• Journal of Mechanical Science and Technology
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• 제19권spc1호
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• pp.350-356
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• 2005

A method of dynamic analysis of mechanical systems considering probabilistic properties is proposed in this paper. Probabilistic properties that result from manufacturing tolerances can be represented by means and standard deviations (or variances). The probabilistic characteristics of dynamic responses of constrained multi-body systems are obtained by two ways : the proposed analytical approach and the Monte Carlo simulation. The formerpaper, necessitates sensitivity information to calculate the standard deviations. In this a direct differentiation method is employed to find the sensitivities of constrained multi-body systems. To verify the accuracy of the proposed method, numerical examples are solved and the results obtained by using the proposed method are compared to those obtained by Monte Carlo simulation.

• Journal of Welding and Joining
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• 제19권2호
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• pp.228-234
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• 2001

A methodology is developed and used to evaluate the response sensitivity of the thermal systems to variations in their design parameters. Technique for computing the sensitivity of temperature distributions to changes in processing parameters needed to decide the more effective laser input parameters for laser surface hardening treatment is considered. In this study, a state equation governing the heat flow in laser surface treatment is analyzed using a three-dimensional finite element method and sensitivity data of the processing parameter obtained using a direct differentiation method is applied to the sensitivity analysis. The interesting processing parameters are taken as the laser scan velocity and laser beam radius ( $r_{ b}$), and the sensitivities of the temperature T versus v and $r_{b}$ are analyzed. These sensitivity results are obtained with another parameters fixed. To verify the numerical analysis results, hardened layer dimensions (width and depth) of the numerical analysis are compared with the experimental ones.nes.

• Journal of Welding and Joining
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• 제16권3호
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• pp.141-147
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• 1998

Design sensitivity analysis of a vehicle system is an essential tool for design optimization and trade-off studies. Most optimization algorithms require the derivatives of cost and constraint function with respect to design in order to calculate the next improved design. This paper presents an efficient algorithm application for the design sensitivity analysis, using the direct differentiation method. A mounting area of suspension that welded on chassis frame is analyzed to show the validity and the efficiency of the proposed method. A mounting area of suspension that welded on chassis frame is analyzed to show the validity and the efficiency of the proposed method.

• Journal of Ship and Ocean Technology
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• 제8권3호
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• pp.50-60
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• 2004

In this paper, a continuum-based design sensitivity analysis (DSA) method is developed for the weakly coupled thermo-elasticity problems. The temperature and displacement fields are described in a common domain. Boundary value problems such as an equilibrium equation and a heat conduction equation in steady state are considered. The direct differentiation method of continuum-based DSA is employed to enhance the efficiency and accuracy of sensitivity computation. We derive design sensitivity expressions with respect to thermal conductivity in heat conduction problem and Young's modulus in equilibrium equation. The sensitivities are evaluated using the finite element method. The obtained analytical sensitivities are compared with the finite differencing to yield very accurate results. Extensive developments of this method are useful and applicable for the optimal design problems incorporating welding and thermal deformation problems.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집C
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• pp.402-407
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• 2001

Sensitivity analysis scheme is developed in the elasto-plastic finite element method with explicit time integration using direct differentiation method. The direct differentiation is concerned with the time integration, constitutive relation, shell element with reduced integration and the contact scheme. Sensitivity analysis results are mainly examined with the highly nonlinear and quasi-static problem with the complicated contact condition. The result shows stable sensitivity especially in the sheet metal forming analysis.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1992년도 하계학술대회 논문집 B
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• pp.567-569
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• 1992

Design sensitivity analysis is proposed for the optimal shape design of three dimensional magnetostatic problems. The direct differentiation method is introduced for design sensitivity analysis and the boundary element method with reduced magnetic scalar potential as the state variable is used to analyze the magnetic characteristics. In the direct differentiation method, the design sensitivity, defined as the total derivative of the objective function with respect to the design variables, is calculated based on the variation of the state variable with respect to the design variable. And the variation of He state variable is calculated by differentiating the both sides of the system matrix equation obtained by applying boundary element method. Through the numerical example with simple electromagnet, the usefullness is proved.

• 대한기계학회논문집A
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• 제29권11호
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• pp.1455-1462
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• 2005

In this paper, we intend to introduce a nonlinear finite element method based on the fully nonlinear potential flow theory in order to simulate the large amplitude sloshing flow in two-dimensional baffled tank subject to horizontally forced excitation. The free surface is tracked by a direct time differentiation scheme with the four-step predictor-corrector time integration method. The flow velocity is accurately recovered from the velocity potential by second-order least square method. In order to maintain the finite element mesh regularity and total mass, the semi-Lagrangian surface tracking method with area conservation is applied. According to the numerical formulae, we perform the parametric experiments by varying the installation height and the opening width of baffles, in order to examine the effects of baffle on the nonlinear liquid sloshing. From the numerical results, the hydrodynamic characteristics of the large amplitude sloshing are investigated.

• 대한전기학회논문지
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• 제41권8호
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• pp.850-857
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• 1992

Design sensitivity analysis is proposed for the optimal shape design of three-dimensional magnetostatic problems. The direct differentiation method is introduced for design sensitivity analysis and the boundary element method with reduced magnetic scalar potential as the state variable is used to analyze the magnetic characteristics. In the direct differentiation method, the design sensitivity, defined as the total derivative of the objective function with respect to the design variables, is calculated based on the variation of the state variable with respect to the design variable. And the variation of the state variable is calculated by differetiating the both sides of the system matrix equation obtained by applying boundary element method. Through the numerical example with simple electromagnet, the usefulness is proved.

• International Journal of Stem Cells
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• 제15권1호
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• pp.14-25
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• 2022

Glia have been known for its pivotal roles in physiological and pathological conditions in the nervous system. To study glial biology, multiple approaches have been applied to utilize glial cells for research, including stem cell-based technologies. Human glial cells differentiated from pluripotent stem cells are now available, allowing us to study the structural and functional roles of glia in the nervous system, although the efficiency is still low. Direct conversion is an advanced strategy governing fate conversion of diverse cell types directly into the desired lineage. This novel strategy stands as a promising approach for preliminary research and regenerative medicine. Direct conversion employs genetic and environmental cues to change cell fate to that with the required functional cell properties while retaining maturity-related molecular features. As an alternative method, it is now possible to obtain a variety of mature cell populations that could not be obtained using conventional differentiation methods. This review summarizes current achievements in obtaining glia, particularly oligodendrocytes and Schwann cells.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2000년도 춘계 학술대회논문집
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• pp.66-72
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• 2000

Aerodynamic sensitivity analysis is performed for the Navier-Stokes equations coupled with two-equation turbulence models using a discrete adjoint method and a direct differentiation method respectively. Like the mean flow equations, the turbulence model equations are also hand-differentiated to accurately calculate the sensitivity derivatives of flow quantities with respect to design variables in turbulent viscous flows. Both the direct differentiation code and the adjoint variable code adopt the same time integration scheme with the flow solver to efficiently solve the differentiated equations. The sensitivity codes are then compared with the flow solver in terms of solution accuracy, computing time and computer memory requirements. The sensitivity derivatives obtained from the sensitivity codes with different turbulence models are compared with each other. Using two-equation turbulence models, it is observed that a usual assumption of constant turbulent eddy viscosity in adjoint methods may lead to seriously inaccurate results in highly turbulent flows.