• Journal of Yeungnam Medical Science
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• 제14권1호
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• pp.77-84
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• 1997

55명의 미숙아를 대상으로 이중 도플러 초음파 검사를 실시하여 대천문을 통한 전 뇌동맥의 혈류속도 및 혈류형태를 조사하였다. 미숙아에서 뇌 혈류속도 및 pulsatility index는 재태기간, 출생 체중, 및 미숙아의 나이 등의 증가에 따라 비례하여 증가하였으나 resistive index는 감소하였다. 뇌실 출혈이 있는 환아 군에서는 특징적인 resistive index의 증가가 보였지만 혈류속도 및 plusatility index는 불규칙하였다. 정상 미숙아의 뇌혈류 관찰 및 환아 군에서의 뇌혈류 검사에서 이중 도플러 초음파 검사는 비침습적이고 재현성도 뛰어나 선별검사로 유용한 방법이라고 생각한다.

• 대한세포병리학회지
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• 제11권1호
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• pp.19-24
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• 2000

Pulmonary hamartomas are uncommon benign tumors, usually discovered radiologically as a solitary coin lesion in asymptomatic individual. The approach to the patient with a peripheral lung nodule has changed with the increasing acceptance of fine needle aspiration cytology(FNAC) as a rapid, safe, inexpensive, and highly accurate diagnostic tool. However, a few reports describing the FNAC findings of pulmonary hamarioma have appeared in the cytologic literature and the experience of FNAC is limited. We reviewed all 9 cases of pulmonary hamartoma with histologic confirmation after FNAC seen at Asan Medical Center since 1995 to evaluate cytologic findings and to determine the value of FNAC in identifying that lesion. Originally, seven of nine patients were diagnosed as pulmonary hamartoma, while two patients were diagnosed as inflammatory lesion and adenocarcinoma of each. On review, eight of nine patients were considered as diagnostic of pulmonary hamartoma. The diagnostic findings in FNAC of pulmonary hamartoma were the presence of fibrillary myxoid tissue with spindle cells as well as hyaline cartilage.

• 한국환경과학회지
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• 제22권3호
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• pp.319-329
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• 2013

In this study, the cause of rapid intensity change of typhoon Nakri(0208) in view of point of a trough-typhoon interaction using diagnostic methods was examined based on 6-hourly GDAPS data from 10 to 13 July, 2002. At 0000 UTC 13 July, high PV(Potential Vorticity) region moved southeastward, reaching to the western edge of the Korean peninsula and near typhoon center at surface and there shows an increasing value of EFC(Eddy Momentum Flux Convergence). Also, as the trough and typhoon approach one another at the same time, the vertical shear(850-200 hPa) increases to more than 15 m/s. Thus, it might be concluded that the trough-typhoon interaction made intensified significantly, providing the fact that typhoon Nakri(0208) underwent substantial weakening while moving northward to around Jeju island.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권1호
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• pp.53-60
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• 2013

In Crohn's disease, mild gastrointestinal bleeding often occurs; however massive gastrointestinal hemorrhage, which can have a dramatic effect on a patient's vital sign, is rare. This could result in potentially life-threatening complications, which can lead to death. Massive hemorrhagic Crohn's disease is not well known and for this reason, they are a diagnostic and therapeutic challenge. Various diagnostic and therapeutic methods are currently being developed and used. The surgical method is often used only as a last measure since this approach has the risk of serious complications that may endanger patients. However, if massive bleeding continues even after all therapeutic methods are used, the surgical method must be implemented. In this case, all therapeutic methods were found to be ineffective; therefore, surgery was used as a last option. Ultimately, the surgical method was found to be successfully used to treat life-threatening hemorrhagic Crohn's disease.

• Nuclear Medicine and Molecular Imaging
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• 제42권sup1호
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• pp.172-176
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• 2008

FDG PET has been used as a diagnostic tool for localization of seizure focus for last 2-3 decades. In this article, the clinical usefulness of FDG PET in the management of patients with epilepsy has been reviewed, which provided the evidences to justify the medicare reimbursement for FDG PET in management of patients with epilepsy. Literature review demonstrated that FDG PET provides an important information in localization of seizure focus and determination whether a patients is a surgical candidate or not. FDG PET has been reported to have high diagnostic performance in localization of seizure focus in neocortical epilepsy as well as temporal lobe epilepsy regardless of the presence of structural lesion on MRI. Particularly, FDG PET can provide the additional information when the results from standard diagnositic modality such as interictal or video-monitored EEG, and MRI are inconclusive or discordant, and make to avoid invasive study. Furthermore, the presence of hypometabolism and extent of metabolic extent has been reported as an important predictor for seizure free outcome. However, studies suggested that more accurate localization and better surgical outcome could be expected with multimodal approach by combination of EEG, MRI, and functional studies using FDG PET or perfusion SPECT rather than using a single diagnostic modality in management of patients with epilepsy. Complementary use of FDG PET in management of epilepsy is worth for good surgical outcome in epilepsy patients.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2014년도 추계학술대회 논문집
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• pp.90-93
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• 2014

In this paper, we have developed a new fault detection method based on vibration signal for rotor machinery. Generally, many methods related to detection of rotor fault exist and more advanced methods are continuously developing past several years. However, there are some problems with existing methods. Oftentimes, the accuracy of fault detection is affected by vibration signal change due to change of operating environment since the diagnostic model for rotor machinery is built by the data obtained from the system. To settle a this problems, we build a rotor diagnostic model by using feature residual based on vibration signal. To prove the algorithm's performance, a comparison between proposed method and the most used method on the rotor machinery was conducted. The experimental results demonstrate that the new approach can enhance and keeps the accuracy of fault detection exactly although the algorithm was applied to various systems.

