• Title/Summary/Keyword: cumulative effect

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Effect of Perfluorobutane Microbubbles on Radiofrequency Ablation for Hepatocellular Carcinoma: Suppression of Steam Popping and Its Clinical Implication

  • Dong Young Jeong;Tae Wook Kang;Ji Hye Min;Kyoung Doo Song;Min Woo Lee;Hyunchul Rhim;Hyo Keun Lim;Dong Hyun Sinn;Heewon Han
    • Korean Journal of Radiology
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    • v.21 no.9
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    • pp.1077-1086
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    • 2020
  • Objective: To evaluate the effect of perfluorobutane microbubbles (Sonazoid®, GE Healthcare) on steam popping during radiofrequency (RF) ablation for treating hepatocellular carcinoma (HCC), and to assess whether popping affects treatment outcomes. Materials and Methods: The institutional review board approved this retrospective study, which included 90 consecutive patients with single HCC, who received percutaneous RF ablation as the first-line treatment. The patients were divided into two groups, based on the presence or absence of the popping phenomenon, which was defined as an audible sound with a simultaneous sudden explosion within the ablation zone as detected via ultrasonography during the procedure. The factors contributing to the popping phenomenon were identified using multivariable logistic regression analysis. Local tumor progression (LTP) and disease-free survival (DFS) were assessed using the Kaplan-Meier method with the log-rank test for performing comparisons between the two groups. Results: The overall incidence of the popping phenomenon was 25.8% (24/93). Sonazoid® was used in 1 patient (4.2%) in the popping group (n = 24), while it was used in 15 patients (21.7%) in the non-popping group (n = 69). Multivariable analysis revealed that the use of Sonazoid® was the only significant factor for absence of the popping phenomenon (odds ratio = 0.10, p = 0.048). There were no significant differences in cumulative LTP and DFS between the two groups (p = 0.479 and p = 0.424, respectively). Conclusion: The use of Sonazoid® has a suppressive effect on the popping phenomenon during RF ablation in patients with HCC. However, the presence of the popping phenomenon may not affect clinical outcomes.

SPIRAL ARM MORPHOLOGY IN CLUSTER ENVIRONMENT

  • Choi, Isaac Yeoun-Gyu;Ann, Hong-Bae
    • Journal of The Korean Astronomical Society
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    • v.44 no.5
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    • pp.161-175
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    • 2011
  • We examine the dependence of the morphology of spiral galaxies on the environment using the KIAS Value Added Galaxy Catalog (VAGC) which is derived from the Sloan Digital Sky Survey (SDSS) DR7. Our goal is to understand whether the local environment or global conditions dominate in determining the morphology of spiral galaxies. For the analysis, we conduct a morphological classification of galaxies in 20 X-ray selected Abell clusters up to z~0.06, using SDSS color images and the X-ray data from the Northern ROSAT All-Sky (NORAS) catalog. We analyze the distribution of arm classes along the clustercentric radius as well as that of Hubble types. To segregate the effect of local environment from the global environment, we compare the morphological distribution of galaxies in two X-lay luminosity groups, the low-$L_x$ clusters ($L_x$ < $0.15{\times}10^{44}$erg/s) and high-$L_x$ clusters ($L_x$ > $1.8{\times}10^{44}$erg/s). We find that the morphology-clustercentric relation prevails in the cluster environment although there is a brake near the cluster virial radius. The grand design arms comprise about 40% of the cluster spiral galaxies with a weak morphology-clustercentric radius relation for the arm classes, in the sense that flocculent galaxies tend to increase outward, regardless of the X-ray luminosity. From the cumulative radial distribution of cluster galaxies, we found that the low-$L_x$ clusters are fully virialized while the high-$L_x$ clusters are not.

