• 동의신경정신과학회지
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• 제32권2호
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• pp.111-127
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• 2021

Objectives: To review and analyze clinical and preclinical evidence of effectiveness, safety, and underlying mechanisms of yokukansan (YKS), a herbal medicine, in alleviating aggression. Methods: Classical records on YKS were searched in the Korean Traditional Medicine Knowledge Database (KTMKD). By searching five electronic databases, prospective clinical studies and preclinical studies of YKS for alleviating aggression/agitation published up to March 30, 2021 were included. Results: Only two classical records on YKS were found from the KTMKD. A total of 11 clinical studies and 15 preclinical studies were found from the five electronic databases. Among 11 clinical studies, seven enrolled patients with dementia and four enrolled patients with other neuropsychiatric disorders. Most clinical studies reported significant improvement in one or more outcomes related to aggression in the YKS group after treatment. Among 15 preclinical studies, all studies except two reported a significant decrease in aggression/agitation-related behavior of YKS or yokukansankachimpihange. Suggested underlying mechanisms of YKS or yokukansankachimpihange for aggression/agitation in these studies included regulation of serotonin receptor, amelioration of abnormal glucocorticoid level related to the hypothalamic-pituitary-adrenal axis, regulation of orexin secretion, amelioration of degeneration in brain cells including glia cells, and suppression of excessive glutamatergic or dopaminergic activity. Conclusions: There were some clinical and preclinical evidence supporting the effectiveness and safety of YKS for alleviating aggression. Given that aggression is the most frequent and destructive symptoms of behavioral and psychological symptoms of dementia, applicability of YKS as a herbal medicine should be further investigated in future high-quality research.

• 임상간호연구
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• 제27권3호
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• pp.233-244
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• 2021

Purpose: The purpose of this study was to investigate the actual utilization of clinical practice guidelines developed by Hospital Nurses Association. Methods: The subjects were 70 nurses who were in charge of guideline distributions in 70 advanced general hospital and general hospitals with 500 beds or more nationwide. Data were collected between June and August, 2020 by mail (return rate: 88.6%). Data were analyzed using descriptive statistics, t-test, and ANOVA with SPSS/WIN 24.0. Results: Among the clinical practice guidelines developed by Hospital Nurses Association, 72.9~90.1% were placed with book and electronic file in nursing department and 24.3~35.8% were placed with book and electronic file in each nursing unit at hospital. The average number of utilized clinical practice guidelines were 3.96±3.88, and average score of guideline utilization was score 2.85±0.79 which means 'use sometimes'. Conclusion: To improve the distribution and utilization of the clinical practice guidelines, it is necessary to enhance the recognition of values of evidence based nursing practice targeting head of nursing department and to stimulate the distribution and utilization of the clinical practice guidelines using diverse education programs for staff nurses.

• Child Health Nursing Research
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• 제24권1호
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• pp.78-90
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• 2018

Purpose: The purpose of this study was to evaluate measurement properties of self-report questionnaires measuring the social adjustment for youth after treatment of childhood cancer. Methods: Social adjustment measurement tools were identified through a two-stage systematic review. First, we searched for articles using self-report questionnaires to measure the social adjustment of youth after the treatment of childhood cancer. The appropriate tools were listed and categorized. Second, using methodological filters, we searched 5 electronic databases for articles examining the measurement properties of the tools when used with youth after the treatment of childhood cancer. The quality of these papers was then evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. Results: Eight tools were frequently used to measure social adjustment. Eight studies investigated the measurement properties of 4 of these tools. The PedsQL 4.0 and MMQL-AF had moderate to strong evidence in some domains, but the rest of the domains had a lack of evidence. The SF-36 and KIDSCREEN-27 were validated for only a few areas. Conclusion: We found a lack of evidence regarding the measurement properties of these tools. More research is required on the measurement properties of tools for use in this population.

• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3389-3394
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• 2011

Isomeric trimethylbenzyl radicals were generated and vibronically excited from precursor 1,2,3,5-tetramethylbenzene, isodurene, with a large amount inert carrier gas helium in a corona excited supersonic expansion (CESE) using a pinhole-type glass nozzle. A long-path monochromator was used to record the visible vibronic emission spectra of the jet-cooled benzyl-type radicals in the $D_1{\rightarrow}D_0$ electronic transition. From the analysis of the spectra, we identified the evidence of the presence of three isomeric trimethylbenzyl radicals in the corona discharge, and obtained the electronic energy and a few vibrational mode frequencies in the ground electronic state for each isomer.

• 한국전기전자재료학회논문지
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• 제14권2호
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• pp.133-138
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• 2001

We studied the optical properties of poly(3-hexylthiophene) for applying to the emitting material of organic electro luminescent device. The infrared spectrum and NMR of synthesized polymer gave good evidence for the conjugation of 3-hexylthiophene monomer unit. We confirmed that poly(3-hexylthiophene) contains the HT(head-to-tail)-HT(head-to-Tail) linkage larger than 65% based on NMR analysis. FTIR and raman spectroscopy show that poly(3-hexylthiophene) has two main vibration levels which have an energy about 0.18eV and 0.36eV. Electronic absorption spectra shifted to the shorter wavelength with increasing temperature, which is related to a conformational transition of the polymer. Photoluminescence spectrum generated at low temperature(10K) is separated at 669nm, 733nm and 812nm that it's because of phonon energy generated from the lattice vibration.

