• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2000.05a
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• pp.465-469
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• 2000

This paper describes a single-chip full-custom implementation of pipelined adaptive decision-feedback equalizer (PADFE) using a 0.25-${\mu}{\textrm}{m}$ CMOS technology for wide-band wireless digital communication systems. To enhance the throughput rate of ADFE, two pipeline stage are inserted into the critical path of the ADFE by using delayed least-mean-square (DLMS) algorithm Redundant binary (RB) arithmetic is applied to all the data processing of the PADFE including filter taps and coefficient update blocks. When compared with conventional methods based on two's complement arithmetic, the proposed approach reduces arithmetic complexity, as well as results in a very simple complex-valued filter structure, thus suitable for VLSI implementation. The design parameters including pipeline stage, filter tap, coefficient and internal bit-width and equalization performance such as bit error rate (BER) and convergence speed are analyzed by algorithm-level simulation using COSSAP. The singl-chip PADFE contains about 205,000 transistors on an area of about 1.96$\times$1.35-$\textrm{mm}^2$. Simulation results show that it can safely operate with 200-MHz clock frequency at 2.5-V supply, and its estimated power dissipation is about 890-mW.

• Journal of the Microelectronics and Packaging Society
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• v.21 no.1
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• pp.31-39
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• 2014

For mobile application, semiconductor packages are increasingly moving toward high density, miniaturization, lighter and multi-functions. Typical wafer level packages (WLP) is fan-in design, it can not meet high I/O requirement. The fan-out wafer level packages (FOWLPs) with reconfiguration technology have recently emerged as a new WLP technology. In FOWLP, warpage is one of the most critical issues since the thickness of FOWLP is thinner than traditional IC package and warpage of WLP is much larger than the die level package. Warpage affects the throughput and yield of the next manufacturing process as well as wafer handling and fabrication processability. In this study, we investigated the characteristics of warpage and main parameters which affect the warpage deformation of FOWLP using the finite element numerical simulation. In order to minimize the warpage, the characteristics of warpage for various epoxy mold compounds (EMCs) and carrier materials are investigated, and DOE optimization is also performed. In particular, warpage after EMC molding and after carrier detachment process were analyzed respectively. The simulation results indicate that the most influential factor on warpage is CTE of EMC after molding process. EMC material of low CTE and high Tg (glass transition temperature) will reduce the warpage. For carrier material, Alloy42 shows the lowest warpage. Therefore, considering the cost, oxidation and thermal conductivity, Alloy42 or SUS304 is recommend for a carrier material.

• The Journal of Internal Korean Medicine
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• v.25 no.3
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• pp.461-472
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• 2004

Objectives : For the screening of neuroprotective effects of medicinal herbs, the complex system of animal models suffer some disadvantages in controlling critical parameters such as blood pressure and body temperature. Additionally, application of drugs to the appropriate brain area sometimes is difficult, due to poor permeability though the blood brain barrier, and so potential protective effects might be masked. Methods : Organotypic hippocampal slice culture (OHSC) method has the advantages of being relatively easy to prepare and of maintaining the general structure, including tissue integrity and the connections between cells. Drugs can easily be applied and neuronal damage can easily be quantified by using tissues and culture media. This study demonstrates neuroprotective effects of Puerariae radix (葛根, PR), Salviae miltiorrhizae radix (丹蔘, SR), Rhei rhizoma (大黃, RR), and Bupleuri radix (柴胡, BR). These were screenedand compared to MK-801, antagonist of NMDA receptors, by using OHSC of 1 week-old Sprague-Dawley rats. Oxygen/glucose deprivation (OGD) were conducted in an anaerobic chamber $(85%\;N_2,\;10%\;CO_2\;and\;5%\;H_2)$ in a deoxygenated glucose-free medium for 60 minutes. Water extracts of each herbs were treated to culture media with $5\;{\mu}g/ml$ for 48 hours. Results : Neuronal cell death in the cultures was monitored by densitometric measurements of the cellular uptake of propidium iodide (PI). PI fluorescence images were obtained at 48 hours after the OGD and medicinal herb treatment. Also TUNEL-positive cells in the CAI and DG regions and LDH concentrations in culture media were measured at 48 hours after the OGD. According to measured data, MK-801, PR, SR and BR demonstrated significant neuroprotective effect against excessive neuronal cell death and apoptosis induced by the OGD insult. Especially, PR revealed similar neuroprotective effect to MK-801 and RR demonstrated weak neuroprotective effect. Conclusions : These results suggest that OHSC can be a suitable method for screening of neuroprotective effects of medicinal herbs. (This work was supported by the research program of Dongguk University and Grant 01-PJ9-PG1-01CO03-0003 from Ministry of Health & Welfare.)

