• 대한의생명과학회지
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• 제29권4호
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• pp.363-370
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• 2023

Human respiratory viral infections such as COVID-19 are highly contagious, so continuous management of airborne viruses is essential. In particular, indoor air monitoring is necessary because the risk of infection increases in poorly ventilated indoors. However, the current method of detecting airborne viruses requires a lot of time from sample collection to confirmation of results. In this study, we proposed a system that can monitor airborne viruses in real time to solve the deficiency of the present method. Air samples were collected in liquid form through a bio sampler, in which case the virus is present in low concentrations. To detect viruses from low-concentration samples, viral RNA was concentrated and extracted using silica-magnetic beads. RNA binds to silica under certain conditions, and by repeating this binding reaction, bulk samples collected from the air can be concentrated. After concentration and extraction, viral RNA is specifically detected through real-time qPCR (quantitative polymerase chain reaction). In addition, based on liquid handling technology, we have developed an automatic machine that automatically performs the entire testing process and can be easily used even by non-experts. To evaluate the system, we performed air sample collection and automated testing using bacteriophage MS2 as a model virus. As a result, the air-collected samples concentrated by 45 times then initial volume, and the detection sensitivity of PCR also confirmed a corresponding improvement.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8281-8285
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• 2016

Background: Helicobacter pylori is a cause of chronic gastritis, peptic ulcer disease, and gastric malignancy, infection being a serious health problem in Thailand. Recently, clarithromycin resistant H. pylori strains represent the main cause of treatment failure. Therefore this study aimed to determine the prevalence and pattern of H. pylori resistance to clarithromycin in Suranaree University of Technology Hospital, Suranree University of Technology, Nakhon Ratchasima, Northeastern Thailand, Nakhon Ratchasima province, northeast of Thailand. Materials and Methods: This hospital-based cross-sectional study was carried out between June 2014 and February 2015 with 300 infected patients interviewed and from whom gastric mucosa specimens were collected and proven positive by histology. The gastric mucosa specimens were tested for H. pylori and clarithromycin resistance by 23S ribosomal RNA point mutations analysis using real-time polymerase chain reactions. Correlation of eradication rates with patterns of mutation were analyzed by chi-square test. Results: Of 300 infected patients, the majority were aged between 47-61 years (31.6%), female (52.3%), with monthly income between 10,000-15,000 Baht (57%), and had a history of alcohol drinking (59.3%). Patient symptoms were abdominal pain (48.6%), followed by iron deficiency anemia (35.3%). Papaya salad consumption (40.3%) was a possible risk factor for H. pylori infection. The prevalence of H. pylori strains resistant to clarithromycin was 76.2%. Among clarithromycin-resistant strains tested, all were due to the A2144G point mutation in the 23S rRNA gene. Among mutations group, wild type genotype, mutant strain mixed wild type and mutant genotype were 23.8%, 35.7% and 40.5% respectively. With the clarithromycin-based triple therapy regimen, the efficacy decreased by 70% for H. pylori eradication (P<0.01). Conclusions: Recent results indicate a high rate of H. pylori resistance to clarithromycin. Mixed of wild type and mutant genotype is the most common mutant genotype in Nakhon Ratchasima province, therefore the use of clarithromycin-based triple therapy an not advisable as an empiric first-line regimen for H. pylori eradication in northeast region of Thailand.

• 대한한의학원전학회지
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• 제22권3호
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• pp.31-51
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• 2009