• Transactions on Electrical and Electronic Materials
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• 제6권3호
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• pp.87-90
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• 2005

$SiO_2$ via-hole etching with a high aspect ratio is a key process in fabricating ULSI devices; however, accumulated charge during plasma etching can cause etching stop, micro-loading effects, and charge build-up damage. To alleviate this concern, charge-up damage sensor was fabricated for the ultimate goal of real-time monitoring of accumulated charge. As an effort to reach the ultimate goal, fabricated sensor was used for electrical potential measurements of via holes between two poly-Si electrodes and roughly characterized under various plasma conditions using statistical design of experiment (DOE). The successful identification of potential difference under various plasma conditions not only supports the evidence of potential charge-up damage, but also leads the direction of future study.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1999년도 추계학술대회 논문집
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• pp.347-349
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• 1999

We have fabricated insulating thin films using p-hexadecoxyphenol(p-Hp) that was formed phenol-formaldehyde resin of crosslinked structure from reaction with formaldehyde by LB technique. For fabricated MIM device, the possibility for insulating layers of electronic were investigated by electrical properties of their LB films according to crosslinking of LB films current-voltage (I-V) properties and frequency-capacitance (C-F) characteristics. We have provided evidence for the high insulating performance of phenol-formaldehyde thin films by the LB method. Conductivity of their LB films was as follows: pure water > 1 % aq. Formaldehyde > heat treatment, in the current-voltage (I-V) characteristics. It is demonstrated that insulation properties of crosslinked p-HP LB films were improved. In capacitance-frequency properties, the heat-treated p-HP LB films for crosslinking showed a low relative dielectric constant.

• 한국기록관리학회지
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• 제12권2호
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• pp.181-205
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• 2012

본 연구는 전자거래에 대한 직접적 이해관계를 갖고 있지 않은 제3자 보관소 제도를 기반으로 하는 전자거래기록관리체계의 제안을 목적으로 한다. 이를 위해 관련 선행연구를 분석하고 전자거래와 전자거래기록의 개념과 유형 및 단계를 이론적 측면에서 살펴본다. 전자거래기록이 가지는 전자기록과 거래기록으로서의 복합적 속성에 대해 논하고, 전자거래기록관리 과정을 생애주기와 관리, 보관주체를 준거로 구분한다. 이를 통해 본 연구는 전자거래의 분쟁을 방지하고 조정할 수 있는 대안으로 신뢰할만한 제3자의 개입이 필수적임을 확인하고, 제3자 전자거래기록보존소를 중심으로 한 신뢰기반 전자거래기록 관리체계를 제안한다. 전자거래기록의 증거력과 관리환경을 살피고 이를 위해 준수해야 할 사항들을 논하는 한편, 거래 유형별 활용 사례들을 계약거래와 교환거래로 구분하여 제시한다.

• 한국전자거래학회지
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• 제8권4호
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• pp.17-32
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• 2003

기업의 기술수용 및 구현과정은 기술 그 자체가 업무성과를 증대시킬 것이라는 가정 하에 기술구현과 정을 설명한 기존연구와는 달리 본 연구는 신뢰와 지배력이 기업간 전자거래시스템 구현 성공에 미치는 영향을 파악하기 위해 56개의 기업간 전자거래시스템 활용기업을 대상으로 하여 기업간 신뢰와 지배력을 감성적 신뢰, 시스템적 신뢰, 정보기술 지배력, 가치사슬 지배력으로 구분하여 조사하였다. 연구결과 기업간 전자거래시스템이 해당 산업 안에서 성공적으로 구현되기 위해서는 해당 산업영역에 대한 정보기술과 가치사슬 지배력 향상에 노력해야 함을 밝혔다.

• 척추신경추나의학회지
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• 제12권1호
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• pp.29-42
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• 2017

Objectives : To determine the evidence of effectiveness and safety of Chuna manual therapy(CMT) for essential hypertension Methods : We searched 11 electronic databases(Pubmed, Web of Science, EMBASE, Cochrane Library, CAJ, KISTI, KISS, NDSL, KMBASE, RISS, DBpia) and related 2 journals up to April 2017. We included randomized controlled trials(RCTs) of testing Chuna manual therapy for hypertension patients. Results : Twenty one RCTs were eligible in our inclusion criteria. The meta-analysis of eighteen studies showed positive results for the using Chuna manual therapy for essential hypertension. Conclusions : There is favorable evidence of Chuna manual therapy for treating essential hypertension with meta-analysis. However, our systematic review has limited evidence to support Chuna manual therapy for essential hypertension because of low quality of original articles and further well-designed RCTs should be encouraged.