• Korean Journal of Radiology
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• 제22권7호
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• pp.1021-1033
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• 2021

Objective: To assess the expression of vascular normalization genes in different molecular subtypes of breast cancer and to determine whether molecular subtypes with a higher vascular normalization gene expression can be identified using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). Materials and Methods: This prospective study evaluated 306 female (mean age ± standard deviation, 50 ± 10 years), recruited between January 2014 and August 2017, who had de novo breast cancer larger than 1 cm in diameter (308 tumors). DCE MRI followed by IVIM DWI studies using 11 different b-values (0 to 1200 s/mm²) were performed on a 1.5T MRI system. The Tofts model and segmented biexponential IVIM analysis were used. For each tumor, the molecular subtype (according to six [I-VI] subtypes and PAM50 subtypes), expression profile of genes for vascular normalization, pericytes, and normal vascular signatures were determined using freshly frozen tissue. Statistical associations between imaging parameters and molecular subtypes were examined using logistic regression or linear regression with a significance level of p = 0.05. Results: Breast cancer subtypes III and VI and PAM50 subtypes luminal A and normal-like exhibited a higher expression of genes for vascular normalization, pericyte markers, and normal vessel function signature (p < 0.001 for all) compared to other subtypes. Subtypes III and VI and PAM50 subtypes luminal A and normal-like, versus the remaining subtypes, showed significant associations with K^trans, k_ep, v_p, and IAUGC_BN90 on DEC MRI, with relatively smaller values in the former. The subtype grouping was significantly associated with D, with relatively less restricted diffusion in subtypes III and VI and PAM50 subtypes luminal A and normal-like. Conclusion: DCE MRI and IVIM parameters may identify molecular subtypes of breast cancers with a different vascular normalization gene expression.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권9호
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• pp.3712-3729
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• 2020

Smoke detection is helpful for early fire detection. With its large coverage area and low cost, vision-based smoke detection technology is the main research direction of outdoor smoke detection. We propose a two-stage smoke detection method combined with block Deep Normalization and Convolutional Neural Network (DNCNN) and visual change image. In the first stage, each suspected smoke region is detected from each frame of the images by using block DNCNN. According to the physical characteristics of smoke diffusion, a concept of visual change image is put forward in this paper, which is constructed by the video motion change state of the suspected smoke regions, and can describe the physical diffusion characteristics of smoke in the time and space domains. In the second stage, the Support Vector Machine (SVM) classifier is used to classify the Histogram of Oriented Gradients (HOG) features of visual change images of the suspected smoke regions, in this way to reduce the false alarm caused by the smoke-like objects such as cloud and fog. Simulation experiments are carried out on two public datasets of smoke. Results show that the accuracy and recall rate of smoke detection are high, and the false alarm rate is much lower than that of other comparison methods.

• 한국전산유체공학회지
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• 제4권1호
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• pp.8-18
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• 1999

In devising a numerical approximation for the convective spatial transport of a fluid mechanical quantity, it is noted that the convective motion of a scalar quantity occurs in one-way, or from upstream to downstream. This consideration leads to a new scheme termed a pure upwind difference scheme (PUDS) in which an estimated value for a fluid mechanical quantity at a control surface is not influenced from downstream values. The formal accuracy of the proposed scheme is third order accurate. Two typical benchmark problems of a wall-driven fluid flow in a square cavity and a buoyancy-driven natural convection in a tall cavity are computed to evaluate performance of the proposed method. for comparison, the widely used simple upwind scheme, power-law scheme, and QUICK methods are also considered. Computation results are encouraging: the proposed PUDS sensitized to the convection direction produces the least numerical diffusion among tested convection schemes, and, notable improvements in representing recirculation of fluid stream and spatial change of a scalar. Although the formal accuracy of PUDS and QUICK are the same, the accuracy difference of approximately a single order is observed from the revealed results.

• 전기학회논문지P
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• 제60권1호
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• pp.27-31
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• 2011

In this paper, the electron transport characteristics in $CF_4$ has been analysed over the E/N range 1~300[Td] by a two-term approximation Boltzmann equation method and by a Monte Carlo simulation. The motion has been calculated to give swarm parameters for the electron drift velocity, longitudinal diffusion coefficient, the ratio of the diffusion coefficient to the mobility, electron ionization and attachment coefficients, effective ionization coefficient, mean energy, collision frequency and the electron energy distribution function. The electron energy distribution function has been analysed in $CF_4$ at E/N=5, 10, 100, 200 and 300[Td] for a case of the equilibrium region in the mean electron energy and respective set of electron collision cross sections. The results of Boltzmann equation and Monte Carlo simulation have been compared with experimental data by Y. Nakamura and M. Hayashi. The swarm parameter from the swarm study are expected to serve as a critical test of current theories of low energy electron scattering by atoms and molecules, in particular, as well as crucial information for quantitative simulations of weakly ionized plasmas.

