• 제목/요약/키워드: expected efficacy

검색결과 488건 처리시간 0.031초

The Inhibition of Epileptogenesis During Status Epilepticus by Ginsenosides of Korean Red Ginseng and Ginseng Cell Culture (Dan25)

  • N.E., Chepurnova;Park, Jin-Kyu;O.M., Redkozubova;A.A., Pravdukhina;K.R., Abbasova;E.V., Buzinova;A.A., Mirina;D.A., Chepurnova;A.A., Dubina;U.A., Pirogov;M., De Curtis;L., Uva;S.A., Chepurnov
    • Journal of Ginseng Research
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    • 제31권3호
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    • pp.159-174
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    • 2007
  • Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one's biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known antiepileptic new generation drugs. The antiepileptic effect of GS was also demonstrated in all models of epilepsy in rats (young and adult), which have studied, in all models of epilepsy including status epilepticus (SE), induced by lithium - pilocarpine. In our experiments in rats new evidences on protective effects were exerted as a result of premedication by GS. Pre-treatment of several GS could induce decrease of the seizures severity and brain structural damage (by MRI), neuronal degeneration in hippocampus. Wave nature of severity of motor seizures during convulsive SE was observed during lithium-pilocarpine model of SE in rats (the first increase of seizures was 30 min after the beginning of SE and the second - 90 min after. The efficacy of treatment on SE by ginsenoside as expected was observed after no less 3 weeks by daily GS i.p. administration. It is blocked SE or significantly decrease the severity of seizures during SE. The implication of presented data is that combination of ginsenosides from Korean Red ginseng and ginseng cell culture Dan25 that could be applied for prevention of epileptical status development. However, a development of optimal ratio of different ginsenosides $(Rb_1$ Rc, Rg, Rf,) should consummate in the new antiepileptic drug development.

인과지도 분석을 통한 긍정심리자본과 21세기 정치리더십의 재고찰 (Reconsideration of Positive Psychological Capital and the 21st century Political Leadership Using Causal Loop Analysis)

  • 박상만;김강훈
    • 한국시스템다이내믹스연구
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    • 제14권4호
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    • pp.113-141
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    • 2013
  • The main purpose of this research is to introduce PsyCap(Positive Psychological Capital) and new leadership helping ordinary people to create positive thinking and leading to social integration in South Korea. Additionally, by looking at conventional leadership theories and by applying the PsyCap to leadership based on causal loop analysis, this study is to seek new approach which political leader is able to communicate with the people and can help the people to build positive mine. Throughout this study, there are several important implications how political leader can lead to social integration and stable political development in South Korea. In particular, when political leader encourage the people to have confidence to take on and put in the necessary effort to succeed at challenging tasks, when political leader make the people a positive attribution (optimism) about succeeding now and in the future, when political leader help the people to persevere toward goals and redirection paths to goals (hope) in order to succeed, and when political leader make the people beset by problems and adversity environment to overcome these concerns, it can be expected political leader to build social integration and the people to create positive thinking which has been emphasized by political leader in South Korea. Finally, 21st century has required new political leadership that the people are able to make positive psychological capital composed by optimism, hope, confidence, and resilience.

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시판 후 의료기기 임상평가를 위한 체계적 문헌고찰 활용 방안 연구: 안과용전기수술기 사례를 중심으로 (A Study on the Application of Systematic Literature Review for Post-Market Clinical Evaluation of Medical Devices: Focused on the Ophthalmic Electrosurgical system)

  • 김병관;최영숙;김미선;양석조
    • 대한의용생체공학회:의공학회지
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    • 제41권1호
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    • pp.35-41
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    • 2020
  • In this study, we examined whether the systematic literature review method used in the field of evidence-based medicine could be used for post-market clinical evaluation of medical devices by modifying them to fit the regulatory perspective of medical devices in Korea. For this purpose, systematic literature review was modified and applied to conduct a clinical literature survey on the ophthalmic electrosurgical system(Trabectome®, NeoMediX Corp) used for the treatment of glaucoma. A total of six documents were finally selected, and clinical safety and efficacy information on the indications of the ophthalmic electrosurgical system were effectively presented. In addition, general safety information and unexpected safety information could be distinguished through comparison with medical device adverse event reporting cases. The method used in this study is expected to be used in various ways throughout post-market medical device safety management system and for the purpose of regulation improvement, especially in the field of ophthalmic electrosurgical system.

