• 한국공작기계학회논문집
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• 제16권6호
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• pp.146-152
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• 2007

An active micro-mixer, which was composed of an oscillating micro-stirrer in the microchannel to provide rapid, effective mixing at high flow, rates was analyzed. The effects of molecular diffusion and disturbance by the stirrer were considered with regard to two types of mixer models: the simple straight microchannel and microchannel with an oscillating stirrer. Two types of mixer models were studied by analyzing mixing behaviors such as their interaction after the stirrer. The mixing was calculated by Lattice Boltzmann methods using the D2Q9 model. In this study, the time-averaged mixing index formula was used to estimate the mixing performance of time-dependent flow. The mixing indices of the two models compared. From the results, it was found that the mixer with an oscillating stirrer was much more enhanced and stabilized. Therefore, an optimum design for a dynamic micro-mixer with an oscillating stirrer was performed using Taguchi method in order to obtain a robust solution. The design parameters were established as the frequency, the length and the angle of the stirrer and the optimal values were determined to be 2, 0.8D and ${\pm}75^{\circ}$, respectively. It was found that the mixing index of the optimal design increased 80.72% compared with that of the original design.

• 한국공작기계학회논문집
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• 제17권5호
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• pp.95-100
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• 2008

An active micro-mixer, which is composed of an oscillating micro-stirrer in the micro-channel to provide effective mixing was optimized. The effects of molecular diffusion and disturbance by the stirrer were considered with regard to two types of mixer models: the simple straight micro-channel and micro-channel with an oscillating stirrer. Two types of mixer models were studied by analyzing mixing behaviors such as their interaction after the stirrer. The mixing was calculated by Lattice Boltzmann methods using the D2Q9 model. In this study, the time-averaged mixing index formula was used to estimate the mixing performance of time-dependent flow. The mixing indices of the two models were compared. From the results, it was found that the mixer with an oscillating stirrer was much more enhanced and stabilized. Therefore, an approximate optimization of an active micro-mixer with an oscillating stirrer was performed using Kriging method with OLHD(Optimal Latin Hypercube Design) in order to determine the optimal design variables. The design parameters were established as the frequency, the length and the angle of the stirrer. The optimal values were obtained as 1.0346, 0.66D and $\pm45^{\circ}$, respectively. It was found that the mixing index of the optimal design increased by 88.72% compared with that of the original design.

• 전력전자학회논문지
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• 제4권3호
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• pp.275-284
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• 1999

3산 전력 시스템에서 불평형 전원의 전압은 대칭좌표법에 의하여 정상, 역상, 영상성분으로 각각 분해 될 수 있고 또한 전력 시스템에 중성선이 없는 경우 영상성분은 부하측에 나타나지 않게 된다. 따라서 중성선이 없는 불평형 시스템에서는 전원측의 역상성분만을 검출하여 보상함으로써 부하측에 평형된 전압을 공급할 수 있을 뿐만 아니라 정상성분의 크기를 제어함으로써 부하에 인가되는 전압의 크기를 조정하는 것이 가능하다. 아울러 이러한 불평형 전압에 의한 각 대칭분은 3상 2상 변환을 통한 동기좌표축상에서의 효율적인 검출이 가능한데, 본 논문에서는 전원의 불평형 성분을 동기좌표축 상에서 순시적으로 검출하여 이를 보상하고 부하의 전압조정 기능 역시 수행하는 순간전압보상기의 보상 알고리즘 및 이때 좌표변환시 필요한 전원의 위상각 정보를 전원의 정상성분에 일치시키는 새로운 위상각 검출 알고리즘을 제안한다. 제안된 보상 시스템의 성능 및 특성을 시뮬레이션을 통하여 해석하고 실험으로써 검증하였다.

• 한국ITS학회 논문지
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• 제12권4호
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• pp.1-10
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• 2013

본 연구는 버스정보가 도로의 통행속도 정보로 활용될 수 있는지를 검토하기 위한 연구이다. 도로통행속도를 파악하기 위해 설치된 지점검지기, 구간검지기로부터 수집되는 정보와 경기도에서 수집되는 버스정보를 속도정보로 가공하여 비교하였다. 버스정보가 교통정보 검지기의 기능을 할 수 있다면, 통행속도 정보를 제공할 수 있다. 이를 위해서는 도로구간의 교통류에 대한 패턴을 인식할 필요가 있다. 본 연구에서는 새로운 접근방법보다는 기존에 검증된 방법을 중심으로 버스정보를 이용한 교통류 패턴 인식 방법을 적용하여 버스정보의 활용 가능성을 제시하였다. 또한 버스정보를 이용하여 모형을 추정하였는데, 단순이동, 지수평활법과 이중이동, 이중지수평활법, ARIMA(p,d,q)모형을 적용하였다. 이 모형들은 평가지표인 100-MAPE, MAE, EC로 비교한 결과 상호 비슷한 결과를 나타냈으나, 단순평균이동법이 가장 우수한 결과를 나타냈다. 이로서 버스정보를 구간의 통행속도로 이용할 경우, 모형의 추정도 가능하다는 것을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9327-9333
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• 2014

