• Anatomy and Cell Biology
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• 제56권3호
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• pp.382-393
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• 2023

Cell clusters are a histological hallmark feature of intervertebral disc degeneration. Clusters arise from cell proliferation, are associated with replicative senescence, and remain metabolically, but their precise role in various stages of disc degeneration remain obscure. The aim of this study was therefore to investigate small, medium, and large size cell-clusters. For this purpose, human disc samples were collected from 55 subjects, aged 37-72 years, 21 patients had disc herniation, 10 had degenerated non-herniated discs, and 9 had degenerative scoliosis with spinal curvature <45°. 15 non-degenerated control discs were from cadavers. Clusters and matrix changes were investigated with histology, immunohistochemistry, and Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Data obtained were analyzed with spearman rank correlation and ANOVA. Results revealed, small and medium-sized clusters were positive for cell proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) in control and slightly degenerated human discs, while large cell clusters were typically more abundant in severely degenerated and herniated discs. Large clusters associated with matrix fissures, proteoglycan loss, matrix metalloproteinase-1 (MMP-1), and Caspase-3. Spatial association findings were reconfirmed with SDS-PAGE that showed presence to these target markers based on its molecular weight. Controls, slightly degenerated discs showed smaller clusters, less proteoglycan loss, MMP-1, and Caspase-3. In conclusion, cell clusters in the early stages of degeneration could be indicative of repair, however sustained loading increases large cell clusters especially around microscopic fissures that accelerates inflammatory catabolism and alters cellular metabolism, thus attempted repair process initiated by cell clusters fails and is aborted at least in part via apoptosis.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2005년도 창립60주년 기념 추계 학술대회
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• pp.66.1-66.1
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• 2005

• Journal of Korean Neurosurgical Society
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• 제42권6호
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• pp.490-491
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• 2007

Air within the spinal canal called pneumorrhachis has been seen rarely. We report a case showing multiple air pockets in the paraspinal and epidural space with vacuum disc and review pathogenesis and treatment of pneumorrhachis.

• Journal of applied mathematics & informatics
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• 제7권3호
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• pp.1005-1015
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• 2000

In the unit disc, we find a sufficient condition to bound the Bergman norm by the weighted Poisson integral where the given weighted is $\mid$t$\mid$dt.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2011년도 춘계학술대회 논문집
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• pp.1257-1258
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• 2011

• Tribology and Lubricants
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• 제18권4호
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• pp.305-311
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• 2002

Three different kinds of brake discs including two coated brake discs and one steel disc were tested under the same experimental conditions on a reduced scale braking test bench. A braking test bench was specially designed to analyse thermo-mechanical and frictional behaviors of two types of brake with different sizes in stop and hold braking modes. Plasma spray coating technique was also used to coat the discs with ceramic powder. During the test four commercial brake pads were coupled with discs. Ceramic coated discs showed good stability in friction coefficient at high speed and high energy braking conditions. But they caused large wear loss of pad mass compared with the steel disc. It was shown that thermal barrier effect in ceramic coated discs adjusted the thermal partition between pad and disc. For a steel disc. it showed fluctuating friction coefficient at high speed but small wear loss of pad mass compared with ceramic coated discs.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2002년도 proceedings of the second asia international conference on tribology
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• pp.429-430
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• 2002

In this study, three kinds of brake: discs including two coated brake discs and one steel disc were tested under the same experimental conditions on a reduced scale braking test bench. Plasma spray coating technique was used to coat ceramic powder on the discs. In the test, four commercial sintered brake pads were coupled with discs. Ceramic coated discs have shown good stability in friction coefficient at high speed and high energy braking conditions. However, ceramic coated discs caused more wear loss of pad mass than the steel disc. It was shown that thermal barrier effect in ceramic coated discs adjusted the thermal partition between pad and disc. Steel disc showed fluctuating friction coefficient at high speed but less wear loss of pad mass than ceramic coated discs.

• The Journal of Korean Physical Therapy
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• 제20권3호
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• pp.69-74
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• 2008

Purpose: The majority of patients with radiculopathy caused by a herniated nucleus pulposus (HNP) heal spontaneously without surgery. The aim of this report is to describe the spontaneous regression of lumbar disc herniation and the results of clinical follow-up. Methods: Three patients with radiating low back pain presented with an extruded intervertebral disc on magnetic resonance imaging (MRI). We performed follow-up with conservative treatment (epidural injection, medication, physical therapy, exercise) and clinical assessments on the 6th, 10th and 22nd months. Results: The extruded intervertebral disc almost complete regressed, and correlated with clinical improvement and follow-up MRI. Conclusion: Conservative treatment can be an effective approach for a herniated lumbar discs if no neurological deficits are present.

• The Journal of Korean Physical Therapy
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• 제25권6호
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• pp.417-421
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• 2013

Purpose: This study was to identify the effect of cervical stabilization exercise on pain and structure in patients with cervical artificial disc replacement. Methods: Forty-four individuals with cervical artificial disc replacement volunteered to participate from FEB 2012 to MAR 2013 in this study. They were allocated to either Experimental Group (EG) or Control Group (CG), with 22 subjects in each group. Subjects from the EG performed cervical stabilization exercise program and subjects from the CG performed isometric exercise program. Assessment tools were made with the Visual Analogue Scale (VAS), Neck Disability Index (NDI), and Cervical Lordosis Angle (CLA). Results: In this study, in within-group and between-group comparison, the EG and CG showed significant differences in all parameters(p<0.05). But EG showed more improvement than CG at all parameters. Conclusion: These findings suggest that cervical stabilization exercise may be favorably used to improve VAS, NDI and CLA in patients with cervical artificial disc replacement. Further studies with larger sample and long-term follow-up period need to generalize the results of this study.

• 자동차안전학회지
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• 제8권1호
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• pp.7-12
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• 2016

In order to analyze the soundness of ventilated disc brake systems, numerical study was performed with various vane shapes. In particular, two different vane type, and the braking time from 3.0 s to 4.5s with the interval of 0.5s were considered. Transient temperature distributions on the ventilated disc brake assembly were calculated using ANSYS CFX ver. 16.1. To elucidate the soundness of ventilated disc brake systems, moreover, the heat transfer coefficients were evaluated. Results were graphically depicted with different geometrical vane configurations and braking time.