• 한국방사선학회논문지
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• 제9권5호
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• pp.307-314
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• 2015

유방 자기공명영상검사 시 확산강조영상에서 발생하는 심장과 폐에 의한 불수의적 움직임 인공물과 감소된 영상영역 에코평면영상기법으로 발생하는 둘러겹침 인공물을 추가적인 사전포화기법을 사용하여 이를 저감화시키고자 하였다. 2014년 08월 1일부터 11월 30일까지 여성 환자 38명을 대상으로 하였으며 사용 장비로는 유방 검사에 최적화된 3.0T와 유방 전용 코일을 사용하였다. 영상의 평가와 분석은 정량적, 정성적 분석을 하였으며 통계적 유의성은 Paired T-test와 Wilcoxon rank test를 하였다. 결과적으로 추가적인 사전포화펄스의 사용으로 정량적인 평가에서는 병변에서 15.69%, 병변 근접 부위에서 13.72%, 지방에서 20.63%의 증가를 보였으며, 대조도 대 잡음비의 경우는 병변과 병변 근접 부위에서 10.58%, 병변과 지방 부위에서 12.03%의 증가로 나타났다. 정성적인 평가에서는 확산경사계수 0에서 22.05%, 1000에서 21.42%, 현성확산계수에서 16.10%의 증가로 나타났으며, 통계적 평가에서는 신호 대 잡음비와 대조도 잡음비, 확산경사계수와 현성확산계수에서 모두 유의한 결과로 나타났다(p<0.05). 따라서 사전포화펄스의 추가적인 사용으로 유방 자기공명영상 검사에서 확산강조영상 획득 시 위상 부호화 방향으로 발생하는 불수의적 움직임 인공물과 둘러겹침 인공물이 감소가 되어 최적의 영상을 얻을 수 있을 것으로 판단된다.

• 한국콘텐츠학회논문지
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• 제14권6호
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• pp.93-107
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• 2014

최근 한국 영화시장은 높은 성장률을 거듭하면서 그 영향력을 해외로 넓히고 있다. 그에 따라 다양한 학문 영역에서 영화시장의 특성을 분석하기 위한 시도가 이루어져 왔다. 본 연구에서는 영화 간의 유사성과 관련성을 기반으로 한 사회 연결망 분석을 통해 국내 시장에서 개봉된 영화들을 몇 개의 군집으로 나누어 그 특성을 분석하였다. 장르, 등급, 배급사, 국적, 규모, 수익성 등의 여러 특성을 활용하여 얻은 연결망은 몇 개의 군집으로 나뉘며, 각각의 군집에 대하여 군집을 규정지을 수 있는 대표적인 특성과 군집 별대표로 선정된 영화들의 특성을 살펴보았다. 분석결과 장르에 비해 상영등급과 국적이 전체 영화시장을 각각의 군집으로 나누는 중요한 기준인 것으로 나타났으며, 영화의 수익성에 있어서도 군집 간 차이가 두드러졌다. 더 나아가 확산 모형의 추정 결과는 영화의 성공과 입소문 효과의 연관성을 보여주고 있으며, 상대적으로 성공을 거두지 못한 영화들의 경우에는 높은 초기수요와 빠른 최대 시점을 갖는 단조 감소의 확산 패턴을 가지는 것으로 나타났다.

• 한국막학회:학술대회논문집
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• 한국막학회 1997년도 추계 총회 및 학술발표회
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• pp.69-70
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• 1997

