• Asian-Australasian Journal of Animal Sciences
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• 제26권12호
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• pp.1672-1679
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• 2013

Linkage disequilibrium between markers or genetic variants underlying interesting traits affects many genomic methodologies. In many genomic methodologies, the effective population size ($N_e$) is important to assess the genetic diversity of animal populations. In this study, dairy cattle were genotyped using the Illumina BoviveHD Genotyping BeadChips for over 777,000 SNPs located across all autosomes, mitochondria and sex chromosomes, and 70,000 autosomal SNPs were selected randomly for the final analysis. We characterized more accurate linkage disequilibrium in a sample of 96 dairy cattle producing milk in Korea. Estimated linkage disequilibrium was relatively high between closely linked markers (>0.6 at 10 kb) and decreased with increasing distance. Using formulae that related the expected linkage disequilibrium to $N_e$, and assuming a constant actual population size, $N_e$ was estimated to be approximately 122 in this population. Historical $N_e$, calculated assuming linear population growth, was suggestive of a rapid increase $N_e$ over the past 10 generations, and increased slowly thereafter. Additionally, we corrected the genomic relationship structure per chromosome in calculating $r^2$ and estimated $N_e$. The observed $N_e$ based on $r^2$ corrected by genomics relationship structure can be rationalized using current knowledge of the history of the dairy cattle breeds producing milk in Korea.

• Asian-Australasian Journal of Animal Sciences
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• 제32권4호
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• pp.485-493
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• 2019

Objective: This study was undertaken to investigate the genetic characteristics of Berkshire (BS), Landrace (LR), and Yorkshire (YS) pig breeds raised in the Great Grandparents pig farms using the single nucleotide polymorphisms (SNP) information. Methods: A total of 25,921 common SNP genotype markers in three pig breeds were used to estimate the expected heterozygosity ($H_E$), polymorphism information content, F-statistics ($F_{ST}$), linkage disequilibrium (LD) and effective population size ($N_e$). Results: The chromosome-wise distribution of $F_{ST}$ in BS, LR, and YS populations were within the range of 0-0.36, and the average $F_{ST}$ value was estimated to be $0.07{\pm}0.06$. This result indicated some level of genetic segregation. An average LD ($r^2$) for the BS, LR, and YS breeds was estimated to be approximately 0.41. This study also found an average $N_e$ of 19.9 (BS), 31.4 (LR), and 34.1 (YS) over the last 5th generations. The effective population size for the BS, LR, and YS breeds decreased at a consistent rate from 50th to 10th generations ago. With a relatively faster $N_e$ decline rate in the past 10th generations, there exists possible evidence for intensive selection practices in pigs in the recent past. Conclusion: To develop customized chips for the genomic selection of various breeds, it is important to select and utilize SNP based on the genetic characteristics of each breed. Since the improvement efficiency of breed pigs increases sharply by the population size, it is important to increase test units for the improvement and it is desirable to establish the pig improvement network system to expand the unit of breed pig improvement through the genetic connection among breed pig farms.

• 한국방사선학회논문지
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• 제12권1호
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• pp.23-30
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• 2018

흉부 단층 합성검사(Chest Digital Tomosynthesis, DTS)시 환자 체형에 따른 0.3 mm 구리 필터의 적용 및 AEC의 감도 변화에 의한 유효선량감소 효과와 폐 결절 검출능력을 평가하여 선량 최적화 조건을 평가하고자 한다. 8개의 인공 결절을 인체 팬텀 폐 영역내에 삽입하고 0.3 mm 구리 필터 적용 유무, 감도 변화에 따라 팬텀의 DTS 영상을 각각 획득하였다. 환자 체형에 따른 비교를 위해 팬텀 사이즈를 세 그룹으로 분류하여 small size에서는 결절이 삽입된 인체 팬텀을 단독으로 사용하였고 Average size에서는 한 개의 PMMA를, Large size에서는 두 개의 PMMA를 인체팬텀 후방에 밀착하여 위치시켰다. 유효선량은 몬테카를로 시뮬레이션을 이용하여 계산 되었고 영상의 화질평가를 위해서 CNR과 SNR 측정을 통한 정량 평가와 인공 결절 검출 수를 통한 검출민감도로 정성평가를 시행하였다. 모든 데이터는 통계학적으로 분석하였다. 유효 선량은 Small size일 때 $26{\mu}Sv$, Average size $70{\mu}Sv$, Large size $133{\mu}Sv$ 감소하였다. 유효선량은 0.3mm 구리 필터의 적용 여부에 따라 유의한 차이가 있었다(p<0.05). 정량적 화질 평가에서는 0.3mmCu필터 사용 시 CNR과 SNR 모두 통계적으로 유의한 차이는 없었다(p>0.05). 또한 정성적 화질평가에서도 결절 검출 민감도는 팬텀 사이즈별 전체 그룹에서 통계적으로 유의한 차이가 없었다(p>0.05). DTS에서 0.3 mmCu필터의 사용은 폐 결절 검출에서 진단적 가치를 유지하면서 환자 피폭선량 감소효과를 얻을 수 있다. 또한 실험에서 Large size 그룹의 경우 유효선량 감소 정도가 두드러진 점으로 보아 실제 체형이 큰 환자의 경우 0.3 mm Cu필터 사용은 더 높은 유효선량 감소 효과를 기대 할 수 있을 것이라 사료된다

