• Nutrition Research and Practice
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• 제16권sup1호
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• pp.126-133
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• 2022

Choline is a water-soluble organic compound that is important for the normal functioning of the body. It is an essential dietary component as de novo synthesis by the human body is insufficient. Since the United States set the Adequate Intakes (AIs) for total choline as dietary reference values in 1998, Australia, China, and the European Union have also established the choline AIs. Although choline is clearly essential to life, the 2020 Dietary Reference Intakes for Koreans (KDRIs) has not established the values because very few studies have been done on choline intake in Koreans. Since choline intake levels differ by race and country, human studies on Koreans are essential to set KDRIs. Therefore, the present study was undertaken to provide basic data for developing choline KDRIs in the future by analyzing data on choline intake in Koreans to date and reference values of choline intake and dietary choline intake status by country and race.

• Asian-Australasian Journal of Animal Sciences
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• 제29권12호
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• pp.1742-1747
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• 2016

A $2{\times}5$ factorial experiment, using 2 dietary methionine levels (0.28% and 0.48%) and 5 dietary choline levels (0, 394, 823, 1,239, and 1,743 mg/kg), was conducted to study the effects of dietary methionine status on choline requirements of starter white Pekin ducks from 7 to 28 days of age. Four hundred eighty 7-d-old male White Pekin ducks were randomly allotted to ten dietary treatments, each containing 6 replicate pens with 8 birds per pen. At 28 d of age, weight gain, feed intake, and feed/gain were measured and the legs of all ducks from each pen were examined for incidence of perosis. Perosis and growth depression were observed in choline-deficient ducks and supplementation of choline reduced perosis and significantly increased weight gain and feed intake regardless of dietary methionine levels (p<0.05). In addition, significant positive effects of dietary methionine supplementation on weight gain, feed intake, and feed/gain were observed at any choline level (p<0.05). Supplementation of 1,743 mg/kg choline in diets alleviated the depression of weight gain and feed intake caused by methionine deficiency at 0.28% methionine level. The interaction between choline and methionine influenced weight gain and feed intake of ducks (p<0.05). At 0.28% methionine level, 1,743 mg/kg choline group caused 4.92% and 3.23% amount of improvement in weight gain and feed intake compared with 1,239 mg/kg choline group, respectively. According to the broken-line regression, the choline requirements of starter Pekin ducks for weight gain and feed intake were 1,472 and 1,424 mg/kg at 0.28% methionine level and 946 and 907 mg/kg at 0.48% methionine level, respectively. It suggested the choline recommendations of starter Pekin ducks on a semi-purified diet were 1448 mg/kg at 0.28% methionine level and 927 mg/kg at 0.48% methionine level, respectively. Compared with the adequate methionine level, menthionine deficiency markedly increased the choline requirements of ducks.

• Journal of Nutrition and Health
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• 제38권4호
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• pp.320-326
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• 2005

This study was conducted to estimate dietary choline intake of Koreans according to gender, age and region by using the data on per capita food intake in 1998 and 2001 and the data on choline contents of foods customarily eaten by Koreans. Sixty-four and 97 kinds of food items were used for the estimation of choline intake in 1998 and 2001, respectively. And these corresponded to approximately $90\%$ of the total amount of food intake and energy intake. Based on these food items and choline content, per capita choline intake of Koreans was estimated to be 623.0 mg and 602.4 mg in 1998 and 2001 respectively , 687.2 mg and 659.1 mg in 1998 and 2001 for male, 560.2 mg and 551.0 mg in 1998 and 2001 for female. While the number of foods considered in estimation was higher in 2001 than 1998, choline intake was lower in 2001. The estimated per capita choline intake of male population was higher than that of female population by 108-127 mg, possibly due to the difference in total amount of food intake. The age group with the highest choline intake was different between 2 time points. Although adolescents of 13- 19 years showed the highest intake (712.0 mg) in 1998, mid-aged adults of 30-49 years showed the highest choline intake (662.2 mg) followed by adolescents (645.7 mg) in 2001. In regional comparison, choline intake of the rural population (588.7 mg and 588.3 mg in 1998 and 2001 respectively) was lower than that of population in small to medium-size cities (625.1 mg and 603.9 mg) or in metropolitan cities (637.7 mg and 602.8 mg). This result revealed that per capita choline intake of the Korean population falls within the adequate range with some differences by age, sex and residing area.

