• Journal of Haehwa Medicine
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• v.10 no.1
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• pp.471-482
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• 2001

Infantile Convulsion, one of common emergency symptoms in pediatrics, arises from sudden derangement of the central nerve system, and can cause a sudden loss of consciousness and spasm. It falls into three categories: Acute Infantile Convulsion, Chronic Infantile Convulsion and Chronic Spleen Convulsion. According to research, approximately 6~7% of all babies undergo spasm more than once. Since the treatment must be done immediately, acupuncture & moxibustion treatment can be one of the most important treatments in this Particular case. Therefore, the focus of this study is on how acupuncture & moxibustion can be utilized in the treatment of Infantile Convulsion, and the literary findings are as follows: 1. The meridian points used on acute infantile convulsion are Sugu(GV26), T'aech'ung(Liv3), Hapkok(LI4). 2. The meridians used on acute infantile convulsion are Governor Vessel(GV), Bladder Meridian(BL), Stomach Meridian(ST). 3. The meridian points used on accompanied symptoms with acute infantile convulsion are Haenggan(Liv2), Yangnungch'on(Liv3) on spasm, Paek'oe(GV14) on opisthotonus, Kokchi(LI11), Taech'u(GV14) on fever, Nogung(P8), Yongch'on(K1) on fainting spell, Chok-samri(S36) on body weakness. 4. The meridian points used on chronic infantile convulsion are Shinguol(CV8), Ch'onchj'u(S25), T'aech'ung(Liv3), Kwanwon(CV4), Ch'ukt'aek(L5). 5. The meridians used on chronic infantile convulsion are Conception Vessel(CV), Governor Vessel(GV), Stomach Meridian(ST). 6. The meridian points used on accompanied symptoms with chronic infantile convulsion are Ch'onchj'u(S25), Kolli(CV11) on diarrhea, Taenung(P7), Shinmun(H7) on fainting spell, Kansu(B18), T'aech'ung(Liv3) on spasm. 7. The meridian Points and meridians are Paek'oe(GV14), Sangsung(GV23), Sugu(GV26) of Governor Vessel(GV) and Choiyung(CV16), Shinguol(CV16) of Conception Vessel(CV) and Taedon(Liv1), Changmun(Liv13).

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.1
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• pp.1-11
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• 2008

Objectives In order to investigate the anticonvulsive effects of Jisungbomuyngtan, the experiments were done in mice. Methods After solid extracts of Jisungbomuyngtan was orally administered to mice, four types of convulsion were induced in mice by ECT, strychnine, picrotoxin, caffein. Each of the time to convulsion and death was measured. Results 1. The solid extracts of Jisungbomuyngtan showed a remarkable effect in delaying the onset of convulsion induced by ECT 2. In case of convulsion induced by strychnine, the solid extracts of Jisungbomuyngtan revealed a slight, but not statistically significant effect. 3. Considerable prolongation of time to death was observed in convulsion induced by picrotoxin due to the anticonvulsive effect of Jisungbomuyngtan. 4. The anticonvulsive effect of Jisungbomuyngtan was not found in convulsion induced by caffein. Conclusions Jisungbomuyngtan effect remarkably in delaying the onset of convulsion induced by ECT. But slightly effect by strychnine. And Jisungbomuyngtan effect in prolonging time to death in convulsion induced by picrotoxin, but not found in convulsion induced by caffein.

• The Journal of Pediatrics of Korean Medicine
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• v.9 no.1
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• pp.221-236
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• 1995

In order to investigate the anticonvulsive effect of Jinkyungondamtang, the experiment were performed in mice. After solid exract of Jinkyungondamtang was orally administered to mice, four types of convulsion were induced in mice by electric shock, strychnine, picrotoxin, and caffeine. Each of the time to elicit the convulsion and to die was observed. Results were as follows: 1. In the case of convulsion induced by electric shock, the lapse of the time to elicit convulsion and the time to die were delayed by oral administration of Jinkyungondam-tang(P<0.05, P<0.025). 2. The solid extracts of Jinkyungondamtang were revealed rem- arkable effect in delaying the time to die induced by stry-chnine (P<0.05). 3. By oral administration of Jinkyungondamtang, the lapse of the time to elicit convulsion and to die were delayed significantly to elicit convulsion inducing by picrotoxin (P<0.05, P<0.05). 4. Considerable prolongation of the lapse of the time to elicit the convulsion was observed in convulsion induced caffeine due to the anticonvulsive effects of Jinkyungondamtang (P<0.05).

