시킬 수 있는 운동기구 관련 특허가 조사되었다. 본 연구 결과를 통해 야외운동기구가 점점 노인과 편의성 중심으로 개발된다는 점과 기업 및 공공기관에서 노인 야외운동기구에 관심 확대가 나타나고 있음을 파악하였다. 향후 실용적이고 편리한 야외운동기구 개발을 위하여 특허 추이 분석 이외에 야외 운동기구 활용 운동 프로그램과 연계한 후속적인 연구가 필요하겠다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7509-7515
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• 2013

To assess the risk of cancers associated with sleep duration using meta-analysis of published cohort studies, we performed a comprehensive search using PubMed, Embase and Web of Science through October 2013. We combined hazard ratios (HRs) from individual studies using meta-analysis approaches. A random effect dose-response analysis was used to evaluate the relationship between sleep duration and cancer risk. Subgroup analyses and sensitivity analyses were also performed. Publication bias was evaluated using Funnel plots and Begg's test. A total of 13 cohorts from 12 studies were included in this meta-analysis, which included 723, 337 participants with 15, 156 reported cancer outcomes during a follow-up period ranging from 7.5 to 22 years. The pooled adjusted HRs were 1.06 (95% CI: 0.92, 1.23; P for heterogeneity =0.003) for short sleep duration, 0.91 (95% CI: 0.78, 1.07; P for heterogeneity <0.0001) for long sleep duration. In subgroup analyses stratified by cancer type, long duration of sleep showed an inverse relation with hormone-related cancer (HR=0.79; 95% CI: 0.65, 0.97; P for heterogeneity =0.009) and a greater risk of colorectal cancer (HR=1.29; 95% CI: 1.09, 1.52; P for heterogeneity =0.346). Further meta-analysis on dose-response relationships showed that the relative risks of cancer were 1.00 (95% CI: 0.99, 1.01; P for linear trend=0.9151) for one hour of sleep increment per day, and 1.00 (95% CI: 0.98, 1.01; P for linear trend=0.7749) for one hour of sleep increment per night. No significant dose-response relationship between sleep duration and cancer was found on non-linearity testing (P=0.5053). Our meta-analysis suggests a positive association between long sleep duration and colorectal cancer, and an inverse association with incidence of hormone related cancers like those in the breast. Studies with larger sample size, longer follow-up times, more cancer types and detailed measure of sleep duration are warranted to confirm these results.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.137-145
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• 2018

우리나라는 가상화폐 전 세계 거래량의 10~30%의 비중을 차지할 정도로 가상화폐 열풍이 뜨거우며, 특히 상대적으로 금융투자 경험이 적고, 소득이 불안정한 20대의 가상화폐 구매 경험은 전 연령대 중 가장 높다. 본 연구는 Q방법론을 활용하여 20대 청년 세대의 가상화폐에 대한 주관적 인식을 유형화하고 각 유형의 특성을 분석하고자 하였다. Q모집단은 인터넷 검색, 심층면접, 문헌검토를 통해 총 337개의 표본을 도출하였고, 최종 51개의 Q진술문을 선정하여 대학생을 포함한 20대 40명의 P표본을 구성하여 Q-분류를 실시하였다. 분석은 PC-QUANL Program을 이용하여 분석하였다. 분석결과, 각 유형간의 의미 있는 차이를 발견하였으며, 각 유형은 '투자수단', '미래기술', '도박 같은 놀이의 일종', '거품 같은 일시적 유행'의 4개의 유형으로 분류하여 명명하였다. 가상화폐에 대한 사회적 관심이 큰 지금의 상황에서 사회구성원들 간의 인식 차이는 사회적 갈등과 논란의 여지가 될 수 있다. 본 연구결과가 후속연구를 비롯한 사회적 논의의 근거자료로 기여할 수 있기를 기대한다.

