• 제목/요약/키워드: facilitated state

검색결과 83건 처리시간 0.029초

협력시스템에서의 접근제어 프레임워크 설계 및 구현 (The Design and Implementation of Access Control framework for Collaborative System)

  • 정연일;이승룡
    • 한국통신학회논문지
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    • 제27권10C호
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    • pp.1015-1026
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    • 2002
  • 최근 협력 시스템에 대한 연구가 증가되면서 협력 작업에 대한 연구와 더불어 협력 시스템 보안에 대한 연구가 중요시되고 있다. 협력 시스템에서 인증 및 암호화의 경우 기존의 정책을 사용하여 시스템의 견고성을 유지할 수 있다. 그러나 접근 제어 정책에서 기존의 정책을 그대로 사용하게 되는 경우 분산 환경, 개방된 네트워크, 다양한 주체와 객체의 존재로 인하여 협력 시스템은 신분, 직무, 그룹, 보안등급, 무결성 등급, 허가권을 포함해야 하는 다양한 접근상황을 고려해야 된다. 이 경우, 낮은 보안 등급의 주체가 높은 보안 등급의 객체로 접근을 허용 하거나, 높은 보안 등급의 주체가 낮은 보안 등급의 객체로 접근을 막아야 하는 복합적 상황을 해결하지 못한다. 더욱이 모든 접근상황을 제어하기 위하여 객체에 여러 접근제어 요소를 포함하여 접근 제어를 알고리즘화 할 경우 불필요한 상황을 모두 고려해야 하기 때문에 시스템의 성능 저하를 야기 시킨다. 이 같은 문제를 해결하기 위하여, 본 논문에서는 협력 시스템의 특징에 맞는 새로운 접근제어 프레임워크를 제안한다. 제안된 접근제어의 특징은 주체 및 객체에 다수의 접근 요소를 정의하여 기존 정책 보다 협력시스템과 같은 복합적인 상황에서 용이하게 적용되도록 하였다. 그리고 객체의 종류를 접근될 요소의 특징에 따라 세 가지로 구분하였고, 구분된 각 객체의 특징에 따라 알고리즘이 구현됨으로 빠르고 원활한 협력 작업이 수행되도록 하였다. 또한, 접근 요소 및 정책 변경이 용이하도록 확장성을 고려하였다. 모의실험 결과 다수의 접근 요소를 사용하였지만 시스템 성능은 접근 제어 정책을 적용하지 않았을 때와 큰 차이를 보이지 않았으며 복합적인 상황의 접근제어에서도 확실한 접근 제어가 가능했다.

영공(領空)과 우주공간(宇宙空間)의 한계(限界)에 관한 법적(法的) 고찰(考察) ("Legal Study on Boundary between Airspace and Outer Space")