Polyimides and related polymers, when synthesized from aromatic monomers, have generally rigid chain structures resulting in a low gas permeability. The rigidity of polymer chains reduces the segmental motion of chains and works as a good barrier against gas transport. To overcome the limit of use as materials of gas separation membranes due to low gas permeability, block copolymers with the incorporation of flexible segments like siloxane linkage and ether linkage have been studied. These block copolymers have microphase-separated structures composed of microdomains of flexible poly(dimethylsiloxane) or polyether segments and of rigid polyimides segments. In case of rigid-flexible block copolymers, the characteristics of both phases for gas permeation are of great difference. The permeation of gas molecules occurs favorably through microdomains of flexible segments, whereas those of rigid segments hinder the permeation of gas molecules. Accordingly the increase of content of flexible segments in a rigid polymer matrix will increase the gas permeability of the membrane linearly. However, this prediction does not satisfy enough many experimental results and in particular the drastic increase of the permeability is observed in a certain volume fraction. It was proposed that the gas transport mechanism is dominated by diffusion rather than gas solubility in a certain content of flexible phase if solution-diffusion mechanism is adopted. However, the transition from solubility-dependent to diffusion-dependent cannot be explained by the understanding of mechanism itself. Therefore, we consider an effective chemical path which permeable phase can form in a microheterogenous medium, and percolation concept is introduced to describe the permeability transition at near threshold where for the first time a percolation path occurs. The volume fraction of both phases is defined as V$_{\alpha}$ and V$_{\beta}$ in block copolymers, and the volume of $\beta$ phase in the threshold forming geometrically a traversing channel is defined as V$_{\betac}$. The formation mechanism of shortest chemical channel is schematically depicted in Fig. 1.

• Korean Membrane Journal
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• 제5권1호
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• pp.43-53
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• 2003

The selectivity of a gas in the carbon molecular sieve membrane (CMSM) can be expressed as the ratio of the product of the diffusivity and the solubility of two different gases. The diffusivity is also expressed as the product of the entropy and the total energy (kinetic and potential energy) in the nano-sized pore of the membrane. The present study calculates the entropic-energy and selectivity of penetrant gases such as H$_2$, O$_2$, N$_2$, and CO$_2$ from the gas-in-a box theory to physically analyze the diffusivity of penetrant gas in slit-shaped pore of CMSM focusing on the restriction of gas motion based on the size difference between penetrant gas pairs. The contribution of each energy term is converted to entropic term separately. By the conjugated calculation for each entropic-energy, the entropic effects on diffusivity-selectivity for gas pairs such as H$_2$/N$_2$, CO$_2$/N$_2$, and O$_2$/N$_2$ were analyzed within active pore of CMSM. In the activated diffusion domain, the calculated value of entropic-selectivity lies between 9.25 and 111.6 for H$_2$/N$_2$, between 3.36 and 6.0 for CO$_2$/N$_2$, and between 1.25 and 16.94 for O$_2$/N$_2$, respectively. The size decrement of active pore in CMSM had the direct effect on the reduction of translational entropic-energy and the contribution of vibrational entropic-energy for N$_2$, O$_2$, and H$_2$ was almost negligible. However, the vibrational entropic term of CO$_2$ might extravagantly affect on the entropic-selectivity.

• 한국컴퓨터그래픽스학회논문지
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• 제10권3호
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• pp.52-60
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• 2004

This paper presents a physically based technique for simulating complex multiphase fluids. This work is motivated by the "stable fluids" method developed by Stam to handle gaseous fluids. We extend this technique to water, which calls for the development of methods for modeling multiphase fluids and suppressing dissipation. We construct a multiphase fluid formulation by combining the Navier-Stokes equations with the level set method. By adopting constrained interpolation profile (CIP)-based advection, we reduce the numerical dissipation and diffusion significantly. We further reduce the dissipation by converting potentially dissipative cells into droplets or bubbles that undergo Lagrangian motion. Due to the multiphase formulation, the proposed method properly simulates the interaction of water with surrounding air, instead of simulating water in a void space. Moreover. the introduction of the non-dissipative technique means that, in contrast 10 previous methods, the simulated water does not unnecessarily lose mass and its motion is not damped to an unphysical extent. Experiments showed that the proposed method is stable and runs fast. It is demonstrated that two-dimensional simulation runs in real-time.

• 한국컴퓨터그래픽스학회논문지
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• 제10권4호
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• pp.13-21
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• 2004

This paper presents a physically based technique for simulating complex multiphase fluids. This work is motivated by the "stable fluids" method developed by Stam to handle gaseous fluids. We extend this technique to water, which calls for the development of methods for modeling multiphase fluids and suppressing dissipation. We construct a multiphase fluid formulation by combining the Navier-Stokes equations with the level set method. By adopting constrained interpolation profile (CIP)-based advection, we reduce the numerical dissipation and diffusion significantly. We further reduce the dissipation by converting potential1y dissipative cel1s into droplets or bubbles that undergo Lagrangian motion. Due to the multiphase formulation, the proposed method properly simulates the interaction of water with surrounding air, instead of simulating water in a void space. Moreover, the introduction of the non-dissipative technique means that, in contrast to previous methods, the simulated water does not unnecessarily lose mass and its motion is not damped to an unphysical extent. Experiments showed that the proposed method is stable and runs fast. It is demonstrated that two-dimensional simulation runs in real-time.