• Journal of Korean Society for Atmospheric Environment
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• v.24 no.3
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• pp.321-328
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• 2008

The number of patient with allergic asthma and atopy have increased in the cities of Korea steadily. In order to elucidate the primary factor, we investigated whether the house dust particles collected from an apartment of the middle classes has promoting effects of allergen-related airway inflammation and airway hyperresponsiveness. Mice were treated with 0.1 mL of 1 mg/mL of house dust particles suspension by intratracheal instillation once weekly for 10 weeks combined with ovalalbumin (OVA) sensitization. Intratracheal instillation of house dust particles and OVA sensitization caused an increase in the level of serum L-lactate dehydrogenase (LDH), immunoglobulun-E (IgE) and histamine, and an elevation in respiratory resistance. It also enhanced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF) of mice, IgE and eotaxin expression in blood, and T helper type 2 cell derived cytokine levels such as of interleukin (IL)-4, IL-13 and IL-5 in the BALF. However, it did not influence T helper type 1 cytokine such as interferon-gamma in the BALF. These results indicate that house dust particles elevate allergen-related airway inflammation and airway hyperresponsiveness in mice and may play an important role in the aggravation of asthma and atopy in Korea.

• Journal of Preventive Medicine and Public Health
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• v.23 no.3 s.31
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• pp.262-273
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• 1990

In order to assess the method which is more sensitive one to detect the early change of lung tissue by the inhaled dust, we have performed the various medical examinations such as chest radiography, pulmonary function test, high resolution chest CT, brnchoalveolar lavage and lung biopsy used bronchoscope and ultrathin bronchoscopy examination to 48 persons. The control group were 8 persons who did not exposed to dust, 40 cases of the experimental group have professionally exposed to the mineral dust. The results were as follows 1. The total number of cells in bronchoalveolar lavage was significantly increased in all of the pneumoconiosis group classified by chest and high resolution chest CT. 2. The composition rate of macrophage to the total number of cells in bronchoalveolar lavage fluid was significantly decreased in all of the pneumoconiosis group compared with the control group. 3. The composition rate of neutophils and lymphocytes to the total number of cells in bronchoalveolar lavage fluid was significantly increased in all of the pneumoconiosis group compared with the control group. 4. The forced expiratory volume in one second ($FEV_{1-0}$), maximal mid-expiratory flow (MMF), and maximal voluntary ventilation (MVV) were significantly increased only in the group of the progressed pneumoconiosis relatively. 5. We observed submucosal edema, anthracotic pigmentation and granuloma formation in transbronchial lung biopsy of the suspected pneumoconiosis (category 0/1) case which is thought to the early change of coal workers' pneumoconiosis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.679-686
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• 2018

A new dust cleaning vehicle is needed to remove fine and ultra-fine particulate matter in subway tunnels. Therefore, the recently developed tunnel cleaning vehicle is equipped with an efficient suction system and cyclone-based prefilter to handle ultra-fine particles. To treat various sizes of particulate matter with an underbody suction system, this paper proposes a cyclone-based prefilter in the suction system and validates the dust removal efficiency through Computational Fluid Dynamics (CFD) analysis using ANSYS FLUENT. Using the created surface and volume mesh, various particle sizes, materials, and fan flow rates, the particles were tracked in the flow with a discrete phase model. As a result, the dust cleaning vehicle at a normal operational speed of 5km/h requires at least a fan flow rate of $1500m^3/min$ and 100mm of suction inlet height from the tunnel track floor. Those suction modules and cyclone-based prefilters in the dust cleaning vehicle reduces the dust accumulation load of the electric precipitator and helps remove the accumulated fine and ultra-fine dust in the subway tunnel.

• Clean Technology
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• v.20 no.3
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• pp.263-268
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• 2014

Using the CFD method, the pressure drop in 6 cyclone dust collectors of different shape were calculated. And the results were compared with results of the conventional theories. Equations of Shepherd and Lapple (1939, 1940), First (1950), Alexander (1949), Stairmand (1949), Barth (1956) were used in the theoretical calculation. In CFD calculations, we used standard k-epsilon model for analysis of turbulent flow, fluid is $25^{\circ}C$ air, the velocity at inlet is 10 m/s and the temperature is $25^{\circ}C$. In CFD analysis results, the pressure distributions along the flow showed similar patterns in different cyclone shapes. But the pressure drop distributions estimated on the conventional theories had big difference in different cyclone shapes. Only First's theory and CFD analysis showed similar results.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.115-121
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• 2017

The efficiency of railway track cleaning vehicle for eliminating fine particulate matter (PM10 and PM2.5) in a subway tunnel depends strongly on the structure of the air blowing and suction system installed under the train. To increase the efficiency of underbody suction system, this paper proposes a novel method to use the Coanda effect for the air blower and dust suction module. In particular, through Computational Fluid Dynamics (CFD) analysis, the flow control device induced by the Coanda effect enables an increase in the overall flow velocity and to stabilize the flow distribution of the suction module at a control angle of $90^{\circ}$. In addition, the flow velocity drop at the edge of the air knife-type blower can be improved by placing small inserts at the edge of the blower. Those 4 modular designs of the dust suction system can help remove the dust accumulated on the track and tunnel by optimizing the blowing and suction flows.

