• BMB Reports
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• 제47권4호
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• pp.184-191
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• 2014

Respiratory syncytial virus (RSV) is the leading cause of respiratory infection in infants and young children. Severe clinical manifestation of RSV infection is a bronchiolitis, which is common in infants under six months of age. Recently, RSV has been recognized as an important cause of respiratory infection in older populations with cardiovascular morbidity or immunocompromised patients. However, neither a vaccine nor an effective antiviral therapy is currently available. Moreover, the interaction between the host immune system and the RSV pathogen during an infection is not well understood. The innate immune system recognizes RSV through multiple mechanisms. The first innate immune RSV detectors are the pattern recognition receptors (PRRs), including toll-like receptors (TLRs), retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), and nucleotide-biding oligomerization domain (NOD)-like receptors (NLRs). The following is a review of studies associated with various PRRs that are responsible for RSV virion recognition and subsequent induction of the antiviral immune response during RSV infection.

• 한국군사과학기술학회지
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• 제26권5호
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• pp.409-421
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• 2023

In the air power, UAVs have played a large and diversified role in performing missions from simple to high-level complex ones. In particular, the suppression of enemy air defenses(SEAD) is very dangerous for a pilot so it is expected that the manned-unmanned teaming(MUM-T) system with tailless stealthy unmanned aerial vehicle(UAV) will greatly enhance effectiveness of the mission while ensuring the pilot safe. This paper describes simulation studies of remote airborne control(RAC) environment for performing the SEAD mission by MUM-T, by which the air force pilot remotely controls tailless UAVs individually or small UAVs in swarm. Through this simulation, air force pilot can derive the concept of MUM-T mission operation with various UAVs in the future, and it can be used to upgrade the MUM-T system by verifying the effectiveness of the mission.

• 융합보안논문지
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• 제14권6_1호
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• pp.129-138
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• 2014

한국은 북한의 핵무기 위협에 우선적으로 대응하여야 하는 상황에 직면해 있다. 전략적으로 대응방향은 한국 자체 및 미국의 억제전력을 강화함과 동시에 현재 상태에서 그에 대한 현실적인 해결책은 선제타격을 통한 사전 제거라는 점도 인정할 필요가 있다. 현재 북한의 미사일 위협은 상존하고 있으며 미사일에 탑재시킬 정도의 핵무기를 소형화하는데 성공하였을 가능성도 매우 높다. 한국은 적의 미사일 방어에 관심을 가져야 하며 대공방어는 하층방어와 상층방어를 중심으로 한 전반적인 미사일 방어 체제의 구축방향을 토의 연구하는 한편 인구밀집 도시와 국가 전략시설을 방호할 수 있는 체계를 구축해야한다. 지금까지 북한의 핵무기 위협과 관련된 쟁점은 6자 회담과 같은 국제적이고 외교적인 접근에 의해 문제를 해결하려고 주 노력을 경주하였는데 이 방법이 과연 효율적인지, 북한의 핵무기 위협에 대한 정보의 신뢰도는 과연 어느 정도 인지와 이것을 기초로 우리 군의 방어태세의 하나인 킬체인(Kill Chain)이 효과적인 방어수단이 될 수 있는가 등이다. 지금까지 우리가 얻은 교훈은 북한이 스스로 핵무기 개발을 포기하지 않는 한 외교적 노력으로만 북한의 핵무기를 개발을 억제하는 것은 불가능하다는 것을 알았다. 외교적인 노력과 더불어 군사적인 방법으로 다양한 억제 대책도 실제로 시행할 수 있도록 준비해야 한다.

• 한국연초학회지
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• 제14권2호
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• pp.168-195
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• 1992

Pulmonary system is a target organ and primary defense mechanism against environmental oxidants and polutants. Enzymatic and nonenzymatic antioxdant defense mechanisms undoubtedly protect the lung from oxidants even endogenous oxidative stress. In addition, new ways of augmenting pulmonary antioxidant defenses are developed, which can be used to support the intrinsic antioxidants. Therefore, improved understanding of antioxidant defense mechanisms will increase our knowledge of the cause and will suggest rational approaches for treating and preventing oxidant-induced lung injury. In this review, we discuss the formation and scavenging of free radicals, and the strategies for antioxidant defense of pulmonary system.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2008년도 학술발표회 논문집
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• pp.410-413
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• 2008

We constructed the regional flood risk and damage magnitude using hazard and vulnerabilities which are climatic, hydrological, socio-economic, countermeasure, disaster probability components for DB construction on the GIS system. Also we developed the Excess Flood Vulnerability index estimation System(EFVS). By the construction of the System, we can perform the scientific flood management for the flood prevention and optional extreme flood defenses according to regional characteristics. In order to evaluate the performance of system, we applied EFVS to Anseong-chen in Korea, and the system's stabilization is appropriate to flood damage analysis.

• 한국항공운항학회지
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• 제27권3호
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• pp.1-14
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• 2019

Cooperative systems among various unmanned vehicles are widely used in various field and emerging. Unmanned vehicles are able to operate various missions without operator onboard and they are highly stable. Collaborative work of multiple unmanned vehicles is emphasized due to the difficulty of recent missions such as SEAD (Suppression of the Enemy Air Defenses), MUSIC (Manned Unmanned Systems Integration Capability), goldentime in the rescue mission. In this study, ROS and Pixhawk were proposed as a method of construction of a collaboration system and framework for an integrated simulation environment for heterogeneous unmanned vehicles is proposed. Totally 5 unmanned vehicles were set for the simulation for the observation of illegal fishing boats. This paper shows the feasibility of the cooperative system using ROS and Pixhawk through the simulation and the experiment.

• IMMUNE NETWORK
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• 제15권2호
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• pp.73-82
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• 2015

Respiratory syncytial virus (RSV) infection is recognized by the innate immune system through Toll like receptors (TLRs) and retinoic acid inducible gene I. These pathways lead to the activation of type I interferons and resistance to infection. In contrast to TLRs, very few studies have examined the role of NOD-like receptors in viral recognition and induction of adaptive immune responses to RSV. Caspase-1 plays an essential role in the immune response via the maturation of the proinflammatory cytokines IL-$1{\beta}$ and IL-18. However, the role of caspase-1 in RSV infection in vivo is unknown. We demonstrate that RSV infection induces IL-$1{\beta}$ secretion and that caspase-1 deficiency in bone marrow derived dendritic cells leads to defective IL-$1{\beta}$ production, while normal RSV viral clearance and T cell responses are observed in caspase-1 deficient mice following respiratory infection with RSV. The frequencies of IFN-${\gamma}$ producing or RSV specific T cells in lungs from caspase-1 deficient mice are not impaired. In addition, we demonstrate that caspase-1 deficient neonatal or young mice also exhibit normal immune responses. Furthermore, we find that IL-1R deficient mice infected with RSV exhibit normal Th1 and cytotoxic T lymphocytes (CTL) immune responses. Collectively, these results demonstrate that in contrast to TLR pathways, caspase-1 might not play a central role in the induction of Th1 and CTL immune responses to RSV.

• IMMUNE NETWORK
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• 제14권3호
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• pp.128-137
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• 2014

Respiratory viruses can induce acute respiratory disease. Clinical symptoms and manifestations are dependent on interactions between the virus and host immune system. Dendritic cells (DCs), along with alveolar macrophages, constitute the first line of sentinel cells in the innate immune response against respiratory viral infection. DCs play an essential role in regulating the immune response by bridging innate and adaptive immunity. In the steady state, lung DCs can be subdivided into $CD103^+$ conventional DCs (cDCs), $CD11b^+$ cDCs, and plasmacytoid DCs (pDCs). In the inflammatory state, like a respiratory viral infection, monocyte-derived DCs (moDCs) are recruited to the lung. In inflammatory lung, discrimination between moDCs and $CD11b^+$ DCs in the inflamed lung has been a critical challenge in understanding their role in the antiviral response. In particular, $CD103^+$ cDCs migrate from the intraepithelial base to the draining mediastinal lymph nodes to primarily induce the $CD8^+$ T cell response against the invading virus. Lymphoid $CD8{\alpha}^+$ cDCs, which have a developmental relationship with $CD103^+$ cDCs, also play an important role in viral antigen presentation. Moreover, pDCs have been reported to promote an antiviral response by inducing type I interferon production rather than adaptive immunity. However, the role of these cells in respiratory infections remains unclear. These different DC subsets have functional specialization against respiratory viral infection. Under certain viral infection, contextually controlling the balance of these specialized DC subsets is important for an effective immune response and maintenance of homeostasis.

• Molecules and Cells
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• 제19권2호
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• pp.228-231
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• 2005

Recent characterization of several genes involved in plant defense responses suggested that ubiquitin-mediated protein degradation has a role in these responses. We isolated two cDNAs (NtUBA1 and NtUBA2) encoding ubiquitin-activating enzyme (E1) from Nicotiana tabacum cv. BY-2. The open reading frames of both encoded 1080 amino acids, corresponding to molecular masses of 120 kDa. The E1s and corresponding transcripts were upregulated by infection with tobacco mosaic virus (TMV) and tomato mosaic virus (ToMV), and to a lesser extent by cucumber mosaic virus (CMV). Furthermore, they were also upregulated by wounding stress, and the plant hormones salicylic acid, jasmonic acid and the ethylene precursor, aminocyclopropane-1-carboxylic acid (ACC). Our findings support the idea that the ubiquitin-proteasome system plays a role in plant disease defenses.

• 한국멀티미디어학회논문지
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• 제20권2호
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• pp.279-288
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• 2017

Nowadays, nations cyber security capabilities play an important role in a nation's defense. Security-critical infrastructures such as national defenses, public services, and financial services are now exposed to Advanced Persistent Threats (APT) and their resistance to such attacks effects the nations stability. Currently Cyber Threat Intelligence (CTI) is widely used by organizations to mitigate and deter APT for its ability to proactively protect their assets by using evidence-based knowledge. The evidence-based knowledge information can be exchanged among organizations and used by the receiving party to strengthen their cyber security management. This paper will discuss on the business process reengineering of the CTI information exchange management for a nationwide scaled control and governance by the government to better protect their national information security assets.