• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
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• pp.180-183
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• 2003

In this work. a potential inexpensive epoxy resin. epoxidized soybean oil (ESO) was synthesized and applied as a toughening agent for 4.4'-tetradiglycidyl diaminodiphenyl methane (TGDDM). The chemical structure of ESO was characterized by FT-IR, $^1H NMR, and ^{13}C NMR$ spectroscopy. The curing behaviors. thermal stabilities. fracture toughness. and flexural strength of TGDDM/ESO blend systems were investigated by using the dynamic DSC. thermogravimetric analysis (TGA). and flexural tests. The thermal stabilities of TGDDM/ESO blend systems were decreased with increasing ESO contents. whereas the critical stress intensity factor ($K_{IC}$) and flexural strength ($\sigma_f$) were increased with ESO contents up to 10 wt% ESO.

• 지식경영연구
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• 제4권2호
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• pp.95-105
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• 2003

The purpose of the current study is to explore what are critical success factors(CSFs) from Posco Engineering and Construction Company's knowledge management practice. From a deep case study of the company, five CSFs are delineated. The first factor is to clarify knowledge management vision and strategy so that people in the company clearly understand directions of where the company goes to implement knowledge management. The second one is to grip the whole picture of knowledge management realms. Narrow eyes for the knowledge management leads to failure. The third factor depends on how to acquire people's cooperation. The fourth one has something to do with a way of approach. Unilateral or delegated approach is fragile for the successful implementation of knowledge management. Shared approach raises the probability of success. The fifth one is to monitor implementation acts and processes.

• 응용통계연구
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• 제3권1호
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• pp.89-103
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• 1990

관측치가 불균형을 이룰 때, Nelson(1988)에 의한 균형 관측치에 관한 이론이 확장될 수 있음을 보여 주고 있다. 이 방법을 이용하여 이원 요인 계획법에서의 교호작용항에 대한 통계량을 구하고, 그래프를 이용한 방법을 제시 하였다.

• 한국수자원학회논문집
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• 제32권4호
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• pp.469-478
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• 1999

한수관내 침전물의 퇴적을 방지하기 위하여는 최저유속과 에너지경사, 관경을 산정하여 제시하여야 되는데 이들 수치를 바로 결정하는 양해법 산정식들을 개발하였다. 이를 위하여 토사의 임계전단력과 상용관 마찰계수 산정을 위하여 지수형 산정식들을 도입하였으며, 이들 지수형 산정식들은 기존 실험관측자료를 이용하여 개발되었다. 제시된 수치들의 적합성을 판별하기 위하여 여러 예들을 본 연구에서 개발된 산정식들을 적용하여 검토하였다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 춘계 학술논문 발표대회 1부
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• pp.181-184
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• 2011

The earlier studies which are related to conflict management for urban regeneration project were based on limited case-studies on a specific phase. In addition, those studies did not considered a multidisciplinary approach for critical factor of conflict occurrence. In this reason, to establish a practical management or a policy is limited. In this paper, 'Good communication and information sharing' and 'Cooperativeness of stakeholders on project' are defined by critical factors for minimization of conflict between stakeholders. Furthermore we analysis the influence of those factors to minimization of conflict using path-analysis. This paper contributes to increase the efficiency of conflict management through understanding influence of each factors.

• IMMUNE NETWORK
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• 제11권6호
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• pp.336-341
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• 2011

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection, should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg) development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.

• 한국발생생물학회지:발생과생식
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• 제21권4호
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• pp.449-456
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• 2017

The germline stem cells of the Drosophila ovary continuously produce eggs throughout the life-span. Intricate regulation of stemness and differentiation is critical to this continuous production. The translational regulator Nos is an intrinsic factor that is required for maintenance of stemness in germline stem cells. Nos expression is reduced in differentiating cells at the post-transcriptional level by diverse translational regulators. However, molecular mechanisms underlying Nos repression are not completely understood. Through three distinct protein-protein interaction experiments, we identified specific molecular interactions between translational regulators involved in Nos repression. Our findings suggest a model in which protein complexes assemble on the 3' untranslated region of Nos mRNA in order to regulate Nos expression at the post-transcriptional level.

• 한국정밀공학회지
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• 제18권1호
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• pp.111-116
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• 2001

A practical scheme to reduce failure of the PCB(Printed Circuit Board) of a monitor is introduced using deformed mode shape under mechanical shock. When the monitor is given critical shock loads, cracks are commonly initiated at the tip of a hole on the PCB. Accordingly, a deformed mode shape of the PCB is obtained using a FEM code to define a weak point on the PCB under mechanical shock, and then the position and direction of the hole is determined to prevent the failure at the critical mode shape. Also, the stress intensity factor around the weak point on the PCB is calculated to check the possibility of fracture by normal tensile stress. In conclusion, present research is useful to assist the practical design of components-layout on the PCB.

• Structural Engineering and Mechanics
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• 제3권3호
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• pp.229-244
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• 1995

The parametric instability behaviour of a plate subjected to localized in-plane compressive or tensile periodic edge loading is studied, considering the effects of damping into the system. Different edge loading cases have been considered. Damping has been introduced in the form of proportional damping. Dynamic instability behaviour under compressive or tensile periodic edge loading shows that the instability regions are influenced by the load band width and its location on the edge. The effects of damping on the instability regions show that there is a critical value of dynamic load factor beyond which the plate becomes dynamically unstable. The critical dynamic load factor increases as damping increases. Damping generally reduces the widths of the instability regions.

• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.42-52
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• 2019

Background: Transforming growth factor ${\beta}$ (TGF-${\beta}$), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect of RA and the role of these signaling molecules on the phosphorylation of Smad2/3 (p-Smad2/3) induced by TGF-${\beta}1$. Methods: A549 epithelial cells and CCD-11Lu fibroblasts were incubated and stimulated with or without all-trans RA (ATRA) and TGF-${\beta}1$ and with MAPK or MEK inhibitors. The levels of p-Smad2/3 were analyzed by western blotting. For animal models, we studied three experimental mouse groups: control, bleomycin, and bleomycin+ATRA group. Changes in histopathology, lung injury score, and levels of TGF-${\beta}1$ and Smad3 were evaluated at 1 and 3 weeks. Results: When A549 cells were pre-stimulated with TGF-${\beta}1$ prior to RA treatment, RA completely inhibited the p-Smad2/3. However, when A549 cells were pre-treated with RA prior to TGF-${\beta}1$ stimulation, RA did not completely suppress the p-Smad2/3. When A549 cells were pre-treated with MAPK inhibitor, TGF-${\beta}1$ failed to phosphorylate Smad2/3. In fibroblasts, p38 MAPK inhibitor suppressed TGF-${\beta}1$-induced p-Smad2. In a bleomycin-induced lung injury mouse model, RA decreased the expression of TGF-${\beta}1$ and Smad3 at 1 and 3 weeks. Conclusion: RA had inhibitory effects on the phosphorylation of Smad induced by TGF-${\beta}1$ in vitro, and RA also decreased the expression of TGF-${\beta}1$ at 1 and 3 weeks in vivo. Furthermore, pre-treatment with a MAPK inhibitor showed a preventative effect on TGF-${\beta}1$/Smad phosphorylation in epithelial cells. As a result, a combination of RA and MAPK inhibitors may suppress the TGF-${\beta}1$-induced lung injury and fibrosis.