• 천문학논총
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• 제26권1호
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• pp.25-35
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• 2011

A diagnostic tool has been proposed to convert the observed surface distribution of hydrogen recombination line intensities into the radial distributions of the electron temperature and the density in HII regions. The observed line intensity is given by an integral of the volume emission coefficient along the line of sight, which comprises the Abel type integral equation for the volume emission coefficient. As the emission coefficient at a position is determined by the temperature and density of electrons at the position, the local emission coefficient resulted from the solution of the Abel equation gives the radial distribution of the temperature and the density. A test has been done on the feasibility of our diagnostic approach to probing of HII regions. From model calculations of an HII region of pure hydrogen, we have theoretically generated the observed surface brightness of hydrogen recombination line intensities and analyzed them by our diagnostic tool. The resulting temperatures and densities are then compared with the model values. For this case of uniform density, errors in the derived density are not large at all the positions. For the electron temperature, however, the largest errors appear at the central part of the HII region. The errors in the derived temperature decrease with the radial distance, and become negligible in the outer part of the model HII region.

• Journal of Trauma and Injury
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• 제36권3호
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• pp.165-171
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• 2023

Trauma remains a significant healthcare burden, causing over five million yearly fatalities. Notably, the liver is a frequently injured solid organ in abdominal trauma, especially in patients under 40 years. It becomes even more critical given that uncontrolled hemorrhage linked to liver trauma can have mortality rates ranging from 10% to 50%. Liver injuries, mainly resulting from blunt trauma such as motor vehicle accidents, are traditionally classified using the American Association for the Surgery of Trauma grading scale. However, recent developments have introduced the World Society of Emergency Surgery classification, which considers the patient's physiological status. The diagnostic approach often involves multiphase computed tomography (CT). Still, newer methods like split-bolus single-pass CT and contrast-enhanced ultrasound (CEUS) aim to reduce radiation exposure. Concerning management, nonoperative strategies have emerged as the gold standard, especially for hemodynamically stable patients. Incorporating angiography with embolization has also been beneficial, with success rates reported between 80% and 97%. However, it is essential to identify the specific source of bleeding for effective embolization. Given the severity of liver trauma and its potential complications, innovations in diagnostic and therapeutic approaches have been pivotal. While CT remains a primary diagnostic tool, methods like CEUS offer safer alternatives. Moreover, nonoperative management, especially when combined with angiography and embolization, has demonstrated notable success. Still, the healthcare community must remain vigilant to complications and continuously seek improvements in trauma care.

• Steel and Composite Structures
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• 제49권6호
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• pp.701-711
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• 2023

In order to fully reflect variation characteristics of composite concrete dam health state, the monitoring data is applied to diagnose composite concrete dam health state. Composite concrete dam lesion development to wreckage is a precursor, and its health status can be judged. The monitoring data are generally non-linear and unsteady time series, which contain chaotic information that cannot be characterized. Thus, it could generate huge influence for the construction of monitoring models and the formulation of corresponding health diagnostic indicators. This multi-scale diagnosis process is from point to whole. Chaotic characteristics are often contained in the monitoring data. If chaotic characteristics could be extracted for reflecting concrete dam health state and the corresponding diagnostic indicators will be formulated, the theory and method of diagnosing concrete dam health state can be huge improved. Therefore, the chaotic characteristics of monitoring data are considered. And, the extracting method of the chaotic components is studied from monitoring data based on fuzzy dynamic cross-correlation factor method. Finally, a method is proposed for formulating composite concrete dam health state indicators. This method can effectively distinguish chaotic systems from deterministic systems and reflect the health state of concrete dam in service.

• Journal of Genetic Medicine
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• 제20권2호
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• pp.31-38
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• 2023

Rare diseases, even though defined as fewer than 20,000 in South Korea, with over 8,000 rare Mendelian disorders having been identified, they collectively impact 6-8% of the global population. Many of the rare diseases pose significant challenges to patients, patients' families, and the healthcare system. The diagnostic journey for rare disease patients is often lengthy and arduous, hampered by the genetic diversity and phenotypic complexity of these conditions. With the advent of next-generation sequencing technology and clinical implementation of exome sequencing (ES) and genome sequencing (GS), the diagnostic rate for rare diseases is 25-50% depending on the disease category. It is also allowing more rapid new gene-disease association discovery and equipping us to practice precision medicine by offering tailored medical management plans, early intervention, family planning options. However, a substantial number of patients remain undiagnosed, and it could be due to several factors. Some may not have genetic disorders. Some may have disease-causing variants that are not detectable or interpretable by ES and GS. It's also possible that some patient might have a disease-causing variant in a gene that hasn't yet been linked to a disease. For patients who remain undiagnosed, reanalysis of existing data has shown promises in providing new molecular diagnoses achieved by new gene-disease associations, new variant discovery, and variant reclassification, leading to a 5-10% increase in the diagnostic rate. More advanced approach such as long-read sequencing, transcriptome sequencing and integration of multi-omics data may provide potential values in uncovering elusive genetic causes.