Nuclear Medicine and Molecular Imaging
- Volume 42 Issue sup1
- /
- Pages.172-176
- /
- 2008
- /
- 1869-3474(pISSN)
- /
- 1869-3482(eISSN)
Clinical Application of $^{18}F-FDG$ PET in Epilepsy
간질에서의 $^{18}F-FDG$ PET의 임상 이용
-
Kim, Yu-Kyeong
(Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital)
-
김유경
(서울대학교 의과대학 핵의학교실, 분당서울대학교병원 핵의학과)
- Published : 2008.12.31
Abstract
FDG PET has been used as a diagnostic tool for localization of seizure focus for last 2-3 decades. In this article, the clinical usefulness of FDG PET in the management of patients with epilepsy has been reviewed, which provided the evidences to justify the medicare reimbursement for FDG PET in management of patients with epilepsy. Literature review demonstrated that FDG PET provides an important information in localization of seizure focus and determination whether a patients is a surgical candidate or not. FDG PET has been reported to have high diagnostic performance in localization of seizure focus in neocortical epilepsy as well as temporal lobe epilepsy regardless of the presence of structural lesion on MRI. Particularly, FDG PET can provide the additional information when the results from standard diagnositic modality such as interictal or video-monitored EEG, and MRI are inconclusive or discordant, and make to avoid invasive study. Furthermore, the presence of hypometabolism and extent of metabolic extent has been reported as an important predictor for seizure free outcome. However, studies suggested that more accurate localization and better surgical outcome could be expected with multimodal approach by combination of EEG, MRI, and functional studies using FDG PET or perfusion SPECT rather than using a single diagnostic modality in management of patients with epilepsy. Complementary use of FDG PET in management of epilepsy is worth for good surgical outcome in epilepsy patients.