• Biomedical Science Letters
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• v.20 no.3
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• pp.173-179
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• 2014

Asian sand dust is known to promote various respiratory symptoms or disorders. For the prevention of harmful health effects by Asian sand dust, the best strategy is known to avoid or reduce exposure to the Asian sand dust. Several studies have shown that Korean red ginseng (RG) has anti-inflammatory and anti-allergic effects. The study aimed to clarify the effect of Korean red ginseng intake on lung inflammation responses to artificial sand dust (ASD) similar to Asian sand dust. BALB/c mice were divided into five groups (n=12) of control (saline), ovalbumin (OVA), OVA with ASD, OVA plus RG with ASD, and OVA plus dexamethasone (DEXA) with ASD. Histopathologic evaluation of lung was conducted. Interleukin (IL)-5, IL-12, interferon (IFN)-${\gamma}$, IL-13, monocyte chemotactic protein (MCP)-1, and eotaxin within bronchoalveolar lavage (BAL) fluid were measured by ELISA. OVA+ASD group significantly increased concentrations of IL-5, IL-13, MCP-1, and eotaxin (P<0.01) compared to the control. OVA+ASD+RG group showed significant decreased levels of IL-2, IL-13, MCP-1 and eotaxin (P<0.01) compared with OVA+ASD. Between RG and DEXA treatment groups, there was no significant difference in all cytokines and chemokines. The inflammatory cells were significantly decreased in treatment groups with RG or DEXA compared to OVA+ASD group. This study suggests a beneficial effect of Korean RG administration in preventing inflammation of lung resulting from Asian sand dust.

• Biomedical Science Letters
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• v.30 no.3
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• pp.169-172
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• 2024

Asthma is a chronic lung disease characterized by wheezing, cough, and chest pain. The objective of this study was to examine asthmatic effect due to house dust mite (HDM) according to age and exposure duration. Asthma induction in young (6 weeks) and old (12 months) aged C57BL6/J mice was accomplished by HDM administration. Bronchoalveolar lavage fluid (BALF) was collected. Inflammatory cells in BALF were counted. Mucus production in lung tissues was evaluated by periodic acid Schiff (PAS) staining. Intraperitoneal (i.p.) and intranasal (IN) injection of HDM induced infiltration of inflammatory cells into lungs of mice. The increase of total cells was higher in young mice than in old mice. Mucus secretion from goblet cells increased after HDM administration, with young mice showing higher mucus production than old mice. In chronic asthmatic state induced by i.p. and IN (three times) injection, old mice exhibited more inflammatory cells, specifically eosinophils, and mucus production than young mice. Our findings suggest that age and exposure duration are critical factors in different manifestations of asthma. Thus, they should be overarchingly considered in drug development for asthma.

• Journal of Mechanical Science and Technology
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• v.20 no.4
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• pp.569-579
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• 2006

In the present study, the unsteady Couette flow with heat transfer of a dusty viscous incompressible electrically conducting fluid under the influence of an exponential decaying pressure gradient is studied without neglecting the Hall effect. The parallel plates are assumed to be porous and subjected to a uniform suction from above and injection from below while the fluid is acted upon by an external uniform magnetic field is applied perpendicular to the plates. The governing equations are solved numerically using finite differences to yield the velocity and temperature distributions for both the fluid and dust particles.

• Communications of the Korean Mathematical Society
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• v.33 no.2
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• pp.571-580
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• 2018

The object of the present paper is to prove the non-existence of pseudo projective Ricci symmetric spacetimes $(PW\;RS)_4$ with different types of energy momentum tensor. We also discuss whether a fluid $(PW\;RS)_4$ spacetime with the basic vector field as the velocity vector field of the fluid can admit heat flux. Next we consider perfect fluid and dust fluid $(PW\;RS)_4$ spacetimes respectively. Finally we construct an example of a $(PW\;RS)_4$ spacetime.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2002.10b
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• pp.373-374
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• 2002

Magnetic fluid seals are used in a wide variety of gas and dust sealing applications. However, it is difficult to seal for liquid because of its characteristic. This study will be a basic guide for a magnetic fluid seal for liquid, especially for blood to be practically used in medical instruments such as rotary blood pumps by clarifying its seal properties. Sealing pressure test, durability test, and hemolysis test have been conducted for this seal. In this study, magnetic fluid, sealing fluid, eccentricity ratio, revolution speed were selected as parameters. As results of the tests, it has been found that the properties of magnetic fluid seal depend on the solvent and the saturation magnetization of magnetic fluid. Therefore, the selection of magnetic fluid is important for this seal. It also has been found that eccentricity ratio of the shaft caused harmful effect for seal properties. In conclusion, it has been showed that magnetic fluid seals could be possibly used in medical instruments such as blood pumps when blood come in contact with magnetic fluids.