• Korean Journal of Optics and Photonics
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• v.15 no.6
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• pp.511-518
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• 2004

Providing marine signal lanterns with advantages of little weight as well as large aperture, a Fresnel lens has been adopted to transfer the beam from the lanterns up to 10 nautical miles (18.53 km). A Fresnel lens with the diameter of 250 mm and 300 mm was designed by a lens design program and optimized by adjusting the groove parameters of the lens. The angular luminous intensity distribution (ALID) of this lens was calculated by using an illumination analysis program considering the ALID of a light bulb. At the best alignment of the bulb, the maximum luminous intensities (MLI) of the lantern were 1000 cd (in the case of 250 mm diameter) and 1300 cd (in the case of 300 mm diameter). These are more than the critical value of 720 cd that is the Korean Standard of MLI for the marine lantern. The ALID was investigated as a function of misalignment from the lens focus to determine the tolerance of the alignment ranges.

• Journal of Korean Society of Steel Construction
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• v.23 no.1
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• pp.99-111
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• 2011

This paper presents an investigation of the structural stability of cable-stayed bridges in the construction stage, using geometric nonlinear finite-element analysis and considering various geometric nonlinearities, such as the sag effect of the cables, the P-${\Delta}$ effects of the girder and mast, and the large displacement effect. Initial shape analysis and construction-stage analysis were performed to determine the equilibrium of the structure in the construction stage. After that, geometric nonlinear analysis was performed to study structural stability. In this study, the weight of the derrick crane and the key segment were considered the main external loads, which were applied to the tip of the center span. The cable arrangement type and the stiffness ratios of the girder and mast were considered the main parameters of the analytic research. Based on the results of the analysis, the change in the buckling mode and critical load factors with respect to the cable arrangement type and the stiffness ratios of the girder and mast was investigated. The buckling modes of the steel cable-stayed bridges in the construction stage were classified, and the ranges of the stiffness ratios of the girder and mast, which show these classified buckling modes, were suggested.

• Korean Journal of Ichthyology
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• v.19 no.2
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• pp.154-159
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• 2007

The oblong rockfish, Sebastes oblongus has recently drawn attention from aquaculturists because of its marketable value and tolerance against winter water temperature in the southern coastal waters of the Korean peninsula. In the study of temperature effect on growth, water temperature $16^{\circ}C$ showed best growth. The upper temperature of the fish showed feeding activity was $27^{\circ}C$ over which the fish showed no longer feeding activity. Stocking density was also a critical factor affecting the growth and survival of the juvenile fish. The best growth was in the density of 200 juveniles/L, while the highest survival was in the density of 100 juveniles/L. A feeding experiment was conducted to determine the effects of feeding frequency on growth and survival. A feeding scheme of twice a day was good enough in the sense of growth, survival, and economy. These results indicate that parameters such as water temperature, density, tank size and feeding frequency are consideration for best seed production of the fish.

• Journal of the Korean Geotechnical Society
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• v.30 no.9
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• pp.41-55
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• 2014

In performing seismic analysis of tunnels, it is a common practice to ignore the rock joints and to assume that the rock mass surrounding the tunnel is continuous. The applicability of this assumption has not yet been validated in detail. This study performs a series of pseudo-static discrete element analyses to evaluate the effect of rock joint on the seismic response of tunnels. The parameters considered are joint intersection location, joint spacing, joint stiffness, joint dip, and interface stiffness. The results show that the joint stiffness has the most critical influence on the tunnel response. The tunnel response increases with the spacing, resulting in localized concentration of moment and shear stress. The response of the tunnel is the lowest for joints dipping at $45^{\circ}$. This is because large shear stresses result in rotation of the principal planes by $45^{\circ}$. In summary, the weathered and smooth, vertical or horizontal, and widely spaced joint set will significantly increase the tunnel response under seismic loading. The tunnel linings are shown to be most susceptible to damage due to induced shear stress, and therefore should be checked in the seismic design.

