• 대한두경부종양학회지
• /
• 제16권2호
• /
• pp.206-211
• /
• 2000

Objectives: Any uptake of I-131 after total thyroidectomy means the remant thyroid tissue or distant metastasis of the thyroid cancer. However diffuse hepatic uptake of I-131 without abnormal uptake was showen in many cases on I-131 whole body scan. The aim of this study was to classify the liver uptake after I-131 scan and to evaluate the analysis of this finding. Materials and Methods: Between 1982 and 1998, 104 patients(l4 males, 90 females) with normal liver function underwent I-131 scan after total thyroidectomy. Prospectively we reviewed the films of the whole body scan and analysed the correlations between results of radioiodine uptake, pathologic diagnosis, prognostic factors, lymphatic metastasis, and thyroid function test. Result: Diffuse hepatic uptake was found in 44 of 104(42%) patients. 10 of 39(26%) patients on I-131 100mCi, and 34 of 63(54%) on I-131 150mCi showed hepatic uptake. 52 of 104(50%) patients was locally invasive thyroid cancer. The rate of the hepatic uptake was no significant differences with the thyroid hormone levels(T3, Free T4) and thyroglobulin between uptake group and non-uptake group. Conclusion: The rate of I-131 uptake was high in high-dose radioiodine treatment group. However, we can not find any correlation among the thyroid functions, the extent of metastasis or the extent of local invasion. We need further study to find out the causes of the hepatic uptake of I-131 after total thyroidectomy, besides liver metabolism of I-131 attached thyroid hormones.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
• /
• pp.905-908
• /
• 2006

The diffuse attenuation coefficient for downwelling irradiance $(K_d({\lambda}))$ is an important parameter for ocean studies. Based on the optical profile data measured during three cruises in the northern South China Sea in autumn from 2003 to 2005, variations in the $K_d({\lambda})spectra$ were analyzed. The variability of $K_d({\lambda})$ shows much distinct features both in magnitude and spectra shape. The $K_d({\lambda})value$ are much higher in costal waters than that of open oceanic waters and the blue-to-green(443/555) ratios of $K_d({\lambda})$ tends to increases with the chlorophyll a concentration ([Chl a]) from open ocean to coastal waters. These characteristics can be explained primarily by the increasing of $a_{w+p}(433)/a_{w+p}(555)$ with [Chl a]. In the short waveband, the relation between $K_d({\lambda})-K_w({\lambda})$ and [Chl a] can be well described by a power law function, suggesting the large contribution of phytoplankton to the variations in $K_d({\lambda})$. As for the spectral model of the diffuse attenuation coefficient, there are good linear relationships between $K_d(490)$ and $K_d({\lambda})$ at other wavelengths, with the slope parameter and the intercept following linear functions within the spectral range $412{\sim}555$ nm. These variabilities of $K_d({\lambda})$ provided much useful information for us to study the bio-optical properties in the northern South China Sea.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권11호
• /
• pp.4769-4775
• /
• 2015

Background: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and thirdly leading cause of cancer-related death worldwide. The estimated risk of hepatocellular carcinoma is 15 to 20 times as high among persons infected with HCV as it is among those who are not infected, with most of the excess risk limited to those with advanced hepatic fibrosis or cirrhosis. Glypican3 (GPC3) plays a key role in relation to signaling with growth factors, regulating the proliferative activity of cancer cells. Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver. GS was suggested as a specific marker for tracing cell lineage relationships during hepatocarcinogenesis. In normal liver, GS expression is seen in pericentral hepatocytes, but not by midzonal or periportal hepatocytes. In HCC, strong and diffuse GS expression in seen in tumor cells. Results: Glypican3 immunopositvity was highly specific and sensitive indicator for hepatocellular carcinoma as well as glutamine synthetase which was found to be a sensitive and specific indicator for development of hepatocellular carcinoma when compared to cirrhosis, liver cell dyspalsia and metastatic carcinomas. Statistical analysis revealed a significant association between GPC3 and GS with tumor size (P=0.003, p=0.006, respectively). Diffuse staining significantly associated with large tumor size while, focal and mixed staining was detected more with small tumor size. Studying the relation with tumor grade also revealed significant association between diffuse GPC3 and GS staining with high tumor grade. Diffuse staining was detected in 91.7% and 100% respectively of poorly differentiated specimens and only in 33.3% and 22.2% of well differentiated specimens. Conclusions: While using GPC3 and GS to screen for premalignant hepatic lesions remains controversial, our data suggest that GPC3 and GS may be a reliable diagnostic immunomarkers to distinguish HCC from benign hepatocellular lesions. However, negative immunostaining should not exclude the diagnosis of HCC.

