• Bulletin of the Korean Chemical Society
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• v.28 no.2
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• pp.200-206
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• 2007

Pharmacophore models for lymphocyte-specific protein tyrosine kinase (P56 LCK) were developed using CATALYST HypoGen with a training set comprising of 25 different P56 LCK inhibitors. The best quantitative pharmacophore hypothesis comprises of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic aliphatic and one ring aromatic features with correlation coefficient of 0.941, root mean square deviation (RMSD) of 0.933 and cost difference (null cost-total cost) of 66.23. The pharmacophore model was validated by two methods and the validated model was further used to search databases for new compounds with good estimated LCK inhibitory activity. These compounds were evaluated for their binding properties at the active site by molecular docking studies using GOLD software. The compounds with good estimated activity and docking scores were evaluated for physiological properties based on Lipinski's rules. Finally 68 compounds satisfied all the properties required to be a successful inhibitor candidate.

• Journal of Energy Engineering
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• v.22 no.3
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• pp.262-269
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• 2013

The residential energy consumption is intimately related with lifestyle of consumers. Therefore, this research suggests the mechanism for the effects of consumer lifestyle on consumer behavior. Specifically, the mediators are imposed of cost perception, propensity for environmental protection and energy conservation-conscious. Also, the lifestyle is composed of the over-consumption, life-centric, life-satisfaction, conservation- conscious and conservation-active type. In results, there are positive relationship between the life-satisfaction, conservation-conscious and conservation-active lifestyle and the propensity for environmental protection, cost perception. Both the cost perception and the propensity for environmental protection are positively related with the conservation- conscious. And positive relationship are appeared between the conservation-conscious and the energy conservation behavior.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.77-81
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• 2015

The unit price contracting is the standard contracting method for highway projects in the U.S. As a result, state highway agencies have collected a large amount of historical bid data that they can use to determine engineer's estimates for future projects. The estimator must carefully consider various characteristics of a new project such as its location to determine an engineer's estimate as accurate as possible before bid letting. Higher cost estimates can result in the loss of the available budget and lower cost estimates may lead to deferral and delay of projects. The study uses the historical bid data obtained from Iowa Department of Transportation and develops a Geographic Information System (GIS) tool to visually show the variation of unit prices over the map using a spatial interpolation technique. The interpolation map can be used to estimate the unit price of the item at any location across Iowa. This noble method allows the estimator to effectively and fully utilize the historical bid data in a very time efficient manner and determine more accurate cost estimation.

• Korean Journal of Construction Engineering and Management
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• v.16 no.4
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• pp.21-29
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• 2015

Construction cost index (CCI) has been published for last 10 years, it's contributed to update the historical cost data, analysis cost fluctuation and evaluate the market price for construction works with direct or indirect manner. CCI is a secondary or processed statistics using the basic statistics of input output table (IO table) and producer price index (PPI) from the Bank of Korea (BOK). So once the basic statistics change, it is required to modify the calculating model of CCI. Recently the BOK changed some fundamental principles and the base year (from 2005 to 2010), that can be used in IO table and PPI. This research analyzed the recent revision of basic statistics and their impacts on CCI, and improved the previous CCI model in response to it. Also the validity of new CCI was verified by analyzing the items and weights utilized in CCI and comparing the related index.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.10
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• pp.1703-1711
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• 2010

Electric power utilities are facing increasing uncertainties regarding the economic, political, societal, environmental constraints under they operate and plan their future systems. The utilities have to integrate consumers' interruption cost representing reliability worth of electricity into the process of determining the optimum investment level. In order to do so, the estimated outage cost must be included into quantitative index corresponding to system capital and operation investment cost to establish an optimal expansion plan. This paper is a study on the outage cost assessment by using macro approach for calculating IEAR(Interrupted Energy Assessment Rates) and the TRELSS(Transmission Reliability Evaluation for Large-Scale Systems) program was used to calculate EENS(Expected Energy Not Served).