The characteristics of Jin's ideas on clinic theory can be arranged as follows. 1. Jin emphasized warming and tonifying[溫補] in treatment and the part that shows this the best is the taking care of[調理] the Vital gate[命門], kidney, liver, and spleen. His ideas were based on his understanding of a human life's origin, and was influenced by Seolgi(薛己), Joheon-ga(趙獻可) and Janggaebin(張介賓)'s Vital gate and source Gi theory(元氣說) so scholastically, he has that in common with them but was later criticized by later doctors such as Oksamjon(玉三尊) as an 'literary doctor(文字醫)' who followed the ideas of "Uigwan(醫貫)". 2. The warming and tonifying school[溫補學派], who were influenced by Taoism, said in their theory of disease outbreak[發病學說] that since one must not hurt one's Yin essence and Yang fire [陰精陽火] there is more deficiency than excess, so that was why they used tonifying methods. Jin was also like them and this point of view is universal in internal medicine, gynecology, pediatric medicine and surgery and so on. 3. Jin, who saw the negative form of pulse diagnosis[診脈] emphasized following symptoms over pulse diagnosis using the spirit of ‘finding truth based on truth[實事求是]' in "Maekgyeolcheonmi(脈訣闡微)", but emphasized 'the combination of pulse and symptoms[脈證合參]'. He understood pulse diagnosis as a defining tool for symptoms, and in "Seoksilbirok(石室秘錄)" simplified pulse diagnosis into 10 methods : floating/sunken(浮沉), slow/fast(遲數), large/fine(大小), vacuous/replete(虛實) and slippery/rough(滑澀). 4. Jin used 'large formulas(大方)' a lot that usually featured a large dose, and in " Bonchosinpyeon(本草新編)" he thought of the seven formulas(七方) and ten preparations(十劑) as the standard when using medicine. He did away with old customs and presented a 'new(新)' and 'extra(奇)' point of view. He especially used a lot of Insam(人蔘) when tonifying Gi and Geumeunhwa(金銀花) when treating sores and ulcers. 5. In the area of surgery Jin gave priority to the early finding and treatment of disease with internal treatment[內治] and was against the overuse of acupuncture. However records of surgical measures in a special situation like lung abscesses(肺癰) and liver abscesses(肝癰), and anesthetic measures using 'Manghyeongju(忘形酒)' and 'Singoiyak(神膏異藥)' and opening the abdomen or skull, and organ transplants using a dog's tongue are important data. 6. Jin stated the diseases of Gi and blood broadly. Especially in the principles of treating blood, blood diseases had to be forwarded[順] and Gi regulation[理氣] was the number one priority and stated the following two treatments. First, in "Jeonggiinhyeolpyeon(精氣引血篇)" of volume 6 of "Oegyeongmieon(外經微言)", for the rules for treating blood he stated the pattern identification of finding Gi in blood and blood in Gi. Second, he emphasized Gi regulation(理氣) in blood diseases and stated that the Gi must be tonifyed after finding the source of the loss of blood.

• 한국산림과학회지
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• 제83권2호
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• pp.229-238
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• 1994

세계 여러지역에서 임목생장과 활력감소가 커다란 문제점으로 대두되고 있는 바, 이 논문은 북미, 유럽 그리고 동아시아에서 대기오염으로 인한 삼림피해에 관해 현재까지 알려진 바를 요약하고 있다. 오염원 주변에서의 삼림쇠퇴는 상당히 오랫동안 인지되어 왔으나, 오염원으로부터 먼거리에 이르기까지 광범위하게 피해를 준 경우는 그리 흔치 않다. 북미지역의 경우, Los Angeles와 Mexico City 주변에서 고농도의 오존으로 인해 삼림쇠퇴가 일어나고 있고, 미국 동부의 고산지대에서는 강산성의 안개에 의한 가문비나무의 내동성 감소로 피해가 있음이 밝혀지고 있다. 유럽의 경우 독일가문비나무가 Mg 결핍과 N 과다공급이 원인이 되어 피해를 입고 있는 것으로 보이며, 지역적으로 삼림쇠퇴현상이 보이기는 하지만 전체적인 임분생장량이나 현존 biomass가 1970년에 비해 1990년에 증가되었다. 동아시아의 경우, 이에 관한 연구가 초기단계에 있는 바, 중국의 여러 공업지대에서 강산성 강우현상을 보이고 삼림쇠퇴의 주원인이 대기오염일 것으로 사료되는 예가 보고되고 있으며, 한국의 대도시와 공단주변에서 대기오염에 의한 삼림피해 현상을 보이고 있다. 전체적으로 볼 때 온대림에서 광범위한 삼림쇠퇴 현상은 보이지 않고 있으며, 지역별로 상이하게 나타나는 삼림쇠퇴의 정확한 원인을 밝혀내기 쉽지 않다. 대면적에 걸쳐 나타날 수 있는 삼림피해에 대비하는 계속적인 감시와 연구가 앞으로의 과제로 남아있다.

