• 제목/요약/키워드: family members

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Family Relationships as a Predictor of COVID-19 Preventive Behavioral Intention and Pandemic Fatigue Among Young Filipino Undergraduates

  • Cleofas, Jerome V.;Oducado, Ryan Michael F.
    • Asian Journal for Public Opinion Research
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    • 제10권4호
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    • pp.277-292
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    • 2022
  • Cognizant of the role of the family in influencing health behaviors among its young members, especially during the time of COVID-19 in the Philippines where stay-at-home measures were in place from March 2020 until March 2022, this study sought to determine the predictive relationship of family relationship to COVID-19 preventive behavioral intention and pandemic fatigue among young Filipino undergraduates. A total of 1,665 undergraduate students participated in this cross-sectional online survey. Findings reveal that family cohesion significantly increases COVID-19 prevention behavioral intention among undergraduates. Moreover, students who report high levels of conflict in the family are less likely to comply with preventive behaviors and exhibit higher levels of pandemic fatigue.

고 3 수험생 어머니의 입시준비 경험에 대한 현상학적 연구 (A Phenomenological Study on the Mothers' Experiences with Children Preparing a College Entrance Examination)

  • 양성은
    • 가정과삶의질연구
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    • 제23권2호
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    • pp.49-61
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    • 2005
  • The study reported a phenomenological analysis of the interviews with 19 mothers who had a child preparing a college entrance examination. The research question was what mothers experienced in supporting their child in his/her study for the examination. Results indicated that 'the senior year in a highschool' was described as the most stressful period affecting all the family members. Mothers' experiences were portrayed from three perspectives: mothers, as family members, experiencing the attachment to her child but conflicts with her husband; mothers, as individuals, adjusting by trying to setting realistic academic goals for her child while supporting him/her physically, emotionally, and spiritually; and mothers, as critics to extrafamily systems, blaming the inconsistency of educational policies. 1bis study was conducted with a holistic view, and highlighted the importance of interactions between traditional ideology about the mother roles and socioeconomic contexts when interpreting mothers' supporting their child in study for a college entrance examination.

Emerging Co-signaling Networks in T Cell Immune Regulation

  • Jung, Keunok;Choi, Inhak
    • IMMUNE NETWORK
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    • 제13권5호
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    • pp.184-193
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    • 2013
  • Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.

Conformational Properties of Disulfide-Free Recombinant Chicken Ovalbumin

  • Jeoung, Yeon-Hee;Yu, Myeong-Hee
    • BMB Reports
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    • 제32권3호
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    • pp.247-253
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    • 1999
  • Chicken egg ovalbumin is a non-inhibitory member of the serpin (serine protease inhibitors) family whose members share a common tertiary fold. In the present study, we succeeded in high-level production of a disulfide-free form of refolded recombinant ovalbumin. Conformational characterization of the recombinant ovalbumim revealed that it is well-folded, following two-state unfolding transition with the midpoint of transition at 4.7 M at $25^{\circ}C$. This value is very close to that of the reduced form of authentic ovalbumin. The recombinant ovalbumin can serve as a model molecule of non-inhibitory serpins in comparative studies with inhibitory members of the serpin family.

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Heat shock transcription factors and sensory placode development

  • Nakai, Akira
    • BMB Reports
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    • 제42권10호
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    • pp.631-635
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    • 2009
  • The heat shock transcription factor (HSF) family consists of at least three members in mammals and regulates expression of heat shock proteins in response to heat shock and proteotoxic stresses. Especially, HSF1 is indispensable for this response. Members of this family are also involved in development of some tissues such as the brain and reproductive organs. However, we did not know the molecular mechanisms that regulate developmental processes. Involvement of HSFs in the sensory development was implicated by the finding that human hereditary cataract is associated with mutations of the HSF4 gene. Analysis of gene-disrupted mice showed that HSF4 and HSF1 are required for the lens and the olfactory epithelium, respectively. Furthermore, a common molecular mechanism that regulates developmental processes was revealed by analyzing roles of HSFs in the two developmentally-related organs.