• 한국안전학회지
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• 제21권4호
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• pp.42-48
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• 2006

The strategies of maintenance and operation are usually established based on the number of flaws and their size distribution obtained from nondestructive inspection in order to preserve safety of the plant. But non destructive inspection results are different from the physical flaws which really exist in the equipments. In case of a single inspection, it is easy to estimate the number of physical flaws using the POD curve. However, we may be faced with some difficulties in obtaining the number of physical flaws from the periodic in-service non destructive inspection data. In this study a simple method for estimating the number of physical flaws from periodic in-service nondestructive inspection data was proposed. In order to obtain the flaw growth history, the flaw growth was simulated using the Monte Carlo method and the flaw size and the corresponding POD value were obtained for each flaw at each periodic inspection time. The flaw growth rate used in the simulation was statistically calculated from the in-service inspection data. By repeating the simulation numerous flaw growth data could be generated and the effective POD curve was obtained as a function of flaw size. From the effective POD curve the number of physical flaws was obtained. The usefulness and convenience of the proposed method was evaluated from several applications and satisfactory results were obtained.

• Animal Bioscience
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• 제36권5호
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• pp.692-703
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• 2023

Objective: The main goals of this investigation were to i) assess the population structure and genetic diversity and ii) determine the efficiency of the ongoing breeding program in a closed flock of Angora rabbits through pedigree analysis. Methods: The pedigree records of 6,145 animals, born between 1996 to 2020 at NTRS, ICAR-CSWRI, Garsa were analyzed using ENDOG version 4.8 software package. The genealogical information, genetic conservation index and parameters based on gene origin probabilities were estimated. Results: Analysis revealed that, 99.09% of the kits had both parents recorded in the whole dataset. The completeness levels for the whole pedigree were 99.12%, 97.12%, 90.66%, 82.49%, and 74.11% for the 1st, 2nd, 3rd, 4th, and 5th generations, respectively, reflecting well-maintained pedigree records. The maximum inbreeding, average inbreeding and relatedness were 36.96%, 8.07%, and 15.82%, respectively. The mean maximum, mean equivalent and mean completed generations were 10.28, 7.91, and 5.51 with 0.85%, 1.19%, and 1.85% increase in inbreeding, respectively. The effective population size estimated from maximum, equivalent and complete generations were 58.50, 27.05, and 42.08, respectively. Only 1.51% of total mating was highly inbred. The effective population size computed via the individual increase in inbreeding was 42.83. The effective numbers of founders (f_e), ancestors (f_a), founder genomes (f_g) and non-founder genomes (f_ng) were 18, 16, 6.22, and 9.50, respectively. The fe/fa ratio was 1.12, indicating occasional bottlenecks had occurred in the population. The six most influential ancestors explained 50% of genes contributed to the gene pool. The average generation interval was 1.51 years and was longer for the sire-offspring pathway. The population lost 8% genetic diversity over time, however, considerable genetic variability still existed in the closed Angora population. Conclusion: This study provides important and practical insights to manage and maintain the genetic variability within the individual flock and the entire population.

• Communications for Statistical Applications and Methods
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• 제9권3호
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• pp.693-701
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• 2002

When the lowest dose level compared with zero-dose control has significant difference in effect, it is referred as minimum effective dose (MED). In this paper, we discuss several nonparametric methods for finding MED using updated rank at each sequential test step in small sample size and suggest new nonparametric procedures based on placement. Monte Carlo Simulation is adapted to compare power and Familywise Error Rate(FWE) of the new procedures with those of discussed nonparametric tests for finding MED.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2000년도 추계학술대회 및 정기총회
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• pp.141-147
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• 2000

For miniaturization of electronic parts and higher productivity, part arrangement job of PCB(printed Circuit Board) has been replaced with complete automated facilities, and contribution which is concerned about this will be expanded continuously. Such part arrangement job of PCB could have lots of influences to entire productivity In this paper, effective grouping method of parts is suggested for the effective insertion path job of PCB concerning the constraints to the size of parts.

