• Journal of The Korean Association of Information Education
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• v.15 no.4
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• pp.525-531
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• 2011

This study is about the system for knowledge management in the Wiki-based project learning. We implement the Wiki-based project learning system which is focused on a new Web paradigm and technology development to grasp the knowledge flow of a learner effectively under a project learning condition. Implementation of the system has used a Web 2.0 technology to easily understand SECI Knowledge Management types which form the Externalization, Combination and Internalization steps. Moreover, the system structure has been designed instinctively for harmonious knowledge use or reuse. As a result of the experiment, we found out that the collaborative knowledge steps moved along the flow of project learning.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4223-4231
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• 2016

Background: Development of new apoptosis-inducing drugs is a promising trend in anticancer therapy. For this purpose several formamidinoderivatives of doxorubicin were synthesized. The aim of our study was to investigate effects of the five formamidinodoxorubicins in the ES-2 human ovarian clear cell carcinoma line, for comparison with data obtained previously for SKOV-3 human ovarian adenocarcinoma cells, to answer the question of whether and to what extent the histological cell type is a possible determinant of sensitivity to tested anthracyclines. Materials and Methods: In our experimental work the following methods were used: spectrophotometric assays with MTT; fluorimetric assays - double staining with Hoechst 33258 and propidium iodide (PI), measurement of caspase-3, -8, -9 activity, intracellular accumulation of DOX and analogues, estimation of drug uptake, mitochondrial transmembrane potential; flow cytometry - phosphatidylserine (PS) externalization with annexin V-FITC and PI fluorochromes. Results: Effects of the derivatives of doxorubicin were partially linked with the specific type of cancer cell although intracellular accumulation and cellular uptake of DOX and derivatives were similar in both. All of the investigated derivatives were considerably more cytotoxic than DOX. Formamidinodoxorubicins were able to induce caspase-dependent apoptotic cell death in both cell types. Conclusions: All new formamidine derivatives of DOX were able to induce caspase - dependent apoptosis in human ovarian cancer cell lines SKOV-3 and ES-2. Obtained results suggested that formamidine derivatives of DOX may be promising candidates for the prospective chemotherapeutic agents for the two different histological subtypes of ovarian cancer.

• Anxiety and mood
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• v.10 no.2
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• pp.157-162
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• 2014

Objective : This study was conducted to evaluate the validity of the Korean Inventory of Interpersonal Problems (K-IIP) with Psychopathic Personality Inventory-Revised (PPI-R) to assess interpersonal problems in Korean criminal offenders with schizophrenia. Methods : The sample consisted of 187 inpatients with schizophrenia who had committed crimes. All participants filled out self-report questionnaires ofPPI-R and K-IIP. Results : The result showed that all scales of K-IIP were correlated highly with the PPI-R total score (r range=0.25-0.65). Correlations with K-IIP scales were highest for Blame Externalization, Rebellious Nonconformity, and Machiavellian Egocentricity scales (r range=0.50-0.66, 0.43-0.64, 0.39-0.58, respectively). All scales of K-IIP exhibited a negative correlation with Social Influences, Stress Immunity, Coldheartedness (C) scale ofPPI-R. Cold/Distant scale ofK-IIP was not correlated with C scale of PPI-R. All scales of K-IIP was highly correlated with PPI-R-factor-2 (r range=0.44-0.71) and negatively correlated with PPI-R-factor-l (r range=-0.03-0.38). Conclusions : Despite of strong correlation between PPI-R total score and K-IIP total score, K-IIP was not correlated with PPI-R-I that represents affective and interpersonal deficits. It suggests K-IIP may not proper for measuring the interpersonal problems of criminal offenders with schizophrenia. It will be needed other assessment scale for measuring the interpersonal problems of psychopathy in criminal schizophrenia.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3281-3287
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• 2016