클라우드 스토리지 서비스의 지속적 사용의도에 영향을 미치는 요인 연구 : 사용자 요인, 시스템 요인, 심리적 전환비용 (Research about Factor Affecting the Continuous Use of Cloud Storage Service : User Factor, System Factor, Psychological Switching Cost Factor)

  • 전창중;이정훈;전인숙
    • 한국전자거래학회지
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    • 제19권1호
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    • pp.15-42
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    • 2014
  • 클라우드 스토리지 서비스는 미래 모바일 및 인터넷 서비스의 핵심적인 인프라 서비스가 될 가능성이 높다. 클라우드 스토리지 서비스와 관련된 많은 기업들은 지속적인 투자를 하고 있으며, 가입자 확보를 위해 노력하고 있다. 이러한 서비스를 제공하는 기업들이 신규 가입자를 확보하고 기존 가입자를 유지하기 위해 사용자들의 서비스 사용의도가 무엇인지 확인할 필요가 있다. 따라서 본 연구에서는 클라우드 스토리지 서비스의 지속적 사용의도에 대한 실증적 연구 수행을 위해 외생 변수를 추가한 확장된 TAM 모형을 기반으로 사용자 수용의도와의 관계를 규명하고자 한다. 연구 결과, 개인의 혁신성, 자기효능감, 기능적 속성, 심리적 전환 비용과 같은 요인이 클라우드 스토리지 서비스의 지속적 사용의도에 영향을 주는 것으로 검증되었으며, 향후 클라우드 스토리지 서비스를 제공하는 기업들의 전략 수립을 위한 방향성을 제공해 줄 수 있을 것으로 기대한다.

과학고등학교 학생들의 수학불안감소와 수학성취도 향상을 위한 인지/행동 훈련의 효과

  • 김보경;조성희;이군현
    • 영재교육연구
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    • 제7권1호
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    • pp.31-50
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    • 1997
  • 'I'his study investigated students' attitude toward mathematics. and how behavior/cognitive training affects level of math anxietv and level of math achievement. Subjects were all the freshmen attending Taejon Science High School, and they were given Mathematics Attitudes Scale and Attributional Style Questionnaire prior to and post training sessions. Twenty out of 84 freshmen voluntarily participated in nine sessions of training program. Participants were asked to do self-evaluation. Math achievement was measured prior to and post training. and was compared between two groups. Training program utilized behavior/cognitive approach. such as understanding one's feeling through muscle relaxation, breathing and meditation; modifying negative attributional style; imitating effective cognitive strategies for math problem solving, and so on. 'I'he result shows that students' math confidence in general was relatively low out of expectation, a nd they perceived teachers not supporting their math abilities :IS much as expected. On the other hand, students in general had strong math achievelment needs, and considered math utility very high. Sex difference was seen in the attitude toward female math abilities, to result that female students had more positive perception than male students. Female students of 'I'aejon Science High School seem free from conventional idea about female abilities including theirs. Participants' ~attitude change was compared with non-participants. and participants showed statistically significant change in their math confidence, and also in their math achievement. Participants had much higher math confidence and ~achievement than non-participants. And, they showed increased level of perceiving teachers' expectation. more realistic in needs, and more involvement in math. Math achievement was found positively related to math confidence, and participants' math achievement change was explained by their belief in math utility. Not only training program effect hut also participants' voluntary involvement and teacher\ulcorner' support of the program and participation seem to increase their math achievement. Based upon the result of study it was suggested that behavior-/cognitive training program be provided along with academic curricula for gifted students of Korea to help their emotional and psychological development enhance the efficacy of their cognitive learning.