• 동의생리병리학회지
• /
• 제26권5호
• /
• pp.577-587
• /
• 2012

Warm disease: Any of various heat disease characterizer by rapid onset and shifts, pronounced heat signs, and a tendency to form dryness and damage yin. Exterior heat sign: exterior heat patterns are characterizer by pronounced heat signs, such as a red sore pharynx and a relatively red tongue with dry fur, the pulse is floating and rapid, cough and the production of thick white or yellow phlegm. If wind-heat evil exist in weifen, it becomes exterior syndrome, and a remedy about that is dispelling wind-heat but when wind-heat evil invades in nasal and throat part so the disease occurs, you need to add relieving sore throat worsens invades in lung it makes disharmony of diffuse in lungs. So a remedy about it is diffuse the lung. disharmony of diffuse in lungs makes metabolic disorder of qi and liquid and humor malfunction therefore it occurs cough and heat-phlegm syndrome. heat from weifen invades the whole of lungs and form lung heat. So a remedy about lung heat is clearing away lung heat, this lung heat makes inevitably bleed in lungs, therefore a remedy in this case is clearing the lung to stop bleeding, or moistening the lung. Exterior heat sign means that exterior syndrome coexists with heat syndrome and it means that a remedy of this syndrome need to mix prescriptions for relieving exterior syndrome and heat-clearing prescriptions to treat this syndrome.

• 대한핵의학회지
• /
• 제17권1호
• /
• pp.33-39
• /
• 1983

Sixty-nine patients with diffuse lung uptake of $^{99m}Tc-tin$ colloid were evaluated to determine the kinds of associated diseases, the incidence of associated liver scan abnormalities, and prognosis. The results were as follows: 1) Diseases associated with diffuse lung uptake included malignancies in 31 patients, infectious diseases in 19, chronic liver diseases in 14, and others in 5. It appeared that the marked degree of lung uptake was associated with severe diseases. 2) Thirty-one of the 69 patients(45%) had abnormal liver size, 43(62%) had space occupying lesions or nonhomogeneity in liver image, 37(54%) had splenomegaly and 45(65%) had increased splenic uptake. Increased bone marrow uptake was found in 48(70%) and renal uptake in 15(22%). As the degree of lung uptake increased, there was a statistically significant (p<0.05) tendency for the incidences of the abnormal liver image and renal uptake to increase. 3) Sixty-two of the 69 patients were followed up for one to 439 days(mean 44 days) after liver scanning. Eleven(18%) were dead, 10(16%) were aggravated, and 13(21%) were improved. Most of improved patients had infectious diseases. It appeared that diffuse lung uptake of $^{99m}Tc-Tn$ colloid was found in the various diseases including malignancies, infections, and chronic liver diseases, and that it was strongly associated with other liver scan abnormalities, but was not necessarily associated with a poor prognosis, particularly when underlying diseases were infections.

• Corrosion Science and Technology
• /
• 제7권1호
• /
• pp.40-44
• /
• 2008

Passive metal forms an interfacial diffuse layer on the surface of passive film by its reaction with $H^+$ or $OH^-$ ions in solution depending on solution pH. There is a critical pH, called pH point of iso-selectivity ($pH_{pis}$) at which the nature of the diffuse layer is changed from the anion-permeable at pH<$pH_{pis}$ to the cation-permeable at pH>$pH_{pis}$. The $pH_{pis}$ for a passivated Fe was determined by examining the effects of pH on the thickness of passive film and on the dissolution reaction occurring on the passive film under a gavanostatic reduction in borate-phosphate buffer solutions at various pH of 7~11. The steady-state thickness of passive film formed on Fe showed the maximum at pH 8.5~9, and further the nature of film dissolution reaction was changed from a reaction producing $Fe^{3+}$ ion at $pH\leq8.5$ to that producing $FeO_2{^-}$ at $pH\geq9$, suggesting that the $pH_{pis}$ of Fe is about pH 8.5~9. In addition, the passive film formed at pH 8.5~9, $pH_{pis}$, was found to be the most protective with the lowest defect density as confirmed by the Mott-Schottky analysis. Pitting potential was decreased with increasing $Cl^-$ concentration at $pH\leq8.5$ due probably to the formation of anion permeable diffuse layer, but it was almost constant at $pH\geq9$ irrespective of $Cl^-$ concentration due primarily to the formation of cation permeable diffuse layer on the film, confirming again that $pH_{pis}$ of Fe is 8.5~9.