• 대한치과기공학회지
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• 제18권1호
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• pp.95-115
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• 1996

The esthetic factor for the esthetic prosthesis were studied on 300 persons. The praaticipants were 150 students registered under the Deparment of Dental Laboratoy Technology, Jisan Junior College at the present day of June, 1995 and their mothers. The results were as follows; 1. The number of persons with 28 teeth in their oralcatity was highest(P<0.01). They complained that they have only 28 teeth bacaues of the loss(deficiency) fo teeth due to their impacted teeth and dental caries. 2. The presons with feelings of dissatisfaction were large in number(P<0.01). They were dissatisfied with an abnormal tooth form(33.5%), tooth position(31.7%), tooth color(31.1%), and tooth size(3.7%) in order(P<0.01). 3. In their facial form, the most numerous were men with square form and women with ovoid form(P<0.01). Among the whloe number fo facial forms it appeared to decresae in the order of ovoied(41.8%), square(32.7%), square+tapered(20.5%), and tapered form(5%)(P<0.01). In a profile form, the most numerous were men with A form and women with B. Among the whole participants the most numerous were persons with B form and persons with A and C form were next in oder of numbers(P<0.01). 4. In discoloration of teeth, the most numerous were persons who have no discoloration. 5. In the esthetic recovery of anterior prosthesis the color matching of proximal teeth was not correct, but the outline of proximal teeth was to be reproduced correctly. 6. In the diastema of teeth, the number of persons who have no diastema was higher than that of persons who have a disatema(P<0.01) Among the persons who have diastema the most numerous were persons who have a diastema, and next were 2, 4, 3 and 5 diastemas in order. 7. In a meeting point of the midline of the body and the tooth the number of person hanving a meeting point was higher than that of persons who did not fit each other(P<0.01). The bias direction of midline teeth appeared to be affected by chewing direction, prosthesis location, and posterior location. 8. The length and width of teeth in the tooth size were suitable(P<0.01). The number of persons who have central teeth longer than lateral teeth was high(P<0.0). 9. In the results of smile analysis, the line form connected with incisal edge of upper canine were parallel(P<0.01). When smile the location fo upper lips should be in accord with the central area of teeth(P<0.01) and lower lip should be atteched to the edge of anterior teeth in order to be esthetic. 10. Among the number of upper teeth we can see the most numerous were 8 teeth and next were 10, 6 and 12 in order.

• 대한치과의사협회지
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• 제49권2호
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• pp.77-84
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• 2011

The benefits of implant supported overdenture are readily apparent for the fully edentulous patients and have been well documented, however, there is deficiency of the studies regarding the combination of implants with removable partial dentures for partially edentulous patients. The purpose of this article is to review the literature concerning implants with removable partial dentures and evaluate the evidence for this clinical approach. Through many clinical case reports and studies we have searched from a broad variety of journals, we present the six considerations needed to contemplate respecting implants with removable partial denture in partially edentulous patients. First, the connection between abutment tooth and removable partial denture has to be rigid and the link between implant and removable partial denture should be hinged. Second, a mesial rest acts better in the point of force distribution for distal extension removable partial denture and splinting between implants is also a favorable choice. Third, T bar has an advantage for implants which are used as abutments in distal extension removable partial denture. Forth, as we all known functional impression is better way to reproduce movement for distal extension removable partial denture. Fifth, indirect retainer and guiding plane on the proximal surfaces of terminal abutment teeth are important in preventing denture base lifting. Sixth, implants in conjunction with removable partial denture is superior in the esthetic and phonetic as well as cost-effective point of view. We also suggest that which place we should install implants for force distribution and which diameter and length of implants should be used. in this review article, we recommend to locate the implant near of the abutment tooth for esthetics or near of first molar position for good stress distribution. The diameter and length of implant also influence to stress distribution. When we compare to conservative partial denture, patients go for removable partial denture using implants due to convenience, better support and retention according to several studies. But it is true that we need to study more on this subject and collect long term follow up cases before we discuss on it. So it is enough to bring this subject into the surface of prosthetic treatment by this article.