• Journal of Nutrition and Health
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• 제39권2호
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• pp.115-120
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• 2006

The purpose of this study is to investigate the concentration of plasma choline of Korean and to clarify the relationship between plasma choline concentration and choline intake. Plasma choline concentration of 30 young adults (15 males, 15 females) aged 20-30 years living in Deajeon metropolitan city are analyzed and their dietary choline intake. Choline content of one day meal was directly analyzed with the use of enzymatic method. Plasma choline concentration from more than 12 hr fasting blood was analyzed by using HPLC-MS. Choline intakes of male subjects were in the range of 253.51-1724.14 mg and those of female subjects were in the range of 240.85-938.06 mg. Mean intakes of choline were $634.53{\pm}353.68mg$ in male subjects and $473.99{\pm}183.76mg$ in female subjects. Plasma choline concentration of total subjects was in the range of 5.08-14.01 ${\mu}mol/L$. Mean plasma choline concentration was $9.19{\pm}2.05{\mu}mol/L$ in male subjects and $8.11{\pm}1.70{\mu}mol/L$ in female subjects. Plasma choline concentration did not show significant correlation with choline intake in male and total subjects, but showed positive correlation with choline intake in female subjects (p<0.05). This result shows that more studies on large scaled samples are needed.

• Journal of Nutrition and Health
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• 제55권2호
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• pp.211-226
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• 2022

콜린은 세포막의 구조적 완전성, 메틸 대사, 아세틸콜린과 같은 신경전달물질 합성, 세포막 (인지질, phospholipids) 투과 신호전달, 지질 및 콜레스테롤 운반과 대사 등에 있어서 복합적으로 작용하고 있는 중요한 영양 성분이다. 콜린은 체내 합성이 가능하지만 요구량을 만족시키기에 불충분하므로 식사를 통해 섭취해야 한다. 미국/캐나다, 호주/뉴질랜드, 유럽, 중국, 대만 등에서는 콜린 충분섭취량과 상한섭취량이 제정되었으나, 일본은 콜린 데이터베이스가 구축되어 있지 않다는 이유로 콜린 Dietary Reference Intakes (DRI) 제정을 고려하고 있지 않다. 우리나라에서도 2020년 Dietary Reference Intakes for Koreans (KDRI) 제·개정 연구에서 콜린의 제정 여부를 검토하였으나 여전히 우리나라 식품을 대상으로 한 콜린 데이터베이스 구축 연구나 한국인을 대상으로 한 콜린 섭취량 조사 등의 연구가 전혀 이루어지지 않고 있어서 콜린 섭취기준의 제정은 어려운 것으로 판단하였다. 다만 2020년 DRI 개·제정을 위한 준비 작업의 일환으로 콜린 섭취량과 질병발생 가능성을 검증하기 위해 1949년부터 최근까지 보고된 문헌검색, 평가 및 문헌요약 작업을 통해 차후 콜린 DRI 제정을 위한 근거를 마련한 것은 본 사업의 성과라고 볼 수 있을 것이다. 인간을 대상으로 한 RCT, 코호트연구, 환자-대조군 연구 및 단면적 관찰 연구를 통해 충분한 양 (400-500 mg/day)의 콜린섭취는 간기능 손상 (지방간), 신경관손상, 심혈관질환 및 유방암 예방의 효과 및 인지기능 개선과 관계가 있는 것으로 판단되는 반면, 높은 수준의 콜린 섭취가 오히려 전립선암과 상관관계가 있다는 부정적인 연구결과도 있었다. 현재로서는 콜린 섭취와 건강결과와의 상관성을 결론짓기에는 연구결과들이 일관성이 부족하고 매우 제한적이고 더욱이 한국인을 대상으로 한 콜린 섭취와 건강결과와의 관련성을 조사한 논문은 전무한 실정이므로 콜린 DRI 제정을 위해서는 한국인을 대상으로 한 충분한 임상실험 결과가 뒷받침되어야 할 것이다.

• Journal of Nutrition and Health
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• 제37권1호
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• pp.61-67
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• 2004

This study was conducted to investigate the choline intake of Korean adults for the purpose of preparing a basal data required for the establishment of choline adequate intake (AI). The subjects of 56 Korean young adults were recruited from college students of 20 to 30 years old in Daejeon city. The aliquots of foods that the subjects ate for one day were collected with use of duplicate food collection method and choline content of one day meal directly was analyzed with the use of enzymatic method. Choline intakes of male subjects were in the range of 353.5∼1222.5 mg and those of female subjects were in the range of 213.1 ∼ 722.3 mg. Mean intakes of choline were 658.2 $\pm$ 243.9 mg/day in male subjects and 423.3 $\pm$ 133.6 mg/day in female, therefore choline intake of men was about 200mg higher than that of women. Median value in total subjects was 496 mg, male's median was 608.8 mg, female's median was 419.9 mg. When the subjects were devided into 4 groups by choline intake, as less than 75%, 75∼100%, 100∼125% and over 125% based on choline AI of USA (males: 550 mg, females: 425 mg), there was no significant difference between men (64.3%) and wemen (67.9%) in the distribution of the subjects whose choline intake is under the range of 75∼125% AI of USA. However, 10.7% of men and 21.4% of female had choline intake less than 75% AI of USA while the cases of choline intake higher than 125% AI were 25% in male and 10.7% in female. Thus, it is assumed that female case in choline-deficient state would be two times more than male. When adjusted by body weight, choline intake was 9.5 $\pm$ 3.4 mg/kg in men,8.1 $\pm$ 3.1 mg/kg in women and 8.8 $\pm$ 3,3 mg/kg in total subjects. And choline intake per 1,000 kcal of men, women and total subjects were 277.1 $\pm$ 78.4 mg, 275.9 $\pm$ 62.1 mg and 276.5 $\pm$ 70.1 mg respectively. From these results, it is suggested that these levels of 276.5 $\pm$ 70.1 mg/ 1,000 kcal or 8.8 $\pm$ 3.3 mg/kg B.W. can be used as a reference value for the establishment of AI of choline for Korean, because overall choline intake of these subjects was not in lower state compared to other nutrients intakes obtained from calculation of the food the subjects had taken.

