• Title/Summary/Keyword: density map

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High-Resolution Microarrays for Mapping Promoter Binding sites and Copy Number Variation in the Human Genome

  • Albert Thomas
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2006.02a
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    • pp.125-126
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    • 2006
  • NimbleGen has developed strategies to use its high-density oligonucleotide microarray platform (385,000 probes per array) to map both promoter binding sites and copy number variation at very high-resolution in the human genome. Here we describe a genome-wide map of active promoters determined by experimentally locating the sites of transcription imitation complex binding throughout the human genome using microarrays combined with chromatin immunoprecipitation. This map defines 10,567 active promoters corresponding to 6,763 known genes and at least 1,196 un-annotated transcriptional units. Microarray-based comparative genomic hybridisation (CGH) is animportant research tool for investigating chromosomal aberrations frequently associated with complex diseases such as cancer, neuropsychiatric disorders, and congenital developmental disorders. NimbleGen array CGH is an ultra-high resolution (0.5-50 Kb) oligo array platform that can be used to detect amplifications and deletions and map the associated breakpoints on the whole-genome level or with custom fine-tiling arrays. For whole-genome array CGH, probes are tiled through genic and intergenic regions with a median probe spacing of 6 Kb, which provides a comprehensive, unbiased analysis of the genome.

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Tool Geometry Optimization and Magnetic Abrasive Polishing for Non-ferrous Material (공구형상 최적화 및 비자성체의 자가연마 특성 연구)

  • Kim, Sang-Oh;You, Man-Hee;Kwak, Jae-Seob
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.19 no.3
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    • pp.313-320
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    • 2010
  • The magnetic abrasive polishing (MAP) process is used to achieve the nano-meter grade polishing results on flat or complicated surface. In previous study, polishing the stainless steel plate which is a non-magneto-material was tried. To polish non-magneto-materials using the MAP process was very difficult because the process was fundamentally possible by the help of a magnetic force. Therefore, it had lower efficiency than magneto-materials such as SM45C. In this study, optimization for tool geometry of the MAP was performed to improve the magnetic force between tool and workpiece. Moreover, a permanent magnet was installed below the non-magneto-material to improve the magnetic force. And then the design of experiments was carried out to evaluate the effect of the MAP parameters on the polishing results.

Study on the Power Performance on WindPRO Prediction in the Southeast Region of Jeju Island (제주 남동부 지역을 대상으로 한 WindPRO의 발전량 예측에 관한 연구)

  • Hyun, Seunggun;Kim, Keonhoon;Huh, Jongchul
    • 한국신재생에너지학회:학술대회논문집
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    • 2010.06a
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    • pp.184.1-184.1
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    • 2010
  • In order to research the way to evaluate wind resource without actual Met Mast data, this paper has been carried out on the southeastern region of Jeju island, Korea. Although wind turbine has been an economical alternative energy resource, misjudging the prediction of lifetime or payback period occurs because of the inaccurate assessment of wind resource and the location of wind turbine. Using WindPRO(Ver. 2.7), a software for wind farm design developed by EMD from Denmark, wind resources for the southeastern region of Jeju island was analyzed, and the performance of WindPRO prediction was evaluated in detail. Met Mast data in Su-san 5.5Km far from Samdal wind farm, AWS in Sung-san 4.5km far from Samdal wind farm, and Korea Wind Map data had been collected for this work.

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ASYMPTOTIC BEHAVIOR OF HARMONIC MAPS AND EXPONENTIALLY HARMONIC FUNCTIONS

  • Chi, Dong-Pyo;Choi, Gun-Don;Chang, Jeong-Wook
    • Journal of the Korean Mathematical Society
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    • v.39 no.5
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    • pp.731-743
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    • 2002
  • Let M be a Riemannian manifold with asymptotically non-negative curvature. We study the asymptotic behavior of the energy densities of a harmonic map and an exponentially harmonic function on M. We prove that the energy density of a bounded harmonic map vanishes at infinity when the target is a Cartan-Hadamard manifold. Also we prove that the energy density of a bounded exponentially harmonic function vanishes at infinity.

Assessing the Land Potential Utilization Status of Watershed Area

  • Malini, Ponnusarny;Park, Ki-Youn;Lee, Hye-Suk;Yoo, Hwan-Hee
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 2008.10a
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    • pp.151-152
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    • 2008
  • The planning and management of the watershed environment require huge amount of information regarding almost all aspects of natural and manmade features of the area. Until lately this study could be achieved through days of exhaustive surveys map generation and tedious calculations. Remote sensing and GIS provides huge temporal database for an area and GIS provides the powerful tool for spatial and non-spatial analysis of remotely sensed data. The paper highlights the assessment of land potentiality using weighed overlay analysis with drainage density, soil, slope and lineament, LULC map was used to identify the utilization area of the watershed. The arithmetic overlay analysis was performed with potential and utilization layer to assess the availability of land for the future development.

