• The Korean Journal of Physiology and Pharmacology
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• 제8권1호
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• pp.1-5
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• 2004

Transient forebrain ischemia results in the delayed neuronal death in the CA1 area of the hippo-campus. The present study was performed to determine effects of aminoguanidine, a selective iNOS inhibitor, on the generation of peroxynitrite and delayed neuronal death occurring in the hippocampus following transient forebrain ischemia. Transient forebrain ischemia was produced in the conscious rats by four-vessel occlusion for 10 min. Treatment with aminoguanidine (100 mg/kg or 200 mg/kg, i.p.) or saline (0.4 ml/100 g, i.p.) was started 30 min following ischemia-reperfusion and the animals were then injected twice daily until 12 h before sacrifice. Immunohistochemical method was used to detect 3-nitrotyrosine, a marker of peroxynitrite production. Posttreatment of aminoguanidine (200 mg/kg) significantly attenuated the neuronal death in the hippocampal CA1 area 3 days, but not 7 days, after ischemia-reperfusion. 3-Nitrotyrosine immunoreactivity was enhanced in the hippocampal CA1 area 3 days after reperfusion, which was prevented by the treatment of aminoguanidine (100 mg/kg and 200 mg/kg). Our findings showed that (1) the generation of peroxynitrite in the hippocampal CA1 area 3 days after ischemia-reperfusion was dependent on the iNOS activity; (2) the postischemic delayed neuronal death was attenuated in the early phase through the prevention of peroxynitrite generation by an iNOS inhibitor.

• 한국위성정보통신학회논문지
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• 제8권2호
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• pp.80-87
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• 2013

통신, 해양, 기상의 세 분야 복합 임무를 수행하는 천리안위성(Communication Ocean Meteorological Satellite: COMS)은 정지궤도 동경 $128.2{\circ}$에서 2011년 4월부터 현재 정상 운영 임무를 수행하고 있다. 세 임무를 수행하기 위해 천리안위성에는 3가지 탑재체인 기상탑재체(Meteorological Imager: MI), 해양탑재체(Geostationary Ocean Color Imager: GOCI), 통신탑재체(Ka-band communication payload)가 실려 있다. 세 가지 임무 운영과 위성 유지 관리를 위해 위성 관제가 실시간 운영으로 수행된다. 위성 실시간 운영은 명령과 원격측정자료를 통해 위성과 직접 통신하는 업무이다. 본 논문에서는 천리안위성의 실시간 운영 특성으로 지상국 장비 구성과 일일, 주간, 월간, 계절별, 연간 운영 업무 특성을 논하였다. 천리안위성의 궤도상 시험(In-Orbit-Test: IOT) 말기와 정상 운영 첫 해가 포함되는 2011년의 1년간 운영 결과에 대한 토의를 통해 성공적인 실시간 운영 결과 확인도 제시하였다.

• Journal of Astronomy and Space Sciences
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• 제30권4호
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• pp.241-246
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• 2013

We have investigated drought periodicities occurred in Seoul to find out any indication of relationship between drought in Korea and solar activities. It is motivated, in view of solar-terrestrial connection, to search for an example of extreme weather condition controlled by solar activity. The periodicity of drought in Seoul has been re-examined using the wavelet transform technique as the consensus is not achieved yet. The reason we have chosen Seoul is because daily precipitation was recorded for longer than 200 years, which meets our requirement that analyses of drought frequency demand long-term historical data to ensure reliable estimates. We have examined three types of time series of the Effective Drought Index (EDI). We have directly analyzed EDI time series in the first place. And we have constructed and analyzed time series of histogram in which the number of days whose EDI is less than -1.5 for a given month of the year is given as a function of time, and one in which the number of occasions where EDI values of three consecutive days are all less than -1.5 is given as a function of time. All the time series data sets we analyzed are periodic. Apart from the annual cycle due to seasonal variations, periodicities shorter than the 11 year sunspot cycle, ~ 3, ~ 4, ~ 6 years, have been confirmed. Periodicities to which theses short periodicities (shorter than Hale period) may be corresponding are not yet known. Longer periodicities possibly related to Gleissberg cycles, ~ 55, ~ 120 years, can be also seen. However, periodicity comparable to the 11 year solar cycle seems absent in both EDI and the constructed data sets.