• 대한지역사회영양학회:학술대회논문집
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• 대한지역사회영양학회 2004년도 추계학술대회
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• pp.157-157
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• 2004

• Nutritional Sciences
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• 제7권2호
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• pp.88-91
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• 2004

New Dietary Reference Intakes (DRIs) forthe United States and Canada have recently been set for both macronutrients and micronutrients, and are likely to be of interest to health professionals in Korea as well. DRIs are now available for nutrients that did not have Recommended Dietary Allowances set in the past (amino acids, n-3 and n-6 fatty acids, total fiber, added sugar, choline, boron, nickel, and vanadium). Furthermore, the units for the DRIs do not always match those traditionally carried on food composition tables (FCTs). FCT developers will also need to consider carrying new variables to allow the calculation of folate intake in $\mu$g of dietary folate equivalents, vitamin E intake as mg of a-tocopherol (not as mg of a-tocopherol equivalents), and vitamin A intake as $\mu$g of retinol activity equivalents (not as $\mu$g of retinol equivalents). Because the new recommendations for upper levels of intake sometimes refer to a specific form or source of a nutrient, nutrients occurring in foods must be separated from added or supplemental forms for vitamin E, niacin, and folate; pharmacological magnesium must be carried as a separate variable; and preformed vitamin A must be separated from vitamin A from carotenoids. For more information on the DRIs, see: www.nap.edu.

• Journal of Nutrition and Health
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• 제56권6호
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• pp.655-666
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• 2023

Purpose: Gestational nutrition has an impact on the growth and development of the fetus. Choline (C) and docosahexaenoic acid (DHA) are important and essential nutrients for humans that play a role in the structural integrity of the membranes as well as signalling. C is used in the synthesis of phosphatidylcholine, and cell membranes are highly enriched with DHA. The dietary intake of C or DHA during pregnancy directly influences fetal development. Currently, there is no evidence to prove the effectiveness of the combined dietary supplementation of both C and DHA during gestation on developmental outcomes in the offspring. Methods: The current study was designed to assess the physical, sensory, and motor development of rat pups born to mothers supplemented with C and/or DHA during the entire gestational period. Pregnant rat dams were divided into the following five groups: Normal control (NC), Saline control (SC), Choline (C), DHA, and Choline+DHA (C+DHA). The NC dams did not receive any supplementation during the entire gestation period. The experimental groups were supplemented with Saline, C, and/or DHA, respectively, during the entire gestation (E0 to delivery). Results: Rat pups (n = 6/group) exposed to combined C and DHA showed significant improvement in birth weight, fur development, eye-opening as well as weight gain on the 7th, 14th, and 21st postnatal day and pinnae detachment (assessed from birth to postnatal day 21) when compared with age-matched NC, SC or C or DHA pups. Further, significant reflex responses were observed in visual placing and bar holding of pups exposed to both C and DHA, whereas the differences in surface righting, negative geotaxis, and grasping reflexes were not significant between the groups. Conclusion: Gestational supplementation of both C and DHA rather than either of them alone is better in enhancing developmental outcomes in rat pups.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2001년도 제18차 정기총회 및 학술발표 PROCEEDINGS
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• pp.49-51
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• 2001

Betaine functions as an osmoregulators in the cells and its inclusion can spare the choline, carcass fat reduction. Thus, two hundred eighty eight of seventy eight weeks old laying hens were fed with 0, 500, 1,000, 2,000 ppm betaine addition during the environmentally high temperature stress. Basal diets contained 16% CP and 2,800 ME. Egg production, feed intake, feed conversion were examined for eight weeks. Egg qualities, liver betaine, blood osmolarity, AntiDiuretic Hormone(ADH) were measured at the end experiment. Egg production of hens fed 500, 2,000 ppm dietary betaine and showed significance between control and 2,000 ppm betaine treatment(P＜0.05). ADH of blood sera tended to increase as dietary supplemental betaine increased. The results of this experiments indicated that dietary supplemental betaine was able to improve the performance, eggshell breaking strength, liver betaine in this experiment.