• Journal of Digital Convergence
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• 제18권3호
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• pp.179-187
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• 2020

In a social environment where population aging is rapidly progressing, the healthcare service market is growing fast with the increasing interest in health and quality of life based on rising income levels and the evolution of technology. In this study, after keywords were extracted from Korean and US patent data published on KIPRIS from 2000 to October 2019, frequency analysis, time series analysis, and keyword network analysis were performed. Through this, the change of technology trends were identified, which keywords related to healthcare was shifted from traditional medical words to ICT words. In addition, although the keywords in Korean patents are 55% similar to those in the US, they show an absolute gap in patent production volume. In the next study, we will analyze various data such as domestic and international research and can obtain meaningful implications in the global market on the identified keywords.

• IT SoC Magazine
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• 통권25호
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• pp.52-53
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• 2008

• IT SoC Magazine
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• 통권25호
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• pp.50-51
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• 2008

• Journal of Convergence for Information Technology
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• 제11권1호
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• pp.175-182
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• 2021

The purpose of this study is to establish the direction of industrial policy by comparing the employment inducement effect on the related industries of the digital bio-healthcare industry. The analysis data used the three-year input-output table measured by the Bank of Korea. First, the research method was rewritten into 7 major industries to compare statistical data by period. Second, the Bank of Korea's industry-related analysis methodology was utilized. Third, the weight was reflected and compared by employment, production, and investment sectors of the digital bio-healthcare industry. As a result of the analysis, first, the employment sector had a higher effect than the average of the entire industry, second, the production sector was low, and third, the investment sector required investment in the service sector. The conclusions drawn from the analysis showed that direct investment and continuous investment are required in the employment sector, the development of professional manpower is urgent, and direct investment and long-term investment are effective in the production sector.

• Biomedical Science Letters
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• 제27권4호
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• pp.216-222
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• 2021

Colorectal cancer (CRC) is major cancer with high incidence and mortality worldwide. It is known that most CRCs arise from precursor adenomatous polyps (APs). Recently, microRNA (miRNA) has been proposed as a biomarker for various cancers including CRC. In this study, the expression patterns of miR-29a in the whole blood (WB) of CRC, AP, and control groups were analyzed by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) to evaluate the expression level of miR-29a in patients with colorectal neoplasm (CRN) including CRC and AP. As a result, the relative expression of miR-29a was significantly decreased in the patients with CRN compared to the control group (P<0.001). The results were in agreement with previous in vitro cell studies and studies that used tissue and feces samples, suggesting that miR-29a in WB may be useful in demonstrating the status of colorectal tissue. Additionally, we divided the control group into healthy control (HC) without any colorectal symptoms and non-tumor control (NTC) with colorectal symptoms but without any CRN. And then the relative expression of miR-29a was also significantly decreased in the NTC group compared to the HC group (P<0.001). Therefore, our study revealed that miR-29a can differentiate patients with CRN from HC group, but they are also involved in the early stage of inflammatory response and cannot be specific biomarkers for CRN.

• Parasites, Hosts and Diseases
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• 제61권3호
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• pp.263-271
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• 2023

The present study aimed to survey the prevalence of chigger mites and Orientia tsutsugamushi (O. tsutsugamushi) infection in the northern regions of Gangwon-do, Korea. From early February to early June 2015, a total of 17,050 chiggers were collected from striped field mice, Apodemus agrarius, in Cheorwon-gun, Hwacheon-gun, Yanggu-gun, and Goseong-gun, which are well-known endemic areas of scrub typhus in Korea. The chiggers were analyzed using molecular genomic methods, as previously described. Among the 7,964 identified chiggers, the predominant species was Leptotrombidium pallidum (76.9%), followed by L. zetum (16.4%), L. orientale (4.3%), L. palpale (0.3%), L. tectum (0.2%), and Neotrombicula tamiyai (1.8%). The chigger index (CI) was highest in Hwacheon (115.58), followed by Cheorwon (97.02), Yanggu (76.88), and Goseong (54.68). Out of the 79 O. tsutsugamushi-positive chigger pools, 67 (84.8%) were identified as the Boryong strain, 10 (12.7%) as the Youngworl strain, and only 2 were the Jecheon strain. Based on the high infestation of chiggers in striped field rodents and the high rate of O. tsutsugamushi infection in chigger mites, Hwacheon-gun and Cheorwon-gun are presumed to be high-risk areas for scrub typhus. Furthermore, L. pallidum, a major vector of scrub typhus, and the dominant O. tsutsugamushi serotype, the Boryong strain, were found in the northern regions of Gangwon-do, Korea.