PMA Activates Stat3 in the Jak/Stat Pathway and Induces SOCS5 in Rat Brain Astrocytes

  • Hwang, Mi-Na;Kim, Kwang Soo;Choi, Yo-Woo;Jou, Ilo;Yoon, Sungpil
    • Molecules and Cells
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    • 제23권1호
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    • pp.94-99
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    • 2007
  • Suppressors of cytokine signaling (SOCS) family members are negative feedback regulators of the Jak/Stat pathway, which is an essential inflammatory signaling pathway. We investigated expression of eight members of the SOCS family in rat astrocytes, using two inflammatory stimulants, PMA and IFN-${\gamma}$. Only a few SOCS genes were induced by both stimulants, and we detected an increase in SOCS5 protein with PMA. PMA activated the Jnk, Erk, p38, and Jak/Stat signal pathways. In addition, it increased the level of activated-Stat3 resulting from tyrosine phosphorylation. A gel-shift assay showed that a protein in nuclear extracts from PMA-treated cells was able to bind to Stat binding elements. These results suggest that activated Stat3 binds to SOCS promoters and leads to their transcriptional induction.

고객 관계지향성 형성에 관한 연구 (A Study on the Relationship-Orientation of Customers toward Business)

  • 오세조;박진용;김평래
    • 한국유통학회지:유통연구
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    • 제4권2호
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    • pp.41-58
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    • 1999
  • The relationship-orientation is an important concept for understanding both of marketing theory and practice. However, not many research have focused on how to develop the relationship-orientation of end users. Therefore, the objective of this research is to confirm the key factors relevant to the relationship-orientation. This research studies(1) the transaction style of individuals, and (2) social influences on the relationship-orientation. Customers want to reduce the number of choice sets because of transaction style, including (1) efficiency of decision making, (2) simplification of information processing, (3) avoidance of future perceived risk, and (4) pursuit of cognitive consistency. Customers are influenced by social factors such as family members, reference groups, and opinion leaders. The following conclusions were drawn based on results of research analysis: (1) efficiency of decision making and avoidance of future perceived risk affect the relationship-orientation, and (2) influences of family members and opinion leaders to the focal relationship affect the relationship-orientation of individuals.

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가족의 사회관계망 구조와 관련변수 (A Study on the Structure of Family Social network)

  • 옥선화
    • 가정과삶의질연구
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    • 제11권1호
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    • pp.176-190
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    • 1993
  • This study intended to analyze the size and composition of social network and to identify their related variables in urban nuclear families. Data were collected through the questionnaires by wives living in Seoul area. The methods of statistical analysis used in the study were the frequency mean percentile and one-way ANOVA. The findings were as follows; 1) The size of social network in urban nuclear families was 10.0 in average and 2-33 in range. 2) The composition of social network were 45.5% in relatives 20.6% in neighbors. 21.8% in friends. 4,7% in coworkers, 4.1% religious group members 2.1% in associational members. and 1.4% in formal supporters. 3) The birth order of husbands was related to the size of social network. The composition of social network was influenced by SES family life cycle husband's birth order housing type residence duration age education employment religion and familism.

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학령전기 아토피피부염 아동 어머니의 스트레스 경험 (Experiences of Stress among Mothers of Preschoolers with Atopic Dermatitis)

  • 권화영;신성례
    • Child Health Nursing Research
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    • 제24권2호
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    • pp.166-177
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    • 2018
  • Purpose: The purpose of this study was to explore and describe the meaning and essence of experiences of stress in mothers of preschoolers with atopic dermatitis. Methods: This study employed a qualitative research design. Seven mothers of preschoolers with atopic dermatitis were interviewed and the data were analyzed using Giorgi's phenomenological method. Results: Five main themes and 12 theme clusters emerged. The 5 main themes were 1) the mother's enduring heartache from the conflict that arise among family members, 2) the complete loss of daily happiness, 3) the steady stream of emotional fluctuations, 4) struggling to bear the heavy financial burden, and, 5) a life of hope accompanied by stress. Conclusion: The results of this study provide an in-depth understanding of stress among mothers of preschoolers with atopic dermatitis. These results can be used in the development of nursing interventions to provide psychological and emotional support for mothers and family members.

A rare pseudomyxoma peritonei with a MSH2 variation of unknown significance and two mutation carrier family members

  • Kim, Yoo Min;Kim, Min Kyu
    • Journal of Genetic Medicine
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    • 제13권1호
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    • pp.55-58
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    • 2016
  • Pseudomyxoma peritonei (PMP) is a rare tumor that usually originates in the appendix, but a small number of cases originate in the ovary. Lynch syndrome (LS) is an autosomal dominant hereditary condition that increases the risk of cancer, particularly in the colon and endometrium. Mutations in the mismatch repair genes (MSH2, MLH1, MSH6, and PMS2) increase the risk of LS. Reported PMP cases with hereditary gene mutations of unknown significance are also rare. Here, we investigated a PMP patient and her family members, who have an MSH2 variant of unknown significance. Physicians have an important role in counseling, management, and surveillance based on genetics and pathogenicity.