• Journal of the Korean Society of Safety
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• v.16 no.4
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• pp.134-139
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• 2001

The Risk assessment regulation(RAR) is one of the essential articles of the Occupational safety and health law for the construction industry along with safety and health management expense and safety organization regulation. However, arguments regarding the working time of the safety assessment documents, the person in charge of documentation, weakness in legislative enforcement etc. are ongoing. Thus this study aims to analyze the effectiveness of RAR for the guidance of enhancing the effectiveness of RAR. The findings are; 1) the effectiveness of RAR is recognized, however the indirect effectiveness ie, enforcement of safety activities, previewing of drawings etc. are bigger than the direct effectiveness of accident prevention, 2) to enhance the effectiveness of RAR site inspection procedure has to be utilized, 3) further research for identifying and getting rid of negative factors in RAR is recommended.

• Molecules and Cells
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• v.40 no.5
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• pp.322-330
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• 2017

This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anti-cancer drug-resistant $Malme3M^R$ cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and $Malme3M^R$ cells. Furthermore, the self-renewal activity and the tumorigenic potential of $Malme3M^R$-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas.

• Journal of Korea Trade
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• v.23 no.4
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• pp.115-130
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• 2019

Purpose - This paper examines the impact of labor market regulations on FDI and the production of foreign firms. Design/methodology - We use an index of employment protection along with data on the FDI and production of foreign affiliates that are provided by the OECD. Findings - The empirical results show that strict employment protection discourages both the production and initial entry of foreign firms, with its impact on production being larger than that on the initial entry decision. The result is robust to various specifications in which instrumental variable estimations are used by applying a unionization rate and a severance pay for redundancy dismissal as instruments, respectively. Therefore, policymakers should not limit their focus to tax incentives, cash grants, and relaxation of market regulations, but they should also extend their attention to labor market deregulation and decreasing non-wage cost to attract more foreign firms into their countries. Originality/value - This paper attempts to answer the question on the impact of employment protection rules on the foreign firm's decisions regarding production as well as initial entry.

• Molecules and Cells
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• v.45 no.11
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• pp.763-770
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• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• Molecules and Cells
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• v.41 no.12
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• pp.1061-1071
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• 2018

From Xenopus embryo studies, the BMP4/Smad1-targeted gene circuit is a key signaling pathway for specifying the cell fate between the ectoderm and neuro-ectoderm as well as the ventral and dorsal mesoderm. In this context, several BMP4/Smad1 target transcriptional factors have been identified as repressors of the neuro-ectoderm. However, none of these direct target transcription factors in this pathway, including GATA1b, Msx1 and Ventx1.1 have yet been proven as direct repressors of early neuro-ectodermal gene expression. In order to demonstrate that Ventx1.1 is a direct repressor of neuro-ectoderm genes, a genome-wide Xenopus ChIP-Seq of Ventx1.1 was performed. In this study, we demonstrated that Ventx1.1 bound to the Ventx1.1 response cis-acting element 1 and 2 (VRE1 and VRE2) on the promoter for zic3, which is a key early neuro-ectoderm gene, and this Ventx1.1 binding led to repression of zic3 transcription. Site-directed mutagenesis of VRE1 and VRE2 within zic3 promoter completely abolished the repression caused by Ventx1.1. In addition, we found both the positive and negative regulation of zic3 promoter activity by FoxD5b and Xcad2, respectively, and that these occur through the VREs and via modulation of Ventx1.1 levels. Taken together, the results demonstrate that the BMP4/Smad1 target gene, Ventx1.1, is a direct repressor of neuro-ectodermal gene zic3 during early Xenopus embryogenesis.

• Journal of the Korean Institute of Gas
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• v.18 no.5
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• pp.12-19
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• 2014

To minimize the risk of corrosion on buried pipeline and to maximize the efficiency of cathodic protection, various indirect inspection techniques have been used for decades. In the United States, 49 CFR has regulated the external corrosion direct assessment for buried pipelines. In Korea, there is no provision for external corrosion direct assessment but there is only, according to the KGS Code, provision that if the survey of the defects of buried pipeline and the leakage test for the pipe were conducted, it is deemed to leakage inspection. We, therefore, have suggested external corrosion direct assessment method appropriate to domestic status through the survey of the regulations and standards of UK and the USA and the investigation of domestic situation on coating damage detection method. The proposed external corrosion direct evaluation method was used as the basis when introducing the precision safety diagnosis regulation for the medium-pressure pipe in Korea.

• Journal of international Conference on Electrical Machines and Systems
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• v.3 no.2
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• pp.169-175
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• 2014

This paper presents an improved direct power control (DPC) strategy for grid-connected voltage source inverter (VSI) under unbalanced and harmonic grid voltage conditions. Based on the mathematic model of VSI with the negative sequence, 5th and 7th harmonic voltage components consideration, a PI controller is used in the proposed DPC strategy to achieve the average output power regulation. Furthermore, vector PI controller with the resonant frequency tuned at the two times and six times grid fundamental frequency is adopted to regulate both negative and harmonic components, and then two alternative targets of the balanced/sinusoidal current and smooth active/reactive output power can be achieved. Finally, simulation results based on MATLAB validate the availability of the proposed DPC strategy.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.187-190
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• 1997

In the past few years, many researchers are interesting of control of mobile robot with nonholonomic constraints. And tracking problems is important as well as regulation in nonholonomic system control. Some researchers have investigated the stable tracking control law for mobile robot. But, few results showed the globally asymptotically stable control method simply. So, we address the design of globally asymptotically stable tracking control law for mobile robot with nonholonomic velocity constraints using simple method. The stabilizability of the controller is derived by Lyapunov direct method. And we analyze the system responses according to the variation of control parameters in line tracking problem. It is derived that the responses represent no overshoot property in line tracking. Examples are two-wheeled mobile robot and car-like mobile robot and the simulation results represent the effectiveness of our method.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.12 no.3
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• pp.59-66
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• 1998

In this paper, the thrust control of PWM Inverter-Fed SLIM(Single-sided Linear Induction Motor) is achieved with Space Vector control and PI control. The trembling of air gap length which is occurred between the primary winding core and the secondary structure of the SLIM must be minimized in order to get quick response characteristics. First, the equivalent circuits and voltage equations of SLIM are shown on th suitable d-q axis which analyze characteristics of the thrust and the normal force. Also, modeling and analysis of the equivalent circuits transferred d-q axis are able to make robust transient torque from the current regulation in the equivalent circuit. These results exemplified the direct drive of SLIM with the reference speed and torque were verified by experiments.

• Journal of international Conference on Electrical Machines and Systems
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• v.1 no.2
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• pp.46-52
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• 2012

This paper proposes a novel single-phase ac-ac converter topology based on the Z-source concept. The converter provides buck-boost function and plays the role of frequency changer. Compared to the traditional ac-dc-ac converter, it uses fewer devices, realizes direct ac-ac power conversion, and has a simpler circuit structure, so as to have higher efficiency and better circuit characteristics. Compared to the traditional matrix converter, it provides a wider voltage regulation range. The circuit topology, operating principle, control method and simulation results are given in this paper, and the rationality and feasibility is verified.