• Journal of applied mathematics & informatics
• /
• v.4 no.2
• /
• pp.563-571
• /
• 1997

In this paper we define CR(completely reachable), MICR(minimal cyclic refinement)and MACR(maximal cyclic refinement)-Modules. We have obtained equivalent statements for minimal cyclic submodule and maximal cyclic submodule. Also we have obtained necessary and sufficient conditions for a module M with MICR to be cyclic or strongly cyclic.

• Journal of the Korean Mathematical Society
• /
• v.35 no.1
• /
• pp.1-9
• /
• 1998

In this paper we define CR(completely reachable), MICR(minimal cyclic refinement) and MACR(maximal cyclic refinement)-Modules. We have obtained equivalent statements for minimal cyclic submodule and maximal cyclic submodule. Also, we have obtained necessary and sufficient conditions for a module M with MICR to be cyclic or strongly cyclic.

• The Korean Journal of Physiology
• /
• v.27 no.2
• /
• pp.151-162
• /
• 1993

In order to investigate the effect of intracellular cyclic GMP on calcium current the whole-cell patch clamp technique with internal perfusion method was used in isolated ventricular myocytes of the rabbit. Cyclic GMP, 8-bromo-cyclic GMP, cyclic AMP, isoprenaline and forskolin were perfused into cells and their effects on calcium current were analysed by applying depolarizing step pulses of + 10 mV in amplitude far 300 msec from holding potential of - 40 mV. Not only cyclic AMP $(100\;{\mu}M)$ but also cyclic GMF $(100\;{\mu}M)$ increased the basal calcium current. 8-Bromo-cyclic GMP $(100\;{\mu}M)$, a good stimulator of the cyclic GMP-dependent protein kinase, also increased the basal calcium current and its peak amplitude of calcium current was larger than that in the presence of cyclic AMP or cyclic GMP alone. In the presence of $100\;{\mu}M$ cyclic GMP or $100\;{\mu}M$ 8-bromo-cyclic GMP, already augmented calcium current was potentiated by intracellular application of $100\;{\mu}M$ cyclic AMP or $1\;{\mu}M$ isoprenaline or $1\;{\mu}M$ forskolin. In the presence of cyclic GMP, acetylcholine reduced the calcium current only when the calcium current was increased by isoprenaline. From the above results it could be concluded that intracellular perfusion with cyclic GMP increases the basal calcium current via a mechanism involving a cyclic GMP-dependent protein kinase.

• The Korean Journal of Pharmacology
• /
• v.13 no.2
• /
• pp.41-48
• /
• 1977

In 1968, Case et al. first studied the importance of cyclic AMP as an intermediate in the action of secretin and cholecystokinin-pancreozymin and they suggested that the action of secretin, not that of cholecystokinin-pancreozymin, may be mediated through cyclic AMP. Recently Albano et al. reported that in the exocrine pancreas each of the two major physiological functions is modulated a specific cyclic nucleotide, enzyme secretion by cyclic GMP, and fluid and ionic secretion by cyclic AMP. But in pancreas still conflicting results have been reported on the role of cyclic nucleotides in enzyme and electrolyte secretion. In these study, the role of cyclic nucleotides in the exocrine pancreatic secretion was examined. The results are as follows. 1) Very strong stimulation on amylase release from guinea pig pancreatic slice was produced by 1 unit of cholecystokinin-pancreozymin but as compared to that of cholecystokinin-pancreozymin very weak response was observed by 1 unit of secretion or $1\;{\mu}g$ of VIP. 2) Both cholecystokinin-pancreozymin and acetylcholine produced a rapid and marked rise in cyclic GMP as well as cyclic AMP in isolated pancreatic tissue. However, both secretin and VIP failed to alter significantly the basal level of cyclic GMP in pancreatic fragments. 3) Atropine inhibited acetylcholine mediated amylase release, but did not affect the cholecystokinin-pancreozymin response. Furthermore, atropine pretreatment produced a marked inhibitory effect on the increase of tissue cyclic nucleotides induced by cholecystokinin-pancreozymin and acetylcholine. In summary, these results suggest that whereas the pancreatic secretion produced by secretin and VIP is modulated by the formation of cyclic AMP, the pancreatic enzyme secretion in response to cholecystokinin-pancreozymin and acetylcholine is triggered by both cyclic AMP and cyclic GMP.

• Nonlinear Functional Analysis and Applications
• /
• v.27 no.2
• /
• pp.261-269
• /
• 2022

The purpose of this paper is to introduce a new generalization class of cyclic mappings, called cyclic generalized 𝜑-weak contraction and obtain a corresponding best proximity point theorem for this cyclic mapping under certain conditions.