• 유통과학연구
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• 제11권2호
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• pp.45-55
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• 2013

Purpose - The development and implementation of OSS (Open Source Software) led to a dramatic change in corporate IT infrastructure, from system server to smart phone, because the performance, reliability, and security functions of OSS are comparable to those of commercial software. Today, OSS has become an indispensable tool to cope with the competitive business environment and the constantly-evolving IT environment. However, the use of OSS is insufficient in small and medium-sized companies and software houses. This study examines the need for OSS Intermediaries in the Software Distribution Channel. It is expected that the role of the OSS Intermediary will be reduced with the improvement of the distribution process. The purpose of this research is to prove that OSS Intermediaries increase the efficiency of the software distribution market. Research design, Data, and Methodology - This study presents the analysis of data gathered online to determine the extent of the impact of the intermediaries on the OSS market. Data was collected using an online survey, conducted by building a personal search robot (web crawler). The survey period lasted 9 days during which a total of 233,021 data points were gathered from sourceforge.net and Apple's App store, the two most popular software intermediaries in the world. The data collected was analyzed using Google's Motion Chart. Results - The study found that, beginning 2006, the production of OSS in the Sourceforge.net increased rapidly across the board, but in the second half of 2009, it dropped sharply. There are many events that can explain this causality; however, we found an appropriate event to explain the effect. It was seen that during the same period of time, the monthly production of OSS in the App store was increasing quickly. The App store showed a contrasting trend to software production. Our follow-up analysis suggests that appropriate intermediaries like App store can enlarge the OSS market. The increase was caused by the appearance of B2C software intermediaries like App store. The results imply that OSS intermediaries can accelerate OSS software distribution, while development of a better online market is critical for corporate users. Conclusion - In this study, we analyzed 233,021 data points on the online software marketplace at Sourceforge.net. It indicates that OSS Intermediaries are needed in the software distribution market for its vitality. It is also critical that OSS intermediaries should satisfy certain qualifications to play a key role as market makers. This study has several interesting implications. One implication of this research is that the OSS intermediary should make an effort to create a complementary relationship between OSS and Proprietary Software. The second implication is that the OSS intermediary must possess a business model that shares the benefits with all the participants (developer, intermediary, and users).The third implication is that the intermediary provides an OSS of high quality like proprietary software with a high level of complexity. Thus, it is worthwhile to examine this study, which proves that the open source software intermediaries are essential in the software distribution channel.

• 천문학회지
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• 제51권3호
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• pp.49-63
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• 2018

We carry out a study of Sub-Millimeter Galaxies (SMGs) in the AKARI NEP-Deep field using the James Clerk Maxwell Telescope (JCMT) SCUBA-2 $850{\mu}m$ source catalog, released as part of the SCUBA-2 Cosmology Legacy Survey (S2CLS) program. The SCUBA-2 $850{\mu}m$ map has a root mean square (rms) noise of $1.2mJy\;beam^{-1}$ and covers an area of $0.60degree^2$. We find four SMGs which have counterparts to Herschel sources with spectroscopic redshifts in the literature. In addition, three dust obscured galaxies (DOGs) detected in Herschel bands are selected as a comparison sample. We derive IR luminosities of SMGs using the CIGALE code, which are similar to those of high redshift SMGs from previous studies. The contribution of AGN to the total IR luminosity in SMGs (2%-11%) is smaller than the lower limit for the one in DOGs (19%-35%), which is consistent with the expectation from the evolutionary scenario of massive galaxies. We search for SMGs in overdense regions as protocluster candidates and investigate four regions, including candidates around three DOGs. Finally, we argue that follow-up spectroscopic observation for the NEP-Deep field will provide crucial information to understand the role of SMGs in the evolution of massive galaxies.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7567-7573
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• 2015

Background: Catastrophic effects of mustard gas as a chemical warfare agent have always been a major problem for those exposed to this agent. In this meta-analysis it was tried to evaluate carcinogenesis, ocular, cutaneous and respiratory complications of mustard gas exposure among Iranians who had been exposed to this agent during the Iran-Iraq war. Materials and Methods: In this meta-analysis, the required data were collected using keywords "mustard gas", "sulfur mustard", "cancer", "neoplasm", "respiratory complications", "ocular complications", "lung disease", "chronic complication", "eye", "skin", "cutaneous complication", "carcinogenesis" and their combination with keywords "Iran", "Iranian", "prevalence", "mortality" and their Farsi equivalent terms from the databases of SID, Iranmedex, Magiran, Pubmed, Science Direct, Google Search engine, Gray Literature and Reference of References. To determine the prevalence of each complication and perform meta-analysis, CMA: 2 (Comprehensive Meta-Analysis) software with a randomized model was used. Results: Of the 542 articles found, 7 national articles, consistent with the aims of this study were selected. Meta-analysis of seven papers revealed that cancer risk, especially cancer of the respiratory system was elevated, so that the relative risk (RR) of cancer role of mustard gas was inconsistent from 2/1 to 4 in this survey. Also prevalence of delayed skin disorders due to sulfur mustard was 94.6%, pulmonary complications 94.5% and ocular complications 89.9%. The incidence of various cancers in victims exposed to mustard gas was 1.7% worldwide where the rate was 2.2% in Iranian victims of the Iraq-Iran war. Conclusions: Based on present study the prevalence of delayed mustard gas related cutaneous, pulmonary and ocular complications is above 90% and risk of carcinogenesis is higher in comparison to worldwide statistics. This may suggest need for long-term and persistent follow-up and rehabilitation procedures for populations exposed to this agent.