Breast cancer is the second most common cancer and second leading cause of cancer deaths in women. Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene mutations have been observed in 25-45% of breast cancer samples. Insulin growth factor binding protein-5 (IGFBP-5) can show different effects on apoptosis, cell motility and survival in breast cancer. We here aimed to determine the association between PIK3CA gene mutations and IGFBP-5 expressions for the first time in breast cancer patients. Frozen tumor samples from 101 Turkish breast cancer patients were analyzed with high resolution melting (HRM) for PIK3CA mutations (exon 9 and exon 20) and 37 HRM positive tumor samples were analyzed by DNA sequencing, mutations being found in 31. PIK3CA exon 9 mutations (Q546R, E542Q, E545K, E542K and E545D) were found in 10 tumor samples, exon 20 mutations (H1047L, H1047R, T1025T and G1049R) in 21, where only 1 tumor sample had two exon 20 mutations (T1025T and H1047R). Moreover, we detected one sample with both exon 9 (E542Q) and exon 20 (H1047R) mutations. 35% of the tumor samples with high IGFBP-5 mRNA expression and 29.4% of the tumor samples with low IGFBP-5 mRNA expression had PIK3CA mutations (p=0.9924). This is the first study of PIK3CA mutation screening results in Turkish breast cancer population using HRM analysis. This approach appears to be a very effective and reliable screening method for the PIK3CA exon 9 and 20 mutation detection. Further analysis with a greater number of samples is needed to clarify association between PIK3CA gene mutations and IGFBP-5 mRNA expression, and also clinical outcome in breast cancer patients.

• 한국구조물진단유지관리공학회 논문집
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• 제18권1호
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• pp.166-173
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• 2014

본 연구에서는 레이저 가진을 이용한 초음파 전파 영상 기반 배관 비파괴 검사에 관해 다룬다. 손상의 영상화를 위해 갈바노미터 기반 레이저 미러 스캐너와 Q-Switch Nd: YAG 레이저 시스템을 사용하였다. 레이저 시스템을 가진원으로 사용하면 빠른 속도로 비접촉 초음파 가진이 가능하며, 온도의 변화가 급격한 환경이나 유해 물질이 포함된 환경에서도 대상 구조물의 원거리 가진이 가능하다. 또한 공간 해상도가 높으며, 입사각이 넓어 표면 형상이 복잡한 대상 구조물도 가진이 가능하다. 본 연구에서는 이러한 레이저 시스템으로부터 생성된 유도 초음파를 단일 PZT 센서를 사용하여 계측하고, 계측된 신호는 레이저 가진점에 해당하는 좌표점에 나열함으로써 2차원 공간좌표 및 시간축을 더한 초음파 전파 영상 생성을 위한 3차원 데이터를 구성한다. 이 데이터를 시간 축에 따라 연속적으로 반복 재생하면 초음파 전파 영상을 구할 수 있다. 이 때 웨이블릿 변환을 이용하여 계측 신호의 특정 주파수 성분을 추출해냄으로써 관찰하고자 하는 특정 유도 초음파 모드를 추출할 수 있다. 이러한 일련의 과정으로부터 획득한 초음파 전파 영상 데이터를 시간-공간 영역에서 주파수-wavenumber 영역으로 변환시켜줌으로써 손상 특성을 추출할 수 있다. 본 연구에서는 손상의 진단 및 위치 추정을 위해 wavenumber 필터링 기술을 적용하였으며, 시스템 검증을 위해 다양한 배관구조물 Testbed를 대상으로 실험을 수행하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제27권3호
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• pp.406-413
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• 2014

A study was conducted to compare the effect of halal slaughter without stunning and gas stun killing followed by bleeding on residual blood content and storage stability of rabbit meat. Eighty male New Zealand white rabbits were divided into two groups of 40 animals each and subjected to either halal slaughter without stunning (HS) or gas stun-kill (GK). The volume of blood lost during exsanguination was measured. Residual blood was further quantified by determination of haemoglobin content in Longissimus lumborum (LL) muscle. Storage stability of the meat was evaluated by microbiological analysis and measuring lipid oxidation in terms of thiobarbituric acid reactive substances (TBARS). HS resulted in significantly higher blood loss than GK. HS had significantly lower residual haemoglobin in LL muscle compared to GK. Slaughter method had no effect on rabbit meat lipid oxidation at 0, 1, and 3 d postmortem. However, at 5 and 8 days of storage at $4^{\circ}C$, significant differences (p<0.05) were found, with meat from the GK group exhibiting significantly higher levels of MDA than that from HS. At day 3, greater growth of Pseudomonas aeroginosa and E. coli were observed in the GK group (p<0.05) with B. thermosphacta and total aerobic counts remained unaffected by slaughter method. At days 5 and 7 postmortem, bacterial counts for all tested microbes were affected by slaughter method, with GK exhibiting significantly higher growth than HS. It can be concluded that slaughter method can affect keeping quality of rabbit meat, and HS may be a favourable option compared to GK due to high bleed out.

