• 대한임상검사과학회지
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• 제38권2호
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• pp.141-146
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• 2006

Vagal nerve stimulation (VNS) has been proposed as a possible way to improve the control of refractory epilepsy. We report the effects following VNS treatment in patients with refractory epilepsy. Seventeen patients with a mean age of 12.8 years, ranging from 5 to 29 years, underwent the implantation of vagal nerve stimulation (Cyberonics, Houston, TX). We reviewed the clinical findings before and after VNS in seizure frequency, number of antiepileptic drugs (AED), and quality of life (QOL). All of the patients had intractable seizures, eleven of the patients had additional medical complications, three had hippocampus atrophy, one had encephalomalacia, five had encephalitis, one had pachygyria, and one had schizencephaly. Thirteen patients had symptomatic partial epilepsies, three patients had Lennox-Gastaut syndrome and one had cryptogenic partial epilepsy. The mean follow up duration was 35 months. The mean reduction of seizure frequency compared with baseline before VNS was 26.1% after 3 months (p<0.005), 41.9% after 6 months (p<0.001), 46.9% after 1 year (p<0.001), and 53% at the latest follow-up (p<0.001). Twelve patients showed an improvement of QOL such as mood, language, alertness, expression, and motor function. The most common side effects were transient hoarseness or voice change or cough, which was detected in six patients (35%) and wound infection in one patient (5%). This study has shown a good anti-seizure effect of VNS, decrease in seizure frequency and improvements in QOL. We concluded that VNS is a beneficial therapy in refractory epilepsy with a non-resectable epileptic focus. Further studies should be focused on the prediction of unresponsiveness and the adjustment of VNS parameters for maximum efficacy in patients with various medical histories.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제21권4호
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• pp.275-282
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• 2015

스마트폰의 주요 기능 중 미디어 콘텐츠 재생이 주요한 비중을 차지하게 되면서 디지털 음원의 단순 재생뿐만 아니라 디지털 음원을 이용한 악기 연습 등 동적 음악 활동 지원 기능들에 대한 요구도 높아지고 있다. 기존에도 MIDI 형식의 음원을 재생하는 플레이어 앱은 존재했지만 단순 재생 기능에 중점을 둔 한계점이 있었다. 이에 본 논문에서는 기존 MIDI 재생기에 악기 연습에 필요한 기능들인 구간 반복 재생, 재생 중 템포 조절, 재생 중 조 바꿈 기능을 구현하였고, MIDI 파일 제작자들이 만든 파일을 사용자가 재생기 내에서 내려 받을 수 있는 기능을 구현하였다. 특히, 내려 받은 MIDI 파일을 암호화하여 구매한 사용자의 재생기 내에서만 재생 가능하게 하는 DRM 기능도 구현하였다. 이를 통해 악기 연주 연습을 하는 사용자들에게 편리한 연습 환경을 제공하고 MIDI 음원의 불법 유통을 막아 MIDI 파일 제작자들의 저작권 보호를 실현하고자 하였다.

• 한국산학기술학회논문지
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• 제17권10호
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• pp.46-53
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• 2016

본 연구는 Q방법론을 통하여 에이즈에 대한 인식을 분석하여, 향후 에이즈 예방캠페인 개발에 기초자료를 제공하는데 그 목적이 있다. 연구의 분석과정은 문헌자료 및 심층면담을 실시하여 Q모집단을 수집하였다. 2014년 10월 20일부터 27일까지 진술문으로 구성된 Q표본을 가지고, 이를 연구 대상자인 P표본이 자가 참조에 따라 분류하는 방식으로 진행되었다. 27개의 Q 표본을 선정하여 20명에게 분류토록 한 결과 모두 3개의 에이즈에 인식에 대한 유형이 도출되었다. 분석된 결과 총 3가지의 유형 즉 제1유형(N=9) : 부정형, 제2유형[(N=6) : 사회적 지지형, 제3유형(N=5) : 이기적 사고형으로 분류되었다. 부정형은 에이즈에 대하여 부정적 견해가 강했고, 사회적 지지형은 우호적 의견을 보였고, 이기적 사고형은 중립적 견해를 보였다. 그리고 각 유형의 특징과 함께 유형별 공통점과 차이점을 살펴보았다. 본 연구의 의미는 인간의 내면을 이해하는데 유용한 Q 방법론을 이용한 연구라는 점과 함께 에이즈 예방 및 관리정책의 효율적 전략을 제안한 점이라 하겠다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5273-5280
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• 2016