• Computational Structural Engineering : An International Journal
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• v.2 no.1
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• pp.19-23
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• 2002

A reliability-based cost-benefit model for the risk management of oil platforms in the formulation of optimal decisions based on life-cycle consideration is proposed. The model is based on structural risk assessments and the integration of social issues and economics into the management decision process. Structural risks result from the platform's exposure to the random environmental loading associated with the offshore site where it is located. Several alternative designs of a typical platform are proposed and assessed from the cost-effectiveness viewpoint. This assessment is performed through the generation of cost/benefit relationships that are used, later on, to select the optimal design.

• Environmental and Resource Economics Review
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• v.10 no.2
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• pp.259-279
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• 2001

This paper investigates the optimal ratio of the ex post cost settled in the total cost paid to the facility-operating agent and the size of compensation for demand promotion efforts made by the trustee. We have extended McAfee and McMillan(1986)'s principal-agent model by incorporating incentives for the demand promotion efforts. We show that cost reducing effort is negatively related with the ratio of the ex post cost settled in the total cost. In addition, the optimal level of demand promotion effort is determined by the size of the compensation and the ratio of the ex post cost settled. A simulation study confirms our findings from a theoretical model.

• Environmental and Resource Economics Review
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• v.11 no.4
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• pp.659-687
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• 2002

This study used a discrete choice model to investigate an association between air pollution and hospital visits for acute respiratory symptoms with the national health interview survey conducted in 1998 in South Korea. The results showed that $NO_2$ and TSP were significantly related to hospital visits in a single-pollutant model, but when they were simultaneously considered, only $NO_2$ remained significant. It was estimated as $NO_2$ level increased by 10%(0.0027ppm) from 0.027ppm (the mean $NO_2$ level), hospital visits increase by 0.176%. This study also measured respondent's out-of-pocket expense and the time cost for commuting and waiting for the visit. We found that on the average, out-of-pocket expense is 5,600 won per hospital visit, but the total cost per hospital visit is measured at 33,440 won with time cost of commuting and waiting at 27,840 won. Time cost was over 63.6~83.3% of the total cost per hospital visit.

• International journal of advanced smart convergence
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• v.1 no.2
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• pp.1-11
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• 2012

IP-based Wireless Sensor Networks (IP-WSNs) are gaining importance for their broad range of applications in health care, home automation, environmental monitoring, industrial control, vehicle telematics, and agricultural monitoring. In all these applications, a fundamental issue is the mobility in the sensor network, particularly with regards to energy efficiency. Because of the energy inefficiency of network-based mobility management protocols, they can be supported via IP-WSNs. In this paper, we propose a network-based mobility-supported IP-WSN protocol called mSFP, or the mSFP: "Multicasting-supported Inter-Domain Mobility Management Scheme in Sensor-based Fast Proxy Mobile IPv6 Networks". Based on [8,20], we present its network architecture and evaluate its performance by considering the signaling and mobility cost. Our analysis shows that the proposed scheme reduces the signaling cost, total cost, and mobility cost. With respect to the number of IP-WSN nodes, the proposed scheme reduces the signaling cost by 7% and the total cost by 3%. With respect to the number of hops, the proposed scheme reduces the signaling cost by 6.9%, the total cost by 2.5%, and the mobility cost by 1.5%. With respect to the number of IP-WSN nodes, the proposed scheme reduces the mobility cost by 1.6%.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.1106-1113
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• 2022

Cost segregation helps reduce tax liabilities by reclassifying real property to personal property and accelerates tax depreciation of a property. A typical cost segregation study requires much time and high costs. This study proposed a BIM integrated cost segregation process that can be applied to any commercial building project. The proposed BIM-based cost segregation process was verified in a new commercial construction project. It approved that this approach can: (1) increase the cash flow for the owner and provide assistance to tax-paying enterprises; (2) enable the contractor to use it as an added value in the bidding process; (3) realize data sharing in a common platform to improve the cost segregation study efficiency and reduce costs and errors; (4) contribute to the asset management in the life cycle of buildings while filling in the blank of cost segregation process. Future studies will focus on the automation of cost segregation and asset management in building construction's life cycle.