• The Korean Journal of Pharmacology
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• v.11 no.2
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• pp.41-46
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• 1975

The isolated strips of tortoise intestine are evaluated as a test organ for bioassay of prostaglandin $E_1$. This preparation responded highly sensitively to $PGE_1$ and $PGE_2$ in picogram concentration range. The mean slope and the value of precision index among the doses of 0.1, 0.3 and 0.5ng/ml in final concentration were 37.7 and 0.143, respectively. And this was relatively insensitive to different prostaglandins; $E_1/E_2{\gtrsim}1$, $E_1/A_2{\sim}50$ and $E_1/F_{2\alpha}{\sim}100$, and showed the dual responses to 5-hydroxytryptamine and histamine; initial contraction followed by relaxation. The dose-ratio inducing the relative equal contraction height for $PGE_1$, acetylcholine, caerulein, angiotensin and barium chloride was 0.4 : 50 : 25 : 10 : 100 in this order. These results suggest that the intestinal strips of the tortoise are suitable for bioassay of prostaglandin $E_1$ and $E_2$ between the doses of 0.1 and 1.0 ng/ml level in the tissue extracts.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.1
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• pp.51-57
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• 2010

It was hypothesized that NaF induces calcium sensitization in $Ca^{2+}$-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with $\beta$-escin and subjected to tension measurement. NaF potentiated the concentration-response curves to $Ca^{2+}$ (decreased $EC_{50}$ and increased $E_{max}$). Cumulative addition of NaF (4.0, 8.0 and 16 mM) also increased vascular tension in $Ca^{2+}$-controlled solution at pCa 7.0 or pCa 6.5, but not at pCa 8.0. NaF-induced vasocontraction and $GTP{\gamma}S$-induced vasocontraction were not additive. NaF-induced vasocontraction at pCa 7.0 was inhibited by pretreatment with Rho kinase inhibitors H1152 or Y27632 but not with a MLCK inhibitor ML-7 or a PKC inhibitor Ro31-8220. NaF induces calcium sensitization in a $Ca^{2+}$ dependent manner in $\beta$-escin-permeabilized rat mesenteric arteries. These results suggest that NaF is an activator of the Rho kinase signaling pathway during vascular contraction.

• Bulletin of the Korean Mathematical Society
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• v.45 no.4
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• pp.717-728
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• 2008

Let H be a real Hilbert space and S = {T(s) : $0\;{\leq}\;s\;<\;{\infty}$} be a nonexpansive semigroup on H such that $F(S)\;{\neq}\;{\emptyset}$ For a contraction f with coefficient 0 < $\alpha$ < 1, a strongly positive bounded linear operator A with coefficient $\bar{\gamma}$ > 0. Let 0 < $\gamma$ < $\frac{\bar{\gamma}}{\alpha}$. It is proved that the sequences {$x_t$} and {$x_n$} generated by the iterative method $$x_t\;=\;t{\gamma}f(x_t)\;+\;(I\;-\;tA){\frac{1}{{\lambda}_t}}\;{\int_0}^{{\lambda}_t}\;T(s){x_t}ds,$$ and $$x_{n+1}\;=\;{\alpha}_n{\gamma}f(x_n)\;+\;(I\;-\;{\alpha}_nA)\frac{1}{t_n}\;{\int_0}^{t_n}\;T(s){x_n}ds,$$ where {t}, {${\alpha}_n$} $\subset$ (0, 1) and {${\lambda}_t$}, {$t_n$} are positive real divergent sequences, converges strongly to a common fixed point $\tilde{x}\;{\in}\;F(S)$ which solves the variational inequality $\langle({\gamma}f\;-\;A)\tilde{x},\;x\;-\;\tilde{x}{\rangle}\;{\leq}\;0$ for $x\;{\in}\;F(S)$.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.2
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• pp.193-199
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• 1998

To elucidate the mechanism involved in the cerebral vascular spasm following subarachnoid hemorrhage (SAH), the effects of the cerebrospinal fluid (CSF) obtained from the SAH patients on the resting tension and its influence on the contractile responses to various vasoactive agents and to hypoxia were investigated in isolated porcine cerebral arteries. All the CSFs containing hemoglobin (Hb) produced contraction and some Hb-free CSFs also elicited contraction. When the Hb-free CSF was separated by microfilter, the filtrate of ＜30,000 MW did not produce contraction, while the fraction above 30,000 MW elicited more marked contractile responses than the unfractionated CSF. The CSF contraction was significantly attenuated in the presence of indomethacin or nimodipine, whereas the contractions induced by KCl, prostaglandin $F_{2{\alpha}}$ ($PGF_{2{\alpha}}$), or endothelin-1 (ET-1) were not affected by the CSF pretreatment. However, the contractile responses induced by 5-hydroxytryptamine (5-HT) and phenylephrine (PE) were markedly potentiated by the pretreatment. Hypoxia-induced vasoconstriction was significantly potentiated by the pretreatment with either unfractionated CSF or the CSF fraction of above 30,000 MW. These results suggest that unknown vasocontractile substance(s) exists in the Hb-free CSF and that the substance, with its MW above 30,000, is activated by hypoxia and acts synergistically with 5-HT and PE, and that extracellular calcium influx and cyclooxygenase are also involved in the cerebral vasoconstrictory effect of Hb-free CSF.

