• Archives of Pharmacal Research
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• v.28 no.2
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• pp.243-248
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• 2005

To improve the skin permeability of piroxicam, a new oil-in-water microemulsion containing $0.5\%$ piroxicam was developed. Among various oils investigated for their suitability as an oil phase for the microemulsion system, oleic acid showed both excellent solubility and skin permeation enhancing effect for piroxicam. Microemulsion existence ranges were identified through the construction of the pseudo-ternary phase diagram. The effect of the content of oleic acid and the ratio of the surfactant/cosurfactant on skin permeation of piroxicam were evaluated with excised rat skins. The optimum formulation with the highest skin permeation rate ($47.14\;{\mu}g/cm^2/h$) consisted of $0.5\%$ piroxicam, $10\%$ oleic acid, $60\%$ Labrasol/ethanol (1:5) and water.

• Journal of the Korea Institute of Military Science and Technology
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• v.15 no.5
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• pp.712-719
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• 2012

Penetrator with enhanced lateral effect(PELE) is a newconcept projectile, without dynamite and fuze. It consists of high-density jacket, closed at its rear end and filled with a low-density filling material. To study the explosion characteristics of PELE, by AUTODYN-3D code, the calculation models of projectile body and bullet target are established and the process of penetrating aluminum-2024 alloy target of PELE is simulated, and the scattering characteristics after penetrating aluminum-2024 alloy target of PELE are studied by different initial velocity. The explicit finite element analysis of PELE fragmentation was implemented with stochastic failure criterion in AUTODYN-3D code. As expansion of filling, the fragments were obtained velocities and dispersed laterally and further more enhancing the damage area largely. The number and shape of the PELE fragments were different depend on impact velocity and incidence angle of filling which fragment generated during penetration and lateral dispersion process.

• Bulletin of the Korean Chemical Society
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• v.30 no.7
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• pp.1481-1484
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• 2009

When isolated phenol or a small phenol-solvent cluster is excited to the $S_1\;state\;of\;{\pi}{\pi}^*$ character, the hydrogen atom of the hydroxyl group dissociates via a ${\pi}{\sigma}^*$ state that is repulsive along the O-H bond. We computationally investigated the substitution effects of an amino group on the excited state hydrogen transfer reaction of phenol. The time-dependent density functional theory (TDDFT) with B3LYP functional was employed to calculate the potential energy profiles of the ${\pi}{\pi}^*$ and the ${\pi}{\sigma}^*$ excited states along the O-H coordinate, together with the orbital shape at each point, as the position of the substituent was varied. It was found that the amino substitution has an effect of lowering the ${\pi}{\sigma}^*$ state and enhancing the excited state hydrogen transfer reaction.

• Journal of the Korean Chemical Society
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• v.62 no.4
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• pp.265-268
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• 2018

The solvolyses of anthraquinone-2-carbonyl chloride (1) were studied kinetically in 27 pure and various mixed solvents. The analysis using the extended Grunwald-Winstein equation in the solvolyses of anthraquinone-2-carbonyl chloride (1) obtained the l value of $2.11{\pm}0.11$, the m value of $0.54{\pm}0.06$, and the correlation coefficient of 0.955. The solvolysis reaction of 1 might proceed via an associative $S_N2$ mechanism enhancing bond making than bond breaking in the transition state (TS). This interpretation is further supported by a relatively large solvent kinetic isotope effect (SKIE, 2.27).

• Korean Journal of Materials Research
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• v.14 no.5
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• pp.363-367
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• 2004

Recently ZnO epitaxial layers have been widely studied as a semiconductor material for optoelectronic devices. Sapphire and silicon are commonly selected as substrate materials for ZnO epitaxial growth. In this communication, we report the effect of the ECR plasma pretreatment of sapphire and silicon substrates on the nucleation in the ZnO ALE (atomic layer epitaxy). It was found that ECR plasma pretreatment reduces the incubation period of the ZnO nucleation. Oxygen ECR plasma enhances ZnO nucleation most effectively since it increases the hydroxyl group density at the substrate surface. The nucleation enhancing effect of the oxygen ECR plasma treatment is stronger on the sapphire substrate than on the silicon substrate since the saturation density of the hydroxyl group is lower at the sapphire surface than that at the silicon surface.

