• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.46 no.5
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• pp.368-375
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• 2018

In the present study, aerodynamic load analysis for a floating off-shore wind turbine was conducted to examine the effect of periodic platform motion in the direction of 6-DOF on rotor aerodynamic performance. Blade-element momentum method(BEM) was used for a numerical simulation, the unsteady airload effects due to the flow separation and the shed wake were considered by adopting a dynamic stall model based on the indicial response method. Rotor induced downwash was estimated using the momentum theory, coupled with empirical corrections for the turbulent wake states. The periodic platform motions including the translational motion in the heave, sway and surge directions and the rotational motion in the roll, pitch and yaw directions were considered, and each platform motion was applied as a sinusoidal function. For the numerical simulation, NREL 5MW reference wind turbine was used as the target wind turbine. The results showed that among the translation modes, the surge motion has the largest influence on changing the rotor airloads, while the effect of pitch motion is predominant for the rotations.

• Journal of Korean Society of Forest Science
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• v.83 no.2
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• pp.229-238
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• 1994

Issues of declining growth and vigor in forests are major concerns in many areas around the world, especially in response to predictions in the 1980s of widespread forest declines. This paper summarizes the current state of knowledge for forests in North America, Europe, and East Asia. Forest declines near point-sources of pollution(such as metal smelters) have been well recognized for a century, but evidence of widespread impacts away from point-sources remains relatively uncommon. In North America, significant forest decline has resulted from high concentrations of ozone near Los Angeles, California, and around Mexico City. Some high-elevation forests of red spruce in the eastern U.S. have declined in the past 20 years ; evidence indicates a role of low-pH fog in reducing they cold-tolerance of spruce. In Europe. most attention has focused on Norway spruce stands that developed yellow foliage, needle loss, and in some cases mortality. This syndrome appears to be related generally to an inadequate supply of magnesium, perhaps coupled with a very high supply of nitrogen. Despite localized areas that show declining trees, overall stand growth and standing biomass in Europe increased from. 1970 to 1990. Much less information is available for East Asia. Many industrialized regions in China have a pH of rain <4.5, and some connections between pollution and forest decline have been suggested. Pollution impacts on forests near cities in Korea include needle chlorosis, reduced needle retention, and declining species diversity. Overall, temperate forests show no widespread declines, and no evidence of substantial effects of pollutants on forest growth or vigor. Small areas showing declining forests may indeed demonstrate pollution impacts, and may provide cause for concerns about future impacts on larger areas.

• Biomolecules & Therapeutics
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• v.20 no.5
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• pp.463-469
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• 2012

Atopic dermatitis is a chronic, inflammatory disease of the skin with increased transepidermal water loss. Both an abnormal inflammatory response and a defective skin barrier are known to be involved in the pathogenesis of atopic dermatitis. Protease activated receptor 2 (PAR2) belongs to a family of G-protein coupled receptors and is activated by both trypsin and a specific agonist peptide, SLIGKV-$NH_2$. PAR2 is expressed in suprabasal layers of the epidermis and regulates inflammatory responses and barrier homeostasis. In this study, we show that nordihydroguaiaretic acid (NDGA) inhibits the PAR2-mediated signal pathway and plays a role in skin barrier recovery in atopic dermatitis. Specifically, NDGA reduces the mobilization of intracellular $Ca^{2+}$ in HaCaT keratinocytes by down-regulating inflammatory mediators, such as interleukin-8, thymus and activation-regulated chemokine and intercellular cell adhesion molecule-1 in HaCaT keratinocytes. Also, NDGA decreases the protein expression of involucrin, a differentiation maker of keratinocyte, in both HaCaT keratinocytes and normal human epidermal keratinocytes. We examined NDGA-recovered skin barrier in atopic dermatitis by using an oxazolone-induced atopic dermatitis model in hairless mice. Topical application of NDGA produced an increase in transepidermal water loss recovery and a decrease in serum IgE level, without weight loss. Accordingly, we suggest that NDGA acts as a PAR2 antagonist and may be a possible therapeutic agent for atopic dermatitis.

• Genomics & Informatics
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• v.16 no.3
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• pp.52-58
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• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• Journal of Korea Water Resources Association
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• v.45 no.1
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• pp.39-52
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• 2012

Surface-subsurface interactions are an intrinsic component of the hydrologic response within a watershed. In general, these interactions are considered to be one of the most difficult areas of the discipline, particularly for the modeler who intends simulate the dynamic relations between these two major domains of the hydrological cycle. In essence, one major complexity is the spatial and temporal variations in the dynamically interacting system behavior. The proper simulation of these variations requires the need for providing an appropriate coupling mechanism between the surface and subsurface components of the system. In this study, an approach for modelling surface-subsurface flow and transport in a fully intergrated way is presented. The model uses the 2-dimensional diffusion wave equation for sheet surface water flow, and the Boussinesq equation with the Darcy's law and Dupuit-Forchheimer's assumption for variably saturated subsurface water flow. The coupled system of equations governing surface and subsurface flows is discretized using the finite volume method with central differencing in space and the Crank-Nicolson method in time. The interactions between surface and subsurface flows are considered mass balance based on the continuity conditions of pressure head and exchange flux. The major module consists of four sub-module (SUBFA, SFA, IA and NS module) is developed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7575-7581
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• 2015

Corticotropin-releasing factor(CRF), one of the stress driven neuropeptides, was widely proposed to influence hair loss and re-growth. For the development of receptor antagonists, the screening system based on intracellular calcium signal process was developed and optimized. The aequorin parental cells were transfected with CRF1 receptor and alpha 16 promiscuous G protein cDNA to establish HEK293a16/hCRF1, a stable cell line for the human CRF1 receptor. In HEK293a16/hCRF1 cells, the range of sauvagine dose response was 12-fold higher($EC_{50}:15.21{\pm}1.83nM$) than in the transiently expressed cells, hence essential conditions for the antagonist screening experiments such as the robust signals and high solvent tolerance were secured. The standard antagonists for the CRF1 receptor, antalarmin and CP154526, resulted $IC_{50}$ values of $414.1{\pm}5.5$ and $290.7{\pm}1.9nM$, respectively. Similar results were presented with frozen HEK293a16/hCRF1 cells. Finally, our HEK293a16/hCRF1 cells with the aequorin based cellular functional assay can be a model system for the development of functional cosmetics and modulators that can have a clinical efficacy on hair re-growth.