• Biomolecules & Therapeutics
• /
• v.20 no.1
• /
• pp.19-26
• /
• 2012

There are many cyclic peptides with diverse biological activities, such as antibacterial activity, immunosuppressive activity, and anti-tumor activity, and so on. Encouraged by natural cyclic peptides with biological activity, efforts have been made to develop cyclic peptides with both genetic and synthetic methods. The genetic methods include phage display, intein-based cyclic peptides, and mRNA display. The synthetic methods involve individual synthesis, parallel synthesis, as well as split-and-pool synthesis. Recent development of cyclic peptide library based on split-and-pool synthesis allows on-bead screening, in-solution screening, and microarray screening of cyclic peptides for biological activity. Cyclic peptides will be useful as receptor agonist/antagonist, RNA binding molecule, enzyme inhibitor and so on, and more cyclic peptides will emerge as therapeutic agents and biochemical tools.

• Geomechanics and Engineering
• /
• v.25 no.2
• /
• pp.89-98
• /
• 2021

The paper presents an experimental study on the strength behaviour of a coral gravelly sand from Vietnam subjected to monotonic and cyclic loading. A series of direct shear tests were carried out to investigate the shear strength behaviour and the factors affecting the shear strength of the sand such as relative density, cyclic load, amplitude of the cyclic load and loading rate. The study results indicate that the shear strength parameters of the coral gravelly sand include not only internal friction angle but also apparent cohesion. These parameters vary with the relative density, cyclic load, the amplitude of the cyclic load and loading rate. The shear strength increases with the increase of the relative density. The shear strength increases after subjecting to cyclic loading. The amplitude of the cyclic load affects the shear strength of coral gravelly sand, the shear strength increases as the amplitude of the cyclic load increases. The loading rate has insignificantly effect on the shear strength of the coral gravelly sand.

• Bulletin of the Korean Mathematical Society
• /
• v.60 no.2
• /
• pp.443-460
• /
• 2023

A binary linear code is said to be a ℤ₂-double cyclic code if its coordinates can be partitioned into two subsets such that any simultaneous cyclic shift of the coordinates of the subsets leaves the code invariant. These codes were introduced in [6]. A ℤ₂-double cyclic code is called reversible if reversing the order of the coordinates of the two subsets leaves the code invariant. In this note, we give necessary and sufficient conditions for a ℤ₂-double cyclic code to be reversible. We also give a relation between reversible ℤ₂-double cyclic code and LCD ℤ₂-double cyclic code for the separable case and we present a few examples to show that such a relation doesn't hold in the non-separable case. Furthermore, we list examples of reversible ℤ₂-double cyclic codes of length ≤ 10.

• Transactions of the Korean Society of Pressure Vessels and Piping
• /
• v.15 no.2
• /
• pp.31-39
• /
• 2019

Cracked component analysis is needed for structural integrity analysis under seismic loading. Under large amplitude cyclic loading conditions, the change in material properties can be complex, depending on the magnitude of plastic strain. Therefore the cracked component analysis under cyclic loading should consider appropriate cyclic hardening model. This study introduces a procedure for determining an appropriate cyclic hardening model for cracked component analysis. The test material was nuclear-grade TP316 stainless steel. The material cyclic hardening was simulated using the Chaboche combined hardening model. The kinematic hardening model was determined from standard tensile test to cover the high and wide strain range. The isotropic hardening model was determined by simulating C(T) test under cyclic loading using ABAQUS debonding analysis. The suitability of the material hardening model was verified by comparing load-displacement curves of cyclic C(T) tests under different load ratios.

• The Korean Journal of Physiology
• /
• v.29 no.1
• /
• pp.39-50
• /
• 1995

This study was designed to clarify the action of cyclic nucleotides, cyclic AMP and cyclic GMP, on phorbol 12,13-dibutyrate (PDBu)-induced contraction in rings isolated from rabbit carotid artery. Arterial rings, 2 mm in width, were myographied isometrically in an isolated organ bath. PDBu produced slowly developing, sustained contraction in rabbit carotid artery, in a dose dependent manner, which was independent of extracellular $Ca^{2+}$ PDBu-induced contraction was relaxed by staurosporine, which suggests that PDBu-induced contraction is mediated by protein kinase C (PKC). $^{45}Ca^{2+}$ uptake by rabbit carotid artery was increased by PDBu during depolarization, but not in control. Isoproterenol and sodium nitroprusside (SNP) relaxed phenylephrine-induced contraction. However, SNP but not isoproterenol relaxed the contraction induced by PDBu. Acetylcholine relaxed PDBu-induced contraction in the presence of the endothelium. 8-bromo-cyclic AMP, a permeable analogue of cyclic AMP, suppressed phenylephrine-induced contraction but not PDBu-induced contraction. 8-bromo cyclic GMP relaxed both of them with dose dependency. A large dose of forskolin relaxed PDBu-induced contraction. PDBu increased cyclic AMP without considerable change in the level of cyclic GMP. Based on these findings, PDBu-induced contraction of rabbit carotid artery was relaxed by cyclic GMP more effectively than cyclic AMP, and the action of cyclic AMP could be mediated by cyclic GMP dependent protein kinase. Therefore it is suggested that the antagonistic action between protein kinase C and cyclic GMP-dependent protein kinase plays a major role in the regulation of vascular tone.