• BMB Reports
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• 제32권1호
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• pp.98-102
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• 1999

Since carbohydrates are major mediators in cell-to-cell adhesion and communication, the development of specific and strong binders against them could generate promising therapeutics. As the first step towards that goal, sugar molecules have to be immobilized to be used as an affinity matrix. The amino functionality in sugar is the most active nucleophile for the immobilization, if the amino group is available. An alternative and general method is to use the hydroxyl group as a direct nucleophile, but the quantitation of immobilized hydroxyl groups is not easily done. To overcome this limitation, we have developed a method to immobilize various isomers of monosaccharides with p-nitrophenyl groups to the beads by using their hydroxyl groups. It was found that the amount of immobilized sugar was independent of the structure of the sugar, but was dependent on the number of hydroxyl groups. We also developed a sensitive method to quantify the amount of immobilized sugar at the picomolar scale by utilizing commercially available glycosidases to release a sensitive reporter molecule, p-nitrophenol, and detect it by HPLC. This new technique would allow a facile quantitation method for immobilized sugar molecules, which could be used as the affinity matrix to develop strong binders against biologically important sugars.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2001년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2001
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• pp.36-43
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• 2001

In Korea, we are absolutely short of earthquake data in good quality from moderate and large earthquakes, which are needed fur the study of strong ground motion characteristics. This means that the best use of the available data is needed far the time being. In this respect, several methods are suggested in this paper, which can be applied in the process of data selection and analysis. First, it is shown that the calibration status of seismic stations can be easily checked by comparing the spectra from accelerometer and velocity sensor both of which are located at the same location. Secondly, it is recommended that S/N ratio in the frequency domain should be checked before discarding the data by only look of the data in time domain. Thirdly, the saturated earthquake data caused by ground motion level exceeding the detection limit of a seismograph are considered to see if such data can be used for spectrum analysis by performing numerical simulation. The result reveals that the saturated data can still be used within the dominant frequency range according to the levels of saturation. Finally, a technique to minimize the window effect that distorts the low frequency spectrum is suggested. This technique involves detrending in displacement domain once the displacement data are obtained by integration of low frequency components of the original data in time domain. Especially, the low frequency component can be separated by using discrete wavelet transform among many alternatives. All of these methods mentioned above may increase the available earthquake data and frequency range.

• Interdisciplinary Bio Central
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• 제3권3호
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• pp.12.1-12.3
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• 2011

Bioinformatics tools and databases are useful for understanding and processing various biological data. Numerous resources are being published each year. It is not a trivial task to find up-to-date relevant tools and databases. Moreover, no server is available to provide comprehensive coverage on bioinformatics resources in all biological fields. Here, we present a directory server called IntoPub that provides information on web resources. First, we downloaded XML-formatted abstracts containing web URLs from the NCBI PubMed database by using 'ESearch-EFetch' function in the NCBI E-utilities. The information is obtained from abstracts in the PubMed by extracting 'www' or 'http' prefixes. Then, we cu-rate the downloaded abstracts both in automatic and manual fashion. As of July 2011, the IntoPub database has 12,118 abstracts containing web URLs from 174 journals. Our anal-ysis shows that the number of abstracts containing web resources has increased signifi-cantly every year. The server has been tested by many biologists from several countries to get opinion on user satisfaction, usefulness, practicability, and ease of use since January 2010. In the IntoPub web server, users can easily find relevant bioinformatics resources, as compared to searching in PubMed. IntoPub will continue to update and incorporate new web resources from PubMed and other literature databases. IntoPub, available at http://into.kobic.re.kr/, is updated every day.

• 농업과학연구
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• 제36권1호
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• pp.57-61
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• 2009

The invasive pest Brontispa longissima(Coleoptera: Chrysomelidae), native to Indonesia and Papua New Guinea, has extended its distribution to Australia, Asia and Pacific islands and caused serious leaf damages of the coconut palm Cocos nuciferain the invaded regions. Although biological control using parasitic wasps has successfully reduced population density and leaf damage levels, this pest and its natural enemies have not been efficiently producedin conventional methods using young leaves of C. nucifera. In the present study, we examined suitability of plants easily available in Thailand and Japan for mass rearing of this pest to develop effective mass rearing system of this pest. Mature, green leaves of the palms were also suitable for immature development and adult reproduction of this pest. Since mature leaves of C. nucifera are more abundant and less contaminated with fungus than the unopened leaf buds, mature leaves could be a promising plant diet for mass rearing of B. longissima. Ornamental palms such as Hyophorbe lagenicaulis and Washingtonia filifera were also suitable for immature development and reproduction of B. longissima. Away from palms, the cattail Typha spp. can sustain immature development and adult reproduction of B. longissima. In the area where C. nucifera is rare or not available, W. filifera or Typha spp. would be good food plants for mass rearing of this pest.

• 한국해양공학회지
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• 제23권4호
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• pp.47-51
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• 2009

Thrust is one of the important performance characteristics of an AUV. At the design stage, the resistance of an AUV at its maximum speed is estimated and then the thrust system is designed, including the propeller diameter, propeller rpm, driving system, and required power. However, it is not possible to be certain that the thrust system has been correctly designed until the AUV is launched and its speed is measured. If data from a propeller open-water test is available, the thrust and torque of the propeller at a certain speed can be estimated. In addition, if the motor's torque characteristics are available, the maximum speed saturated by the induced propeller torque can be estimated. In this paper, an easy technique for estimating the maximum speed of an AUV will be shown, even in a case where additional resistance is gained from appendages not considered at the design stage. Furthermore, the thrust performance changes by adjusting the diameter of the propeller can be easily investigated.

