Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지
DOI QR코드

DOI QR Code

Implant survival and risk factor analysis in regenerated bone: results from a 5-year retrospective study

  • Hong, Ji-Youn (Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University) ;
  • Shin, Eun-Young (Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University) ;
  • Herr, Yeek (Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University) ;
  • Chung, Jong-Hyuk (Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University) ;
  • Lim, Hyun-Chang (Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University) ;
  • Shin, Seung-Il (Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University)
  • Received : 2020.03.31
  • Accepted : 2020.08.17
  • Published : 2020.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: The aims of this study were to evaluate the 5-year cumulative survival rate (CSR) of implants placed with guided bone regeneration (GBR) compared to implants placed in native bone, and to identify factors contributing to implant failure in regenerated bone. Methods: This retrospective cohort study included 240 patients who had implant placement either with a GBR procedure (regenerated bone group) or with pristine bone (native bone group). Data on demographic features (age, sex, smoking, and medical history), location of the implant, implant-specific features, and grafting procedures and materials were collected. The 5-year CSRs in both groups were estimated using Kaplan-Meier analysis. Risk factors for implant failure were analyzed with a Cox proportional hazards model. Results: In total, 264 implants in the native bone group and 133 implants in the regenerated bone group were analyzed. The 5-year CSRs were 96.4% in the regenerated bone group and 97.5% in the native bone group, which was not a significant difference. The multivariable analysis confirmed that bone status was not an independent risk factor for implant failure. However, smoking significantly increased the failure rate (hazard ratio, 10.7; P=0.002). Conclusions: The 5-year CSR of implants placed in regenerated bone using GBR was comparable to that of implants placed in native bone. Smoking significantly increased the risk of implant failure in both groups.

Keywords

Acknowledgement

This work was supported by a grant from Kyung Hee University in 2017 (KHU-20170845).

