• BMB Reports
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• v.55 no.8
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• pp.370-379
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• 2022

Human pregnancy is a delicate and complex process where multiorgan interactions between two independent systems, the mother, and her fetus, maintain pregnancy. Intercellular interactions that can define homeostasis at the various cellular level between the two systems allow uninterrupted fetal growth and development until delivery. Interactions are needed for tissue remodeling during pregnancy at both fetal and maternal tissue layers. One of the mechanisms that help tissue remodeling is via cellular transitions where epithelial cells undergo a cyclic transition from epithelial to mesenchymal (EMT) and back from mesenchymal to epithelial (MET). Two major pregnancy-associated tissue systems that use EMT, and MET are the fetal membrane (amniochorion) amnion epithelial layer and cervical epithelial cells and will be reviewed here. EMT is often associated with localized inflammation, and it is a well-balanced process to facilitate tissue remodeling. Cyclic transition processes are important because a terminal state or the static state of EMT can cause accumulation of proinflammatory mesenchymal cells in the matrix regions of these tissues and increase localized inflammation that can cause tissue damage. Interactions that determine homeostasis are often controlled by both endocrine and paracrine mediators. Pregnancy maintenance hormone progesterone and its receptors are critical for maintaining the balance between EMT and MET. Increased intrauterine oxidative stress at term can force a static (terminal) EMT and increase inflammation that are physiologic processes that destabilize homeostasis that maintain pregnancy to promote labor and delivery of the fetus. However, conditions that can produce an untimely increase in EMT and inflammation can be pathologic. These tissue damages are often associated with adverse pregnancy complications such as preterm prelabor rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). Therefore, an understanding of the biomolecular processes that maintain cyclic EMT-MET is critical to reducing the risk of pPROM and PTB. Extracellular vesicles (exosomes of 40-160 nm) that can carry various cargo are involved in cellular transitions as paracrine mediators. Exosomes can carry a variety of biomolecules as cargo. Studies specifically using exosomes from cells undergone EMT can carry a pro-inflammatory cargo and in a paracrine fashion can modify the neighboring tissue environment to cause enhancement of uterine inflammation.

• Development and Reproduction
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• v.26 no.3
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• pp.99-105
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• 2022

Styrene is the precursor of polystyrene. Human exposure to styrene could occur in occupational and residential settings and via food intake. Styrene is metabolized to styrene-7,8-oxide by cytochrome P450 enzyme. In the present study, we investigated the cytotoxicity mediated by styrene and styrene-7,8-oxide in TM3 testicular Leydig cells in vitro. We first monitored the nuclear fragmentation in Leydig cells after exposure to styrene or styrene-7,8-oxide. Hoechst 33258 cell staining showed that styrene exposure in TM3 Leydig cells did not exhibit nuclear fragmentation at any concentration. In contrast, nuclear fragmentation was seen in styrene-7,8-oxide-exposed cells. These results indicate that cytotoxicity-mediated cell death in Leydig cells is more susceptible to styrene-7,8-oxide than to styrene. Following styrene treatment, procaspase-3 and XIAP protein levels did not show significant changes, and cleaved (active) forms of caspase-3 were not detected. Consistent with the western blot results, the active forms of caspase-3 and XIAP proteins were not prominently altered in the cytoplasm of cells treated with styrene. In contrast to styrene, styrene-7,8-oxide induced cell death in an apoptotic fashion, as seen in caspase-3 activation and increased the expression of XIAP proteins. Taken together, the results obtained in this study demonstrate a fundamental idea that Leydig cells are capable of protecting themselves from cytotoxicity-mediated apoptosis as a result of styrene exposure in vitro. It remains unclear whether the steroid-producing function, i.e., steroidogenesis, of Leydig cells is also unaffected by exposure to styrene. Therefore, further studies are needed to elucidate the endocrine disrupting potential of styrene in Leydig cells.

• Journal of the Korea Society of Computer and Information
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• v.26 no.12
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• pp.201-212
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• 2021

This study attempted to compare the pattern with the absorption layer by analyzing the pattern of commercially available urinary incontinence panty products. Through this, it tried to obtain basic data necessary for the development of functional urinary incontinence panty for active seniors. Twelve commercially available products were decomposed to analyze size and patterns, and appearance and clothing pressure were evaluated through 3D simulation. As a result of comparing the size and pattern of urinary incontinence panty, it was analyzed that the size difference between parts was large even though the product was called the same. Products from the same brand also showed a big difference depending on design and absorption. As a result of the appearance evaluation for the 3D simulation, it was found that there were significant differences between products in all items such as the front, side, and back. Product No. 9 was analyzed to be the best except for the waist fit on the side. In the evaluation of clothing pressure, most of them were marked in red except for products 1, 2, and 8 due to the nature of the panty product. In the future, it is thought that actual wearing experiments and size standardization studies on urinary incontinence pants should be conducted.