• 한국식품영양과학회지
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• 제33권10호
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• pp.1634-1640
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• 2004

울산광역시의 도시 여중생 129명과 울주군의 농촌의 여중생 182명을 대상으로 하여 혈액검사와 설문지를 통해 연구 대상자의 일반적인 사항, 식사 섭취량, 식생활 태도와 식습관들을 조사하고 혈액검사를 통해 혈액성분을 분석하여 도시와 농촌을 비교 분석하였다. 도시 여중생의 평균 신장은 157.8$\pm$4.9 cm, 농촌이 157.7$\pm$5.1 cm이며 체중은 도시가 51.7$\pm$10.3 kg이고 농촌이 51.9$\pm$9.2 kg이었다. 체질량지수(BMI)는 도시가 20.7$\pm$3.3, 농촌이 20.8$\pm$3.2으로 모두 정상범위에 속하고, PIBW(percent ideal body weight)는 도시가 100.3$\pm$13.2%, 농촌이 100.6$\pm$13.4%으로 신체발달지수면에서는 도시와 농촌의 차이가 없었다. 대상자의 식사시간의 규칙성에 대한 질문에는 도시여중생의 경우 '불규칙적이다(19명)'와 '대체로 불규칙적이다(28명)'로 응답한 학생이 47명으로 전체의 36.4%에 해당하였으며, 농촌여중생은 '대체로 불규칙적이다', '불규칙적이다'로 대답한 학생이 83명으로 전체의 47.7%로 조사되어, 농촌 여중생이 도시 보다 불규칙적인 식습관을 갖는 것으로 드러났다. 대상자의 식습관 문제점에 대한 질문에는 '맵고 짠 음식을 선호한다'와 '식사시간이 불규칙적이다'라고 응답한 대상자가 농촌여중생이 도시여중생보다 유의적으로 높게 조사되었다. 대상자의 식품군별 섭취빈도를 비교해보면 농촌여중생이 도시 여중생보다 우유$.$유제품(p<0.001), 김치(p<0.05), 두부, 된장, 콩류(p<0.001)의 섭취빈도가 낮게 조사되었다. 대상자의 총 열량 섭취량을 보면 도시 여중생은 영양권장량의 82.0%, 농촌여중생은78.6%에 불과하여 열량섭취가 권장량에 못 미치는 것으로 조사되었으며, 농촌여중생의 섭취가 약간 낮았으나 도시 여중생과 유의적인 차이를 보이지는 않았다. 단백질 평균 섭취량은 도시 여중생은 권장량의 95.2%를 섭취하는 것으로 조사되었으며, 농촌여 중생은 권장량의 86.4%에 해당되어 도시보다 유의적으로(p<0.05) 낮은 섭취수준을 나타내었다. 철의 섭취량은 도시여중생이 권장량 대비 89.8%, 농촌이 80.9%를 나타내고, 칼슘은 도시여중생이 권장량 대비 78.5%, 농촌이 68.8%로서 가장 부족된 섭취를 하는 영양소로 조사되었다. 도시와 농촌의 영양소 섭취량을 비교하여 보면 지방, 탄수화물, 총열량을 제외한 모든 영양소에서 농촌이 도시보다 유의적으로 낮은 영양소 섭취수준을 보이는 것으로 조사되었다. 본 연구에서의 hemoglobin 농도는 도시지역은 13.28 g/dL, 농촌지역은 12.51 g/dL로 농촌여중생이 유의적으로 낮은 수치를 나타내었으며 hematocrit치는 도시 37.82%, 농촌 38.13%로 도시와 농촌간에 유의적인 차이를 나타내지 않았다. 빈혈 기준인 12 g/dL미만을 기준으로 평가한 빈혈빈도를 살펴보면, 도시지 역 여중생 이 6.1%이었고, 농촌지역 여중생은 34.6%으로 농촌이 도시보다 유의적으로 높게 조사되었다. 본 연구결과 농촌여중생이 도시 여중생보다 hemoglobin농도와 RBC수가 유의적으로 낮은 것으로 조사되었고, hemoglobin농도로 평가한 빈혈비율이 매우 높은 것으로 나타났다 이의 원인으로 도시여중생에 비해 농촌여중생의 낮은 영양섭취상태, 낮은 식품군별 섭취빈도, 불규칙 한 식사습관이 원인으로 지적될 수 있겠다. 여중생의 경우 급격한 신체 성장과 월경으로 인한 혈액 손실 등으로 철요구량은 매우 높으므로 이시기의 철영양상태의 향상을 위한 영양교육과 함께 철영양상태가 심각한 경우에는 식사조절과 함께 철보충제의 복용이 반드시 필요하다고 본다. 앞으로도 여중생의 철영양상태 파악을 위해 농촌지역을 포함한 다양한 지역으로 확대하여 매년 계속적인 검사를 통하여 빈혈빈도를 파악하여 대상에 맞는 적절한 영양교육 및 홍보가 이루어져야 할 것으로 본다.