• The Journal of Korean Medical History
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• v.21 no.1
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• pp.71-76
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• 2008

Infantile convulsion has always been the subject of concern as it is a common yet fatal disease among infants. During the Koryo dynasty and the early years of Chosun dynasty animal and mineral medicinal materials were used to relieve heat. These are replaced with more subtle medicinal materials later on in the Chosun dynasty when differentiation of chronic and acute infantile convulsion first emerged. As such, perception on appropriate medicinal materials is constantly renovated in the course of time.

• Clinical and Experimental Pediatrics
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• v.61 no.4
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• pp.129-131
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• 2018

Purpose: The association between hypercalciuria and febrile convulsion is controversial. The present study aimed to investigate the statistical association between hypercalciuria and childhood febrile convulsions. Methods: Overall, 160 children aged 6 months to 5 years, including 80 children with febrile convulsion and 80 febrile children without convulsion (comparison group), were recruited. All laboratory tests, including 24-hour urine calcium, were undertaken in an academic clinical laboratory. Results: Forty-five children of the febrile convulsion group (60%) and 30 of the comparison group (40%) had hypercalciuria. There was a significant difference between the 2 groups (P=0.02). Conclusion: Our results indicated that there is a statistical association between convulsion and hypercalciuria in children. Since we found this association with a cross-sectional assessment, further studies, especially prospective and controlled designs, are needed.

• The Journal of Pediatrics of Korean Medicine
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• v.18 no.2
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• pp.209-223
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• 2004

Objective : This study was performed to investigate the knowledge, concerns, attitudes of mothers about febrile convulsion in order to suggest education programs. Methods : The subjects of questionnaire investigation were 142 mothers visited pediatrics in Gyeongju dongguk oriental hospital between 3 september and 16 December 2004 with child under 5 years of age. Results : The rate of incorrect answer was 46.0%, experienced mothers had significant high scores than non-experienced mothers in knowledge. Mothers believed reccurent febrile convulsion will cause brain damage(88.7%), considered every febrile convulsion child will have another FC(68.3%). Mothers anticipated inserting object into the child's mouth(72.5%), rushing the child to the hospital(67.6%) during convulsion. Mothers concerned about the risk of subsequent epilepsy(70%) and experienced mothers measured the child's body temperature more frequently than before(66.7%). Conclusions : Answered mothers had inadequate knowledge, high concerns, and didn't know proper management. This suggests that enough information is needed to mothers and proper education programs should be developed in febrile convulsion.

• The Journal of Pediatrics of Korean Medicine
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• v.20 no.1
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• pp.195-206
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• 2006

Objective : The purpose of this study is to investigate the current trends of children patients with convulsion. Children convulsion patients who visited the Pediatric Department of the Oriental Medicine hospital were investigated and analyzed. Method : 90 children complaining convulsion who visited the Department of Pediatrics of Kyung Hee University Oriental Medicine Hospital, between March, 2005 and October 2005 were statistically analyzed. Results : The percentage of boys outnumbered the girls. The percentage of children under the age of 5 18 66.7%. The percentage of children with family history is 43%. The majority of children had visited the hospital twice (n=21). As for intercurrent diseases, there were URI, C.P., ADHD, CHD, sequela of encephalitis and etc. As for the result of EEG examinations, 25 children were normal and 18 were abnormal. As for the appearance of seizures, Tonic-Clonic seizure was the most common seizure among the children (n=13). As for the type of convulsion, simple febrile convulsion was the most common (n=35). As for the curative effect. the percentage of children who showed improvement to treatment was 41.2%. Jangdambosintang, sunbangpaedoktang, gamichodeungeunm, gamichungeumchowitang and etc were the most frequently prescribed medicines.

