• Journal of Integrative Natural Science
• /
• v.7 no.2
• /
• pp.87-91
• /
• 2014

Amyloid beta ($A{\beta}$) peptide has been implicated in the pathogenesis of Alzheimer's disease and has been reported to induce apoptotic death in cell culture. Cysteine Proteases, a family of enzymes known as caspases, mediate cell death in many models of apoptosis. In the present study, we examined the caspase activity and cell death in $A{\beta}$-treated SHSY5Y cells, as an attempt to elucidate the relationship between the type of caspase and $A{\beta}$-induced cell death. $A{\beta}$ at 20 ${\mu}M$ induce activation of caspase-3, 8 and 9 activity, but not the caspase-1. Caspase-3, 8 and 9 were processed by Ab treatment, consistent with the activity assay. Inhibition of the caspase activities by the selective inhibitors, however, marginally affected the cell death induced by $A{\beta}$. Taken together, the results indicate that $A{\beta}$-induced cell death may be independent of caspase activity and rather, the enzymes might be activated as a result of the cell death.

• Journal of Environmental Health Sciences
• /
• v.39 no.1
• /
• pp.19-31
• /
• 2013

Objectives: Elevated temperatures during summer months have been reported since the early 20th century to be associated with increased daily mortality. However, future death impacts of high temperatures resulting from climate change could be variously estimated in consideration of the future changes in historical temperature-mortality relationships, mortality, and population. This study examined the future death burden of high temperatures resulting from climate change in Seoul over the period of 2001-2040. Methods: We calculated yearly death burden attributable to high temperatures stemming from climate change in Seoul from 2001-2040. These future death burdens from high temperature were computed by multiplying relative risk, temperature, mortality, and population at any future point. To incorporate adaptation, we assumed future changes in temperature-mortality relationships (i.e. threshold temperatures and slopes), which were estimated as short-term temperature effects using a Poisson regression model. Results: The results show that climate change will lead to a substantial increase in summer high temperature-related death burden in the future, even considering adaptation by the population group. The yearly death burden attributable to elevated temperatures ranged from approximately 0.7 deaths per 100,000 people in 2001-2010 to about 1.5 deaths per 100,000 people in Seoul in 2036-2040. Conclusions: This study suggests that adaptation strategies and communication regarding future health risks stemming from climate change are necessary for the public and for the political leadership of South Korea.

• Journal of the Korean Society of Safety
• /
• v.31 no.3
• /
• pp.96-101
• /
• 2016

Previous literature has been investigated various aspects of accident occurrence and prevention in construction field. However, those studied were limited in that they only focused on the death accident without considering the loss time accident. Based on this, the goal of current study was to investigate the nature of the loss time accident, and compare the results with the death accident. Results showed that 1) the occurrence rate of death accident was significantly higher in the form work, temporary work, and steel frame work; 2) the temporary work showed significantly higher occurrence rate of the loss time accident and the death accident as compared to others; 3) ratio of the loss time accident to the death accident in domestic construction field was 50:1; 4) fall accident showed biggest occurrence rate in both the loss time accident and the death accident; and 5) more that 80% of workers in both the loss time accident and the death accident was between 41 and 65 years old.

• Korean Journal of Veterinary Research
• /
• v.4 no.1
• /
• pp.27-33
• /
• 1964

In the treatment of mice Aureomycin, Oil penicillin, Achromycin, Ambrasynth and Terramycin were effective on the Black-leg disease when they were administered about 4 to 5 hours before the death of control animals. Synthomycetin, however, was observed to be effective when administered 8 hours or more before the control death. Streptomycin seemed to be rather less effective than Black leg antiserum. It was not effective at all when given 19 hours before the death of control animal although there was a delay of taking death by 5 hours in the treated group. As was in mice, Streptomycin was little effective in the treatment of calves, while other antibiotics showed fine efficacy on the diseased animals. The diseased animals, when given with anitibiotics 37 hours before the death of control showed the rise of temperature($41^{\circ}C$ or more), swelling and redness on the site of infection and then recovcred to normal stage. In the treatment of calves, Aureomycin only delayed the taking death of the deseased animals by 111 hours when administered 4 hours before the death of control animals. And other antibiotics, when given 4 hours before the death of control animals were effective, although the deseased animls developed symptoms such as hard breathing, anorexia and dropsical swellings. Oil penicillin was observed to be comparatively larger in its efficacy on the treatment of Black leg disease.

• Journal of Korean Clinical Nursing Research
• /
• v.25 no.3
• /
• pp.323-332
• /
• 2019

Purpose: This study aimed to identify the factors affecting the terminal care stress of nurses in intensive care units in terms of their death perception, attitude toward terminal care, and mental health. Methods: This descriptive study collected data from 118 nurses in intensive care units in one tertiary referral hospital and three general hospitals. The instruments used in the study were the Terminal Care Stress Assessment Tool, the View of Life and Death Scale, the Frommelt Attitudes toward Nursing Care of the Dying Scale (FATCOD), and the Mental Health Assessment Tool. The data were analyzed by t-test, ANOVA, Pearson's correlation coefficient, and multiple regression. Results: There was a significant positive correlation between terminal care stress and death perception (r=.31, p<.001). The factors significantly influencing the terminal care stress of the participants included gender (β=.33, p<.001), religion (β=.24, p=.004), and death perception (β=.35, p<.001), and the overall explanatory power was 23.1% (F=12.73, p<.001). Conclusion: To decrease terminal care stress among nurses, establishing the death perception of nurses based on value clarification about death may be necessary. Furthermore, this study suggests an intervention study examining the effect of an education program on terminal care stress among ICU nurses.