• Biomedical Science Letters
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• 제29권2호
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• pp.66-74
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• 2023

Triglyceride (TG) accumulation can cause monocytic death and suppress innate immunity. However, the signaling pathways involved in this phenomenon are not fully understood. This study aimed to examine whether inducible nitric oxide synthase (iNOS) is involved in the TG-induced death of THP-1 monocytes. Results showed that iNOS was upregulated in TG-treated THP-1 monocytes, and iNOS inhibition blocked TG-induced monocytic death. In addition, TG-induced poly (ADP-ribose) polymerase (PARP) cleavage and caspase-3 and -7 activation were suppressed by iNOS inhibition. Furthermore, the expression of X-linked inhibitor of apoptosis protein (XIAP) and survivin, which inhibit caspase-3 and -7, was reduced in TG-treated THP-1 monocytes, but iNOS inhibition recovered the TG-induced downregulation of XIAP and survivin expression. Considering that TG-induced monocytic death is triggered by caspase2 and -8, we investigated whether caspase-2 and -8 are linked to the TG-induced expression of iNOS in THP-1 monocytes. When the activities of caspase-2 and -8 were inhibited by specific inhibitors, the TG-induced upregulation of iNOS and downregulation of XIAP and survivin were restored in THP-1 monocytes. These results suggest that TG-induced monocytic death is mediated by the caspase-2/caspase-8/iNOS/XIAP and survivin/executioner caspase/PARP pathways.

• The Journal of Bigdata
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• 제7권1호
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• pp.29-36
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• 2022

The prevalence of stress and depression among emotional workers is increasing due to the rapid increase in emotional labor and service workers. However, the current mental health management of emotional workers is difficult to consider the emotional response at the time of stress situations, and the existing mental health management is limited because the individual's base state is not reflected. In this study, we present mental healthcare digital twin solution technology, a personalized stress risk management solution. For mental health risk management due to emotional labor, a solution simulation is performed to accurately predict stress risk through synchronization/modeling of dynamic objects in virtual space by extracting individual stress risk factors such as emotional/physical response and environment into various modalities. It provides a mental healthcare digital twin solution for predicting personalized mental health risks that can be configured with modalities and objects tailored to the environment of emotional workers and improved according to user feedback.

• Journal of Digital Convergence
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• 제15권11호
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• pp.251-259
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• 2017

Recently, the smart healthcare industry that grafted the Internet of Things (IoT) onto the healthcare and medical services is being highlighted. Smart healthcare refers to the healthcare and medical services offered on the basis of information communication technologies including application, wearable devices and platforms, etc. The number of next generation smart healthcare devices are increasing in the smart healthcare industry through the combination of information technology (IT) and Bio Technology (BT), which are the most active areas among the 6T, which are the areas of the next generation industry. With the emergence of a diverse range of smart healthcare systems or devices, whether the smart healthcare system can be linked with other systems organically and the security and quality of the system have become important elements of evaluation. In this Study, the characteristics and service types of smart healthcare systems were examined, and the trends in the technology and industry of the smart healthcare system were analyzed. Moreover, this Study aims to develop the evaluation method for security and standards for quality evaluation by deducing the factors for the evaluation of smart healthcare system on the basis of the results of aforementioned examination. It is anticipated that this can induce improvement of quality and development of highly reliable products of a smart healthcare system, and will become the core technology to substitute the technology protection barrier.

• Journal of Digital Convergence
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• 제6권3호
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• pp.139-147
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• 2008

-Healthcare란 건강관련 정보를 시간과 공간의 제약 없이 수집, 처리, 전달, 관리할 수 있게 해줌으로써 원격지 의료서비스를 제공하는 것을 말한다. 본 논문은 USN을 활용하여 원격에서 측정된 의료정보를 수집하여 서버에 전달하는 미들웨어 시스템을 시뮬레이션 했다. 헬스 케어기기에서 측정된 데이터를 USN을 통해 원격지의 서버로 전송하는데, 데이터의 전송에는 근거리 무선통신기술인 Zigbee를 사용하였다. 이러한 과정에서 헬스 케어기기와 서버사이에 미들웨어를 두어 측정된 이진코드 데이터를 텍스트데이터로 변환하여 서버의 헬스케어 시스템에 저장한다. 서버에 저장된 환자들의 의료정보는 의료진이 활용할 수 있도록 했다. 또한, 미들웨어 시스템에서는 데이터의 필터링을 통해 불필요한 데이터를 삭제해 서버의 부하를 줄여서, 외부 어플리케이션의 질의에 대한 정보제공을 용이하게 했다.