• Journal of Electrochemical Science and Technology
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• v.7 no.4
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• pp.316-326
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• 2016

Development and discovery of efficient, cost-effective, and robust electrocatalysts are imperative for practical and widespread implementation of water electrolysis and fuel cell techniques in the anticipated hydrogen economy. The electrochemical reactions involved in water electrolysis, i.e., hydrogen and oxygen evolution reactions, are complex inner-sphere reactions with slow multi-electron transfer kinetics. To develop active electrocatalysts for water electrolysis, the physicochemical properties of the electrode surfaces in electrolyte solutions should be investigated and understood in detail. When electrocatalysis is conducted using nanoparticles with large surface areas and active surface states, analytical techniques with sub-nanometer resolution are required, along with material development. Scanning electrochemical microscopy (SECM) is an electrochemical technique for studying the surface reactions and properties of various types of electrodes using a very small tip electrode. Recently, the morphological and chemical characteristics of single nanoparticles and bio-enzymes for catalytic reactions were studied with nanometer resolution by combining SECM with atomic force microscopy (AFM). Herein, SECM techniques are briefly reviewed, including the AFM-SECM technique, to facilitate further development and discovery of highly active, cost-effective, and robust electrode materials for efficient electrolysis and photolysis.

• Journal of the Korea Society of Computer and Information
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• v.24 no.5
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• pp.27-33
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• 2019

One of serious security threats is a botnet-based attack. A botnet in general consists of numerous bots, which are computing devices with networking function, such as personal computers, smartphones, or tiny IoT sensor devices compromised by malicious codes or attackers. Such botnets can launch various serious cyber-attacks like DDoS attacks, propagating mal-wares, and spreading spam e-mails over the network. To establish a botnet, attackers usually inject malicious URLs into web source codes stealthily by using data hiding methods like Javascript obfuscation techniques to avoid being discovered by traditional security systems such as Firewall, IPS(Intrusion Prevention System) or IDS(Intrusion Detection System). Meanwhile, it is non-trivial work in practice for software developers to manually find such malicious URLs which are hidden in numerous web source codes stored in web servers. In this paper, we propose a security defense system to discover such suspicious, malicious URLs hidden in web source codes, and present experiment results that show its discovery performance. In particular, based on our experiment results, our proposed system discovered 100% of URLs hidden by Javascript encoding obfuscation within sample web source files.

• Proceedings of the CALSEC Conference
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• 2004.02a
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• pp.112-116
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• 2004

· Dynamic Pricing vs. Fixed Pricing Auctions make both buyers and sellers engage in the price discovery process, Auctions of various kinds will replace the fixed pricing model that now pervades much of the web(pmitted)

• The Journal of Society for e-Business Studies
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• v.18 no.3
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• pp.211-222
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• 2013

Discovering zones which a1re sets of geographically adjacent regions are essential in sophisticated urban developments and people's movement improvements. While there are some studies that separately focus on movements between particular regions and zone discovery, they show limitations to understand people's movements from a wider viewpoint. Therefore, in this research, we propose a clustering based analysis method that aims at discovering movement patterns, which involves zones and their relations, based on a big data of smart card transaction systems. Moreover, the effectiveness of discovered movement patterns is quantitatively evaluated by using the proposed metrics. By using a real-world dataset obtained in Seoul metropolitan subway networks, we investigate and visualize hidden movement patterns in Seoul.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.10-18
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• 2014

Purpose: Among different PET/CT devices which are composed of same PET model but different CT models, SUV, usually used for quantitative evaluation, was measured to assess the accuracy of follow up scans in different PET/CT and confirm that interequipment compatibility is useful in arranging the PET/CT exam appointment. Materials and Methods: Using ACR PET Phantom, PET NEMA IEC Body Phantom, SNM Chest Phantom and Ge-68 cylinder Phantom, $SUV_{mean}$ and $SUV_{max}$ was measured by 3 different models of PET/CT (Discovery 690, Discovery 690Elite and Discovery 710, GE) made in same company. ANOVA was used to evaluate the significant difference in the result. Results: In the result, the average of $SUV_{max}$ was D690 (25 mm-1.82, 16 mm-1.75, 12 mm-1.73, 8 mm-1.44), D690E (25 mm-1.76, 16 mm-1.92, 12 mm-1.78, 8 mm-1.55) and D710 (25 mm-1.84, 16 mm-1.89, 12 mm-1.77, 8 mm-1.61) in ACR Phantom, D690 (25 mm-2.26, 16 mm-2.25, 12 mm-1.92, 8 mm-1.85), D690E (25 mm-2.45, 16 mm-2.25, 12 mm-2.05 8 mm-1.91) and D710(25 mm-2.49, 16 mm-2.20, 1 2mm-2.30, 8 mm-2.05) in PET NEMA IEC Body Phantom, D690-1.04, D690E-1.10 and D710-1.09 in SNM Chest Phantom and D690-0.81, D690E-0.81, D710-0.84 in Ge-68 cylinder Phantom. The differences between average SUV of 4 phantoms were $SUV_{mean}$-1.87%, $SUV_{max}$-2.15%. And also as a result of ANOVA analysis, there was no significant difference statistically. Conclusion: If different models of PET/CT have same specification of PET system, there was no significant difference in $SUV_{mean}$ and $SUV_{max}$ even though they have different CT system. And also differences of $SUV_{mean}$ and $SUV_{max}$ in phantom images were under 5% which many manufacturers recommend. Therefore, follow up scan will be possible using different PET/CT if it has same specification of PET system with the previous PET/CT. This information will enable the accurate comparative analysis when conducting follow up scans and be helpful to schedule PET/CT exam more effectively.

