• Journal of Gastric Cancer
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• v.11 no.3
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• pp.155-161
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• 2011

Purpose: To determine the diagnostic utility of a frozen section biopsy in patients undergoing endoscopic submucosal dissection (ESD) for early gastric neoplasms with obscure margins even with chromoendoscopy using acetic acid and indigo carmine (AI chromoendoscopy). Materials and Methods: The lateral spread of early gastric neoplasms was unclear even following AI chromoendoscopy in 38 patients who underwent ESD between June 2007 and May 2011. Frozen section biopsies were obtained by agreement of the degree of lateral spread between two endoscopists. Thus, frozen section biopsies were obtained from 23 patients (FBx group) and not in the other 15 patients (AI group). Results: No significant differences were observed for size, histology, invasive depth, and location of lesions between the AI and FBx groups. No false positive or false negative results were observed in the frozen section diagnoses. Adenocarcinoma was revealed in three patients and tubular adenoma in one, thereby changing the delineation of lesion extent and achieving free lateral margins. The rates of free lateral resection margins and curative resection were significantly higher in the FBx group than those in the AI group. Conclusions: Frozen section biopsy can help endoscopists perform more safe and accurate ESD in patients with early gastric neoplasm.

• The Plant Pathology Journal
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• v.33 no.5
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• pp.441-449
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• 2017

Citrus canker is an important bacterial disease of citrus in several regions of the world. Strains of Xanthomonas citri type-A (Xc-A) group are the primary pathogen where citrus canker occurs. After Xc-A entered the Northeast of Argentina in 1974, the disease spread rapidly from 1977 to 1980 and then slowed down and remained moving at slow pace until 1990 when it became endemic. Citrus canker was detected in Northwest Argentina in 2002. This paper presents the main steps in the fight of the disease and the management strategies that have been used to control citrus canker at this time. We think the process might be usefull to other countries with the same situation. Results from more than 40 years of research in Northeast (NE) Argentina indicate that we are at the limit of favorable environment for the disease. The severity of citrus canker is greatly affected by the environment and El $Ni{\tilde{n}}o$ Southern Oscillation (ENSO) phenomenon which causes cyclic fluctuations on the disease intensity in the NE region. Weather-based logistic regression models adjusted to quantify disease levels in field conditions showed that the environmental effect was strongly modulated by the distance from a windbreak. Production of healthy fruits in citrus canker endemic areas is possible knowing the dynamics of the disease. A voluntary Integrated Plan to Reduce the Risk of Canker has been in place since 1994 and it allows growers to export unsymptomatic, uninfested fresh fruit to countries which are free of the disease and require healthy, pathogen free fruits. The experience from Argentina can be replicated in other countries after appropriate trials.

• Korean Journal of Head & Neck Oncology
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• v.21 no.1
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• pp.48-52
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• 2005

Objectives: Castleman's disease(CD) is a lymphoproliferative disorder of unknown etiology. To elucidate the clinicopathologic characteristics of CD, we retrospectively reviewed our experience. Methods: Fifteen patients with CD of the neck and mediastinum were identified. Patients were divided into two groups: group I had an unicentric CD and group II had multicentric CD. The histology of CD was divided into 3 subtypes: hyaline-vascular(HV), plasma cell(PC), and mixed. Results: The study included 12 cases of group I, 3 cases of group II in the clinical aspect and 10 cases with HV, 3 cases with PC, 2 cases with mixed type in the histologic aspect. Of group I patients who underwent complete surgical excision, all are currently free of disease. The clinical course of group II patients was variable. Of two patients with multicentric plasma cell CD who were treated, one remain free from disease and the other had a local recurrence in the neck. One patient with multicentric mixed CD died of disease after 30 months of presentation. Conclusion: Surgical resection is recommend for patients with the unicentric CD, regardless of histologic subtype. Patients with multicentric disease do not benefit from surgical resection and should be candidates for multimodality therapy.

• Proceedings of the Korean Society of Life Science Conference
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• 2001.09a
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• pp.34-34
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• 2001

• JSTS:Journal of Semiconductor Technology and Science
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• v.7 no.3
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• pp.151-160
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• 2007

We report the label-free biomolecules detection based on nanomechanical micro cantilevers operated in dynamic mode for detection of two marker proteins (myoglobin and creatin kinase-MB (CK-MB)) of acute myocardical infarctions. When the specific binding between the antigen and its antibody occurred on the fuctionalized microcantilever surface, mechanical response (i.e. resonant frequency) of microcantilevers was changed in lower frequency range. We performed the label-free biomolecules detection of myoglobin and CK-MB antigen in the low concentration (clinical threshold concentration range) as much as 1 ng/ml from measuring the dynamic response change of micro cantilevers caused by the intermolecular force. Moreover, we estimate the surface stress on the dynamic microcantilevers generated by specific antibody-antigen binding. It is suggested that our dynamic microcantilevers may enable one to use the sensitive label-free biomolecules detection for application to the disease diagnosis system based on mechanical immuno-sensor.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.18 no.3
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• pp.149-159
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• 2015