References

  1. Aghaloo TL, Moy PK. Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement? Int J Oral Maxillofac Implants 2007;22 Suppl:49-70.
  2. Chiapasco M, Zaniboni M, Boisco M. Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clin Oral Implants Res 2006;17 Suppl 2:136-59. https://doi.org/10.1111/j.1600-0501.2006.01357.x
  3. Nyman S, Lang NP, Buser D, Bragger U. Bone regeneration adjacent to titanium dental implants using guided tissue regeneration: a report of two cases. Int J Oral Maxillofac Implants 1990;5:9-14.
  4. Benic GI, Hammerle CH. Horizontal bone augmentation by means of guided bone regeneration. Periodontol 2000 2014;66:13-40. https://doi.org/10.1111/prd.12039
  5. Sanz-Sanchez I, Ortiz-Vigon A, Sanz-Martin I, Figuero E, Sanz M. Effectiveness of lateral bone augmentation on the alveolar crest dimension: a systematic review and meta-analysis. J Dent Res 2015;94:128S-42S. https://doi.org/10.1177/0022034515594780
  6. Schenk RK, Buser D, Hardwick WR, Dahlin C. Healing pattern of bone regeneration in membraneprotected defects: a histologic study in the canine mandible. Int J Oral Maxillofac Implants 1994;9:13-29.
  7. Gher ME, Quintero G, Assad D, Monaco E, Richardson AC. Bone grafting and guided bone regeneration for immediate dental implants in humans. J Periodontol 1994;65:881-91. https://doi.org/10.1902/jop.1994.65.9.881
  8. Dahlin C, Lekholm U, Becker W, Becker B, Higuchi K, Callens A, et al. Treatment of fenestration and dehiscence bone defects around oral implants using the guided tissue regeneration technique: a prospective multicenter study. Int J Oral Maxillofac Implants 1995;10:312-8.
  9. Buser D, Dula K, Belser UC, Hirt HP, Berthold H. Localized ridge augmentation using guided bone regeneration. II. Surgical procedure in the mandible. Int J Periodontics Restorative Dent 1995;15:10-29.
  10. Simion M, Trisi P, Piattelli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodontics Restorative Dent 1994;14:496-511.
  11. Donos N, Mardas N, Chadha V. Clinical outcomes of implants following lateral bone augmentation: systematic assessment of available options (barrier membranes, bone grafts, split osteotomy). J Clin Periodontol 2008;35:173-202. https://doi.org/10.1111/j.1600-051X.2008.01269.x
  12. Chiapasco M, Zaniboni M. Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review. Clin Oral Implants Res 2009;20 Suppl 4:113-23. https://doi.org/10.1111/j.1600-0501.2009.01781.x
  13. Clementini M, Morlupi A, Canullo L, Agrestini C, Barlattani A. Success rate of dental implants inserted in horizontal and vertical guided bone regenerated areas: a systematic review. Int J Oral Maxillofac Surg 2012;41:847-52. https://doi.org/10.1016/j.ijom.2012.03.016
  14. Milinkovic I, Cordaro L. Are there specific indications for the different alveolar bone augmentation procedures for implant placement? A systematic review. Int J Oral Maxillofac Surg 2014;43:606-25. https://doi.org/10.1016/j.ijom.2013.12.004
  15. Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol 2008;35:203-15. https://doi.org/10.1111/j.1600-051X.2008.01271.x
  16. Klinge B, Flemmig TF; Working Group 3. Tissue augmentation and esthetics (Working Group 3). Clin Oral Implants Res 2009;20 Suppl 4:166-70. https://doi.org/10.1111/j.1600-0501.2009.01774.x
  17. Beretta M, Cicciu M, Poli PP, Rancitelli D, Bassi G, Grossi GB, et al. A restrospective evaluation of 192 implants placed in augmented bone: long-term follow-up study. J Oral Implantol 2015;41:669-74. https://doi.org/10.1563/AAID-JOI-D-14-00123
  18. Seibert JS. Reconstruction of deformed, partially edentulous ridges, using full thickness onlay grafts. Part I. Technique and wound healing. Compend Contin Educ Dent 1983;4:437-53.
  19. van Steenberghe D, Quirynen M, Naert I. Survival and success rates with oral endosseous implants. In: Lang NP, Karring T, Lindhe J, editors. Proceedings of the 3rd European Workshop on Periodontology: Implant Dentistry. Berlin: Quintessence; 1999. p.242-254
  20. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81. https://doi.org/10.1080/01621459.1958.10501452
  21. Telleman G, Raghoebar GM, Vissink A, den Hartog L, Huddleston Slater JJ, Meijer HJ. A systematic review of the prognosis of short (<10 mm) dental implants placed in the partially edentulous patient. J Clin Periodontol 2011;38:667-76. https://doi.org/10.1111/j.1600-051X.2011.01736.x
  22. Mezzomo LA, Miller R, Triches D, Alonso F, Shinkai RS. Meta-analysis of single crowns supported by short (<10 mm) implants in the posterior region. J Clin Periodontol 2014;41:191-213. https://doi.org/10.1111/jcpe.12180
  23. Zitzmann NU, Scharer P, Marinello CP. Long-term results of implants treated with guided bone regeneration: a 5-year prospective study. Int J Oral Maxillofac Implants 2001;16:355-66.
  24. Benic GI, Jung RE, Siegenthaler DW, Hammerle CH. Clinical and radiographic comparison of implants in regenerated or native bone: 5-year results. Clin Oral Implants Res 2009;20:507-13. https://doi.org/10.1111/j.1600-0501.2008.01583.x
  25. Hammerle CH, Jung RE, Feloutzis A. A systematic review of the survival of implants in bone sites augmented with barrier membranes (guided bone regeneration) in partially edentulous patients. J Clin Periodontol 2002;29 Suppl 3:226-31. https://doi.org/10.1034/j.1600-051X.29.s3.14.x
  26. Mayta-Tovalino F, Mendoza-Martiarena Y, Romero-Tapia P, Alvarez-Paucar M, Galvez-Calla L, CalderonSanchez J, et al. An 11-year retrospective research study of the predictive factors of peri-implantitis and implant failure: analytic-multicentric study of 1279 implants in Peru. Int J Dent 2019;2019:3527872.
  27. Sesma N, Pannuti C, Cardaropoli G. Retrospective clinical study of 988 dual acid-etched implants placed in grafted and native bone for single-tooth replacement. Int J Oral Maxillofac Implants 2012;27:1243-8.
  28. Chuang SK, Wei LJ, Douglass CW, Dodson TB. Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations. J Dent Res 2002;81:572-7. https://doi.org/10.1177/154405910208100814
  29. Noda K, Arakawa H, Kimura-Ono A, Yamazaki S, Hara ES, Sonoyama W, et al. A longitudinal retrospective study of the analysis of the risk factors of implant failure by the application of generalized estimating equations. J Prosthodont Res 2015;59:178-84. https://doi.org/10.1016/j.jpor.2015.04.003
  30. Sanchez-Perez A, Moya-Villaescusa MJ, Caffesse RG. Tobacco as a risk factor for survival of dental implants. J Periodontol 2007;78:351-9. https://doi.org/10.1902/jop.2007.060299
  31. Mesa F, Munoz R, Noguerol B, de Dios Luna J, Galindo P, O'Valle F. Multivariate study of factors influencing primary dental implant stability. Clin Oral Implants Res 2008;19:196-200. https://doi.org/10.1111/j.1600-0501.2007.01450.x
  32. Kang DY, Kim M, Lee SJ, Cho IW, Shin HS, Caballe-Serrano J, et al. Early implant failure: a retrospective analysis of contributing factors. J Periodontal Implant Sci 2019;49:287-98. https://doi.org/10.5051/jpis.2019.49.5.287
  33. Chung DM, Oh TJ, Lee J, Misch CE, Wang HL. Factors affecting late implant bone loss: a retrospective analysis. Int J Oral Maxillofac Implants 2007;22:117-26.
  34. Strietzel FP, Reichart PA, Kale A, Kulkarni M, Wegner B, Kuchler I. Smoking interferes with the prognosis of dental implant treatment: a systematic review and meta-analysis. J Clin Periodontol 2007;34:523-44. https://doi.org/10.1111/j.1600-051X.2007.01083.x
  35. Tran DT, Gay IC, Diaz-Rodriguez J, Parthasarathy K, Weltman R, Friedman L. Survival of dental Implants placed in grafted and nongrafted bone: a retrospective study in a university setting. Int J Oral Maxillofac Implants 2016;31:310-7.
  36. Moy PK, Medina D, Shetty V, Aghaloo TL. Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants 2005;20:569-77.
  37. Zinser MJ, Randelzhofer P, Kuiper L, Zoller JE, De Lange GL. The predictors of implant failure after maxillary sinus floor augmentation and reconstruction: a retrospective study of 1045 consecutive implants. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:571-82. https://doi.org/10.1016/j.oooo.2012.06.015
  38. Al-Nawas B, Schiegnitz E. Augmentation procedures using bone substitute materials or autogenous bone - a systematic review and meta-analysis. Eur J Oral Implantology 2014;7 Suppl 2:S219-34.
  39. Machtei EE. The effect of membrane exposure on the outcome of regenerative procedures in humans: a meta-analysis. J Periodontol 2001;72:512-6. https://doi.org/10.1902/jop.2001.72.4.512