• Journal of Digital Contents Society
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• v.8 no.3
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• pp.269-277
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• 2007

Web service is an important technology to develop business to business e-commerce application. From a business perspective of time to market, dynamic evolution offers flexibility that software can adapt to unforeseen and fluctuating business requirements. OWL-S, based on OWL, is a service ontology language. The semantics provided by OWL support automation of service discovery, invocation, and service composition. In this paper we propose a framework to support dynamic evolution of service-oriented applications. We extend use-case analysis method to derive service description by defining requirements concept and mapping from requirement concept to activity diagram. A prototype is provided to show the validity of this framework.

• Natural Product Sciences
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• v.21 no.4
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• pp.273-277
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• 2015

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.

• IMMUNE NETWORK
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• v.24 no.1
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• pp.1.1-1.6
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• 2024

IL-18 binding protein (IL-18BP) was originally discovered in 1999 while attempting to identify an IL-18 receptor ligand binding chain (also known as IL-18Rα) by subjecting concentrated human urine to an IL-18 ligand affinity column. The IL-18 ligand chromatography purified molecule was analyzed by protein microsequencing. The result revealed a novel 40 amino acid polypeptide. To isolate the complete open reading frame (ORF), various human and mouse cDNA libraries were screened using cDNA probe derived from the novel IL-18 affinity column bound molecule. The identified entire ORF gene was thought to be an IL-18Rα gene. However, IL-18BP has been proven to be a unique soluble antagonist that shares homology with a variety of viral proteins that are distinct from the IL-18Rα and IL-18Rβ chains. The IL-18BP cDNA was used to generate recombinant IL-18BP (rIL-18BP), which was indispensable for characterizing the role of IL-18BP in vitro and in vivo. Mammalian cell lines were used to produce rIL-18BP due to its glycosylation-dependent activity of IL-18BP (approximately 20 kDa). Various forms of rIL-18BP, intact, C-terminal his-tag, and Fc fusion proteins were produced for in vitro and in vivo experiments. Data showed potent neutralization of IL-18 activity, which seems promising for clinical application in immune diseases involving IL-18. However, it was a long journey from discovery to clinical use although there have been various clinical trials since IL-18BP was discovered in 1999. This review primarily covers the discovery of IL-18BP along with how basic research influences the clinical development of IL-18BP.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.3-5
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• 1997

Properties of a good drug include safety, efficacy, half-life and bioavailability. With the current approach to drug discovery based on receptor-based and cell-based screening methods, compounds are frequently moved into development with poor bioavailability. With low bioavailability, drug administration is typically limited to parenteral routes, thus limiting the potential wide-spread utility of these therapeutic agents. The first and most important factor limiting a drug's bioavailability is the intestinal membrane permeability which in turn determines the maximum fi:action of the dose administered that can be absorbed. We have recently utilized new intubation methods for performing permeability measurements in humans and establishing a fundamental human data base for correlating intestinal jejunal membrane permeabilities with permeabilities determined in other systems, e.g., animals, tissue culture, as well as physical chemical properties.

• The Journal of Society for e-Business Studies
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• v.16 no.2
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• pp.39-71
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• 2011

Lately, developing systems fully interoperable with others is considered an essential element for successful projects, as not only do e-commerce becomes ubiquitous but also distributed systems' paradigm spreads. However, since definitions of interoperability vary by viewpoints, it is still difficult to have the same understanding and evaluation criteria on interoperability. For instance, various interoperability parties in military use different definitions of interoperability, and its T&E is not conducted according to the definition, but only to levels of information exchange. In this paper, we proposed a new definition of interoperability as followsm First of all, we collected existing and various interoperability definitions, extracting key components in each of them. Second, we statistically analyzed those components and applied the association rules discovery in data mining. We compared existing interoperability definitions to ours. From this research, we found associations among the components from various definitions applying market-basketanalysis, redefining interoperability. Key findings of this research can contribute to a unified viewpoint on the definition, level, and evaluation items of interoperability.