• Restorative Dentistry and Endodontics
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• 제39권4호
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• pp.258-264
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• 2014

Objectives: This in vitro study aimed to investigate the ability of Candida albicans (C. albicans) and Enterococcus faecalis (E. faecalis) to penetrate dentinal tubules of instrumented and retreated root canal surface of split human teeth. Materials and Methods: Sixty intact extracted human single-rooted teeth were divided into 4 groups, negative control, positive control without canal instrumentation, instrumented, and retreated. Root canals in the instrumented group were enlarged with endodontic instruments, while root canals in the retreated group were enlarged, filled, and then removed the canal filling materials. The teeth were split longitudinally after canal preparation in 3 groups except the negative control group. The teeth were inoculated with both microorganisms separately and in combination. Teeth specimens were examined by scanning electron microscopy (SEM), and the depth of penetration into the dentinal tubules was assessed using the SMILE view software (JEOL Ltd). Results: Penetration of C. albicans and E. faecalis into the dentinal tubules was observed in all 3 groups, although penetration was partially restricted by dentin debris of tubules in the instrumented group and remnants of canal filling materials in the retreated group. In all 3 groups, E. faecalis penetrated deeper into the dentinal tubules by way of cell division than C. albicans which built colonies and penetrated by means of hyphae. Conclusions: Microorganisms can easily penetrate dentinal tubules of root canals with different appearance based on the microorganism size and status of dentinal tubules.

• BMB Reports
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• 제52권11호
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• pp.659-664
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• 2019

Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs) obtained from Vav1-deficient ($Vav1^{-/-}$) and wild-type (WT) mice to differentiate into mature OCs upon stimulation with macrophage colony stimulating factor and receptor activator of nuclear kappa B ligand in vitro. Our results suggested that Vav1 deficiency promoted the differentiation of BMMCs into OCs, as indicated by the increased expression of tartrate-resistant acid phosphatase, cathepsin K, and calcitonin receptor. Therefore, Vav1 may play a negative role in OC differentiation. This hypothesis was supported by the observation of more OCs in the femurs of $Vav1^{-/-}$ mice than in WT mice. Furthermore, the bone status of $Vav1^{-/-}$ mice was analyzed in situ and the femurs of $Vav1^{-/-}$ mice appeared abnormal, with poor bone density and fewer number of trabeculae. In addition, Vav1-deficient OCs showed stronger adhesion to vitronectin, an ${\alpha}_v{\beta}_3$ integrin ligand important in bone resorption. Thus, Vav1 may inhibit OC differentiation and protect against bone resorption.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제47권5호
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• pp.365-372
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• 2021

Objectives: Mandibular fractures vary significantly with respect to epidemiological and demographic parameters among populations. To date, no study has evaluated these aspects of mandibular fractures in Nuh, Mewat, Haryana, India. To retrospectively analyze the incidence, age and sex distributions, etiology, anatomic distribution, occlusal status, treatment modality provided, and their correlation in patients who suffered isolated mandibular fractures. Materials and Methods: The records of maxillofacial injury patients who reported to the Department of Dentistry, SHKM Government Medical College from January 2013 to December 2019, were retrieved from our database, and necessary information was collected. The data collected were analyzed statistically using IBM SPSS ver. 21. Results: Totals of 146 patients and 211 fractures were analyzed. There were 127 males and 19 females with an age range of 3-70 years (mean age, 26 years). Road traffic accident (RTA) was the most common cause of fracture (64.4%), followed by fall (19.9%), assault (15.1%), and sports injury (0.7%). Of all patients, 42.5% had bilateral fractures, 31.5% had left side fracture, 21.2% had right side fracture, 3.4% sustained midline symphyseal fracture, and 1.4% had symphyseal fracture along one side of the mandible. Site distribution was as follows: parasymphysis (34.6%), angle (23.7%), condyle (20.4%), body (12.8%), symphysis (4.3%), ramus 2.4%, and dentoalveolar 1.9%. The most common facture combination was angle with parasymphysis (17.8%). Occlusion was disrupted in 69.2% patients. Closed reduction was the predominant treatment modality. Conclusion: The data obtained from retrospective analyses of maxillofacial trauma increase the understanding of variables and their outcomes among populations. The results of the present study are comparable to those of the literature in some aspects and different in others.