• Human Ecology Research
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• v.60 no.4
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• pp.609-623
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• 2022

As human life and welfare become more valued in the Fourth Industrial Revolution era, the role and mission of human ecology are expanding. Therefore, a career exploration and education program for high school students covering all the academic fields of human ecology may be necessary. To investigate what would be needed to develop such a program, a focus group interview (FGI) targeting experts within the same field and a survey targeting high school students were conducted. As a result of the FGI, a total of 3 categories and 7 subcategories were identified. The three categories included "human ecology and high school education," "human ecology and career choices," and "education program development and management in human ecology." The results of the high schoolers' survey showed that they had a moderate level of awareness about careers related to human ecology majors, but their interests and known information about human ecology programs in universities were low. Within the sub-content of each major, the contents with the highest educational needs were fashion product management, nutrition by disease, housing market analysis, personal financial management, and children's rights and welfare. If a career exploration and education program is implemented in the future, the most preferred type is a mentoring program by professors, students, and graduates in the field of human ecology. In conclusion, it is necessary to develop and implement an integrative education program about human ecology majors based on the educational needs of high school students.

• The Research Journal of the Costume Culture
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• v.31 no.4
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• pp.411-429
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• 2023

Modernism is an internationally accepted design style. In addition, traditional Korean costume is not the clothing of the past, but its form is also used in modern fashion. Therefore, the purpose of this study is to examine the social and cultural contents of the morphological structure of traditional Korean costume, in order to derive the design characteristics of modernism and examine the global applicability of traditional Korean costume structure. For this study, photographic materials from museums, schematic drawings of relics, and Hanbok production books published by government agencies were analyzed. Further, this study examined traditional Korean costume, especially the modernism characteristics derived from Paul Greenhalgh and previous studies. The results are as follows. First, The traditional Korean costume is a cut based on basic shapes, along with a silhouette appears according to the background of the times. Second, the characteristics of modernism can be divided into universality, functionality, and simplicity. Third, as a result of analyzing the form structure of traditional Korean costume based on the characteristics of modernism, universality is expressed as standardized form, functionality as practical aesthetics, and simplicity as sustainable diversity. Furthermore, Korean costume has a difference in that was greatly influenced by various Eastern ideas and aesthetics of the late Joseon Dynasty. These findings provide a perspective of modern reinterpretation of the uniqueness and universality of traditional Korean costume in line with globalization by utilizing the design characteristics of modernism, an international style.

• Journal of Service Research and Studies
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• v.12 no.3
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• pp.60-69
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• 2022

In this study, to verify the effectiveness of the persona-type consumer analysis data service, a study was conducted focusing on the consumer analysis service use case of www.ethno-mining.com. The case was targeted at the 'Small Business Design Difficulty Resolving Support Project' of the Gangwon Institute of Design Promotion. The progress of this study was to develop a questionnaire to measure the user satisfaction and effectiveness of the service, study the consumer analysis data of the persona method of the www.ethno-mining.com system, study related theories, compare similar services, and conduct questionnaires; The results were analyzed and tested. In the result of testing the participants in the 'Small Business Design Difficulty Resolving Support Project' of the Gangwon Design Promotion Institute, the persona-style consumer analysis data got a positive response in terms of user satisfaction, and a regression that measures the effectiveness of the service on the company's R&D In the analysis, it was found that there are practical effects for companies by reducing time, reducing costs, smooth communication between developers, securing expertise in consumer analysis, and improving the overall quality of R&D during R&D.

• Journal of the Korean Applied Science and Technology
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• v.39 no.2
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• pp.294-302
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• 2022

This study attempted to investigate the effect of improving damaged hair by preparing a hair improving agent with basil oil and applying it to damaged hair. An experimental material was added to a perm base agent containing 0 g, 3 g, 6 g, 9 g of basil oil to prepare the preparation. It was applied to sample hair bleached at 8 levels with the prepared formulation. Each sample and damaged hair were measured and analyzed. The measurement method measured tensile strength, absorbance and gloss using methylene blue to determine the effect of improving maternal quality. Statistical analysis was conducted on the reliability of the study results. Studies have shown that all samples with basil oil have higher tensile strength than damaged hair. As a result of the absorbance analysis using methylene blue, it was found that the absorbance was lower than that of damaged hair in all samples. Gloss measurement showed that all samples showed increased luster compared to damaged hair. In conclusion, basil oil was found to improve damaged hair. In the future, research on various types of oil and research methods is needed.