• 대한치과교정학회지
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• 제25권4호
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• pp.375-401
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• 1995

성장기 골격성 제III급 부정교합의 원인은 상악 열성장, 하악 과성장과 두 양상의 조합형태로 나뉠 수 있다. 이중 상악 열성장을 동반한 성장기 골격성 제III급 부정교합의 경우, 상악골 전방견인 장치의 사용이 추천되고 있는데, 이러한 장치의 치료효과는 상악골의 전하방 이동과 하악골의 후하방 회전으로 알려져 있다. 국내외 선학들에 의해 상악골 전방견인 장치의 치료효과에 대한 많은 동물실험과 임상실험 결과가 발표되었으나, 연조직 측모 변화에 대한 연구는 미비한 상태이고, 또한 치료를 받은 환자간의 치료효과에 대한 비교도 부족한 상태이다. 이에 저자는 상악골 열성장으로 인한 성장기 골격성 제III급 부정교합으로 진단받고, 상악골 전방견인 장치로 치료 받은 93명의 환자를 성별, 치료개시 나이별, 구개봉합 opening여부(구강내 장치), 안모성장 형태에 따라 분류하여, 각 유형에 따라 어떠한 경조직과 연조직 측모의 변화가 관찰되는지 여부와, Angle씨 제 I 급 부정교합의 정상군 20명과 상악골 전방견인 장치로 치료받은 환자 사이에 경조직과 연조직에 있어서 성장량과 치료량에 어떠한 관계가 있는지 비교하여 다음의 결론을 얻었다. 1. 상악골 전방견인 장치 사용시 골격적 계측항목과 치아와 연조직 계측항목에서 성장량보다 많은 치료에 의한 변화량을 관찰할 수 있었다. 2. 남녀별 치료개시 나이에 따른 상악골 전방이동량과 하악골의 후하방 회전량에는 유의차가 없었다. 3. R.P.E.에서 La-Li보다 유의성 있는 상악골(A point)의 전방이동을 보였으며, 상악 전치의 순측 돌출이 La-Li를 사용하였을때 보다 감소되었다. 4. 안모성장 형태에 따라서는 상악골 전방이동량에는 유의차가 없었으나, 하악골의 후하방 회전을 나타내는 계측치에서 counterclockwise군이 clockwise군보다 많은 변화를 나타냈다. 5. 상순과 하순의 후경변화는 하부 골조직과 상하악 치아의 위치변화와 높은 상관관계를 보였으며, 상순의 고경과 nasolabial angle이 증가하고, mentolabial angle이 감소되었다.

