• The Journal of Pediatrics of Korean Medicine
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• v.24 no.1
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• pp.126-133
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• 2010

Objectives In this study, we evaluated the therapeutic effects of Gami-Bojungikgitang and Gami-Jwagwieum for bleomycin-induced lung fibrosis in mice. Methods Extracted lyophilization, Gami-Bojungikgitang (96g) and Gami-Jwagwieum (118g) boiled, filtered, depressed, concentrated, and are obtained. They were divided into five groups: normal, group IA; Animal group treated with bleomycin observed on the 21th day, group IB; Animal group treated with bleomycin observed on the 42th day, group IIA; Animal group treated with bleomycin and Gami-Bojungikgitang. Gami-Jwagwieum observed on the 21th day, group IIB; Animal group treated with bleomycin and Gami-Bojungikgitang/Gami-Jwagwieum observed on the 42th day. Mice are used on the 42th day and as a result, bronchoalveolar lavages fluid is obtained. Counting total number of cells, different ratio of macrophage, lymphocyte, and neutrophil are established. Results In animal group treated with bleomycin and Gami-Bojungikgitang, total cell count decreased by 50% in 3 weeks compared to animal group with non-administrated Gami-Bojungikgitang. However, total cell count in 6 weeks increased compared to 3 weeks although total cell count still decreased compared to animal group with non-administrated Gami-Bojungikgitang. In the view of differential cell counts in bronchoalveolar lavages fluid in treatment group on 3 and 6 weeks, neutrophile was a few and lymphocyte decreased. In animal group treated with bleomycin and Gami-Jwagwieum, total cell count decreased by 50% in 3 and 6 weeks compared to animal group with non-administrated Gami-Jwagwieum. In the view of differential cell counts in bronchoalveolar lavages fluid in treatment group on 3 and 6 weeks, lymphocyte also decreased. Conclusions Gami-Bojungikgitang and especially Gami-Jwagwieum for bleomycin-induced lung fibrosis in mice were effective in total cell count and differential cell count.

• Journal of Digital Contents Society
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• v.18 no.8
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• pp.1671-1676
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• 2017

In theses days, data has been explosively generated in diverse industrial areas. Accordingly, many industries want to collect and analyze these data to improve their products or services. However, collecting user data can lead to significant personal information leakage. Local differential privacy (LDP) proposed by Google is the state-of-the-art approach that is used to protect individual privacy in the process of data collection. LDP guarantees that the privacy of the user is protected by perturbing the original data at the user's side, but a data collector is still able to obtain population statistics from collected user data. However, the prevention of leakage of personal information through such data perturbation mechanism may cause the significant reduction in the data utilization. Therefore, the degree of data perturbation in LDP should be set properly depending on the data collection and analysis purposes. Thus, in this paper, we develop the simulation tool which aims to help the data collector to properly chose the degree of data perturbation in LDP by providing her/him visualized simulated results with various parameter configurations.

• The Plant Pathology Journal
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• v.15 no.5
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• pp.295-301
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• 1999

Many of plant defense responses are consequence of transcriptional activation of related genes. We have developed a modified differential screening procedure to isolate tobacco genes that are involved in the defense responses against TMV infection. A cDNA library was constructed from Nicotiana glutinosa leaves infected by TMV under temperature shift conditions. Each of plasmid DNA in the library was hybridized on a set of slot blots to a pool of cDNA probes prepared from either TMV-infected or mock-treated tobacco leaves. Among 900 plasmid DNAs, 81 clones exhibiting significantly enhanced or reduced level of hybridization to either probe were selected for nucleotide sequencing. The clones were listed into 61 genes considering redundancy between the sequences. The genes were identified to be defense-related genes including PR-genes and genes involved in primary or secondary metabolisms. This results supports the implication that plant defense process entails a major shift in total cellular metabolisms rather than activation of a limited number of defense-related genes. Expression patterns of a number of defense-related genes. Expression patterns of a number of selected genes were examined in northern blot analyses. It is notable that the clone 630 of unknown function exhibits expression pattern similar to those of previously known PR-genes. Experiments to elucidate the roles in defense mechanism of a couple of genes newly identified in this study are in progress.

• Journal of Veterinary Science
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• v.21 no.6
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• pp.91.1-91.15
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• 2020

Background: Sulforaphane (SFN) is an isothiocyanate compound present in cruciferous vegetables. Although the anti-inflammatory effects of SFN have been reported, the precise mechanism related to the inflammatory genes is poorly understood. Objectives: This study examined the relationship between the anti-inflammatory effects of SFN and the differential gene expression pattern in SFN treated ob/ob mice. Methods: Nitric oxide (NO) level was measured using a Griess assay. The inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels were analyzed by Western blot analysis. Pro-inflammatory cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and IL-6) were measured by enzyme-linked immunosorbent assay (ELISA). RNA sequencing analysis was performed to evaluate the differential gene expression in the liver of ob/ob mice. Results: The SFN treatment significantly attenuated the iNOS and COX-2 expression levels and inhibited NO, TNF-α, IL-1β, and IL-6 production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. RNA sequencing analysis showed that the expression levels of 28 genes related to inflammation were up-regulated (> 2-fold), and six genes were down-regulated (< 0.6-fold) in the control ob/ob mice compared to normal mice. In contrast, the gene expression levels were restored to the normal level by SFN. The protein-protein interaction (PPI) network showed that chemokine ligand (Cxcl14, Ccl1, Ccl3, Ccl4, Ccl17) and chemokine receptor (Ccr3, Cxcr1, Ccr10) were located in close proximity and formed a "functional cluster" in the middle of the network. Conclusions: The overall results suggest that SFN has a potent anti-inflammatory effect by normalizing the expression levels of the genes related to inflammation that were perturbed in ob/ob mice.