• 디지털융복합연구
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• 제15권8호
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• pp.25-32
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• 2017

본 연구의 목적은 사회서비스와 함께 성장한 심리와 운동의 융합 적 차원의 심리운동 관련 연구를 다양하게 분석하여 향후 심리운동의 연구의 문제점을 찾고 다양한 연구를 위한 발전방안을 제공하고자 한다. 2013년부터 2017년 3월까지의 국내에서 연구 된 심리운동 연구를 논문 검색을 통하여 수집 분석하였다. 심리운동 관련 연구는 석사학위 30편, 박사학위 6편, 학술지 14편 총 50편의 연구를 분석하였다. 50편의 연구는 유형별 분포, 대상별 분포, 연구설계 유형, 종속변인 유형, 중재 회기를 분석하였다. 분석결과 주로 2013년 이후 연구사례가 하락세를 보이며 연구대상은 특정계층의 연구가 주를 이루고 있다. 연구 설계는 단일대상, 양적연구 순으로 종속변인은 운동발달, 사회성, 정서행동의 순으로 분석되었으며 중재회기는 11~20회, 21~30회의 가장 많이 중재되었다. 연구결과에 변화는 사회성, 운동발달, 행동변화의 순으로 분석되었다. 융합 적 프로그램을 기반으로 한 심리운동의 연구는 대상의 범위확대, 연구방법 및 변인의 다양화가 필요하며 활발한 후속 연구화 함께 향후 사회서비스의 기여와 함께 융합 적 방안을 제시하고 진행 되어야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3403-3410
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• 2014

Context: Interest exits in whether TNF-alpha antagonists increase the risk of breast cancer and total malignancies in patients with rheumatoid arthritis (RA). Objectives: To analyze the risk of malignancies, especially breast cancer, in patients with RA enrolled in randomized control trials (RCTs). Methods: A systematic literature search for RCTs from 1 January 1998 to 1 July 2013 from online databases, such as PubMed, WILEY, EMBASE, ISI web of knowledge and Cochrane Library was conducted. Studies included RCTs that compared the safety of at least one dose of the five TNF-${\alpha}$ antagonists with placebo or methotrexate (MTX) (or TNF-${\alpha}$ antagonists plus MTX vs placebo plus MTX) in RA patients for more than 24 weeks and imported all the references into document management software EndNote${\times}6$. Two independent reviewers selected studies and extracted the data about study design, patients' characteristics and the type, number of all malignancies. Results: 28 RCTs from 34 records with 11,741 patients were analyzed. Of the total, 97 developed at least one malignancy during the double-blind trials, and breast cancer was observed in 17 patients (17.5% of total malignancies). However, there was no statistically significant increased risk observed in either the per protocol (PP) model (OR 0.65, 95%CI [0.22, 1.93]) or the modified intention to treat (mITT) model (OR 0.75, 95%CI [0.25, 2.21]). There were also no significant trend for increased risk of total malignancies on anti-TNF-${\alpha}$ therapy administered at approved doses in either model (OR, 1.06, 95%CI [0.64, 1.75], and OR, 1.30, 95%CI [0.80, 2.14], respectively). As to the two models, modified intention to treat model analysis led to higher estimation than per protocol model analysis. Conclusions: This study did not find a significantly increased risk of breast cancer and total malignancies in adults RA patients treated with TNF-${\alpha}$ antagonists at approved doses. However, it cannot be ignored that more patients developed malignancies with TNF-${\alpha}$ antagonists therapy compared with patients with placebo or MTX, in spite of the lack of statistical significance, so that more strict clinical trials and long-term follow-up are needed, and both mITT and PP analyses should be used in such safety analyses.