• Journal of the Korean Geotechnical Society
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• v.36 no.10
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• pp.33-39
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• 2020

A geological repository has been considered as an option for the disposal of high-level radioactive waste (HLW). The HLW is disposed in a host rock at a depth of 500~1,000 meters below the ground surface based on the concept of engineered barrier system (EBS). The EBS is composed of a disposal canister, buffer material, backfill material, and gap-filling material. The compacted bentonite buffer is very important since it can restrain the release of radionuclide and protect the canister from the inflow of ground water. The saturation of the buffer decreases because high temperature in a disposal canister is released into the surrounding buffer material, but saturation of the buffer increases because of the inflow of ground water. The unsaturated properties of the buffer are critical input parameters for the entire safety assessment of the engineered barrier system. In Korea, Gyeongju bentonite can be considered as a candidate buffer material, but there are few test results of the unsaturated properties considering temperature variation. Therefore, this paper conducted experiment of soil-water characteristic curve for the Gyeongju compacted bentonite considering temperature variation under a constant water content condition. The relative error showed approximately 2% between test results and modified van-Genuchten model values.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3613-3618
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• 2014

Stathmin, also called oncoprotein 18, is a founding member of the family of microtubule-destabilizing proteins that play a critical role in the regulation of mitosis. At the same time stathmin has been recognized as one of responsible factors in cancer cells. The aim of this study was to assess stathmin status, its correlations with clinicopathological parameters and its role as a progosnostic marker in EC patients. The protein and mRNA levels of stathmin were examined byimmunohistochemistry (IHC) and in situ hybridization in 100EC tissues and adjacent noncancerous tissues. mRNA and protein expression of stathmin in three EC cell lines(EC9706, ECa109, EC1 commonly used in research) were also analyzed using immunocytochemistry, western blot and in situ hybridization. The prognostic value of Stathmin expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. We showed that stathmin expression was significantly higher in EC tissues than in adjacent noncancerous tissues. High stathmin immunostaining score in the EC was positively correlated with tumor differentiation, Tumor invasion, Lymph node metastases, and TNM stage. In addition, we demonstrated that three EC cell lines examined, were constitutively expressing a high level of stathmin. Of those, EC-1 showed the strongest mRNA and protein expression for the stathmin analyzed. Kaplan-Meier analysis showed that significantly longer 5-year survival rate was seen in EC patients with high Stathmin expression, compared to those with low expression of Stathmin expression. Furthermore, multivariate Cox proportional hazard analyses revealed that Stathmin was an independent factors affecting the overall survival probability. In conclusion, our data provide a basis for the concept that stathmin might be associated with EC development and progression. High levels of Stathmin expression in the tumor tissues may be a good prognostic marker for patients with EC.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.8 no.3
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• pp.91-100
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• 1988

Assuming that tidal level is constantly changed with an amplitude of 10 meters and a cycle of 12 hours, the slope stability for a typical dyke is analysed. The variation of pore water pressure within the dyke during the tidal change is obtained using a computer program, FLUMP, which is incorporated with saturated-unsaturated and transient flow. The results show that the variation of free water surface and distribution of pore water pressure within the dyke during the tidal fluctuations can be clearly predicted with the computer program. When a tide is lowered to the minimum level, the predicted pressure head is higher than the level of the free water surface in some parts of the dyke; that is, excess pore water pressure is generated in a zone affected by the tidal change. Also an unsaturated zone which shows negative pore water pressure is temporally created when a tide is lowered. The shear strength of the zone can be predicted based on the proposal suggested by Fredlund et al. It is emphasized that the excess pore water pressure generated during tidal fluctuations and strength parameters for the unsaturated zone should be considered in analyzing the slope stability of dykes. When those are considered, the critical slip surface seems to be located below the free water surface obtained when a tide is at the lowest.