• Transactions of the Korean hydrogen and new energy society
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• v.14 no.2
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• pp.131-137
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• 2003

Backfire occurrence must be controlled for the practical use of hydrogen fueled engine. It was found from preceeding studies that crevice volume around piston rings could effect a backfire occurrence. In this study, a possible countermeasure to backfire occurrence was evaluated by using multi point ignition method around piston ring. The results showed that backfire limited equivalence ratio was increased by a little due to a enhancing effect of mixture combustion around piston crevice volume.

• Journal of Information Technology Applications and Management
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• v.13 no.2
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• pp.41-54
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• 2006

In this paper, we investigate the inter-organizational information systems effect to supply chain partnerships, and subsequently to the performance. The conceptual model for the causal relationships among interorganizational systems usage, interaction, partnership, and supply chain performances has been developed. Theoretical framework is based on the partnership research in relationship marketing area, and the interaction model from IMP group. The questionnaires are designed to test the hypotheses of the conceptual model. The survey result supports our hypotheses that collaborative IT effects to increase the interaction between the firms, and interaction causes to enhance the partnership quality. Also, the level of partnership shows strong positive correlation with the supply chain performances. Despite the limitations of collected sample data size, our study reveals the fact that inter-organizational information systems contribute to supply chain performance through enhancing the interaction and partnership level between the supply chain partners. Our research result is distinct from the most extant literatures that investigated the firm's collaboration impact on interorganizational systems usage.

• Proceedings of the KIEE Conference
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• 1996.11a
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• pp.267-269
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• 1996

In this work, the influence of wire type conducting particles on the insulation reliability of GIS has been systematically investigated when outer electrode was dielectric coated by epoxy resin. For this purpose, coaxial cylinder-type electrode was adopted in 362 kV chamber and various size of Cu conducting particle was used and different gas pressure was applied. To prove the coating effect on the gas insulation, different thickness of epoxy coated outer electrode have been considered and the lift-off voltage and flashover voltage have been analyzed. The results show that the dielectric coated electrode has an remarkable influence on the reducing particle behavior in GIS system and enhancing the GIS insulation reliability.

• Journal of the Korean institute of surface engineering
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• v.27 no.1
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• pp.3-11
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• 1994

Cyclic hot corrosion studies have been carried out on(82~94) wt. % Fe-(5, 10, 15) wt. % Cr alloys con-taining either (1, 3)wt. % of Si or Pt as minor alloying elements in molten salts of($Na_2SO_4$+NaCl) between 820 and $920^{\circ}C$. Si or Pt decreased corrosion rate with the most pronounced effect being observed for alloys having 15wt. %Cr. Especially, as Si or Pt contents are increased from 1 to 3 wt. %, improved corrosion resistance was obtained. The beneficial effect of Si addition is due to the presence of the Si-rich second phase along the grain boundaries as well as the formation of the protective $SiO_2$layer between substrates and oxide scale. The Pt addition also increased the corrosion resistance by enhancing the formation ($Cr_2O_3$+layers and by increasing the adherence of the oxide scale.

• Journal of Ginseng Research
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• v.39 no.1
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• pp.1-6
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• 2015

Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpigmentation, darkening skin color by excessive pigmentation, is a major concern for Asian people with yellowe-brown skin. A variety of hypopigmenting agents have been used, but treating the hyperpigmented condition is still challenging and the results are often discouraging. Panax ginseng has been used traditionally in eastern Asia to treat various diseases, due to its immunomodulatory, neuroprotective, antioxidative, and antitumor activities. Recently, several reports have shown that extract, powder, or some constituents of ginseng could inhibit melanogenesis in vivo or in vitro. The underlying mechanisms of antimelanogenic properties in ginseng or its components include the direct inhibition of key enzymes of melanogenesis, inhibition of transcription factors or signaling pathways involved in melanogenesis, decreasing production of inducers of melanogenesis, and enhancing production of antimelanogenic factor. Although there still remain some controversial issues surrounding the antimelanogenic activity of ginseng, especially in its effect on production of proinflammatory cytokines and nitric oxide, these recent findings suggest that ginseng and its constituents might be potential candidates for novel skin whitening agents.