• Bulletin of the Korean Chemical Society
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• v.33 no.10
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• pp.3397-3406
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• 2012

Three types of spherulitic morphologies have been investigated in dual substrate mode of Belousov-Zhabotinsky (BZ) type reaction system. Prior to growth of spherulites, three distinct patterning behaviors have been observed sequentially during the reaction process. Initial and the early-phase of reaction showed the emergence of concentric ring-like wave patterns. A colloidal-state of reaction consists of numerous fine solid particles, which forms primarily some nucleation centers of dendritic characters. The nucleation centers were found to grow in sizes and shapes with the progress of reaction. It leads to growth of dendritic-like spherulitic crystal patterns. The resultant spherulites showed transitions in their morphologies, including sea-weeds and rhythmic spherulitic crystal patterns, by the effects substituted organic substrate and in the higher concentration of bromate-initiator respectively. The branching mechanism and crystal ordering of spherulitic textures were studied with help of optical microscope (OPM) and scanning electron microscope (SEM). Characteristics of crystal phases were also evaluated using X-ray diffraction (XRD) and differential thermal analysis (DTA). Results indicated that the compositions of reactants and crystal orderings were interrelated with morphological transitions of spherulites as illustrated and described.

• Korea Journal of Hospital Management
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• v.24 no.4
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• pp.70-84
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• 2019

Purposes: Despite a lot of prior studies on psychological empowerment on positive outcomes, the objectives of this paper were to examine the role of psychological empowerment on informal learning and the mediation role of informal learning between psychological empowerment and outcome variables focused upon physical therapists working in hospital industry. Methodology: Using survey methods, the data were collected from 198 physical therapists who have worked in Ulsan city and attended in annual meeting. Findings: Results showed that psychological empowerment predicted informal learning positively but differences in mediational mechanism. Specifically, the path between psychological empowerment and proactive behavior partially mediated but no mediating effect between psychological empowerment and helping behavior. This study identified the main role of psychological empowerment on informal learning, and it expands on positive functions of the concept to learning area in organizations. The other results help advanced understanding of differential mechanism through informal learning in the process between psychological empowerment and both outcomes. Practical Implications: The current study contributes to expend the area of prior findings on psychological empowerment to learning activities implemented by individual volunteer effort. For hospitals operating the teams of physical therapy, the significance for considering psychological empowerment is highlighted as for individual growth related to job and for change behavior in the individual level.

• Journal of the Korea Concrete Institute
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• v.16 no.4 s.82
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• pp.557-564
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• 2004

This paper introduces a study carried out to investigate sodium sulfate attack caused by various reactive products. Experiments were performed on mortar and paste specimens made with ordinary Portland cement (OPC) conforming to KS L 5201 Type I. The water-cement ratios were varied from 0.35 to 0.55. It was found from the laboratory study that the water-cement ratio may be a key to control the deterioration of OPC matrix during sodium sulfate attack. Furthermore, X-ray diffraction (XRD) confirmed that ettringite, gypsum and thaumasite were the main products formed by sodium sulfate attack. These findings were well supported by thermal analysis through differential scanning calorimetry (DSC), and confirmed the long-term understanding that deterioration mechanism by sodium sulfate attack is a complicated process. Most importantly, deterioration due to sodium sulfate attack is characterized as the drastic reduction in compressive strength as well as the expansion (especially in cement matrix with a higher water-cement ratio).

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.8 no.1
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• pp.138-144
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• 1998

$\alpha$-$Fe_2O_3$ fine powders with the sizes smaller than 0.5 $\mu \textrm{m}$ were prepared by the solvolysis and condensation reaction using iron(III) nitrate and ethanol as starting materials. The variation of pH and the change of FT-IR absorption peak were observed to study the reaction mechanism of iron(III) nitrate solution. In addition, the decomposition mechanism of the precipitated gel was investigated by differential scanning calorimeter, X-ray diffractometer and FT-IR spectrometer. Scanning electron microscope and BET method were performed to analyze the effects of Iron (III) nitrate concentration and reaction temperature on the particle size of $\alpha$-$Fe_2O_3$ powders.

• The korean journal of orthodontics
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• v.25 no.5 s.52
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• pp.641-654
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• 1995

The purpose of this report is to present the cause and treatment of posterior open bite. Posterior open bite is the open bite limited to posterior teeth. These problem usually are attributed to a mechanical interference with the eruption process, either ankylosis or some soft tissue interference. But, in some patient, lateral open bite is due to a disturbance of the eruptive mechanism itself and other disease or side effect following other treatment. Distinguising cause of posterior open bite, lack of eruption due to some external interference with eruption or primary failure of eruption mechanism, is important clinically because this determines the prognosis for orthodontic treatments. The characteristics, differential diagnosis with posterior open bite due to other etiologies and the treatment of these problems are presented and discussed,.

• Journal of Institute of Control, Robotics and Systems
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• v.17 no.12
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• pp.1248-1255
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• 2011

In daily life, another major role of human hand is a communicative function using hand gestures besides grasp function. Therefore, if amputees can express their intention by the prosthetic hand, they can much actively participate in social activities. Thus, this paper propose myoelectric multi-function prosthetic hand which can express 6 useful hand gestures such as Rock, Scissors, Paper, Indexing, Ok and Thumb-up. It was designed as under-actuated structure to minimize volume and weight of the prosthetic hand. Moreover, in order to effectively control various hand gestures by only two EMG sensors, we propose a control strategy that the signal type are expanded as "Strong" and "Light", and hand gestures are hierarchically classified for the intuitive control. Finally, we prove the validity of the developed prosthetic hand with the experiment.