The Effect Estimation of Heavy Metals on the Microbial Activity during Leaf Litter Decomposition (낙엽분해동안 미생물 활성에 미치는 중금속의 영향 추정)

  • Shim, Jae-Kuk;Shin, Jin-Ho;Yang, Keum-Chul
    • Korean Journal of Environment and Ecology
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    • v.25 no.6
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    • pp.887-892
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    • 2011
  • This study was to find out influence of heavy metal concentration in plant on microbial activities during decomposition of Artenmisia princeps var. orientalis and Equisetum arvense collected from an abandoned mine and control site in Cheongyang-gun Chungcheongnam-do. Microbial respiration rate showed the highest value at the time of the first collection, and then tended to decline over time. The highest microbial respiration rate appeared in leaf litters with low heavy metal contents, and A. princeps var. orientalis and E. arvense collected and decomposed at the control site showed the fastest decomposition rate. For both A. princeps var. orientalis and E. arvense, litters with low heavy metal content appeared to have higher microbial biomass. There was apparent quantitative correlation between decomposition rate and cumulative respiration rate of leaf litters, and between decomposition rate and microbial biomass of leaf litters. Thus, the study result showed that leaf litter with higher heavy metal content had a negative impacts on the growth and activity of microbial decomposer during decomposition processes.

Development of a Modified Standardized Precipitation Index by Considering Effects of the Dry Period and Rainfall (무강수일수와 강우효과를 고려한 개선된 표준강수지수 개발)

  • Lee, Jun-Won;Kim, Gwang-Seob
    • Journal of Korea Water Resources Association
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    • v.45 no.4
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    • pp.409-418
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    • 2012
  • A modified standardized precipitation index was developed by considering the length of dry period and surface run-off effect. The official reports and newspapers on drought from 1973 to 2009 were quantified to evaluate drought indices. The developed index was evaluated using the receiver operating characteristic analysis. In order to suggest improved drought index, we cut the precipitation amount that may do not contribute the mitigation of drought and weight dry period by considering cumulative distribution, decile distribution of dry periods. Drought detection capability of the suggested index has improved by weighting of dry period effects and considering precipitation amounts contributing drought mitigation.

EFFECT OF MILK YIELD ON GROWTH OF MULTIPLE CALVES IN JAPANESE BLACK CATTLE (WAGYU)

  • Shimada, K.;Izaike, Y.;Suzuki, O.;Kosugiyama, M.;Takenouchi, N.;Ohshima, K.;Takahashi, M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.5 no.4
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    • pp.717-722
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    • 1992
  • An experiment was conducted to examine the feasibility of producing multiple calves using embryo transfer in Japanese Black cattle. Milk yield of cows and forage intake of calves were measured for 11 cows with single calves, 14 cows with twins and one cow with triplets. The means of 26 weeks cumulative milk yield were 854, 1028 and 1271 kg for cows having singles, twins and triplets, respectively. Male birth weights for single calves, twins and triplet were 34.9, 26.6 and 19.9 kg, and female ones were 31.7, 24.1 and 22.1 kg, respectively. Weight and daily gain of calves were affected by weeks (W), sex (S), the number of calves (N), parity, birth season, $W{\times}N$, $S{\times}N$ and regression on milk yield. Growth rate was higher for single calves than for twins until about 9 weeks of age, then weights increased at a similar rate. Male calf weaning weights for singles, twins and triplets were 207.0, 177.1 and 162.2 kg, and those for females were 185.4, 151.6 and 180.4 kg, respectively. Average regression coefficients of calf growth on milk yield were significant, and single calf was affected more than twin calves by increment of milk yield. As the number of calves per cow increased, hay intake of calves decreased and concentrate intake tended to increase between 6 and 13 weeks of age.