• 한국학교ㆍ지역보건교육학회지
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• 제6권
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• pp.75-87
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• 2005

The purpose of this study was to describe elementary school students' health communication needs based on school-based health fairs by students' demographic characteristics and school health education experiences. A self-administered survey was conducted to a total of 851 fifth-grade students in 8 elementary schools in Seoul. For survey participant sampling, Seoul area was divided into four districts: north, south, east, and west, and two elementary schools were selected from each district by the stratified convenient sampling process. Three class 5th-grade students in each selected school finished the survey. Questionnaires and survey instruction letters were delivered to vice-principals in the designated schools and the vice-principals managed the survey process. The survey Questionnaire included demographic characteristics (sex, parent's marital status, parents' educational status, famil financial status, the person whom was with after school, and daily computer hour), health education experiences (health education at school, and school health education satisfaction), and health communication types. The health communication types were reorganized into eight types based on comprehensive literature review on health fairs (or child and adolescence. The health communication types were 'health exam and advice fair,''health promotion advertising and campaign,' 'health-related exhibition and experience fair,' 'profession visit-in-school education,' 'health-related VCR or movie festival,' 'health-related institute visits,' 'internet health counseling,' and 'telephone health counseling.' Regarding demographic characteristics, sex, family financial status, and academic performance were significant factors related to health communication need scores (p <.05). Girl, high level of family financial status, and excellent academic performance score were related to high score of health communication need. In terms of school health education experience, taking regular class for health education and satisfaction with school health education were linked to higher health communication need scores. This result discusses that experience and satisfaction with school health education largely contribute to building participants' health communication concepts and needs.

• 한국학교보건학회지
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• 제22권1호
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• pp.73-83
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• 2009

Purpose: The purpose of this study was to develop a comprehensive health promotion program for North Korean young adult defectors in South Korea. Methods: The comprehensive health promotion program consisted of nutrition, mental healthcare, physical activity and sexual behavior was developed on the basis of need assessment results. For the evaluation of the program, 70 North Korean young adults who were attending two alternative schools for North Korean defectors were recruited. The program had taken place once a week for 13 or 19 weeks. Effectiveness of the health promotion program was evaluated using anthropometric measurement, 3-day food records and a questionnaires that comprised the Hospital Anxiety and Depression Scale (HADS), the Short Form with 36 questions (SF-36) and health behaviors. The surveys were proceeded at the beginning and after the program. Results: After health promotion program, participants' height was significantly increased (p=0.004) and body fat mass (0=0.004) and percentage of body fat mass (p=0.003) were significantly decreased. The number of subjects who ate breakfast alone was decreased whereas the number of subjects who ate breakfast with friends was increased (p<0.001). There were no significant changes in dietary intakes, mental health status and quality of life. North Korean young adult defectors' willingness to participate and interests in the health promotion program were high, however the practice rate was low. Conclusion: The health promotion program could induce interests and willingness to participate, but bring about limited effects on the health behaviors. These results imply that a health promotion program for North Korean young adult defectors should have a long-term strategy as well as short-term plan. Furthermore, it should be based on their health problems, health related behaviors, academic performance and daily life matters.

• International Journal of Industrial Entomology and Biomaterials
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• 제14권2호
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• pp.121-126
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• 2007

Obesity is a major risk factor for cardiovascular disease. In our case study using animal models for disease states such as obesity or hypertension, we found that, Isaria sinclairii remarkably reduced body weight and ameliorated metabolic abnormalities in Zucker and SHR rats. Genetically obese (fa/fa) Zucker rats were one animal model chosen for this study. Four groups of rats received a standard diet and were treated orally with the following test samples daily for 8 weeks: saline (negative control), ethanol extracts of I. sinclairii, hot water extract of I. sinclairii, or $Xenical^{(R)}$ (30 mg/kg, positive control). Mild reductions (6.3%) in body weight gain were observed in the groups treated with the hot water extract of I. sinclairii compared to the control after 8 weeks. Interestingly, organ weight was greatly reduced by this Dongchunghacho (I. sinclairii), in parallel with the mild reductions in body weight gain and reductions in abdominal fat (adipose tissue). Also observed was a 4.1 % decrease in the ratio of heart weight/body weight compared to the control group. As a hypertensive animal model, SHR (spontaneously hypertensive rat) and WKY (Wistar Kyoto) rats were also administered these extracts for one month. Treatment with the hot water extract of I. sinclairii caused greater reductions in body weight gain for the SHR group (10.9%) compared to the WKY group's (5.2%). Based on these results, I. sinclairii extracts contain selective action for anti-obesity activity, naturally occurring candidate for regulation of body weight increase, as demonstrated in the present study.

• 한국동물위생학회지
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• 제32권1호
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• pp.77-82
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• 2009

Salmonella (S.) Typhimurium infection in pigs is a major source of human foodborne salmonellosis. Recently, the swine industry in Korea has been suffered from salmonellosis causing severe economic loss to farms. Organic acids have antibacterial activity which prevents bacteria from multiplying by reducing the pH in the gastrointestinal tract. The aim of the present study is to evaluate whether $Salstop^{(R)}$ mixed with organic acids is able to have influence on growth performance and whether it prevents against S. Typhimurium in weaning pigs. Four experimental treatments were examined: general diet added with 0.3% of $Salstop^{(R)}$ after S. Typhimurium ($1.0{\times}10^{10}CFU/ml$) challenge, group A; commercial feed after Salmonella ($1.0{\times}10^{10}CFU/ml$) challenge, group B; commercial feed and $Salstop^{(R)}$, group C; commercial feed, Group D. At the end of the study, no significant differences in daily body weight gain and feed intake were observed between groups treated with $Salstop^{(R)}$ and groups treated without, whereas feed conversion ratio (FCR) tended to be improved in groups treated with $Salstop^{(R)}$ between days 1 to 14. Serological and microbiological evolution of the infection were examined by ELISA and microbiological culture from serums and fecal samples, respectively. In groups that challenged by S. Typhimuriums, the group without $Salstop^{(R)}$ showed higher prevalence and bacterial shedding compared to the groups treated with $Salstop^{(R)}$. Our results suggest that the administration of $Salstop^{(R)}$ could be used to promote feed efficiency and to reduce the prevalence of salmonellosis in weaners.