• 보건교육건강증진학회지
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• 제12권1호
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• pp.83-110
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• 1995

The purpose of this study was to investigate the status of the problematic behavior for the demented elderly and the stress among family members, and the effects of the problematic behavior upon the stress in order to offer the basic data for the adult and the elderly health education about dementia. For this purpose, 70 families who were resident in Seoul and Inchon were surveyed by quetionnaires. This was carried out from 26 July, 1994 to 11 September, 1994. Datum was analysed by using SPSS\PC+ including percentage, mean, t - test, ANOVA, Pearson correlation. So, the results of this study were as follows: 1. In view of socia-demographic characteristics, female were 82.9%, and of the female daughters-in-law of the demented elderly were 44.9%. 40th years old were 32.9% and 88.6% wase married. The christian were 34.8%, those who graduated university 47.1%, and those who had a job 32.9%. 2. Of the demented elderly, female were 74.3%, 80 years old were 37.1%, and their average age was seventy-seven point one years old. 66.2% of the elderly has been lived alone and the christian were 27.5%. In addition, those who graduated elementary school were 66.5%. 3. Of the behavior problem for the demented elderly, Activities of the Daily Living(ADL) was the most severe problem. The 2nd was cognitive function problem, the 3th, change of personality, the 4th, emotional disturbance, and the last, misconduct behavior. 4. For the status of behavior problems, females were more severe than male, and 80th years elderly ware the most severe groups. The longer disease period was, the severe problematic behaviors were, and in 4-6 years of the disease period the status was the highest(p＜0.05). Those who diagnosed the disease had more severe problems(p＜0.001). 5. The orders of the stress among family members caring for the demented elderly in this study were as follows : 1. The deficiency of supporting network 2. Decrease of elderly's cognitive activities 3. Assistance of BADL(Basic Activities of Daily Living) 6. Elderly's abnormal behavior 5. Assistance of IADL(Instrumental Activities of Daily Living), 6. As for the status of the stress among family members, female respondants were higher than male. On the ages, 20th years' stress score were the highest. Daughters-in-law were stressed more than other family members. The longer the time of caring per day was, the highest the status of the stress(p＜0.05), 7. Those who caring for female elderly and more than 80 years had more stressed. When the elderly was received the diagnosis, the family members were more stressed. On the disease period, 1-2 years was the highest and after 2 years the status of the stress was decreased and more than 6 years was the lowest(p＜0.05). 8. Behavior problems of the demented elderly were closely associated to the stress for family members. Of the problems, change of personality was the most related factor(r = 0.6552). The factors of Basic Activities of the Daily Living(BADL) was most correlated on assistance of Basic Activities of Daily Living (BADL), emotional disturbance the assistance of IADL(Instrumental Activities of Daily Living). Change of personality was most related to the stress of the decrease of cognitive activities and elderly's abnormal behavior. The deficiency of supporting network was most related to misconduct behavior.

• 농촌지도와개발
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• 제13권1호
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• pp.149-171
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• 2006

This is a pilot study on rural women's psychological trap to define some obstacles to self directed learning. During few decades, according to major crop of each farm household has shifted from rice to other crops like as vegetables, fruits, horticultures, livestock, etc., women's role or labor sharing of women in farming has been also increased. Although women are important human resources, till now, there is no a research or an approach to rural woman on the view of individual human being. Therefore this study will contribute to understand woman's behavior or attitudes based on psychological description at each person's experiences. For this study, the data was collected from 23 women leaders who participated in a training course in 2005, through the scale of Jeffrey E. Young & Janet S. Klosko which was developed to improvement of one's repetitious behavior based on cognitive psychological care. It was categorized into 11types of psychological trap of one person, named as follows; (1) trap of being deserted by someone (2) trap of disbelief and being ill-treated (3) trap of weakness (4) trap of dependence (5) trap of emotional deprivation (6) trap of feelings of alienation among society (7) trap of deficiency (8) trap of anxiety to failure (9) trap of subordination (10) trap of the merciless standard by self-estimation (11) trap of the sense of privilege. From the data, the average age of subjects was 52.8years old, and the educational back of subjects was higher than general rural women. In both of the trap of weakness and the trap of the merciless standard by self-estimation, the ratio of over and 4 point score of 6 points was 71.4% and 76.2%. It means most of subjects have experienced fear of unexpected calamity(trap of weakness), and mental press hard for efforts to meet one's ideal standard(trap of the merciless standard by self-estimation). Especially the trap of the merciless standard by self-estimation may have relation with rural women's over burden from farming and local society activities.