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다목적 안과용 레이저 시스템 안전성 성능평가 및 임상적 유효성평가 가이드라인 수립을 위한 연구 (A Study on Safety, Performance and Clinical effectiveness Test Guideline of Versatile Ophthalmic Laser System)

  • 김유림;유우진;박호준;장원석
    • 대한의용생체공학회:의공학회지
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    • 제40권6호
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    • pp.250-259
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    • 2019
  • Ophthalmic Laser System is widely used in Selective Laser Trabeculoplasty of Open Angle Glaucoma and Ocular Hypertension. Versatile ophthalmic laser system is a medical device with technology that checks the condition of the treatment area by irradiating a continuous laser pulse on the treatment area, and monitoring the microbubble reaction caused by the temperature increase of the melanosome through the ultrasonic signal and the optical signal sensor. It performs selective laser treatment without damaging the photoreceptor by controlling the wavelength of the laser when microbubbles are detected. This study aims to suggest a guideline for evaluating safety, performance and clinical effectiveness of Versatile Ophthalmic Laser System in accordance with the growing technology. International Standards, Regulations, and Clinical Trial Protocols were investigated and analyzed for this study. As a result of this study, the safety, performance and clinical effectiveness test guideline for Versatile Ophthalmic Laser System were proposed. This guideline will ensure the safety and efficacy of Medical device, and furthermore it is expected to be able to promote the development of technology development by supporting a clinical trial plan.

Optical Properties Analysis of SiNx Double Layer Anti Reflection Coating by PECVD

  • Gong, Dae-Yeong;Park, Seung-Man;Yi, Jun-Sin
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2009년도 제38회 동계학술대회 초록집
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    • pp.149-149
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    • 2010
  • The double-layer antireflection (DLAR) coatings have significant advantages over single-layer antireflection (SLAR) coatings. This is because they will be able to cover a broad range of the solar spectrum which would enhance the overall performance of solar cells. Moreover films deposited at high frequency are expected to show excellent and UV-stable passivation in the refractive index that we adopted. In this work, we present a novel DLAR coating using SiNx:H thin films with refractive indices 1.9 and 2.3 as the top and bottom layers. This approach is cost effective when compared to earlier DLAR coatings with two different materials. SiNx:H films were deposited by Plasma enhanced chemical vapor deposition (PECVD) technique using $SiH_4$, $NH_3$ and $N_2$ gases with flow rates 20~80sccm, 200sccm and 85 sccm respectively. The RF power, plasma frequency and substrate temperature for the deposition were 300W, 13.56 MHz and $450^{\circ}C$, respectively. The optimum thickness and refractive indices values for DLAR coatings were estimated theoretically using Macleod simulation software as 82.24 nm for 1.9 and 68.58 nm for 2.3 respectively. Solar cells were fabricated with SLAR and DLAR coatings of SiNx:H films and compared the cell efficacy. SiNx:H> films deposited at a substrate temperature of $450^{\circ}C$ and that at 300 W power showed best effective minority carrier lifetime around $50.8\;{\mu}s$. Average reflectance values of SLAR coatings with refractive indices 1.9, 2.05 and 2.3 were 10.1%, 9.66% and 9.33% respectively. In contrast, optimized DLAR coating showed a reflectance value as low as 8.98% in the wavelength range 300nm - 1100nm.

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하천수 BOD 예측을 위한 용존 자연유기물질의 synchronous 형광 스펙트럼 분석 (Examining Synchronous Fluorescence Spectra of Dissolved Organic Matter for River BOD Prediction)