• Economic and Environmental Geology
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• v.49 no.1
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• pp.43-52
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• 2016

The essential role of the Division of Earth Sciences(EAR) in the Directorate of Geoscience(GEO) of National Science Foundation of America(NSF) is to support basic research aimed at acquiring fundamental knowledge of the Earth system that can be directly applied to the United States' strategic needs. The 2011 Committee on New Research Opportunities in the Earth Sciences(NROES) of the National Academy of Sciences(NAS) identified specific areas of the basic earth science research scope of the EAR that were poised for rapid progress during the next decade. Quantified by interdisciplinary approaches, the Committee highlighted the following topics relating to the EAR Deep Earth Processes and Surface Earth Processes sections: (1) the early Earth; (2) thermochemical internal dynamics and volatile distribution; (3) faulting and deformation processes; (4) interactions among climate, the Earth surface processes, tectonics, and deep Earth processes; (5) co-evolution of life, environment, and climate; (6) coupled hydrogeomorphic-ecosystem response to natural and anthropogenic change; and (7) interactions of biogeochemical and water cycles in terrestrial environments. We also promote future research challenges such as the critical zone studies. In order to promote more active such a huge future research challenges, additional research support policies are needed.

• Journal of the Korean Society of Safety
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• v.11 no.4
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• pp.143-150
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• 1996

This is an explicit-Implicit, finite element analysis for linear as well as nonlinear hygrothermal stress problems. Additional features, such as moisture diffusion equation, crack element and virtual crack extension(VCE ) method for evaluating J-integral are implemented in this program. The Linear Elastic Fracture Mechanics(LEFM) Theory is employed to estimate the crack driving force under the transient condition for and existing crack. Pores in materials are assumed to be saturated with moisture in the liquid form at the room temperature, which may vaporize as the temperature increases. The vaporization effects on the crack driving force are also studied. The Ideal gas equation is employed to estimate the thermodynamic pressure due to vaporization at each time step after solving basic nodal values. A set of field equations governing the time dependent response of porous media are derived from balance laws based on the mixture theory Darcy's law Is assumed for the fluid flow through the porous media. Perzyna's viscoplastic model incorporating the Von-Mises yield criterion are implemented. The Green-Naghdi stress rate is used for the invariant of stress tensor under superposed rigid body motion. Isotropic elements are used for the spatial discretization and an iterative scheme based on the full newton-Raphson method is used for solving the nonlinear governing equations.

• Ocean and Polar Research
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• v.43 no.4
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• pp.205-217
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• 2021

A shallow channel between Jeju and Udo Islands, which is located in the northeastern Jeju Island, is influenced by storm- or typhoon-induced currents and surface waves as well as strong tidal currents. This study examines the typhoon-induced current and wave patterns in the channel, using Acoustic Doppler Current Meter (ADCP) measurements and an ocean-wave coupled modeling experiment. Three typhoons were chosen - Chaba (2016), Soulik (2018), and Lingling (2019) - to investigate the responses of currents and waves in their pathways. During the pre-typhoon periods, dominant northward flow and wave propagation were observed in the channel due to the southeasterly winds before the three typhoons. After the passage of Chaba, which passed over the eastern side of Jeju Island, the northward flow and wave propagation were totally reversed to the opposite direction, which was attributed to the strong northerly winds on the left side of the typhoon. In contrast, in the cases of Soulik and Lingling, which passed over the western side of Jeju Island, strong southerly winds on the right side of the typhoons continuously intensified the northward current and wave propagation in the channel. The model-simulated current and wave fields reasonably coincided with observational data, showing southward/northward flow and wave propagation in response to the right/left side of the typhoon pathways. Typhoon-induced downwind flows, and surface waves could enhance up to 2m/s and 3m due to the strong winds that lasted for more than 12 hours. This suggests that the flow and wave patterns in the Udo channel are highly sensitive to the pathway of typhoons and accompanying winds; thus, this may be a crucial factor with regard to the movement of seabed sediments and subsequent coastal erosion.

• Journal of Technology Innovation
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• v.31 no.2
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• pp.173-214
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• 2023

Investments in new technologies have grown significantly in size, and science and technology have a large and complex impact on society at large. With people's great interest in technology, the government has the duty to accurately assess the influence of new technologies on society to facilitate their acceptance in society. For this purpose, technology impact assessment should be performed to facilitate a social consensus. There has been research on the initial methods of technology assessment for 50 years. Following various academic studies and discussions based on numerous new technology response policies, coupled with the examination of trends and changes over time, academia and policymakers around the world have paid attention to the multilateral analysis of the impact of new technologies on future society. This study focuses on research changes such as the stage of forecasting factors that should consider the technology assessment of new technologies, despite differences between the development methods for the assessment between developed countries and South Korea. The analysis yielded three factors of technological understanding of awareness, professionalism, and gender characteristics, in addition to a previously identified factor. The three factors are then suggested as forecasting factors for new technology. The findings of this study provide both academic and policy evidence for technology assessment based on the country's Framework Act on Science and Technology.