Bioactive compounds extracted from leaves and twigs of Goniothalamus griffithii include pinocembrin (PCN) and goniothalamin (GTN). The objectives of this study were to investigate the cytotoxic activities of PCN and GTN and their influence on molecular signaling for cell death in several human cancer cell lines compared to normal murine fibroblast NIH3T3 cells. GTN exhibited the most potent cytotoxicity against MCF-7 > HeLa > HepG2 > NIH3T3 cells with $IC_{50}$ values of 7.33, 14.8, 37.1 and $65.4{\mu}M$, respectively, whereas PCN was cytotoxic only to HepG2 cells with $IC_{50}$ values of ${\sim}80{\mu}M$. Apoptotic cell death was confirmed by staining the cells with annexin V-FITC and propidium iodide (PI) employing flow cytometry. Apoptosis was shown by externalization of phosphatidylserine in goniothalamin-treated MCF-7 cells in a dose response manner. Positive PI-stained cells with the typical morphology of apoptotic cells were increased dose-dependently. Furthermore, reduction of mitochondrial transmembrane potential was found in goniothalamin-treated MCF-7, HepG2 and HeLa cells. GTN treatment in MCF-7 increased caspase-3, -8 and -9 activities while GTN-induced HeLa cells showed an increase of both caspase-3 and -9 activities. But an increased caspase-8 activity was demonstrated in GTN- and PCN-treated MCF-7 and HepG2 cells, respectively. Taken together, GTN- and PCN-induced human cancer cell apoptosis was through different molecular mechanisms or signaling pathways, which might be due to different machineries in different types of cancer cells, as evidenced by the compound-modulated caspase activities in both intrinsic and/or extrinsic pathways.

• Informatization Policy
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• v.23 no.2
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• pp.3-18
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• 2016

Radical paradigm shift is being expected due to the coming of the so-called intelligent society. In the intelligent society, things or machines are able to use intelligence for the first time in history and this will bring about fundamental changes at every corner of human society. This article analyzes views of the world in order to figure out basic directions of this paradigm shift. A dualistic view of world mediated by technology is suggested for a new world view of the intelligent society, based on comparison of a traditional dualistic view of world between human-nature and a tripartite view of world between human-machine-nature. This article summarizes paradigms of the intelligent society into four ; externalization of intelligence, productivity explosion, platform society, and self-organizing society. These new paradigms will provide lots of benefits such as intelligence augmentation, production capacity increase, and self-organizing effect. But at the same time, it will increase risks of system failure because of loss of human control on technologies. In conclusion, it is argued that human choices and efforts will decide the future of the intelligent society becuase the paradigm shift is value neutral in essence.

• The Journal of the Korea Contents Association
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• v.15 no.6
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• pp.191-202
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• 2015

This research aims to analyse gender identity and its internal meanings through the main character, Laurence, of the movie (2012) directed by French-Canadian film maker Xavier Dolan. Study examines performative gender identity revealed through the fashion images of Laurence who was born biologically as a man; depending on a theory of Judith Butler who represented a parody, repeatability action, and incorporation as an effect of gender identity. Also 'Internalization of others' and 'Dis-identification' are presented as an internal meanings of Laurence's gender identity which appeared on his(her) fashion images. Laurence parodies woman's fashion styles in repetition to obtain feminity as his(her) appearance. His(her) repetitive actions are construing an internalizing others(women) and visualizing a new-self to become a stylized doer. Dis-identification signifies that gender can be reconstructed regarding the differences of the place and the time and reconstructed outside can be analyzed as externalization of internalization. 'Becoming a woman' means more than what it sounds like to Laurence. It means a new signification of being a woman or redefining gender identity. That is something can be called a genuine transformation and a grant leap for Laurence.

• Parasites, Hosts and Diseases
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• v.49 no.1
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• pp.17-23
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• 2011