Objective: To evaluate stromal cells of the bone marrow microenvironment (BMM) in bone marrow trephine biopsy (BMTB) specimens, with a focus on fibronectin, tumor necrosis factor- alpha (TNF-${\alpha}$) and L-selectin in Non-Hodgkin's lymphoma (NHL) patients, before and after therapy. Materials and Methods: A total of 80 de novo NHL patients, 64 with B-cell lymphomas 80%, (follicular cell lymphoma (FCL) in 32, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in 12, and diffuse large cell lymphoma in 20) and 16 with T-cell lymphomas (20%) all diagnosed as T-Lymphoblastic lymphomas, were evaluated before and after therapy. For comparison, 25 age and sex matched BM donors, were included as a control group. BMTB material and BM aspirates were taken for morphological assessment of stromal cells, the plasma of these samples being examined for $TNF{\alpha}$ and L-selectin by ELISA, and fibronectin by radial immunodiffusion (RID). Results: BM stromal cells comprising reticular macrophages and fibroblasts were elevated in 53.3% of NHL cases at diagnosis, while BM fibronectin levels were decreased and BM $TNF{\alpha}$ and L-selectin were higher than in controls (p<0.05). In NHL cases, elevated values of BM $TNF{\alpha}$ and BM L-selectin were associated with signs of aggressive disease, including >1 extra nodal sites, detectable B symptoms, high grade, BM and CNS invasion, and a high International prognostic index (IPI) (p<0.05). Conclusion: BMM components, $TNF{\alpha}$, L-selectin and fibronectin, in NHL can be useful in evaluating disease activity, extent and response to treatment and as prognostic markers according to the IPI.

• 정보보호학회논문지
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• 제29권5호
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• pp.1205-1219
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• 2019

데이터 기반 경제시대에서 데이터 활용능력이 경쟁력이 됨에 따라 개인정보의 보호와 더불어 개인정보의 활용을 통한 경제적 부가가치를 창출하려는 노력이 함께 강조되고 있다. 이 가운데 등장한 EU의 PSD2(the second Payment Service Directive)는 정보 주체의 '정보이동권'을 근거로 개인의 자기결정권을 보장하면서 데이터의 활용과 유통을 촉진하는 마이데이터 정책으로 전 세계 오픈뱅킹 정책의 시초가 되고 있다. 이러한 추세에 따라 우리나라 정부도 국내 금융업권별 실정을 반영하여 마이데이터 정책을 적극적으로 추진하고 있다. 하지만, 마이데이터 정책으로 인해 금융정보의 유통 및 활용 범위가 커진 만큼 개인정보의 유출 및 오남용, 해킹 등 위험도 커진 것도 사실이다. 본 연구에서는 EU PSD2가 어떻게 국내 금융분야 마이데이터 정책에 반영되어 추진되고 있는지를 살펴본다. 그리고 국내 마이데이터 정책의 개인정보보호 위험 사항을 개인정보 생명 주기별로 나누어 식별한 후 이러한 위험에 대한 법적 기술적 대응책을 제시하고자 한다.

• Human Ecology Research
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• 제57권4호
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• pp.523-534
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• 2019

This study identifies correlations between the use of media devices, communication ability, and executive function difficulties for third grade students, as well as investigates the moderating effect of a child's communication ability. Data from the 10th (2017) Panel Study on Korean Children [PSKC] was employed (N=557). Descriptive statistics, Pearson's correlation and hierarchical regression were used along with SPSS 25.0(IBM Co., Armonk, NY, USA). The results were as follows. First, the executive function difficulties in the third-grade showed a significant positive correlation with media device use. While also, showing a negative correlation with a child's communication ability. Media devices use and communication ability has a significant negative correlation. Second, a child's communication ability has a moderating effect in relation to the use of media devices and executive function difficulties. The difficulty of executive function showed a reciprocal increase to a child's use of media devices and indicated a discriminatory effect of a child's communication ability. In conclusion, this study shows that communication ability is important as a personal factor for children who control the negative effects of media devices. Therefore, it is necessary to provide and support an environment for the development of a child's communication ability.