• Biomolecules & Therapeutics
• /
• v.27 no.5
• /
• pp.484-491
• /
• 2019

Glioblastoma is the most aggressive common brain tumor in adults. Curcumin, from Curcuma longa, is an effective antitumor agent. Although the same proteins control both autophagy and cell death, the molecular connections between them are complicated and autophagy may promote or inhibit cell death. We investigated whether curcumin affects autophagy, which regulates curcumin-mediated tumor cell death in A172 human glioblastoma cells. When A172 cells were incubated with $10{\mu}M$ curcumin, autophagy increased in a time-dependent manner. Curcumin-induced cell death was reduced by co-incubation with the autophagy inhibitors 3-methyladenine (3-MA), hydroxychloroquine (HCQ), and LY294002. Curcumin-induced cell death was also inhibited by co-incubation with rapamycin, an autophagy inducer. When cells were incubated under serum-deprived medium, LC3-II amount was increased but the basal level of cell viability was reduced, leading to the inhibition of curcumin-induced cell death. Cell death was decreased by inhibiting curcumin-induced autophagy using small interference RNA (siRNA) of Atg5 or Beclin1. Therefore, curcumin-mediated tumor cell death is promoted by curcumin-induced autophagy, but not by an increase in the basal level of autophagy in rapamycin-treated or serum-deprived conditions. This suggests that the antitumor effects of curcumin are influenced differently by curcumin-induced autophagy and the prerequisite basal level of autophagy in cancer cells.

• Journal of muscle and joint health
• /
• v.27 no.3
• /
• pp.229-237
• /
• 2020

Purpose: This paper aims to clarify the concept of well-dying in the sociocultural context of Korea. Methods: Walker and Avant's method was chosen for the concept analysis. Through a literature review of 36 papers, the attributes and definition of well-dying were derived. Results: The literature revealed that in Korean society, well-dying is defined as the process of actively preparing for death throughout life. The attributes of the concept are a reflection on death, death acceptance, searching for meaning, transcendence, advance decision-making, and sharing values with family. The motivation for thinking about death, the hope of dying with dignity, and the Korean cultural view of death precede the concept, followed by dying with dignity, personal and family happiness, and improved quality of life and death. Conclusion: This study may lead to the unification of concept use based on mutual understanding, thus enabling effective communication in research, education, and clinical settings. This can be the rationale for the development of tools and educational programs as well as establishing policies related to well-dying in Korea.

• Journal of the Daesoon Academy of Sciences
• /
• v.19
• /
• pp.213-250
• /
• 2005

Until 1970's, mankind have not had definite perspectives on what life after the death was like, which is one of the most important problems for them. Their concepts of the 'life and death problem' has been distorted by the dogmas of the established religions such as Buddhism or Christianity on heaven and hell. But the mankind came to have wholly different views on the life after death thanks to the studies by Raymond Moody Jr. or Elizabeth Quebler-Ross in the mid-1970's. This is the studies on the so-called 'near-death experience(NDE)' which made humankind be able to have scientific approach to the life after death for the first time in their history. What attracts our attention at this point is, however, that the arguements of the NDErs on humman destiny accurately coincide with those of the established religions. In the NDE, most of the experiencers have an encounter with the personal being, symbolized by the Light, through whom they learnt that the devotion(or love) to the neighborhood and the gain of the wisdom are the sole meaning of life. With this result, we can recognize why essential virtues maintained by the established religions until now such as ultimate compassion, unconditional love, forgiveness, or insightful learning are so significant, and that our studies of the NDE are very important in this respect.

• Journal of Korean Medical classics
• /
• v.3
• /
• pp.1-150
• /
• 1989

Oriental medicine thinks life and death as the following. 1. The universe seems to be a kind of organism which is divided into 3 branches, as Heaven, Earth and Man. Man is not created from nihil by the Creator. Heaven and Earth by their interaction operate to produce man. This is similiar that zygote is not created from nihil, and that sperm and ovum are transformed into zygote by their interaction. The symbolic meaning of sperm is Heaven, and that of ovum is Earth. Mind and body, as well as spirit and body, are not the real, but artificial words for the purpose of observing and expressing one man. So there is not spiritual substance as distinct from body. The expected life span of man is subjected to change, and is always becoming through life. Fate, the Creator and the world to come cannot be said to be. 2. After one's death, man is transformend into Heaven and Earth. Dying is this process of transformation. Although man comes into existence and closes one's life, the total life of the universe does not change. The criteria of determination of death is not in cell death, but in somatic death. Somatic death divided into 2 branches, one is heart-lung death, the other is brain death. For the standard of health changes ceaselessly as time goes by, aging and dying is not the process of losing health. Because of mind cannot be seperated from body, we'll feel at ease bodily and mentally in healthy dying. The completion of lifetimes is the value of healthy dying. 3. From the viewpoint of these, we must think to let a person die healthily is the right medical ethics. The way to let a person die healthily is divided into 3 branches, one is treatment, another is prevention and the other is promotion of health. We should treat and prevent death of sickness, but take care of healthy dying.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.12
• /
• pp.7148-7159
• /
• 2014

This study examined the relationship between the death perceptions and attitudes of the severely diseased persons in hospice facilities based on their general characteristics. The surveys were conducted from March 10 to July 31, 2013 on 149 patients at hospice facilities in ${\bigcirc}$ city, Gyeonggi-do. The data was analyzed by the SPSS WIN 18.0. First, positive death attitudes showed significant differences according to the patients' general characteristics (F=6.218, p<.001). Second, the patients' death attitudes by their death perceptions showed meaningful results (F=6.634, p<.001). Third, the death attitudes revealed a positive relation with hospice use (r=.496, p<.001). Overall, patients, who have positive death perceptions and attitudes, have high expectations for hospice use and these results support for welfare policies to encourage hospice use of severely diseased persons.