  • 허진;박민혜
    • 한국물환경학회지
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    • 제23권2호
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    • pp.236-243
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    • 2007
  • Fluorescence measurements of dissolved organic matter (DOM) have the superior advantages over other analysis tools for the applications to water quality management due to their rapid analysis. It is known that protein-like fluorescence characteristics are well corelated with microbial activities and biodegradable organic matter. In this study, potential biochemical oxygen demand (BOD) predictor were explored using the fluorescence peak intensities and/or the integrated fluorescence intensities derived from synchronous fluorescence spectra and the first derivative spectra of river samples. A preliminary study was conducted using a mixture of a river and a treated sewage to test the feasibility of the approach. It was demonstrated that the better BOD predictor can be derived from synchronous fluorescence spectra and the derivatives when the difference between the emission and the excitation wavelengths (${\Delta}{\gamma}$) was large. The efficacy of several selected fluorescence parameters was rivers in Seoul. The fluorescence parameters exhibited relatively good correlation coefficients with the BOD values, ranging from 0.59 to 0.90. Two parameters were suggested to be the optimum BOD predictors, which were a fluorescence peak at a wavelength of 283 nm from the synchronous spectrum at the ${\Delta}{\gamma}$ value of 75 nm, and the integrated fluorescence intensity of the first derivatives of the spectra at the wavelength range between 245 nm and 280 nm. Each BOD predictor showed the correlation coefficients of 0.89 and 0.90, respectively. It is expected that the results of this study will provide important information to develop a real-time efficient sensor for river BOD in the future.

가상공간을 활용한 예비교사 수업실습 프로그램 개발 (Developing a teaching practice program for pre-service teachers using a virtual space)

  • 박정환;정동욱;김영태;윤성철
    • 한국산학기술학회논문지
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    • 제12권9호
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    • pp.3878-3886
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    • 2011
  • 이 연구는 가상공간과 수업실습의 특성을 반영하여 가상공간을 활용한 예비교사 수업실습 프로그램을 개발하는 것이다. 이를 위해 문헌연구와 예비연구를 통해 가상공간에서의 수업실습 프로그램 개발 목표, 수업실습 팀 편성, 수업실습 조건이 분석되었다. 이러한 예비 연구를 기반으로 최종 개발된 실습 프로그램의 효과 검증을 위하여 99명의 예비교사에게 이 프로그램이 적용되었으며, 이 중 46명의 예비교사가 평가에 참여하였다. 평가 결과 이 프로그램은 예비교사들의 교수효능감에 긍정적 변화를 가져온 것으로 나타났다. 이 프로그램이 교사양성과정에서 효과적으로 사용되고, 학교현장에서의 실제적 수업실습에 연계되어 활용되기를 기대한다.

이해중심 SW기초교육 프로그램의 컴퓨팅사고 효과성 검증 연구 (A Study on the Verification of Computational Thinking Effectiveness of Understanding-Oriented SW Basic Education Program)

  • 오경선;권정인
    • 디지털융복합연구
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    • 제17권10호
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    • pp.23-35
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    • 2019
  • 많은 대학교가 4차 산업혁명이라는 시대적 흐름에 따라 컴퓨팅사고로 문제해결력을 지닌 인재양성을 위해 SW교육을 활발히 진행하고 있다. 본 연구는 비전공대상의 컴퓨팅사고 향상을 위한 이해중심의 SW교육과정이 필요하다고 보았으며 이를 실현하는 구체적 개입으로 이해중심의 SW기초교육을 소개하고 그 효과성을 확인하고자 하였다. 이러한 목적을 달성하기 위해 백워드설계모형을 적용한 활동중심 컴퓨팅사고 교육과 프로그래밍교육을 하나의 이해중심의 SW기초교육 프로세스로 설계하였다. 이후 15주 수업에 적용하고, 3차례에 걸쳐 검사를 실시하여 비전공자들에 대한 컴퓨팅사고의 정의적인 측면을 분석하였다. 연구 결과 활동중심의 SW기초교육의 컴퓨팅사고효능감과 컴퓨팅사고인식에 있어서 긍정적인 효과를 검증하였다. 본 연구는 특정대학의 일부 학생들을 대상으로 실시하여 연구결과를 일반화하는데 다소 무리가 있으나, 교육 현장에서 백워드설계모형을 적용한 이해중심의 SW기초교육이 컴퓨팅사고를 향상시킬 수 있는 효율적인 방법의 하나로 적용될 수 있을 것으로 기대한다.