Effect of Incorporation of Hairy Vetch on Nitrous Oxide Emission from Soils Cultivated with Maize (옥수수 재배지에서 헤어리베치의 토양환원이 아산화질소 배출에 미치는 영향)

  • Han, Hae Ri;Lee, Hyun Ho;Hong, Chang Oh
    • Korean Journal of Environmental Agriculture
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    • v.38 no.4
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    • pp.237-244
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    • 2019
  • BACKGROUND: Impact of incorporating hairy vetch into soil on mitigating nitrous oxide (N2O) emissions from maize field in South Korea has not been investigated, whereas impacts on soil properties and nutrients for crops have been investigated. Therefore, this study was conducted to examine N2O emission from upland soil incorporated with hairy vetch for one year in maize field. METHODS AND RESULTS: Hairy vetch was grown in an upland soil from November, 2017 to May, 2018 and incorporated into soil on May 25 of 2018. Control and conventional treatment (NPK) were included for comparison. Gas samples were collected weekly for a year to examine N2O emissions from the soil. Chemical nitrogen (N) fertilizer stimulated N2O emission in short term resulting in the greatest cumulative N2O emission in NPK (6.72 kg N2O ha-1) compared to the control (4.04 kg N2O ha-1) and hairy vetch-incorporated field (5.43 kg N2O ha-1), and the greatest yield of maize from NPK, because total N input was much greater by NPK (186 N kg ha-1) than by hairy vetch (81.6 N kg ha-1). CONCLUSION: Incorporation of hairy vetch reduced N2O emissions from the maize compared to the NPK-treated field. However, further research on improving crop productivity with incorporation of hairy vetch is needed.

Empirical Investigation on Information Breach Effect on the Market Value of the Firm: Focused on Source and Long Term Performance (정보유출이 기업가치에 미치는 효과분석: 원천 및 장기성과)

  • Kwon, Sun Man;Han, Chang Hee
    • The Journal of Society for e-Business Studies
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    • v.21 no.2
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    • pp.81-96
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    • 2016
  • This paper analyzes the impact of information breach on shareholder value by measuring the stock price reaction associated with the announcements of data breach. The breach firms in the sample lost, on average, 1.3% of their market value, amounting to 98.9 million won of loss within two-day of the event period after the announcement. We examine the abnormal returns in various categories (i.e., source, type, size, etc.) of information breach. Although the market does not react significantly to the announcements of outside breach, we find statistically significant market reactions to inside breach. We estimate abnormal returns over the following 60 days. The mean 60-day cumulative abnormal return and BHAR (buy-and-hold abnormal returns) are both significantly far from zero. We conclude that there is a coherent market reaction following the announcement. The difference between the market reactions to IT firms and Non-IT firms is statistically significant. But breach amount, firm size, and the year the breach occurred do not show to be significant variables.

The effect of low-dose intravenous bisphosphonate treatment on osteoporosis in children with quadriplegic cerebral palsy

  • Moon, Soon Jeong;An, Young Min;Kim, Soon Ki;Kwon, Young Se;Lee, Ji Eun
    • Clinical and Experimental Pediatrics
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    • v.60 no.12
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    • pp.403-407
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    • 2017
  • Purpose: Quadriplegic children with cerebral palsy are more susceptible to osteoporosis because of various risk factors that interfere with bone metabolism. Pamidronate is effective for pediatric osteoporosis, but there are no guidelines for optimal dosage or duration of treatment in quadriplegic children with osteoporosis. We aimed to evaluate the efficacy of low-dose pamidronate treatment in these patients. Methods: Ten quadriplegic patients on antiepileptic drugs (6 male, 4 female patients; mean age, $10.9{\pm}5.76years$), with osteoporosis and gross motor function classification system level V, were treated with pamidronate (0.5-1.0 mg/kg/day, 2 consecutive days) every 3-4 months in a single institution. The patients received oral supplements of calcium and vitamin D before and during treatment. The lumbar spine bone mineral density (BMD) z score and biochemical markers of bone metabolism were measured regularly during treatment. Results: The main underlying disorder was perinatal hypoxic brain damage (40%, 4 of 10). The mean cumulative dose of pamidronate was $4.49{\pm}2.22mg/kg/yr$, and the mean treatment period was $10.8{\pm}3.32months$. The BMD z score of the lumbar spine showed a significant increase from $-4.22{\pm}1.24$ before treatment to $-2.61{\pm}1.69$ during treatment (P=0.008). Alkaline phosphatase decreased during treatment (P=0.037). Significant adverse drug reactions and new fractures were not reported. Conclusion: Low-dose pamidronate treatment for quadriplegic children with cerebral palsy increased lumbar BMD and reduced the incidence of fracture.