• Nuclear Engineering and Technology
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• 제54권8호
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• pp.2924-2932
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• 2022

Motivated by learning from experience and exploiting existing knowledge in civil nuclear operations, we have developed in-house generic Probabilistic Safety Assessment (PSA) models for pressurized and boiling water reactors. The models are computationally light, handy, transparent, user-friendly, and easily adaptable to account for major plant-specific differences. They cover the common internal initiating events, frontline and support systems reliability and dependencies, human-factors, common-cause failures, and account for new factors typically overlooked in many PSAs. For quantification, the models use generic US reliability data, precursor analysis reports, the ETHZ Curated Nuclear Events Database, and experts' opinions. Moreover, uncertainties in the most influential basic events are addressed. The generated results show good agreement with assessments available in the literature with detailed PSAs. We envision the models as an unbiased framework to measure nuclear operational risk with the same "ruler", and hence support inter-plant risk comparisons that are usually not possible due to differences in plant-specific PSA assumptions and scopes. The models can be used for initial risk screening, order-of-magnitude precursor analysis, and other research/pedagogic applications especially when no plant-specific PSAs are available. Finally, we are using the generic models for large-scale precursor analysis that will generate big picture trends, lessons, and insights.

• 한국산업정보학회논문지
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• 제15권5호
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• pp.89-95
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• 2010

각종 정보가 범람하고 있는 현대에서 메모는 간단한 기록을 통해 쉽게 정보를 관리할 수 있는 수단으로 자리 잡았다. 특히, 정보화시대의 도래로 널리 보급된 컴퓨터 상에서 사용가능한 전자 메모는 비즈니스 사회에서 매우 유용하게 이용되고 있다. 점차적으로 지능화 되어가는 비즈니스 환경을 고려하여 본 논문에서는 해당 환경에서 지능적으로 정보를 관리할 수 있는 다기능 전자 메모 시스템을 제안한다. 제안된 방법에서는 데이터베이스를 활용한 메모 정보 관리를 통해 시공간의 제약을 줄인다. 더불어, 해당 시스템은 음악 재생, 화면 캡쳐 및 일정관리 등의 기능을 지원한다. 이러한 기능들은 비즈니스 환경에서 제안된 시스템의 활용도를 높여준다.

• Structural Monitoring and Maintenance
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• 제10권2호
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• pp.117-132
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• 2023

The most prevalent and oldest type of structure is unreinforced masonry (URM) structures; URM walls are still a widely used construction material in India and many other developing countries due to their simplicity, ease of construction, economic sustainability, and ability to be built with locally available materials. URM walls are significantly weak while carrying lateral loads. The poor performance of URM walls during earthquakes has necessitated investigating an effective method for strengthening a newly built masonry building or retrofitting an old structure. Wire mesh, being cost-effective and easily available, satisfies the requirements to strengthen new and old URM buildings. The use of wire mesh to strengthen and retrofit the URM structure is simple to use, quick to construct, and inexpensive, especially in developing nations where heavy machinery and highly qualified labour are lacking. The current paper reviews the effectiveness of steel wire mesh as a reinforcing material for enhancing masonry strength. The finding gave encouraging results for the field application of wire mesh.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.47-51
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• 2013

Existing buildings now represent the greatest opportunity to improve building energy efficiency. Building performance analysis is becoming increasingly important because decision makers can have a better visualization of their building's performance and quickly make the solution for improving building energy efficiency and reducing environmental impacts. Nowadays, building information models (BIMs) have been widely created during the design phase of new buildings, and it can be easily imported to third party software to conduct various analyses. However, a BIM is not always available for all existing buildings. Even if a BIM is available during the design and construction phases, it is very challenging to keep updating it while a building is aged. A manual process to create or update a BIM is very time consuming and labor intensive. A laser scanning technology has been a popular tool to create as-is BIM. However it still needs labor-intensive manual processes to create a BIM out of point clouds. This paper introduces automatic as-is simplified BIM creation from point clouds for energy simulations. A framework of decision support system that can assist decision makers on retrofits for existing buildings is introduced as well. A case study on a residential house was tested in this study to validate the proposed framework, and the technical feasibility of the developed system was positively demonstrated.

• 한국기계가공학회지
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• 제14권6호
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• pp.49-56
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• 2015

For designing working devices of construction equipment, it is necessary to consider not only sufficient working ability but also available working range. Therefore, it is important to select the appropriate pivot positions of links. This paper presents a study on selection of pivot points of links used in construction equipment. To analyze the effect of each pivot point, a design program for pivot selection is developed. A conventional pivot design method requires a complicated process because it needs to create a certain working position manually to evaluate its performance. However, the developed program includes an automatic link assembly algorithm; thus, the working device can easily be analyzed by using pivot information of links. The developed program also included a kinematic/static analysis module and characteristic analysis algorithms. Therefore, it is possible to easily analyze a working device model created through the automatic assembly algorithm, whereby users can easily analyze the effect of each link pivot point for the actual product design.