• Journal of dental hygiene science
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• v.23 no.2
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• pp.88-92
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• 2023

Background: Aphthous stomatitis is a common disease of the oral mucosa and its pathogenesis is associated with several risk factors. Frequently, minor ulcers are idiopathic in nature and often resolve naturally. However, those ulcers are painful and sensibly compromise patients' eating. There are different treatment strategies for the clinical management of oral aphthae. Methods: The present study assessed the efficacy of a film-forming cream in accelerating the healing and diminishing the pain associated with minor aphthae in a randomized fashion design. The test product (AphtoFix^®) was compared with placebo cream in a cohort of patients with a diagnosis of minor recurrent stomatitis. Patients were randomly distributed into two groups and were followed for 10 days. The primary outcomes included the number of days until symptoms were relieved and the number of days to complete healing. Results: Thirty-six patients completed the follow-up, eighteen per group. All lesions eventually healed within day 10. However, patients in the test group experienced significantly less pain, already from day 1. Patients in the test group also showed a faster healing rate of the lesion with an average of 7 days against the 9 days required for patients in the control group. Conclusion: The present study supported the utility of a film-forming in cream in relieving the patient from symptoms associated with aphthous stomatitis already at day 1 of product use. Patients also displayed faster healing of the lesions when compared to the control group. Further studies with greater sample size and patient stratification according to age and risk factors are recommended to support the present findings.

• The Research Journal of the Costume Culture
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• v.31 no.3
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• pp.277-295
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• 2023

The Body Appreciation Scale-2 (BAS-2) measures the extent to which individuals feel, accept, and respond to their own bodies in a positive manner. Given the research need to explore positive body image and its associations with various sociocultural factors and related consequences among individuals with various cultural backgrounds, several studies have established the psychometric properties and factor structures of the BAS-2 in different languages and samples with different characteristics. The current study investigated the psychometric properties and measurement invariance of a Korean version of the BAS-2 in an older Korean adult population (599 older Korean adults with the average age of 70 years). Data were collected using both online and offline (paper-based) survey questionnaires. The results of exploratory factor analyses and confirmatory factor analysis evidenced the unidimensional factor structure and measurement invariance of the Korean BAS-2 among older Korean men and women, after dropping item 1. Scalar invariance was supported across gender, and men and women did not significantly differ in observed mean scores of the Korean BAS-2. The results also supported good convergent validity and criterion validity. Incremental validity was demonstrated by predicting self-esteem over and above measures of age, BMI, subjective financial and health status, body esteem, and ageism. High internal reliability and test-retest reliability over a 2-week period were confirmed. Overall, the results of this study support the reliable use of a Korean BAS-2 to measure positive body image among older Koreans after excluding item 1.

• (The)Study of the Eastern Classic
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• no.55
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• pp.223-264
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• 2014

Yeoncheon Hong Seok-joo(淵泉 洪奭周: 1774-1842) faithfully followed a policy of restoration of literary style of king Jeongjo. He was an young vassal after 1794 and influenced by Jeongjo because Yeoncheon was around the king. Furthermore, he had comparatively favorable working period as a vassal(仕宦期, 1795-1836) after death of Jeongjo(1800) while establishing his own academic viewpoint. Therefore, a study about art theory of Yeoncheon Hong Seok-joo is one about logical system to accept various desires for change of then while not getting rid of scope of Neo-Confucianism after Jeongjo. It is catched that exchange of Hong Seok-joo and Jeong Yak-yong was made relating to study of Sangseo. Hong Seok-joo and Jeong Yak-yong absorbed in study of Sangseo, which is come from putting importance on 6 scriptures (經) among studies of scriptures by both of them. Through this, they aimed to re-discover ideology of original Confucian studies as one for cultivating oneself and governing people (修己治人之學). Dasan and Yeoncheon have something in common that they were young vassals who were cultivated as a guarding power for Jeongjo centered on Gyujanggak. They were largely fit to view of literature(文體觀) of Jeongjo. Hong Seok-joo distinguished function of prose(文) and poetry(詩) into teaching moral(明敎) and moving people(感人) in the category of Mun-yi-jae-do(文以載道) based on thoughts of 'literature is linguistic device for Taoism '(道本文末)' which is a core concept of literature theory based on Neo-Confucianism. He gave a careful attention on instructional and social function in prose while on emotional understanding that puts importance on temper and the secrets of nature in poetry. Hong Seok-joo regarded moral impression and edification through this as a core of artistic creation based on Segyoseol(世敎說). Furthermore, expressions such as 'Heunggwangunwon(興觀群怨)' or 'Yeohangguyo(閭巷謳謠) which are mentioned as important elements in his artistic works put importance on actual existence of objective things in artistic activity and this is connected to an attitude to require description fit to fact. So, it is assumed that such expression style aimed for features of genre painting in painting arts. Understanding of the study of ancient documents by Yeoncheon developed from critical perspective. He criticized the study of ancient documents, saying it as first, Pasoijisul(破碎之術), second, Dotaekjisul(塗澤之術), third, Hoimojisul(毁侮之術). Jeong Yak-yong criticized ' theory on the Odes' from viewpoint of theory of Mun-yi-jae-do(文以載道) based on Neo-Confucianism. He stressed political and social function of Sipeon and general poetry in "the Odes" and reinterprets discourses about poetry of Zhu Xi based on his own opinion. He says that poems of national fashion do political and social criticism. The theory of national fashion by Jeong Yak-yong clearly discloses his thoughts that stress practical role of noblemen in the social and political context.