• Current Optics and Photonics
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• 제5권3호
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• pp.278-288
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• 2021

We propose a characterization method for the scattering property of microspheres using spectroscopic optical coherence tomography (OCT). To prove the effectiveness of the proposed method, we prepare solutions of different concentrations using microspheres ranging from 28 to 2300 nm in diameter. Time-frequency analysis is performed on the measured interference spectrum of each solution, and the resulting spectroscopic information is converted into histograms for centroid wavelengths. The histograms present a very sensitive response to changes in the concentration and size of microspheres. We classify them into three categories according to their characteristics. When the histogram of each category is replaced with the corresponding calculated value of the scattering coefficient, each category is mapped to a different scattering-coefficient region. It is expected that the proposed method could be used to investigate the optical characteristics of a biological sample from OCT images, which would be helpful for optical diagnostic and therapeutic applications.

• 천문학회보
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• 제45권1호
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• pp.45.2-46
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• 2020

Various processes, such as space weathering and granular convection, are occurring on asteroids' surfaces. Estimation of the surface exposure timescale is essential for understanding these processes. The Hayabusa mission target asteroid, (25143) Itokawa (Sq-type) is the only asteroid whose age is estimated from remote sensing observations as well as sample analyses in laboratories. There is, however, an unignorable discrepancy between the timescale derived from these different techniques. The ages estimated based on the solar flare track density and the weathered rim thickness of regolith samples range between 102 and 104 years [1][2]. On the contrary, the ages estimated from the crater size distributions and the spectra cover from 106 to 107 years [3][4]. It is important to notice that there is a common drawback of both age estimation methods. Since the evidence of regolith migration is found on the surface of Itokawa [5], the surficial particles would be rejuvenated by granular convection. At the same time, it is expected that the erasure of craters by regolith migration would affect the crater size distribution. We propose a new technique to estimate surface exposure age, focusing on the bright mottles on the large boulders. Our technique is less prone to the granular convection. These mottles are expected to be formed by impacts of mm to cm-sized interplanetary particles. Together with the well-known flux model of interplanetary dust particles (e.g., Grün, 1985 [6]), we have investigated the timescale to form such mottles before they become dark materials again by the space weathering. In this work, we used three AMICA (Asteroid Multi-band Imaging Camera) v-band images. These images were taken on 2005 November 12 during the close approach to the asteroid. As a result, we found the surface exposure timescales of these boulders are an order of 106 years. In this meeting, we will introduce our data analysis technique and evaluate the consistency among previous research for a better understanding of the evolution of this near-Earth asteroid.

• 한국응용과학기술학회지
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• 제36권2호
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• pp.592-599
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• 2019

This study is to stabilize insoluble and unstable active ingredient which is Idebenone (INCI name: hydroxydecyl ubiquinone) in a multi-lamellar vesicle (MLV) and to stabilize it in the skin care cosmetics. Idebenone is good effective raw material in the treatment of Alzheimer's disease in the medical field and a powerful antioxidant in dermatology. It is well known as a substance that inhibits the formation of melanin and cleans the skin pigment. However, it did not dissolve in any solvent and it was difficult to apply in cosmetic applications. Niosome vesicle was able to develop a nano-particle by making a multi-layer of idebenone encapsulated with a nonionic surfactant, hydrogenated lecithin and glycine soja (soybean) sterols and passing it through a high pressure microfluidizer. Idebenone niosome vesicle (INV) has been developed to have the ability to dissolve transparently in water and to promote transdermal penetration. The appearance of the INV was a yellowish liquid having specific odor, and the particle size distribution of INV was about 10~80 nm. The pH was 5~8 (mean=6.8). This capsulation with idebenone was stored in a $45^{\circ}C$ incubator for 3 months and its stability was observed and quantitatively measured by HPLC. As a result, the stability of the sample encapsulated in the niosome vesicle (97.5%) was about 66.3% higher than that of the non-capsule sample of 32.5%. Idebenone 1% INV was used for the efficacy test and clinical trial evaluation as follows. The anti-oxidative activity of INV was 38.2%, which was superior to that of 12.8% tocopherol (control). The melanin-reducing effect of B16 melanoma cells was better than INV (17.4%) and Albutin (control) (9.6%). Pro-collagen synthesis rate was 128.2% for INV and 89.3% for tocopherol (control). The skin moisturizing effect was 15.5% better than the placebo sample. The elasticity effect was 9.7% better than the placebo sample. As an application field, INV containing 1% of idebenone is expected to be able to develop various functional cosmetic formulations such as skin toner, ampoule essence, cream, eye cream and sunblock cream. In addition, it is expected that this encapsulated material will be widely applicable to emulsifying agents for skin use in the pharmaceutical industry as well as the cosmetics industry.