• Physical Therapy Korea
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• v.29 no.4
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• pp.269-273
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• 2022

Background: Neuromuscular electrical stimulation (NMES) is used for muscle strengthening. While voluntary muscle contraction follows Henneman et al.'s size principle, the NMES-induced muscle training disrespects the neurophysiology, which may lead to unwanted changes (i.e., declined balance ability). Objects: We examined how the balance was affected by abdominal muscle training with the NMES. Methods: Fifteen young adults (10 males and 5 females) aged between 21 and 30 received abdominal muscle strengthening with NMES for 23 minutes. Before and after the training, participants' balance was measured through one leg standing on a force plate with eyes open or closed. Outcome variables included mean distance (MDIST), root mean square distance (RDIST), total excursion (TOTEX), mean velocity (MVELO), and 95% confidence circle area (AREA) of center of pressure data. Two-way repeated measures analysis of variance was used to test if these outcome variables were associated with time (pre and post) and vision. Results: All outcome variables were not associated with time (p > 0.05). However, all outcome variables were associated with vision (p = 0.0001), and MVELO and TOTEX were 52.4% (45.5 mm/s versus 95.6 mm/s) and 52.4% (364.1 mm versus 764.5 mm) smaller, respectively, in eyes open than eyes closed (F = 55.8, p = 0.0005; F = 55.8, p = 0.0005). Furthermore, there was no interaction between time and vision (F = 0.024, p = 0.877). Conclusion: Despite the different neurophysiology of muscle contraction, abdominal muscle strengthening with NMES did not affect balance.

• Journal of the korean academy of Pediatric Dentistry
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• v.33 no.4
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• pp.606-614
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• 2006

The purpose of this study was to evaluate the polymerization contraction of composite resin(Tetric $ceram^{(R)}$, Ivoclar Vivadent Liechtenstein) according to various liners(Tetric $flow^{(R)}$, Ivoclar Vivadent, Liechtenstein/$Ionosit^{(R)}$, DMG, German/ $Vitrebond,^{TM}$ 3M-ESPE, USA). The strain gauge method was used for measurement of polymerization shrinkage strain. Specimens were divided by 8 groups according to curing units and liners. Group A, E: Tetric $ceram^{(R)}$ bulk filing, Group B, F: Tetric $flow^{(R)}$ lining, Tetric $ceram^{(R)}$ filling, Group C, G: $Ionosit^{(R)}$ lining, Tetric $ceram^{(R)}$ filling, Group D, H: $Vitrebond^{TM}$ lining, Tetric $ceram^{(R)}$ filling. Group A, B, C and D were cured using the conventional halogen light($XL3000^{TM}$ 3M ESPE, USA) for 40 seconds at $400mW/cm^2$. Group E, F G and H were cured using light emitted diode(LED) light(Elipar Freelight $2^{TM}$, 3M-ESPE, USA) for 15 seconds at 800 $mW/cm^2$. Strain gauge attached to each sample was connected to a strainmeter. Measurements were recorded at each second for the total of 750 seconds including the periods of light application. Obtained data were analyzed statistically using Repeated measures ANOVA and Tukey test. The results of this were as follows : 1. Contraction stresses in flowable resin and glass ionomer lining group were lower than that in compomer lining group(p<0.05). 2, Contraction stresses in LED curing light groups were higher than that in halogen curing light groups, but there was no significant difference (p>0.05).

• Bulletin of the Korean Mathematical Society
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• v.49 no.3
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• pp.481-493
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• 2012

Let $S$ be a upper triangular operator such that $M^L_S:\mathcal{U}_2{\rightarrow}\mathcal{U}_2$ defined by $M^L_S(F)=SF$ is a contraction. Then there exists an unitary linear system whose state space is the extension space $\tilde{D}_L$(S) associated with $\mathcal{H}_L$(S).

• Nonlinear Functional Analysis and Applications
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• v.27 no.2
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• pp.233-247
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• 2022

In the present manuscript, we employ the concepts of Θ-map and Φ-map to define a strong (𝜃, 𝜙)s-contraction of a map f in a b-metric space (M, d_b). Then we prove and derive many fixed point theorems as well as we provide an example to support our main result. Moreover, we utilize our results to obtain many results in the settings of metric and G-metric spaces. Our results improve and modify many results in the literature.

• Journal of the military operations research society of Korea
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• v.8 no.1
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• pp.77-98
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• 1982

Experiments have been performed for estimating the individual muscle capabilities of the biceps brachii and the quadriceps femoris muscle. The surface EMG has been recorded on the bellies of the biceps brachii and the quadriceps femoris muscle during isometric contractions at $50\%,\;75\%,\;and\;100\%$ MVC. The rectified EMG amplitudes of the maximum voluntary contraction (MVC) were in the range of $2.8\~3.0\;mV\;and\;6.9\~7.2\;mV$ the biceps brachii and the quadriceps femoris, respectively. In the biceps brachii, Type S motor units were recruited in the range of $41\~49\%$ MVC; and Type F motor units were recruited in the range of $51\~59\%$ MVC, In the quadriceps femoris, Type S, Type SF, and Type F motor units were recruited in the ranges of $31\~38\%,\;33\~48\%$, and $21\~29\%$ MVC respectively.

• Journal of Korean Institute of Industrial Engineers
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• v.5 no.2
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• pp.21-36
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• 1979

Static muscle contractions when prolonged or frequently repeated result in discomfort, fatigue, and musculosketal injuries. An analytic and quantitative model has been developed in order to expand the working knowledge on muscle fatigue. In this paper, three Markov models of muscle fatigue are developed. These models are based on motor unit fatigue-recovery characteristics obtained from information on motor unit behavior as it relates to fatigue and graded exertions. Three successively more realistic models are developed that involve: (1) homogeneous motor units with intensity-dependent fatigue rates and state-independent recovery rates (the HMSI model); (2) homogeneous motor units, intensity-dependent fatigue rates and state-dependent recovery rates (the HMSD model); and (3) non-homogeneous motor units (i.e., Type S and Type F), intensity-dependent fatigue rates and state-dependent recovery rates (the HMSD model). The result indicate that a simple stochastic model provide a means to analyze the complex nature of muscle fatigue in sequential static exertions.