• Tuberculosis and Respiratory Diseases
• /
• 제43권3호
• /
• pp.461-466
• /
• 1996

Diffuse alveolar hemorrhage is a very rare manifestation in Henoch-Schoenlein purpura. Recently we experience a case of diffuse alveolar hemorrhage associated with Henoch-Schoenlein purpura which was diagnosed by typical clinical manifestation and renal biopsy. A 25 year old male was admitted due to hemoptysis and dyspnea. Chest X-ray, HRCT and BAL revealed diffuse alveolar hemorrhage. He also had a history of skin rash, polyarthralgia, and hematochezia with abdominal pain. Renal biopsy which was taken for the evaluation of microscopic hematuria showed IgA nephropathy. Under the diagnosis of Henoch-Schoenlein purpura, we treated him with solumedrol pulse therapy, plasma-pheresis and prednisolone with cytoxan. After then he showed marked improvement in clinical manifestation and was discharged with prednisolone and cytoxan.

• 디지털융복합연구
• /
• 제13권9호
• /
• pp.489-495
• /
• 2015

BI-RADS의 구분에 따라 Algorithm의 변화로 영상의 질을 개선하는 기법을 이용하여 시각적 가시화의 차이를 일치도와 민감도로 평가하였다. 유방촬영을 시행한 172명을 대상으로 유방촬영의 판독소견과 자료 체계의 신뢰도를 평가하였다. Category 5단계(C0,C1,C2,C3,C4), 유방 실질 함유량 4단계(Fatty, Fibroglandular, Heterogeneous nodular, Diffuse dense), 병변 3종류(석회화, 결절, 종괴)로 분류하여 TE와 PV의 신뢰도를 평가하고, 민감도와 진단의 일치도, 정확도를 평가함으로 다방면의 융복합적 분석을 하였다. TE보다 PV가 병변의 신뢰도와 민감도와 정확도가 높았다. 유방 실질 함유량에 따른 평가에서 정확도는 PV가 높았다. TE에서는 Fatty는 모두에서, Fibroglandular는 종괴와 석회화가, Diffuse dense는 결절과 석회화가 구별이 용이하였다. PV에서는 Fatty는 모두에서, Fibroglandular는 결절, Heterogeneous nodular은 결절과 종괴, Diffuse dense는 결절과 석회화가 구별이 용이하였다. 민감도는 결절은 Fatty, Fibroglandular, Heterogeneous nodular에서 TE가 더 민감했고, 종괴에서는 Heterogeneous nodular, Diffuse dense에서 TE가 더 민감했으며, 석회화에서는 모두에서 TE가 더 민감하였다. 이에 Algorithm 기법을 적절히 변화시켜 활용한다면 진단과 판독에 정확성을 높일 것이라 사료된다.

• Tuberculosis and Respiratory Diseases
• /
• 제52권2호
• /
• pp.174-178
• /
• 2002

기침 및 호흡곤란 주소로 내원한 43세 남자 환자에서 흉부 전산화 단층촬영 및 기관지경하 생검으로 다른 장기의 침범 없이 폐에만 국한된 미만성 기관기관지형 유전분증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국지능시스템학회논문지
• /
• 제16권3호
• /
• pp.332-337
• /
• 2006

It has been suggested that the endoscopic color of intramucosal gastric carcinoma is correlated with mucosal vascularity within the carcinomatous tissue. The development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, using a hemoglobin index. The aim of this study was to make a software program to calculate the hemoglobin index (IHb) and then investigate whether the mucosal IHb determined from the electronic endoscopic data is a useful marker for evaluating the color of intramucosal gastric carcinoma, in particular with regard to its value for discriminating between the histologic types. The mean values of IHb for the carcinoma (IHb-C) and the mean values of IHb for the surrounding non-cancerous mucosa (IHb-N) were calculated in 75 intestinal-type and 34 diffuse-type gastric carcinomas. Then, we analyzed the ratio of the IHb-C to IHb-N. The mean IHb-C/IHb-N ratio in the intestinal-type carcinoma group was higher than that in the diffuse-type carcinoma group (1.28$\pm$0.19 vs. 0.81$\pm$0.18, respectively, p<0.001). When the cut-off point of the C/N ratio was set at 1.00, the accuracy rate, the sensitivity, the specificity, and the positive and negative predictive values of a C/R ratio below 1.00 for the differential diagnosis of diffuse-type carcinoma from intestinal-type carcinoma were 94.5%, 94.1%, 94.7%, 88.9% and 97.3%, respectively. IHb is useful for quantitative measurement of the endoscopic color in intramucosal gastric carcinoma and the IHb-C/IHb-N ratio would be helpful in distinguishing diffuse-type carcinoma from intestinal-type carcinoma.