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IMAGE DENOISING BASED ON MIXTURE DISTRIBUTIONS IN WAVELET DOMAIN

  • Bae, Byoung-Suk;Lee, Jong-In;Kang, Moon-Gi
    • Proceedings of the Korean Society of Broadcast Engineers Conference
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    • 2009.01a
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    • pp.246-249
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    • 2009
  • Due to the additive white Gaussian noise (AWGN), images are often corrupted. In recent days, Bayesian estimation techniques to recover noisy images in the wavelet domain have been studied. The probability density function (PDF) of an image in wavelet domain can be described using highly-sharp head and long-tailed shapes. If a priori probability density function having the above properties would be applied well adaptively, better results could be obtained. There were some frequently proposed PDFs such as Gaussian, Laplace distributions, and so on. These functions model the wavelet coefficients satisfactorily and have its own of characteristics. In this paper, mixture distributions of Gaussian and Laplace distribution are proposed, which attempt to corporate these distributions' merits. Such mixture model will be used to remove the noise in images by adopting Maximum a Posteriori (MAP) estimation method. With respect to visual quality, numerical performance and computational complexity, the proposed technique gained better results.

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Pore Filling Theory of Liquid Phase Sintering and Microstrcture Evolution (액상소결의 기공채움 이론과 미세구조 발달)

  • 이성민
    • Journal of Powder Materials
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    • v.6 no.1
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    • pp.81-87
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    • 1999
  • Based on the pore filling theory, the microstructure evolution during liquid-phase sintering has been analyzed in terms of interrelationship between average grain size and relative density. For constant liquid volume fraction, the microsturucture trajectories reduced to a single curve in a grain size(x)-density(y) map, regardless of grain growth constant. The slope of curves in the map was inversely proportional to average pore size, while it increased fapidly with liquid volume fraction. Increase in pore volume fraction retarded the densification considerably, but showed marginal effect on the slope. The activation energy of densification was predicted to be the same as that of grain growth as long as the liquid volume fraction is constant for any temperature range studied. The present analyses on microstricture evolution may demonstrate the usefulness of pore filling theory and provide a guideline for process optimization of liquid-phase sintering.

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Flow Pattern Identification of Vertical Upward Two-Phase Flow Using the Attractor-Density-Map Analysis of the Void Fraction Signal in the Nonlinear Phase Space (비선형 위상공간에서의 기포 분율 신호의 끌개밀도분식을 이용한 수직 상향 이상유동의 유동패턴분류)

  • Kim, Nam-Seok;Lee, Jae-Young
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.28 no.11
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    • pp.1398-1406
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    • 2004
  • The nonlinear signals from an impedance meter for the area average void fraction in two-phase flow have been analyzed to construct a phase space trajectory. The pseudo phase space was constructed with the time delay and proper dimensions. The time delay and the embedding dimension were chosen by the average mutual information and by the false nearest neighborhood, respectively. The attractor-density-map of projected states was used to produce the two dimensional probability distribution functions (2D-PDF). Since the developed 2D-PDF showed clear distinction of the flow patterns, the flow regime identification was made with three rules and with the 2D-PDF. Also, the transition criteria of Mishima-Ishii agree well with the present results.

Development of the Local Map Construction Algorithm Using an Ultrasonic Array Sensor System (초음파 배열센서 시스템을 이용한 국부지도작성 알고리즘의 개발)

  • 이상룡;박상혁;이종규
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.18 no.11
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    • pp.2902-2912
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    • 1994
  • The ultrasonic array sensor system, consisting of one transmitter and fourreceivers instead of the traditional combination of a transmitter and a receiver is proposed in order to identify the location of objects. From the theoretical analysis and the experimental results, it is found that this new array sensor system could derive the information on the position of objects accurately, while the traditional sensor system could provide only the informatioin on the distance to objects. This sensor system is used to develop a sonar-based local mapping algorithm. The local map is used to find the existence of possible gates, through which the mobile robots can pass, and to select the suitable one in order for the robots to reach the goal safely in the presence of obstacles. The performance of the proposed local map algorithm is demonstrated experimentally in a small working area with several obstacles. It is found that the quality of the resulting local map is sufficient for the avoidance of collisions between the robots and obstacles and for the selection of the suitable gate leading to the goal. It is also shown that the global map of the working area could be obtained by integrating several local maps constructed from different locations and that it matches the actual layout of the working area well.