• Journal of the Korean Data and Information Science Society
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• 제20권6호
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• pp.1103-1118
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• 2009

유한모집단의 평균 또는 합계를 추정하고자 하는 경우 모집단 단위들의 배열순서는 중요한 의미를 갖는다. 본 논문에서는 표집률의 역수가 짝수이고 표본 크기가 홀수인 경우 선형추세를 갖는 모집단의 평균 또는 합계를 추정하기 위한 두 가지의 방법을 제시하였다. 첫째 방법은 Singh 등(1968)의 변형계통표집을 일반화한 방법으로 표본을 뽑은 뒤, 추정량을 정하는 과정에서 보간법을 사용한 것이며, 둘째 방법은 변형계통표집으로 표본을 뽑은 뒤, 회귀추정법으로 모수를 추정하는 것이다. Cochran (1946)의 무한초모집단 모형에 근거를 둔 기대평균제곱오차를 기준으로 하여 기존의 방법들과 제시된 방법들을 비교하였으며, 제시된 두 방법 간의 상호 비교도 시행하였다.

• 응용통계연구
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• 제13권2호
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• pp.457-476
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• 2000

본 연구에서는 선형추세를 갖는 모집단에 대한 효율적인 표본추출방법과 모평균 추정법을 제안하였다. 이 방법은 계통추출을 확장한 중심균형계통추출을 써서 표본을 뽑은 뒤 표본평균보다 수정된 추정량을 써서 모평균을 추정하는 것이다. 수정된 추정량을 정하는 데에 보간법의 개념을 사용하였다. 제안된 추정량과 기존의 방법에 으한 추정량들의 효율을 Cochran(1946)의 무한초모집단모형에 근거를 둔 기대평균제곱오차를 기준으로 하여 비교하였다. 제안된 방법은 표본크기 n($\geq$5)이 홀수이고 추출률의 역수인 $textsc{k}$가 짝수인 경우에 사용하기 위한 것이다. 모의실험을 이용한 예어서도 역시 좋은 결과가 얻어졌다.

• Asian-Australasian Journal of Animal Sciences
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• 제27권9호
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• pp.1368-1372
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• 2014

Several studies arduously reported that gayal (Bos frontalis) is an independent bovine species. The population size is shrinking across its distribution. In Bangladesh, it is the only wild relative of domestic cattle and also a less cared animal. Their body size is much bigger than Bangladeshi native cattle and has prominent beef type characters along with the ability to adjust in any adverse environmental conditions. Human interactions and manipulation of biodiversity is affecting the habitats of gayals in recent decades. Besides, the only artificial reproduction center for gayals, Bangladesh Livestock Research Institute (BLRI), has few animals and could not carry out its long term conservation scheme due to a lack of an objective based scientific mission as well as financial support. This indicates that the current population is much more susceptible to stochastic events which might be natural catastrophes, environmental changes or mutations. Further reduction of the population size will sharply reduce genetic diversity. In our recent investigation with 80K indicine single nucleotide polymorphism chip, the $F_{IS}$ (within-population inbreeding) value was reported as $0.061{\pm}0.229$ and the observed ($0.153{\pm}0.139$) and expected ($0.148{\pm}0.143$) heterozygosities indicated a highly inbred and less diverse gayal population in Bangladesh. Prompt action is needed to tape the genetic information of this semi-domesticated bovine species with considerable sample size and try to investigate its potentials together with native zebu cattle for understanding the large phenotypic variations, improvement and conservation of this valuable creature.