  • 최완식
    • 항공우주정책ㆍ법학회지
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    • 제2권
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    • pp.31-67
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    • 1990
  • One of the first issues which arose in the evolution of air law was the determination of the vertical limits of airspace over private property. In 1959 the UN in its Ad Hoc Committee on the Peaceful Uses of Outer Space, started to give attention to the question of the meaning of the term "outer space". Discussions in the United Nations regarding the delimitation issue were often divided between those in favour of a functional approach ("functionalists"), and those seeking the delineation of a boundary ("spatialists"). The functionalists, backed initially by both major space powers, which viewed any boundary as possibly restricting their access to space(Whether for peaceful or military purposes), won the first rounds, starting with the 1959 Report of the Ad Hoc Committee on the Peaceful Uses of Outer Space which did not consider that the topic called for priority consideration. In 1966, however, the spatialists, were able to place the issue on the agenda of the Outer Sapce Committee pursuant to Resolution 2222 (xxx1). However, the spatialists were not able to present a common position since there existed a variety of propositions for delineation of a boundary. Over the years, the funtionalists have seemed to be losing ground. As the element of location is a decisive factor for the choice of the legal regime to be applied, a purely functional approach to the regulation of activities in the space above the Earth does not offer a solution. It is therefore to be welcomed that there is clear evidence of a growing recognition of the defect inherent to such an approach and that a spatial approach to the problem is gaining support both by a growing number of States as well as by publicists. The search for a solution of the problem of demarcating the two different legal regimes governing the space above the Earth has undoubtedly been facilitated, and a number of countries, among them Argentina, Belgium, France, Italy and Mexico have already advocated the acceptance of the lower boundary of outer space at a height of 100km. The adoption of the principle of sovereignty at that height does not mean that States would not be allowed to take protective measures against space activities above that height which constitute a threat to their security. A parallel can be drawn with the defence of the State's security on the high seas. Measures taken by States in their own protection on the high seas outside the territorial waters-provided that they are proportionate to the danger-are not considered to infringe the principle of international law. The most important issue in this context relates to the problem of a right of passage for space craft through foreign air space in order to reach outer space. In the reports to former ILA Conferences an explanation was given of the reasons why no customary rule of freedom of passage for aircraft through foreign territorial air space could as yet be said to exist. It was suggested, however, that though the essential elements for the creation of a rule of customary international law allowing such passage were still lacking, developments apperaed to point to a steady growth of a feeling of necessity for such a rule. A definite treaty solution of the demarcation problem would require further study which should be carried out by the UN Outer Space Committee in close co-operation with other interested international organizations, including ICAO. If a limit between air space and outer space were established, air space would automatically come under the regime of the Chicago Convention alone. The use of the word "recognize" in Art. I of chicago convention is an acknowledgement of sovereignty over airspace existing as a general principle of law, the binding force of which exists independently of the Convention. Further it is important to note that the Aricle recognizes this sovereignty, as existing for every state, holding it immaterial whether the state is or is not a contracting state. The functional criteria having been created by reference to either the nature of activity or the nature of the space object, the next hurdle would be to provide methods of verification. With regard to the question of international verification the establishment of an International Satelite Monitoring Agency is required. The path towards the successful delimitation of outer space from territorial space is doubtless narrow and stony but the establishment of a precise legal framework, consonant with the basic principles of international law, for the future activities of states in outer space will, it is still believed, remove a source of potentially dangerous conflicts between states, and furthermore afford some safeguard of the rights and interests of non-space powers which otherwise are likely to be eroded by incipient customs based on at present almost complete freedom of action of the space powers.

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Dynamic modeling of LD converter processes

  • Yun, Sang Yeop;Jung, Ho Chul;Lee, In-Beum;Chang, Kun Soo
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 1991년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 22-24 Oct. 1991
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    • pp.1639-1645
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    • 1991
  • Because of the important role LD converters play in the production of high quality steel, various dynamic models have been attempted in the past by many researchers not only to understand the complex chemical reactions that take place in the converter process but also to assist the converter operation itself using computers. And yet no single dynamic model was found to be completely satisfactory because of the complexity involved with the process. The process indeed involves dynamic energy and mass balances at high temperatures accompanied by complex chemical reactions and transport phenomena in the molten state. In the present study, a mathematical model describing the dynamic behavior of LD converter process has been developed. The dynamic model describes the time behavior of the temperature and the concentrations of chemical species in the hot metal bath and slag. The analysis was greatly facilitated by dividing the entire process into three zones according to the physical boundaries and reaction mechanisms. These three zones were hot metal (zone 1), slag (zone 2) and emulsion (zone 3) zones. The removal rate of Si, C, Mn and P and the rate of Fe oxidation in the hot metal bath, and the change of composition in the slag were obtained as functions of time, operating conditions and kinetic parameters. The temperature behavior in the metal bath and the slag was also obtained by considering the heat transfer between the mixing and the slag zones and the heat generated from chemical reactions involving oxygen blowing. To identify the unknown parameters in the equations and simulate the dynamic model, Hooke and Jeeves parttern search and Runge-Kutta integration algorithm were used. By testing and fitting the model with the data obtained from the operation of POSCO #2 steelmaking plant, the dynamic model was able to predict the characteristics of the main components in the LD converter. It was possible to predict the optimum CO gas recovery by computer simulation

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결정화도에 따른 Li3V2(PO4)3 음극의 전기화학적 특성 (Electrochemical Characteristics of Li3V2(PO4)3 Negative Electrode as a Function of Crystallinity)