• 한국전기전자재료학회논문지
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• 제33권6호
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• pp.475-482
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• 2020

For electronic paper displays using electrophoresis, the response time and reflectivity of the image panel fabricated by filtering are analyzed. For the filtering process, a square wave and ramp wave are applied to white charged particles with a unique q/m value. We divide the sample panels into #1 to #4 according to the applied waveform in the filtering process. Step waves comprising two steps are used to drive the panel; therefore, we divide the driving conditions into D1~D4. The applied voltage at the first stage of the half cycle of the driving waveform moves the charged particles attached via the image force from the electrode, and the applied voltage at the second stage moves the floating charged particles by detaching. As mentioned, four types of driving conditions (D1 to D4) classified according to the half cycle of the driving waveform are applied to the samples #1 to #4), which are classified according to four types of filtering process. When driving condition D1 is applied to the four types of sample panels, the rise time of #1 is 1.59s, #2 is 1.706s, #3 is 1.853s, and #4 is 1.235s, resulting in #4 being relatively faster compared with other sample panels, and showing the same trend in other driving conditions. As a result, we confirm that applying the driving condition D1 causes abrupt movement of the white charged particles injected into the cell. When the same driving waveform (D1) is applied to each sample, reflectivities of 32.1% for #1, 31.4% for #2, 27.9% for #3, and 63.4% for #4 are measured. From the experiment, we confirm that the driving condition D1 (1s of 3.5 V, 9s of 3.0 V) and ramp wave #4 in filtering are desirable for good reflectivity and response time. Our research is expected to contribute to the improvement of the filtering process and optimization of the driving waveform.

• 한국산림과학회지
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• 제105권1호
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• pp.48-62
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• 2016

본 연구는 덕유산국립공원 향적봉 및 중봉 아고산대를 대상으로 총 48개소의 고정방형구를 설치하여 Z-M 식물사회학적 방법으로 군락유형분류와 임분 구조를 분석하였던 바, 신갈나무군락군에서 군락단위로 가문비나무군락, 까치박달군락, 피나무군락으로 분류되었으며 가문비나무군락은 물참대군, 백당나무군으로 세분되었다. 군단위로 물참대군은 복장나무소군과 까치밥나무소군으로 세분되었으며, 백당나무군은 각시원추리소군과 귀룽나무소군으로 세분되었다. 중요치를 분석한 결과, 교목층을 구성하는 주요 종으로는 신갈나무(23.9%), 구상나무(14.7%), 주목(10.2%), 가문나무(8.2%), 사스래나무(7.4%)로 나타났으며, 아교목층은 시닥나무(18.6%), 당단풍나무(18.4%), 신갈나무(8.9%)로 나타났으며, 관목층은 철쭉(20.7%), 당단풍나무(17.4%), 노린재나무(8.5%)로 나타났다. 식생단위 1의 지표종은 산수국, 들메나무, 물참대와 같은 아고산의 적습한 계곡부 또는 전석지 환경을 선호하는 종들이 나타났다. 종다양도는 식생단위 1, 4, 5는 생육환경이 이질적이고 복잡하거나 국소적인 교란이 있었을 것으로 사료된다. 가문비나무군락의 하위단위인 복장나무아군, 까치밥나무아군, 각시원추리아군, 귀룽나무아군의 식생단위 1, 2, 3, 4는 유사도 지수가 0.5 이상으로 식생단위 간 유사도가 높은 경향으로 나타나, 식생단위 간 구성종의 차이가 크지 않은 것으로 판단된다.

• 한국전기전자재료학회논문지
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• 제24권7호
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• pp.563-567
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• 2011

The most widely used piezoelectric ceramics are lead oxide based ferroelectrics (PZT). However, the toxicity of lead oxide and its high vapor pressure during processing have led to a demand for alternative lead-free piezoelectric materials. We synthesized Lead-free piezoelectric ceramics of $0.96(K_{0.5}Na_{0.5})NbO_3-0.04SrZrO_3+x$ mol% $ZrO_2$ [KNN-SZ+$xZrO_2$; x= 0~0.10] doped with 0.1 wt% $MnO_2$ by a conventional solid state method. We investigated the piezoelectric properties and microstructures of these disk samples sintered in reduced atmosphere in order to evaluate the possibility of the multilayered piezoelectric ceramics having the base metal such as Ni as a internal electrode. All of these KNN-SZ samples sintered in 3%$H_2-97%N_2$ atmosphere at $1,140^{\circ}C$ exhibit pure perovskite structure irrespective of the content of $ZrO_2$. Meanwhile, the sintering denisty and piezoelectric properties such as $K_p$, $Q_m$ and $d_{33}$ of KNN-SZ samples as a function of $ZrO_2$ content show the maxima ($k_p$=28.07%, $Q_m$= 101.34, $d_{33}$= 156 pC/N) at x= 0.04 and it is likely that there is some morphotropic phase boundary(MPB) in this KNN-SZ+$xZrO_2$ composition system. These results indicate that the ceramic composition is a promising candidate material for applications in lead free multilayer piezoelectric ceramics.