• Asian-Australasian Journal of Animal Sciences
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• 제26권12호
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• pp.1672-1679
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• 2013

Linkage disequilibrium between markers or genetic variants underlying interesting traits affects many genomic methodologies. In many genomic methodologies, the effective population size ($N_e$) is important to assess the genetic diversity of animal populations. In this study, dairy cattle were genotyped using the Illumina BoviveHD Genotyping BeadChips for over 777,000 SNPs located across all autosomes, mitochondria and sex chromosomes, and 70,000 autosomal SNPs were selected randomly for the final analysis. We characterized more accurate linkage disequilibrium in a sample of 96 dairy cattle producing milk in Korea. Estimated linkage disequilibrium was relatively high between closely linked markers (>0.6 at 10 kb) and decreased with increasing distance. Using formulae that related the expected linkage disequilibrium to $N_e$, and assuming a constant actual population size, $N_e$ was estimated to be approximately 122 in this population. Historical $N_e$, calculated assuming linear population growth, was suggestive of a rapid increase $N_e$ over the past 10 generations, and increased slowly thereafter. Additionally, we corrected the genomic relationship structure per chromosome in calculating $r^2$ and estimated $N_e$. The observed $N_e$ based on $r^2$ corrected by genomics relationship structure can be rationalized using current knowledge of the history of the dairy cattle breeds producing milk in Korea.

• The Plant Pathology Journal
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• 제32권3호
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• pp.201-208
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• 2016

The main areas for field-grown vegetable production in Iran were surveyed during the years of 2012-2014 to determine the occurrence of begomoviruses infecting these crops. A total of 787 leaf samples were collected from vegetables and some other host plants showing virus-like symptoms and tested by an enzymelinked immunosorbent assay (ELISA) using polyclonal antibodies produced against Tomato yellow leaf curl virus (TYLCV). According to the ELISA results, 81 samples (10.3%) positively reacted with the virus antibodies. Begomovirus infections were confirmed by polymerase chain reaction (PCR) using previously described TYLCV-specific primer pair TYLCV-Sar/TYLCV-Isr or universal primer pair Begomo-F/Begomo-R. The PCR tests using the primer pair TYLCV-Sar/TYLCV-Isr resulted in the amplification of the expected fragments of ca. 0.67-kb in size for ELISA-positive samples tested from alfalfa, pepper, spinach and tomato plants, confirming the presence of TYLCV. For one melon sample, having a week reaction in ELISA and no reaction in PCR using TYLCV-specific primers, the PCR reaction using the primer pair Begomo-F/Begomo-R resulted in the amplification fragments of the expected size of ca. 2.8 kb. The nucleotide sequences of the DNA amplicons derived from the isolate, Kz-Me198, were determined and compared with other sequences available in GenBank. BLASTN analysis confirmed the begomovirus infection of the sample and showed 99% identities with Tomato leaf curl New Delhi virus (ToLCNDV); phylogenetic analysis supported the results of the database searches. This study reports the natural occurrence of TYLCV in different hosts in Iran. Our results also reveal the emergence of ToLCNDV in Iranian cucurbit crops.

• 한국철도학회논문집
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• 제10권6호
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• pp.742-750
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• 2007

본 논문은 장래 도입되는 KTX2 고속차량을 이용한 중련편성 운영계획 최적화를 위한 방법론 제시를 목적으로 한다. 중련편성 운영계획 최적화를 위한 수리적 모형을 제시하고, 제안된 수리적 모형의 적용방안을 제시한다. 특히 확률적 수요를 고려한 모형을 수립하여, 계획수립 단계에서 수요의 확률적 요소를 보다 현실적으로 반영하고, 모형내에서 좌석 서비스 수준을 직접 조정할 수 있다.

• 한국해양학회지:바다
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• 제13권4호
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• pp.333-341
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• 2008

청계만에는 3개의 방조제(창포, 복길, 구일)가 위치하고 있고 이로부터 유입되는 담수로 인한 환경의 변화가 예상된다. 이를 조사하기 위해 2006년 11월(가을), 2007년 2월(겨울), 5월(봄), 8월(여름)에 각 방조제 앞에서 3개 정점을 선정하였다. 각 방조제 정점에서 대발생은 갈수기인 2007년 2월에 대형식물플랑크톤에 의해 발생하였고 풍수기에는 중 형식물플랑크톤이 우점하는 분포를 나타냈다. 각 방조제 정점에서 풍수기에는 담수의 유입으로 인하여 염분과 투명도는 낮고 암모늄과 인산염은 갈수기인 2007년 2월보다 높게 나타났지만 식물플랑크톤 생체량은 낮게 나타났는데 이는 담수의 유입으로 인한 높은 탁도나 염분의 급격한 감소가 영양염류보다 더 영향을 미치는 것으로 사료된다. 즉 본 조사해역에서 갈수기인 2007년 2월에는 식물플랑크톤의 성장에 영양염류가 영향을 미치지만 풍수기에는 높은 탁도나 급격한 염분변화가 영양염류보다 더 큰 영향을 미치는 것으로 판단된다.