• Journal of Periodontal and Implant Science
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• 제50권6호
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• pp.379-391
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• 2020

Purpose: The aims of this study were to evaluate the 5-year cumulative survival rate (CSR) of implants placed with guided bone regeneration (GBR) compared to implants placed in native bone, and to identify factors contributing to implant failure in regenerated bone. Methods: This retrospective cohort study included 240 patients who had implant placement either with a GBR procedure (regenerated bone group) or with pristine bone (native bone group). Data on demographic features (age, sex, smoking, and medical history), location of the implant, implant-specific features, and grafting procedures and materials were collected. The 5-year CSRs in both groups were estimated using Kaplan-Meier analysis. Risk factors for implant failure were analyzed with a Cox proportional hazards model. Results: In total, 264 implants in the native bone group and 133 implants in the regenerated bone group were analyzed. The 5-year CSRs were 96.4% in the regenerated bone group and 97.5% in the native bone group, which was not a significant difference. The multivariable analysis confirmed that bone status was not an independent risk factor for implant failure. However, smoking significantly increased the failure rate (hazard ratio, 10.7; P=0.002). Conclusions: The 5-year CSR of implants placed in regenerated bone using GBR was comparable to that of implants placed in native bone. Smoking significantly increased the risk of implant failure in both groups.

• 융합정보논문지
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• 제9권9호
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• pp.201-209
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• 2019

일부 대학생의 구강건강신념과 주관적 구강건강 인지-지각요인의 융합연구로 2019년 4월 1일부터 6월 14일까지 동의한 학생 216명을 대상으로 하였다. 통계분석은 평균과 표준편차, t-test, One-way ANOVA, 상관관계는 Pearson's correlation test로 실시하였다. 구강건강신념은 유익성이 3.87점이었고, 구강건강지식 11.9점, 5점척도인 구강건강중요성 1.50점, 구강건강관심 2.36점, 구강건강상태는 2.67점으로 나타났다. 구강건강신념과 주관적 구강건강 인지-지각요인과의 상관관계는 구강건강신념은 구강건강지식(r=0.294, p<0.01)과 구강건강상태(r=0.406, p<0.01)에서 양의 상관관계가 나타났다. 대학생의 구강건강신념의 변화와 주관적 구강건강 인지-지각 능력이 향상될 수 있도록 끊임없는 구강보건교육의 필요하며, 대학생의 특성에 맞는 구강보건교육 프로그램이 개발되어야 한다.

• 한국융합학회논문지
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• 제9권11호
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• pp.145-152
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• 2018

본 연구의 목적은 근로자의 건강행위실천 및 직업적 특성과 치주질환 간의 관련성 분석을 통해 근로자의 구강건강 증진사업에 필요한 기초자료를 제공하는 것이다. 2015년도 국민건강영양조사를 이용하여 만 19세 이상 총 1,737명의 근로자를 연구대상으로 하였으며, 자료는 SPSS 24.0 프로그램을 이용하여 분석하였다. 근로자의 건강행위실천에 따른 치주질환 위험도는 흡연, 비만, 유산소 신체활동 실천에서 통계적으로 유의한 차이를 보였으며, 직업특성에 따른 치주질환 위험도에서는 직업의 종류, 근무상태, 정규직여부에서 통계적으로 유의한 차이를 보였다. 이상의 결과에서 근로자의 치주질환은 건강행위실천과 사회경제적 수준에 영향을 받기에 근로자의 건강행위실천을 위한 사업주들의 적극적인 관리와 저소득층을 위한 구강보건의료정책 개발을 통한 의료서비스 양극화 해소가 필요할 것으로 사료된다.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.161-169
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• 2018