  • 구준환;박경진;류지헌;오승모
    • 전기화학회지
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    • 제15권1호
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    • pp.27-34
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    • 2012
  • 열처리 온도를 $600^{\circ}C$$800^{\circ}C$로 다르게 하여 비정질 및 결정질구조의 탄소를 포함하는 $Li_3V_2(PO_4)_3/C$분말을 각각 합성하였으며, 결정성에 따른 리튬 이차전지용 음극으로의 특성을 비교하였다. 결정질 $Li_3V_2(PO_4)_3/C$은 추가반응에 의하여 리튬이 저장되기 때문에 260 mAh $g^{-1}$의 제한된 용량만을 지니고 있음에 비하여, 비정질 $Li_3V_2(PO_4)_3/C$는 3가의 바나듐이 금속상태에 근접할 정도로 가역적으로 반응되어 460 mAh $g^{-1}$의 큰가역용량을 발현함을 확인하였다. 이는 비정질 구조에서 기인하는 특성으로 유연한 구조로 인한 새로운 리튬의 저장공간이 확보되는 것 때문이라 할 수 있다. 또한, 비정질 $Li_3V_2(PO_4)_3/C$는 비정질 구조에 기인하는 선형적인 충방전 곡선을 지니고 있어 정확한 충전심도의 예측이 용이할 뿐만 아니라, 결함구조에서 유발된 리튬이온의 향상된 확산성으로 인하여 우수한 속도 특성도 나타내고 있다.

'매향' 딸기 번식을 위한 플라스틱 백 재배시 상토 물리.화학성이 모주생육과 자묘 발생에 미치는 영향 (Influence of Physico.Chemical Properties of Root Substrates on the Growth of Mother Plants and the Occurrence of Daughter Plants during the Propagation of 'Maehyang' Strawberry Using a Bag Culture System)

  • 최종명;박지영;고관달
    • 농업과학연구
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    • 제37권2호
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    • pp.191-197
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    • 2010
  • The objective of this research was to determine the influence of the physical and chemical properties of root substrates used during the production of 'Maehyang' strawberry propaguleson the growth of the mother plants and the rate of daughter plant formation. Plants were cultured in plastic bags containing six different formulations of root substrates composed of: a) 50% coir dust and 50% perlite (5:5 by volume, A), b) 60% coir dust and 40% perlite (6:4, B), c) 70% coir dust and 30% perlite (7:3, C), d) 70% coir dust and 30% coconut chip (7:3 D), e) 60% coir dust and 40% coconut chip (60:40, E), or f) 50% sphagnum peat and 50% vermiculite (50:50, F). All media formulations contained a moderate level of base fertilizers. Physical and chemical properties of each formulation were determined before plant establishment and after 120 days of stock plant culture and runner production. Total porosity (TP) and container capacity (CC) of all substrate formulations were higher than 85% and 55%, respectively, allowing a suitable range of air and water holding characteristics. Formulation F provided the highest TP and CC values among the all substrate modifications evaluated. Substrate formulations A, B, C and F had higher electrical conductivity (EC) and $NO_3{^-}$-N concentrations than formulations D and E, when determined before and after plant culture. Formulations A, B, C, and F, having higher EC readings, also performed better as root substrates thanthe formulations D and E in increasing fresh and dry weights of the runners as well as the production of daughter plants per plant. The 'Maehyang' strawberry plants grown in the formulation F had the highest tissue N content, followed by those grown in substrate B, A, C, or D for 120 days after transplanting. Formulation F also facilitated accumulation of higher tissue phosphorus (P) and copper (Cu) contents compared to other treatments. Results of this experiment suggest that the chemical properties, rather than physical properties, of root substrates had a major influence on the growth of mother plants and the occurrence of healthy daughter plants during the bag-culture phase of propagation.

통감부의 기록장악과 조선침략 (Control of Records by the Residency-General and Japanese Invasion of Joseon)

  • 이영학
    • 기록학연구
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    • 제41호
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    • pp.213-260
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    • 2014
  • 이 논문은 일제가 1905년 12월에 조선에 통감부를 설치하면서 관제를 개편하고 기록을 장악해가면서 조선을 침탈해가는 과정을 고찰한 글이다. 일제는 1906년에 통감부를 설치하여 조선의 내정권을 강화해 간 후에 관제를 개편하면서 조선의 관료제를 동원하여 조선의 실상을 파악해갔다. 관제의 개편을 통하여 현용기록과 비현용기록을 관리함으로써 조선의 실상을 정확히 파악하고, 그를 바탕으로 조선의 침략을 원활히 수행해갔던 것이다. 구체적으로는 규장각의 기록을 정리함으로써 역사기록을 파악하고, 정부의 현용기록을 장악하면서 조선 내부의 취약적인 부분을 간취하고, 다른 한편으로 '시정개선(施政改善)'이라는 명분을 내세우고 개혁을 빙자하면서 조선을 침략해들어왔던 것이다. 실제의 사례를 들면 다음과 같다. 첫째 궁내부 규장각을 장악하여 규장각에 소장하고 있었던 역사기록을 정리하는 일을 수행하였다. 2년에 걸쳐 조사사업을 수행하고 대한제국의 역사기록을 정리함으로써 조선의 역사적 흐름과 그 핵심을 파악하였다. 둘째 정부의 준현용 기록을 수집 정리하였다. 그것이 본격화한 것은 1910년 8월에 대한제국이 멸망한 후였다. 대한제국의 멸망 후 정부기록을 조선총독부 취조국에서 이관받아 정리하여 조선의 상황을 파악하고 장악해갔다. 셋째 정부와 황실 재산에 관한 문건을 대대적으로 정리하여, 황실재산 중 일부를 제외하고 국유재산으로 환원시켰다.