• Journal of Oriental Neuropsychiatry
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• v.10 no.2
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• pp.1-27
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• 1999

For experimental studies on the anticonvulsion effect and it was measured in mice that toxigenic effect, influence on the central nervous system, anticonvulsion effect, mechanism of anticonvulsion effect by change of GABA level and glutamic acid in brain, effect of the creation and degradation system of brain oxygen free radicals in convulsion. The results were obtained as follows: 1. Samulanshintang was perfect medicine without toxigenic effect. 2. Pretreatment of Samulanshintang did not influence on the central nervous system. 3. Pretreatment of Samulanshintang did not influence on maximal electric seizure(MES), strychnine, bicuculine and picrotoxin, but pentylenetrazol(PTZ)-induced convulsion significantly decreased. 4. Effect of Samulanshintang except for Jinsa on the PTZ-Induced convulsion decreased. 5. Effect of Samulanshintang fragrance(SMATF) and Samulanshintang distiled water(SMATW) on the PTZ-induced convulsion did not influence. 6. Decrease of brain GABA level in PTZ-induced convulsion was increased by pretreatment of Samulanshintang. 7. Decrease of brain glutathione content in PTZ-induced convulsion was increased by pretreatment of Samu- lanshintang. 8. GABA-T activity increased by PTZ-induced was controlled by the pretreatment of Samulanshintang. 9. Increase of brain lipid peroxide content in PTZ-induced convulsion was decreased by pretreatment of Samulanshintang. 10. Significant increase of brain xanthine oxidase and aldehyde oxidase activities in PTZ-induced was controlled by pretreatment of Samulanshintang. 11. Decrease of brain superoxide dismutase(SOD), catalase and glutathione peroxidase activities in PTZ-induced was decreased by pretreatment of Samulanshintang. From the above results, Samulanshintang was perfect medicine without toxigenic effect and was recognized anticonvulsion effect by decreasing brain glutamic acid level and increasing brain GABA level. Samulanshintang have an effect on creation and degradation system of brain oxygen free radicals in convulsion, thus it was considered that Samulanshintang could be applied in convulsive disorder as epilepsy, febrile seizure and spasm etc.

• Journal of Oriental Neuropsychiatry
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• v.5 no.1
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• pp.69-79
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• 1994

In order to prove the effectiveness for anticonvulsion and analgesic of Ukgansan, Ukgansan added Jinphi Banha and Ukgansan added Chunma by experiment, experimental animals(mouse) are injected with strychnine, picrotoxin and caffeine to cause convulsion and ovserved the consumed time from convulsion to death. Comparing data with control group and observation data for frequency of writhing syndrome caused by acetic acid and phenylquinone show the results as follows : 1. Anticonvulsion effect on the convulsion induced by strychnine it was significantly effective in all sample groups. 2. Anticonvulsion effect on the convulsion induced by picrotoxin it was significantly effective in sample A and B. 3. Anticonvulsion effect on the convulsion induced by caffeine it was not recognized in all sample groups. 4. Analgesic effect on the pain induced by acetic acid it was significantly effect in sample A and C. 5. Analgesic effect on the pain induced by phenylquinone it was significantly effective in sample A and C. The results show that Ukgansan can be an effectual cure on anticonvulsion and analgrsic, Ukgansan added Jinphi·Banha on anticonvulsion, and Ukgansan added Chunma on analgesic.

• The Journal of Korean Medicine
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• v.23 no.3
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• pp.211-222
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• 2002

Currently convulsion is considered to be a chronic central nerve disease characterized by involuntary and severe muscle contraction or spasm. In many recent studies, convulsion's mechanism is due to unbalance between stimulation and suppression of the central nerve system, such as GABA and glutamic acid. Objectives : This study was performed to examine the anticonvulsant effects of Podam-hwan on brain GABA levels and glutamate content in picrotoxin-induced convulsions and to determine the inhibitory activity on GABA transaminase. Methods : Brain GABA levels and glutamate content in the brains of picrotoxin-induced mice using reverse phase HPLC method, anticonvulsant effect in vivo, and the inhibitory effect on GABA transaminase activity in vivo have been investigated. Results : Podam-hwan significantly lengthened the onset time of picrotoxin-induced convulsion at a concentration of 15mg/kg, but did not show a dose-dependent pattern. Also, Podam-hwan shortened the duration of convulsion by 52.2% at a dose of 30mg/kg in comparison with the control group. Podam-hwan inhibited dose-dependently GABA transaminase activity by 35.5% at 30mg/kg, comparing with the control gmup. Podam-hwan also increased the brain GABA level by 38.7% and 68.8% at doses 15mg/kg and 30mg/kg, respectively. In addition, Podam-hwan decreased the brain glutamate level by 9.6% and 17.8% at doses 15mg/kg and 30mg/kg, respectively. