• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.583-589
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• 2011

Fluorescence correlation spectroscopy (FCS) is a sophisticated and an accurate analytical technique used to study the diffusion of molecules in a solution at the single-molecule level. FCS is strongly affected by many factors such as the stability of the excitation power, photochemical processes, mismatch between the refractive indices, and variations in the cover glass thickness. We have studied FCS near the surface of a cover glass by using rhodamine 123 as a fluorescent probe and have observed that the surface has a strong influence on the measurements. The temporal autocorrelation of FCS decays with two characteristic times when the confocal detection volume is positioned near the surface of the cover glass. As the position of the detection volume is moved away from the surface, the FCS autocorrelation becomes one-component decaying; the characteristic time of the decay is the same as the faster-decaying component in the FCS autocorrelation near the surface. This observation suggests that the faster component can be attributed to the free diffusion of the probe molecules in the solution, while the slow component has its origin from the interaction between the probe molecules and the surface. We have characterized the surface contribution to the FCS measurements near the surface by changing the position of the detection volume relative to the surface. The influence of the surface on the diffusion of the probe molecules was monitored by changing the chemical properties of the surface. The surface contribution to the temporal autocorrelation of the FCS strongly depends on the chemical nature of the surface. The hydrophobicity of the surface is a major factor determining the surface influence on the free diffusion of the probe molecules near the surface.

• 대한전자공학회논문지TC
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• 제38권5호
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• pp.9-15
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• 2001

원통형 공동 공진기를 이용한 유전체의 전자기적 특성들의 측정 방법에 대해 기술한다. 여기에 관련된 유전체의 전자기적 특성들은 비유전율, 손실 반젠트, Q factor 등이 있다. 동심 유전체 봉이 삽입된 원통형 공동 공진기에서 $TE_{011}$ 모드의 사용이 제한되었다. $TE_{011}$ 모드는 유전체 봉과 공진기 벽면 틈에 의한 공진주파수 민감도가 가장 덜 민감하게 변화하였다. 동심 유전체 봉이 삽입된 원통형 공동 공진기의 $TE_{011}$ 모드를 사용하는 방법과 새롭게 제안된 non-decaying 모드의 정확한 전자계 표현은 유전체의 전자기적 특성들의 정확한 측정을 위해 소개되었다.

• 대한기계학회논문집B
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• 제30권10호
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• pp.996-1002
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• 2006

Experiments in methane-air low strain rate counterflow diffusion flames diluted with nitrogen have been conducted to study the behavior of flame extinction and edge flame oscillation in which flame length is less than the burner diameter and thus lateral conduction heat loss in addition to radiative heat loss could be remarkable at low global strain rates. Critical mole fraction at flame extinction is examined with velocity ratio and global strain rate. Onset conditions of edge flame oscillation and flame oscillation modes are also provided with global strain rate and added nitrogen mole fraction to fuel stream (fuel Lewis number). It is seen that flame length is closely relevant to lateral heat loss, and this affects flame extinction and edge flame oscillation considerably. Edge flame oscillations in low strain rate flames are experimentally described well and are categorized into three: a growing oscillation mode, a decaying oscillation mode, and a harmonic oscillation mode. The regime of flame oscillation is also provided at low strain rate flames. Important contribution of lateral heat loss even to edge flame oscillation is clarified

• 지질공학
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• 제11권3호
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• pp.255-267
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• 2001

지하 50m의 화강암반내 단층지역에 위치한 지하 방사성폐기물 처분장 인접지역에서의 열, 수리, 및 역학적 연성거동을 비교하고 분석하였다. 해석에는 2차원 해석코드인 UDEC을 사용하였다. 해석모델은 화강암반, 처분공내의 압축 벤토나이트로 둘러싸인 PWR 사용후 핵연료 처분용기, 및 처분동굴내에 채워진 혼합 벤토나이트를 포함한다. 수리-역학적, 열-역학적, 및 열-수리-역학적 연성거동을 비교 및 분석하였다. PWR 사용후 핵연료내의 방사성 물질로부터 나오는 시간의존 방사성 붕괴열이 처분장 및 인접지역에 미치는 영향을 분석하였다. 수리해석에는 steady state flow 알고리즘을 사용하였다.

• Biomolecules & Therapeutics
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• 제25권3호
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• pp.259-265
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• 2017

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.

• 분석과학
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• 제25권6호
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• pp.447-459
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• 2012

본 연구에서는 염처리 음식물의 냄새성분 배출특성을 파악하고자 스팸을 조사대상으로 선정하여 시간경과에 따른 휘발성화학물질의 발생특성을 파악하고자 하였다. 이를 위하여 총 9 일 동안 5 회에 걸쳐 시료를 채취 후 GC/MS 시스템과 GC/PFPD 시스템을 이용하여 분석하였다. 분석 결과 연구기간 동안 환원황, 알데하이드, 케톤류의 냄새성분들이 주로 발생하는 것으로 나타났다. 신선기에 해당하는 E-0, E-1일은 hydrogen sulfide의 농도가 각각 1465 ${\mu}g/m^3$ (60.0%), 455 ${\mu}g/m^3$ (28.0%)로 가장 높게 나타났다. OAV (악취활성값) 또한 E-0 일은 19.4 (78.3%), E-1 일은 6.02 (41.7%)로 가장 높게 나타났다. 부패기에 해당하는 E-3, E-6, E-9일에는 ketone류의 acetone이 각각 451 (43.2%), 369 (64.2%), 1150 ${\mu}g/m^3$ (70.2%)로 나타났다. 그 뒤를 이어 2,3-butanedione이 각각 17.6 (1.68%), 16.1 (2.80%), 179 ${\mu}g/m^3$ (10.9%)로 나타났다. 이들 성분의 실질적인 냄새 기여도를 OAV로 비교하면, acetone은 0.001 (0.01%)이하로 미미한 수준이지만, 2,3-butanedione은 1.14-11.6 (14.5-76.2%)으로 높게 나타났다. 본 연구의 결과, 신선기에는 환원황 그룹, 신선기와 부패기의 중간 시점에는 알데하이드 그룹, 부패기에는 케톤 그룹 성분들이 가장 중요한 냄새 요인으로 작용하는 것을 확인하였다.

• 설비공학논문집
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• 제1권4호
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• pp.265-275
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• 1989

An experimental study of decaying swirl air flow has been obtained by tangential inlet in a straight tube with Reynolds number range 20,000~40,000. The friction factor, swirl angle, velocity profiles and turbulent intensity are measured by using micro-manometer and hot-wire anemometer. It is found that the swirl flow behaviors depend on the swirl intensity along the test tube.

• 대한기계학회논문집B
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• 제24권2호
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• pp.280-287
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• 2000

Laboratory measurements were made of wall pressure fluctuations in a separated and reattaching flow over a backward-facing step. An array of 32 microphones along the streamwise direction was utilized. Various statistical properties of pressure fluctuations were scrutinized. The main emphasis was placed on the flow inhomogeneity along the streamwise direction. One point statistics such as the streamwise distribution of rms pressure and autospectra were shown to be generally consistent with other studies. The coherences and wavenumber spectra in the streamwise directions were indicative of the presence of dual modes in pressure; one is the large-scale vortical structure in low frequency and the other is the boundary-layer-like decaying mode in high frequency.

• Bulletin of the Korean Chemical Society
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• 제24권8호
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• pp.1069-1074
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• 2003

A theoretical description and experimental demonstration of homodyne-detected two-color transient grating (2-C TG) signal are presented. By treating the coupled bath degrees of freedom as a collection of harmonic oscillators and using a short-time expansion method, approximated nonlinear response functions were obtained. An analytic expression for the two-color transient grating signal was obtained by carrying out relevant Gaussian integrals. The initial rising and decaying parts of the 2-C TG signal is shown to be critically dependent on the ultrafast inertial component of the solvation correlation function. The experimental results confirm the predictions of the theoretical model.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제52권4호
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• pp.185-191
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• 2003

In this Paper, we propose an accurate and stable solution of the transient electromagnetic response from three-dimensional arbitrarily shaped conducting objects by using a time domain magnetic field integral equation. This method does not utilize the conventional marching-on in time (MOT) solution. Instead we solve the time domain integral equation by expressing the transient behavior of the induced current in terms of temporal expansion functions with decaying exponential functions and Laguerre·polynomials. Since these temporal expansion functions converge to zero as time progresses, the transient response of the induced current does not have a late time oscillation and converges to zero unconditionally. To show the validity of the proposed method, we solve a time domain magnetic field integral equation for three closed conducting objects and compare the results of Mie solution and the inverse discrete Fourier transform (IDFT) of the solution obtained in the frequency domain.