• 한국지하수토양환경학회지:지하수토양환경
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• 제22권3호
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• pp.27-41
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• 2017

This study dealt with the characteristics and the interrelations of hydrogeological parameters such as hydraulic conductivity, dispersivity and effective porosity of unconsolidated sediments for providing the basic data necessary for the planning of the management and preservation of groundwater quality in the Nakdong River Delta of Busan City, Korea. Groundwater quality in this area has been deteriorated due to seawater intrusion, agricultural fertilizer and pesticide, industrial wastewater, and contaminated river water. The physical properties (grain size distribution, sediment type, sorting) and aquifer parameters (hydraulic conductivity, effective porosity, longitudinal dispersivity) were determined from grain size analysis, laboratory permeability test and column tracer test. Among 36 samples, there were 18 Sand (S), 7 Gravelly Sand (gS), 5 Silty Sand (zS), 5 Muddy Sand (mS), and 1 Sandy Silt (sZ). Hydraulic conductivity was determined through a falling head test, and ranged from $9.2{\times}10^{-5}$ to $2.9{\times}10^{-2}cm/sec$ (0.08 to 25.6 m/day). From breakthrough curves, dispersivity was calculated to be 0.35~3.92 cm. Also, effective porosity and average linear velocity were obtained through the column tracer test, and their values were 0.04~0.46 and 1.06E-04~6.49E-02 cm/sec, respectively. Statistical methods were used to understand the interrelations among aquifer parameters of hydraulic conductivity, effective porosity and dispersivity. The relation between dispersivity and hydraulic conductivity or effective porosity considered the sample length, because dispersivity was affected by experimental scale. The relations between dispersivity and hydraulic conductivity or effective porosity were all in inverse proportion for all long and short samples. The reason was because dispersivity was in inverse proportion to the groundwater velocity in case of steady hydrodynamic dispersion coefficient, and groundwater velocity was in proportion to the hydraulic conductivity or effective porosity. This study also elucidated that longitudinal dispersivity was dependent on the scale of column tracer test, and all hydrogeological parameters were low to high values due to the sand quantity of sediments. It is expected that the hydrogeological parameter data of sediments will be very useful for the planning of groundwater management and preservation in the Nakdong River Delta of Busan City, Korea.

• 지질공학
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• 제24권3호
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• pp.353-362
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• 2014

다공질 암석의 공극구조는 그 암석의 수리-역학적 거동에 매우 큰 영향을 미친다. 다공질 암석의 공극구조 특성을 표현하는 대표적인 방법은 공극률, 공극크기분포, 방향성 등이 있다. 암석의 유효공극률은 실험적으로 비교적 쉽게 구할 수 있지만, 공극의 크기분포 특성을 파악하는 것은 매우 어려운 실정이다. 본 연구에서는 X-ray CT를 이용하여 대표적 다공질 암석인 베레아 사암의 공극구조 중 공극크기분포를 이미지 기반으로 평가하였다. 공극크기분포 평가를 위해 본 연구에서는 이미지 필터링, 이진화, 골격화 등의 이미지 기반 처리 작업을 수행하였으며, 국부 두께평가 및 star chord를 이용하여 베레아 사암의 공극크기분포를 구하였다. 본 연구에서 제시된 X-ray CT 기반의 공극크기분포 평가방법을 이용하여 향후 다공질 재료의 공극구조 평가에 새롭고 효율적인 방안을 제시하고자 하였다.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.3139-3145
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• 2014

본 논문에서는 가유전체 기판을 이용하여 소형화한 마이크로파 대역의 링 하이브리드 커플러 설계에 대하여 기술한다. 가유전체 기판은 다수의 비어홀을 제 2기판에 삽입하여 유효 커패시턴스를 크게 증가시킨 구조를 갖는다. 가유전체 기판의 유효유전율은 표준형 기판에 비하여 크게 증가하게 되는데, 이에 의하여 동일한 전기적 길이 대비 물리적 길이가 크게 감소하므로 마이크로파 전송선로를 소형화시킬 수 있다. 이런 원리를 마이크로파 무선회로 설계에 적용한 사례를 보이기 위하여 가유전체 기판을 이용하여 3GHz대 링 하이브리드 커플러를 설계하고 실제로 제작 및 측정한 결과를 제시한다. 설계된 소형화된 링 하이브리드 커플러는 표준형에 비하여 전기적 성능은 유사하면서도 65%의 크기를 가진다. 측정된 전력분배비는 각각 -3.05dB와 -3.135dB이며, 두 출력간의 위상차는 동위상일 때 3도, 역위상일 때 176도로 이상적인 값과 매우 유사하다. 이로써 가유전체 기판구조로 소형화된 링 하이브리드 커플러의 설계가 타당함을 보인다.