Genetic radiation risks: a neglected topic in the low dose debate

  • Schmitz-Feuerhake, Inge;Busby, Christopher;Pflugbeil, Sebastian
    • Environmental Analysis Health and Toxicology
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    • v.31
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    • pp.1.1-1.13
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    • 2016
  • Objectives To investigate the accuracy and scientific validity of the current very low risk factor for hereditary diseases in humans following exposures to ionizing radiation adopted by the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection. The value is based on experiments on mice due to reportedly absent effects in the Japanese atomic bomb (A-bomb) survivors. Methods To review the published evidence for heritable effects after ionising radiation exposures particularly, but not restricted to, populations exposed to contamination from the Chernobyl accident and from atmospheric nuclear test fallout. To make a compilation of findings about early deaths, congenital malformations, Down's syndrome, cancer and other genetic effects observed in humans after the exposure of the parents. To also examine more closely the evidence from the Japanese A-bomb epidemiology and discuss its scientific validity. Results Nearly all types of hereditary defects were found at doses as low as one to 10 mSv. We discuss the clash between the current risk model and these observations on the basis of biological mechanism and assumptions about linear relationships between dose and effect in neonatal and foetal epidemiology. The evidence supports a dose response relationship which is non-linear and is either biphasic or supralinear (hogs-back) and largely either saturates or falls above 10 mSv. Conclusions We conclude that the current risk model for heritable effects of radiation is unsafe. The dose response relationship is non-linear with the greatest effects at the lowest doses. Using Chernobyl data we derive an excess relative risk for all malformations of 1.0 per 10 mSv cumulative dose. The safety of the Japanese A-bomb epidemiology is argued to be both scientifically and philosophically questionable owing to errors in the choice of control groups, omission of internal exposure effects and assumptions about linear dose response.

Effect of high temperature on mineral uptake, Soluble carbohydrates partitioning and cucumber yield

  • Sung, Jwakyung;Lee, Suyeon;Lee, Yejin;Ha, Sangkeun;Sonn, Yeonkyu
    • Korean Journal of Agricultural Science
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    • v.41 no.4
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    • pp.291-298
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    • 2014
  • Plastic film houses are directly associated with increases in plant growth and yield of vegetable crops through a year round cultivation, however, at the same time temperature stresses are one of fates which are difficult to avoid during crop growth. The objective of this study was to examine the translocation and distribution of minerals (N, P, K) and carbohydrates as well as seasonal fluctuation of mineral uptake and carbohydrate production in cucumber plant grown under moderately high temperature. The temperature treatments consisted of 2-layers film houses (optimal temp.) and 3-layers (high temp.). Shoot growth of cucumber plants were linearly increased until 14 weeks after transplanting (WAT) without any significant difference between both temperatures, and the slowdown was observed from 16 WAT. The level of soluble sugar and starch was slightly greater in optimal temperature compared to the high. Cumulative accumulation of soluble sugar was significantly different before and after 12 WAT in both treatments, whereas starch level represented a constant increase. Monthly production of soluble sugar reached the peak between 12 to 16 WAT, and starch peaked between 4 to 8 WAT and 12 to 16 WAT. Total uptake of N, P and K in optimal and high temperature conditions was $18.4g\;plant^{-1}$ and 17.6 for N, 4.7 and 5.1 for P, and 37.7 and 36.2 for K, respectively, and the pattern of monthly N uptake between optimal and high temperatures was greater in early growth stage, whereas was greater in mid growth stage in both P and K. Thus, this study suggests that moderately high temperature influences much greater to photosynthesis and carbohydrate production than plant biomass and mineral uptake. On the basis of the present result, it is required to indentify analysis of respiration rates from plant and soil by constantly increasing temperature conditions and field studies where elevated temperatures are monitored and manipulated.