• 한국산업보건학회지
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• 제23권1호
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• pp.1-10
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• 2013

Objectives: The present study investigated the potential subacute toxicity of 1,4-dichlorobutane (1,4-DCB) by a 2-week repeated oral dose in male Sprague-Dawley rats. Materials and Methods: The test chemical was administered once daily by gavage to male rats at dose levels of 0, 74, 222, 667, and 2000 mg/kg/day for 2 weeks. All rats were sacrificed at the end of treatment period. During the test period, clinical signs, mortality, body weights, food and water consumption, urinalysis, hematology, serum biochemistry, gross findings, and organ weights were examined. Results: At 2000 mg/kg/day, treatment-related clinical signs, as evidenced by hypothermia, decreased locomotor activity, piloerection, lying on side, and prone position were observed. All the rats were found dead on test day 2. At 667 mg/kg/day, polyuria, suppressed body weight gain, food consumption, and spleen and thymus weights, and increased adrenal gland and liver weights were observed.Hematological and serum biochemical investigations revealed increases in the alanine aminotransferase, alkaline phosphataseand total bilirubinand decreases in the serum $Na^+$ level, white blood cell count and lymphocyte ratio. There were no treatment-related adverse effects in the 74 and 222 mg/kg/day groups. Conclusions: In the present experimental conditions, target organs were determined to be spleen, thymus,and liver. The no-observed-adverse-effect level was considered to be 222 mg/kg/day in male rats.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.482-489
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• 2020

G protein-coupled receptor kinase 5 (GRK5) has been considered as a potential target for the treatment of heart failure as it has been reported to be an important regulator of pathological cardiac hypertrophy. To discover novel scaffolds that selectively inhibit GRK5, we have identified a novel small molecule inhibitor of GRK5, KR-39038 [7-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-2-(2-chlorophenyl)-6-fluoroquinazolin-4(3H)-one]. KR-39038 exhibited potent inhibitory activity (IC₅₀ value=0.02 µM) against GRK5 and significantly inhibited angiotensin II-induced cellular hypertrophy and HDAC5 phosphorylation in neonatal cardiomyocytes. In the pressure overload-induced cardiac hypertrophy mouse model, the daily oral administration of KR-39038 (30 mg/kg) for 14 days showed a 43% reduction in the left ventricular weight. Besides, KR-39038 treatment (10 and 30 mg/kg/day, p.o.) showed significant preservation of cardiac function and attenuation of myocardial remodeling in a rat model of chronic heart failure following coronary artery ligation. These results suggest that potent GRK5 inhibitor could effectively attenuate both cardiac hypertrophy and dysfunction in experimental heart failure, and KR-39038 may be useful as an effective GRK5 inhibitor for pharmaceutical applications.

• 대한지역사회영양학회지
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• 제8권1호
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• pp.91-101
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• 2003

The purpose of this study was to investigate the compliance and need for diet therapy among diabetics and their caregivers. A total of 625 respondents participated in this survey. Appropriate management for long-term blood glucose control and difficult-to-manage cases appeared to be diet therapy, physical activity, medical treatment and folk remedies, in that order. The most important educational avenues for diet therapy were books, magazines and TV, Most respondents were educated in diet therapy within a year after diagnosis and had practiced diet therapy for over four years. The most common diet therapy Practices were food selection and Quantity control. Of the specific problems in practicing diet therapy, time and labor, taste, and meal planning appeared to be equally difficult factors. The prevailing diet therapy skills were controlling food amounts at breakfast and supper, and selecting food for lunch and refreshments. Respondents practicing both skills were about 20% of the participants; this shows the need to improve the current situation. The nutrients most frequently considered in diet therapy practice were simple sugars (sugar and sweet goods) , total fats and cholesterol. Since the perception of the role of dietary fiber among respondents was very low, nutrition education about the importance of dietary fiber and food sources of dietary fiber was needed. Diabetics seemed to be concerned about diabetic menus. Three difficult problems in planning diabetic menus were daily menu planning, patient's preferences, and the calculation of calories. As a means of nutrition counseling, they preferred interviews. The higher the educational status and the lower the age, the higher the preference was for internet or PC counseling. Therefore, it is necessary to develop nutrition educational programs so that diabetics can obtain practical knowledge of diet therapy. Furthermore, it is also necessary to develop additional means of informing diabetics about menu planning, while still considering Korean dietary behavior.