Imaging of Facial Nerve With 3D-DESS-WE-MRI Before Parotidectomy: Impact on Surgical Outcomes

  • Han-Sin Jeong;Yikyung Kim;Hyung-Jin Kim;Hak Jung, Kim;Eun-hye Kim;Sook-young Woo;Man Ki Chung;Young-Ik Son
    • Korean Journal of Radiology
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    • 제24권9호
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    • pp.860-870
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    • 2023
  • Objective: The intra-parotid facial nerve (FN) can be visualized using three-dimensional double-echo steady-state water-excitation sequence magnetic resonance imaging (3D-DESS-WE-MRI). However, the clinical impact of FN imaging using 3D-DESS-WE-MRI before parotidectomy has not yet been explored. We compared the clinical outcomes of parotidectomy in patients with and without preoperative 3D-DESS-WE-MRI. Materials and Methods: This prospective, non-randomized, single-institution study included 296 adult patients who underwent parotidectomy for parotid tumors, excluding superficial and mobile tumors. Preoperative evaluation with 3D-DESS-WE-MRI was performed in 122 patients, and not performed in 174 patients. FN visibility and tumor location relative to FN on 3D-DESS-WE-MRI were evaluated in 120 patients. Rates of FN palsy (FNP) and operation times were compared between patients with and without 3D-DESS-WE-MRI; propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to adjust for surgical and tumor factors. Results: The main trunk, temporofacial branch, and cervicofacial branch of the intra-parotid FN were identified using 3D-DESS-WE-MRI in approximately 97.5% (117/120), 44.2% (53/120), and 25.0% (30/120) of cases, respectively. The tumor location relative to FN, as assessed on magnetic resonance imaging, concurred with surgical findings in 90.8% (109/120) of cases. Rates of temporary and permanent FNP did not vary between patients with and without 3D-DESS-WE-MRI according to PSM (odds ratio, 2.29 [95% confidence interval {CI} 0.64-8.25] and 2.02 [95% CI: 0.32-12.90], respectively) and IPTW (odds ratio, 1.76 [95% CI: 0.19-16.75] and 1.94 [95% CI: 0.20-18.49], respectively). Conversely, operation time for surgical identification of FN was significantly shorter with 3D-DESS-WE-MRI (median, 25 vs. 35 min for PSM and 25 vs. 30 min for IPTW, P < 0.001). Conclusion: Preoperative FN imaging with 3D-DESS-WE-MRI facilitated anatomical identification of FN and its relationship to the tumor during parotidectomy. This modality reduced operation time for FN identification, but did not significantly affect postoperative FNP rates.

Yohimbine이 가토두개내압상승(家兎頭蓋內壓上昇)에 따른 혈압상승(血壓上昇)에 미치는 영향(影響) (Effects of Yohimbine on the Pressor Response to Raised Intracranial Pressure in Rabbits)