The aim of this study was to assess the cytotoxic effects of various concentrations of miltefosine on Leishmania major (MRHO/IR/75/ER) and L. tropica (MHOM/IR/02/Mash10) promastigotes and to observe the programmed cell death features. The colorimetric MTT assay was used to find L. major and L. tropica viability and the obtained results were expressed as 50% inhibitory concentration (IC50). Also, 50% effective doses (ED50) for L. major and L. tropica amastigotes were also determined, Annexin-V FLUOS staining was performed to study the cell death properties of miltefosine using FAGS analysis. Qualitative analysis of the total genomic DNA fragmentation was performed by agarose gel electrophoresis. Furthermore, to observe changes in cell morphology, promastigotes were examined using light microscopy. In both strains of L. major and L. tropica, miltefosine induced dose-dependent death with features of apoptosis, including cell shrinkage, DNA laddering, and externalization of phosphatidylserine. The IC50 was achieved at 22 ${\mu}M$ and 11 ${\mu}M$ for L. major and L. tropica after 48 hr of incubation, respectively. ED50 of L. major and L. tropica amastigotes were 5.7 ${\mu}M$ and 4.2 ${\mu}M$, respectively. Our results indicate that miltefosine induces apoptosis of the causative agent of cutaneous leishmaniasis in a dose-dependent manner. Interestingly, L. major did not display any apoptotic changes when it was exposed to miltefosine in concentrations sufficient to kill L. tropica.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.21 no.1
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• pp.37-44
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• 2010

Objectives ： The purpose of this study was to evaluate gender differences with respect to the internalization or externalization of symptoms according to the amount of time spent engaged in extracurricular education. Methods ： The study included a community sample of 755 boys and girls (mean age, 6.6 years), collected from five elementary schools in Gunpo, South Korea. Primary caregivers completed a questionnaire which included information on demographics, the amounts of time children spent in extracurricular education and with other activities, and an adapted form of the Behavior Assessment System for Children (BASC-2). Gender differences regarding externalizing and internalizing behavior problems were examined according to extracurricular education. Results ： With respect to the boys, there was a difference in the frequency of those who had externalizing behavior problems according to their time spent in extracurricular education. In contrast, the girls exhibited no difference. With respect to those children who spent a lot of time engaged in extracurricular education, there was a gender-specific difference only with respect to externalizing behavior problems. Conclusion ： A gender-specific difference exists only in terms of externalizing behavior problems according to time spent engaged in extracurricular education.

• Journal of Convergence for Information Technology
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• v.10 no.3
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• pp.176-184
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• 2020

The purpose of this study was to investigate whether group play therapy is effective in reducing problem behaviors of children with developmental disabilities. The subjects of study were in special schools and 5 children with disabilities using short-term care centers for the disabled, The research period was 12 sessions of 40 minutes twice a week using winter vacation from January 2, 2018 to January 28, The measuring tool, K-CBCL, was used to observe behavioral changes qualitatively. The summary of this study is as follows. First, children with disabilities significantly reduced their aggressiveness, atrophy, depression, and anxiety, and increased their activity during each session. Second, problem behaviors decreased after the intervention of group play therapy, and there were more decreases in internalization problems than externalization problems. The results of this study suggest that group play therapy is meaningful in reducing problem behavior according to the individual characteristics of children with disabilities.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.4
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• pp.154-160
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• 2021

Objectives: This study identified the association between excessive exposure to screen media and behavioral and emotional problems in elementary school students. Methods: A total of 331 parents of children aged 7-10 years were recruited from "The Kids Cohort for Understanding of Internet Addiction Risk Factors in Early Childhood (K-CURE)" study. Children's demographics, household media ownership, screen time, and behavioral/emotional problems were assessed using a parental questionnaire. Children's behavior/emotional problems were measured using the Korean version the of Child Behavior Checklist (K-CBCL) score. Results: The total K-CBCL score in the screen overuse group was 51.18±9.55, significantly higher than 47.28±10.09 in the control group (t=2.14, p=0.05). For each subscale, the externalization score (51.65±10.14, 48.33±8.97, respectively; t=2.02, p<0.05), social problem score (55.41±6.11, 53.24±5.19, respectively; t=2.27, p<0.05), and rule breaking behavior score (55.71±6.11, 53.24±5.19, respectively; t=2.27, p<0.05) were significantly higher in the screen overuse group than in the control group. In addition, the screen overuse group also had a significantly higher usage rate than the control group, even if limited to smartphones, not only on weekdays (3.56±2.08, 1.87±2.02, respectively; t=-4.597, p<0.001) but also weekends (1.62±0.74, 1.19±0.83, respectively; t=-3.14, p=0.003). Conclusion: The study suggested that screen media overuse patterns in children in Korea are particularly relevant to the excessive use of smartphones and are related to higher risks of emotional and behavioral problems.