• Advances in concrete construction
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• 제8권3호
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• pp.225-237
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• 2019

Although applying self-consolidating concrete (SCC) in many modern structures is an inevitable fact, the high consumption of cement in its mixing designs has led to increased production costs and adverse environmental effects. In order to find economically viable sources with environmentally friendly features, natural pozzolan pumice and blast furnace slag in 10-50% of replacement binary designs have been investigated for experiments on the properties of fresh concrete, mechanical properties, and durability. As a natural pozzolan, pumice does not require advanced equipment to prepare for consumption and only needs to be powdered. Pumice has been the main focus of this research because of simple preparation. Also to validate the results, in addition to the control specimens of each design, fly ash as a known powder has been evaluated. Moreover, ternary mixes of pumice and silica fume were investigated to enhance the obtained results of binary mixes. It was concluded that pumice and slag powders indicated favorable performance in the high percentage of replacement.

• 한국추진공학회지
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• 제22권2호
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• pp.138-151
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• 2018

본 논문에서는 재사용 발사체와 발사체의 회수과정에서 사용된 기술에 대해 소개하고 분석한다. 이를 위하여 세계 각국의 재사용 발사체를 조사하였으며 발사체 회수 부분에 따라 기술을 분류하였다. 특히, 실제 비행에 성공한 Space X의 Falcon 9과 Blue Origin의 New Shepard의 회수과정을 중심으로 조사하였으며 비행 조건에 따라 적용된 기술들을 분석하여 특징들을 나열하였다. 이를 통하여 추후 한국형 발사체가 발사 비용을 절감하기 위해 사용할 수 있는 재사용 기술들에 대해 소개하고자 한다.

• 대한안전경영과학회지
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• 제14권4호
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• pp.247-258
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• 2012

It seems most important for a manufacturing company to be well aware of its relationship with suppliers. This is why it is essential to analyze and control the structural relationship among CEO's characteristics, relations between suppliers and manufacturers and new product development performances affected by such relations. The present study may be summed up as follows: First, from the analysis of characteristics of manufacturing company's CEO and relations between suppliers and manufacturers, it could be verified that CEO's characteristics exercised influence upon sharing of product development process and upon cooperation for technical manpower, but not upon sharing of core technologies, signifying the fact that nothing could be more important than the role of CEO who has strong will to improve his or her relations with suppliers; and Second, from the analysis of relations between suppliers and manufacturers as well as relations between management and new product development performances, it became evident that both management performance and product development performance were affected by sharing of product development process. It was also known that cooperation for technical development process had influence upon the product development performance but not upon the management performance. Furthermore, the analysis showed that both management performance as well as product development performance were affected by sharing of core technologies.

• 약학회지
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• 제57권1호
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• pp.1-7
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• 2013

Induction of effective and increased levels of antibody production may be major points in vaccine development. This is especially the case when the antigenic sources are carbohydrates. Thus, in our Lab various types of formulations such as liposomal and conjugate vaccines have been researched. However, the fastidious formulation process and high costs are a problem. For this reason, there is currently a focus on utilizing immunoadjuvants. In this present study, we tested whether ginsenosides Re (a panaxdiol) and Rg1 (a panaxtriol) from Panax ginseng have immunoadjuvant activity against the cell wall of Candida albicans (CACW). The resulting data showed that Rd and Rg1 caused LPS-treated B lymphocytes to be proliferative. Rd had greater proliferation activity than that of Rg1. In the murine model of antibody production, CACW combined with Rd [CACW/Rd/IFA] or Rg1 [CACW/Rg1/IFA] increased the production of antibodies specific to C. albicans when compared to the antibody production by [CACW/IFA]-induction, which was used as a negative control (P<0.05). In the case of [CFA/Rd/IFA], the antibody production was almost twice as that of the CFA. In addition, formulations containing either had a prolonged antibody inducing activity as compared to the CFA formula. In conclusion, Rd and Rg1 have an immunologic activity, and yet Rd can be a better candidate than Rg1 for a new immunoadjuvant.