  • 김종문
    • 대한약리학회지
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    • 제19권1호
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    • pp.123-131
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    • 1983
  • 1) Urethane 마취가토(痲醉家兎)에서 경뇌막외강내(硬腦膜外腔內)에 삽입(揷入)한 balloon을 통(通)한 가압(加壓) 및 두개내압기종방법(頭蓋內壓記種方法)에 의하여 내압(內壓)을 상승(上昇)시키고, 이 내압상승(內壓上昇)에 따른 혈압상승(血壓上昇)에 미치는 ${\alpha}_2-adrenoceptor$ antagonist인 yohimbine의 영향(影響)을 관찰(觀察)하였다. 2) 내압(內壓)은 가압(加壓)balloon 내(內) 식염수주입(食鹽水注入)으로 주입초기(注入初期) 에는 완만(緩慢)하게 그 후 점차(漸次) 급격(急激)하게 상승(上昇)하였다. 이에 따라 혈압(血壓)은 처음에 경미(輕微)한 하강경향(下降傾向)을 보인 후 급격(急激)하게 상승(上昇)하였고, 더욱 내압(內壓)을 상승(上昇)시키면 혈압(血壓)은 심(甚)한 하강(下降)을 보였다. 최고혈압상승정도(最高血壓上昇程度)는 원혈압(元血壓)의 $49{\pm}2.4%$(32예(例) 평균(平均)${\pm}SE)$의 증가(增加)였으며, 이때에 가압(加壓)balloon 내(內)로 주입(注入)된 식염수양(食鹽水量)은 $1.22{\pm}0.15\;ml$, 내압(內壓)은 $165{\pm}6.4\;mmHg$였다. 3) 측뇌실내(側腦室內) yohimbine$(50{\mu}g)$은 혈압자체(血壓自體) 영향(影響)을 미치지 못하였으나, 본양(本量)의 yohimbine 투여후(投與後)에는 가압(加壓)balloon내(內)에 대조동물(對照動物)에서보다 훨씬 적은 양(量)의 식염수주입(食鹽水注入)으로 내압(內壓) 및 혈압(血壓)이 상승(上昇)하였다. 즉(卽) 최고혈압상승(最高血壓上昇) (6예평균(例平均, $57{\pm}4.5%)$이 나타날 때의 가압(加壓)balloon 내(內)에 주입된 식염수양(食鹽水量)은 $0.83{\pm}0.02\;ml$, 내압(內壓)은 $164{\pm}9.6\;mmHg$였다. 4) $Clonidine(30\;{\mu}g)$의 측뇌실내(側腦室內) 주입후(注入後) 혈압자체(血壓自體)는 하강(下降)되었고 이때 가압(加壓)balloon 내 식염수주입(食鹽水注入)에 의한 내압상승(內壓上昇)은 대조군(對照郡)보다 순화(純化)되었으며 혈압상승(血壓上昇)은 거의 볼 수 없었다. 5) $Clonidine(30\;{\mu}g)$투여(投與)로 하강(下降)된 혈압(血壓)은 $yohimbine(500\;{\mu}g)$투여(投與)로 거의 원혈압(原血壓)으로 회복(回復)되었고, 이때 내압(內壓)을 상승(上昇)시키면 대조군(對照郡)에서와 같은 내압상승(內壓上昇)에 따른 혈압상승(血壓上昇)이 나타났다. 6) 본실험(本實驗) 성적(成績)은 가토(家兎)에서 ${\alpha}_2-adrenoceptor$ antagonist가 뇌(腦)에 존재(存在)할 때는 두개뇌압상승(頭蓋腦壓上昇)에 따른 혈압상승(血壓上昇)이 촉진(促進)되고 또한 ${\alpha}_2-adrenoceptor\;agonist$에 의한 두개뇌압상승(頭蓋腦壓上昇)에 따른 혈압상승(血壓上昇)의 억제(抑制)가 나타나지 않음을 가리키고 있다.

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Himawari-8 정지궤도 위성 영상을 활용한 딥러닝 기반 산불 탐지의 효율적 방안 제시 (Efficient Deep Learning Approaches for Active Fire Detection Using Himawari-8 Geostationary Satellite Images)

  • 이시현;강유진;성태준;임정호
    • 대한원격탐사학회지
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    • 제39권5_3호
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    • pp.979-995
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    • 2023
  • 산불은 예측이 어려운 재해이기 때문에 실시간 모니터링을 통해 빠르게 대응하는 것이 중요하며, 정지 궤도 위성 영상은 광역을 짧은 시간 간격으로 모니터링할 수 있어 산불 탐지 분야에 활발히 이용되고 있다. 기존의 위성 영상 기반 산불 탐지 알고리즘은 밝기 온도의 통계량 분석을 통한 임계값 기반으로 이상치를 탐지하는 방향으로 진행되어 왔다. 그러나 강도가 약한 산불을 탐지하기 어렵거나, 적절한 임계값 설정의 어려움으로 일반화 성능이 저하되는 한계점이 있어 최근에는 기계학습을 이용한 산불 탐지 알고리즘들이 제시되고 있다. 현재까지는 random forest, VanillaConvolutional neural network (CNN), U-net 구조 등의 비교적 간단한 기법이 적용되고 있다. 따라서, 본 연구에서는 정지궤도 위성인 Advanced Himawari Imager를 이용하여 동아시아와 호주를 대상으로 State of the Art (SOTA)딥러닝 기법을 적용한 산불 탐지 알고리즘을 개발하고자 하였다. SOTA 모델은 EfficientNet과 lion optimizer를 적용하여 개발하고, Vanilla CNN 구조를 사용한 모델과 산불 탐지 결과를 비교하였다. EfficientNet은 동아시아와 호주에서 0.88 및 0.83의 F1-score를 기록함으로써 CNN (동아시아: 0.83, 호주: 0.78)에 비해 뛰어난 성능을 입증하였다. EfficientNet에 불균형 문제 해결을 위한 weighted loss, equal sampling, image augmentation 기법 적용 시, 동아시아와 호주에서 각각 0.92와 0.84의 F1-score를 기록함으로써 적용 전(동아시아: 0.88, 호주: 0.83)에 비하여 성능이 향상되었음을 확인하였다. 본 연구를 통하여 제시된 SOTA 딥러닝 기법의 산불 탐지에의 적용 가능성과 딥러닝 모델의 성능 향상을 위해 고려해야 할 방향은 향후 산불탐지 분야에 대한 딥러닝 적용에 도움이 될 것으로 기대된다.