본 연구는 여대생의 음주 동기가 음주 행동에 미치는 영향을 살펴보고자 시행되었으며, 여대생의 음주 행태를 살펴보는 것은 본인의 학업과 건강뿐만 아니라 미래의 출산을 위해서 필요하다. 연구 대상은 20대 여대생 296명을 대상으로 진행하였고, 연구 자료는 SPSS 24.0과 AMOS 22 통계프로그램을 이용하여 분석하였다. 연구의 결과, 여대생의 스트레스에 가장 영향을 주는 것은 학업과 인간관계였다. 또한, 음주가 학업에 미치는 영향에 따른 인식은 음주 문제의 요소가 더 크고, 음주 문제를 통하여 불안을 인식한 여대생은 음주의 행동을 변화하고자 하였다. 다음으로 음주의 동기 중 개인의 내적, 외적 동기에서 음주가 유익하다고 생각하면, 음주 행동을 유지하고, 음주의 문제를 느끼면 음주의 행동에 변화를 주는 것으로 나타났다. 위 결과를 통하여, 여대생이 선호하는 음주를 파악하고, 음주 동기에 따른 음주문화를 살펴보는 것으로, 음주에 대한 부정적 위험을 줄이는 방법에 이바지하고자 한다.

• 한국융합학회논문지
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• 제10권5호
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• pp.43-50
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• 2019

본 연구는 여성의 건강요인과 대사증후군의 상관성을 연구하기 위해 2012-2014년 국민건강영양조사 원시자료를 이용하여 최종 6743명을 분석대상자로 하였다. 여성건강과 대사증후군과의 관련성을 보기 위한 나이 지역, 가구수입, 흡연, 직업을 보정 한 모델에서 폐경 전보다 폐경후가 1.44배 (95% CI:1.09-1.90)로 높아 유의하였고 첫 출산 연령군은 25세 이하 출산 연령군에 비교하여 26-30 세 그룹에서는 0.81배 (95% CI: 0.68-0.98), 31세 이상은 0.62배 (95% CI: 0.45-0.87)로 첫출산 연령이 높아질수록 대사증후군의 위험이 감소하였다. 결론적으로 대사증후군은 폐경과 첫출산 연령과 밀접하게 연관되어 있으며 향후 여성을 대상으로 하는 교육 프로그램을 개발함에 있어서 기초자료로 활용하고자 한다.

• 융합정보논문지
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• 제11권4호
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• pp.176-185
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• 2021

본 연구는 대전, 대구 4곳의 지역자활센터 프로그램 참여 근로자 415명을 대상으로 2020년 9월 5일~30일까지 설문조사를 실시하였다. 연구목적은 자활 참여 근로자들의 구강 증상을 살펴보고 심리적 불안의 매개변수가 구강건강 삶의 질에 미치는 영향에 대하여 살펴보고자 한다. 연구결과 구강건조증, 악관절, 치주 질환 증상 모두 구강건강 삶의 질에 유의한 영향을 미치는 것으로 나타났으며, 심리적 불안 요인은 부분 매개효과를 나타냈다. 주관적 구강 증상 경험은 부정적인 불안 상태로 이어져 구강건강 삶의 질을 더욱 저하시키는 결과를 보였다. 추후 자활 근로자들을 위한 심리 상담 프로그램 확대 및 정기적인 구강보건교육을 위한 구강보건정책 개선에 기초자료로 활용될 것이다.

• 보건의료산업학회지
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• 제12권2호
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• pp.63-73
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• 2018

Objectives : This study aimed investigate general characteristics, vaccination status and health beliefs related to vaccination for herpes zoster and to identify variables. Methods : The structured questionnaire was conducted from March 31, 2016 to April 20, 2016 with 312 outpatients who visited a university hospital. The data were analyzed by frequency analysis, t-test, $x^2-test$, correlation analysis and logistic regression analysis via SPSS statistics 22.0. Results : The vaccination rate of the herpes zoster was 16.0% and the vaccination cost was the most common reason for rejecting inoculation. More highly educated people with more than a university degree(OR=4.28, p=.002), those with higher susceptibility to herpes zoster(OR=1.56, p=.000), those more aware of the benefits of vaccination(OR=1.51, p=.009) and those with lower disability for vaccination(OR=0.74, p=.003) were more likely to be vaccinated. Conclusions : Therefore, to increase the vaccination rate of herpes zoster in adults over 50 years old, continuous publicity and education are needed to emphasize the susceptibility of herpes zoster and the benefit of vaccination. In addition, it is necessary to develop policies at the national level for the expensive vaccination cost that obstructs vaccination.