Crohn's disease is a chronic idiopathic inflammatory disease of the intestines characterized by frequent relapse and remission. It often develops in children and adolescents, who are vulnerable to repeated exposure to ionizing radiations. Magnetic resonance enterography (MRE) is an increasingly important radiation-free imaging modality that is used to evaluate pediatric patients with Crohn's disease. MRE can evaluate extraluminal and extraintestinal abnormalities as well as the status of the bowel wall. In addition, MRE has an advantage in the evaluation of the small bowel involvement. MRE can be used for the initial diagnosis of Crohn's disease, and can aid in the assessment of disease activity and complications such as penetrating and fibrostenotic diseases. The aims of this article are to review the MRE technique for obtaining diagnostic and high-quality images and to discuss interpretations of imaging findings in patients with Crohn's disease.

• Journal of applied mathematics & informatics
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• v.31 no.3_4
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• pp.443-456
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• 2013

In this paper we consider a model with demographics for sexually transmitted diseases (STDs) spread on scale-free networks. We derive the epidemic threshold, which is depend on the birth rate, the natural death rate and other parameters. The absence of a threshold in infinite scale-free network is proved. For a hard cut off scale-free network, we also analyze the stability of disease-free equilibrium and the persistence of STDs infection. Two immunization schemes, proportional scheme and targeted vaccination, are studied and compared. We find that targeted strategy is more effective on scale-free networks.

• Journal of Practical Agriculture & Fisheries Research
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• v.23 no.1
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• pp.27-30
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• 2021

Vaccination for swine food and mouth disease (FMD) has been using needle injection. Needle injection can cause lesions of injection site on muscle and lymph node, leading to consumer's complain and Korea Pork's image deterioration. Needle-free injections have been developing to solve this issues. The current study performed to evaluate the frequency of muscle and lymph node lesions after vaccination using needle-free injection. Needle-free injection significantly decreased the lesions on the injection site compared with the needle injection(36 vs. 16%, p < 0.05). Based on the result, needle-free injection can enhance the quality of pork and decrease consumer's complains. Further study should perform to validate potential of needle-free injection by investigating antibody formation rate, work efficiency, and economic cost.

• Journal of Multimedia Information System
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• v.9 no.1
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• pp.21-32
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• 2022

Early-stage diagnosis of Alzheimer's Disease (AD) from Cognitively Normal (CN) patients is crucial because treatment at an early stage of AD can prevent further progress in the AD's severity in the future. Recently, computer-aided diagnosis using magnetic resonance image (MRI) has shown better performance in the classification of AD. However, these methods use a traditional machine learning algorithm that requires supervision and uses a combination of many complicated processes. In recent research, the performance of deep neural networks has outperformed the traditional machine learning algorithms. The ability to learn from the data and extract features on its own makes the neural networks less prone to errors. In this paper, a dense neural network is designed for binary classification of Alzheimer's disease. To create a classifier with better results, we studied result of different activation functions in the prediction. We obtained results from 5-folds validations with combinations of different activation functions and compared with each other, and the one with the best validation score is used to classify the test data. In this experiment, features used to train the model are obtained from the ADNI database after processing them using FreeSurfer software. For 5-folds validation, two groups: AD and CN are classified. The proposed DNN obtained better accuracy than the traditional machine learning algorithms and the compared previous studies for AD vs. CN, AD vs. Mild Cognitive Impairment (MCI), and MCI vs. CN classifications, respectively. This neural network is robust and better.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.27 no.3
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• pp.146-157
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• 2024

Purpose: Celiac disease (CD) is one of the most prevalent food-related illnesses in children, with a global prevalence of approximately 1.4%. CD can create an emotional burden, particularly on mothers, who are mainly responsible for managing challenges related to adherence to a gluten-free diet, high food costs, and food problems in schools and social areas. There is a gap in the literature, and parental experiences of raising children with CD should be explicitly examined. This qualitative study sought to provide insights into the experiences of parents raising a child with CD in the Turkish context. Methods: This study used a descriptive qualitative research methodology and conducted individual semi-structured video-based dyadic interviews with 19 parents. Results: Participants experienced both challenges and motivators through management of their children's CD. Analyses of the interview transcripts through the data uncovered three main themes focusing primarily on parental concerns: (1) parental challenges in child's disease management, (2) supportive care needs, and (3) parental expectations. Conclusion: A multidisciplinary team should approach the child and family immediately after diagnosis, and facilities should support parents with continuing education and psychological, financial, and social assistance.