조직.기관의 분화와 유전자 발현의 조절, 최근의 진보 (Recent Advancement in the Differentiation of Tissues and Organs and Regulation of Gene Expression)

  • Harn, Chang-Yawl
    • 식물조직배양학회지
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    • 제24권1호
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    • pp.1-35
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    • 1997
  • Fertilized egg, by successive cell divisions, differentiates into different tissues and organs with various structures and functions. Different cells and tissues contain different proteins, products of selective gene expression. Not all the genes in any genomes are equally active, temporal and spatial gene expression being the general rule. Present paper attempts to review the tanscriptional mechanisms or the initiations of transcription from several angles. In some of the organisms the genes in the process of transcription or the genes in the inactive state can be seen under the light microscope. Some bands of Drosophila polytene chromosomes may exhibit a swollen or puff appearance under certain conditions. A puff, unfolded or decondensed form of chromomere, represents sets of intense transcriptional activity or RNA synthesis. The heterochromatic X chromosome whose genes remain inactive in the female mammals can be visualized as a dark staining structure called Barr body, Configuration of chromatin differs between transcribed and nontranscribed chromatin. Modification to the chromatin facilitates RNA synthesis. The movement of large polymerase molecule along the DNA would probably be facilitated if some modifications of the chromatin configuration is effected. Methylation of cytosines in CG sequences is associated with inactive genes. Methylation can play a role in determination of mammalian cells during embryogenesis. Demethylation is necessary for the gene to be expressed during development A histone modification that is also known to be correlated with transcriptional capacity of chromatin is acetylation of the lysine residues of the core histones. Chromatin containing a high level of histone acetylation is very sensitive to DNase 1. For the transcription to occur TBP must first bind to the TATA box. Another TF, TF IIB, then binds to the promoter-TBP complex, facilitating the access of RNA polymerase to the transcription initiation site. As recently as eight years ago researchers assumed that histones were irrelevant to the regulation of gene expression. Histones combine with the DNA to form nucleosome of the chromatin. Histones are vital participant in gene regulation. Histone and basal factors compete for access to TATA box. When DNA is exposed to basal factors before histones are introduced, the basal factors assemble on TATA boxes preventing the access of histones, allowing transcription to occur, for transcription to begin, activator protein at the upstream activation sequence or enhancer must interact with the tail of histone H4 at TATA box and cause the histone role particle to dissociate from the TATA box leading to partial breakup of the histone core particle and allowing the basal factors to bind to the TATA box. New concept of genomic flux in contrast to the old concept of static genome has been developed based on the powerful new molecular techniques. Genomic changes such as repetitive DNAs and transposable elements, it is assumed but not yet proved, may affect some of the developmental patterns that characterize particular cells, tissues, organs, and organisms. In the last decade or so remarkable achievement have been made in the researches of the structures and functions of TFs and the specific target sequences located in promoters or enhancers where these TFs bind. TFs have independent domains that bind DNA and that activate transcription. DNA binding domain of TFs serves to bring the protein into the right location. There are many types of DNA binding domains. Common types of motifs can be found that are responsible for binding to DNA. The motifs are usually quite short and comprise only a small part of the protein structure. Steroid receptors have domains for hormone binding, DNA binding, and activating transcription. The zinc finger motif comprises a DNA binding domain. Leucine zipper consist of a stretch of amino acids with a leucine residue in every seventh position Two proteins form a dimer because they interact by means of leucine zippers on similar α-helical domain. This positions their DNA binding basic domains for interaction with the two halves of a DNA sequence with dyad symmetry of TGACTCA, ACTGAGT.

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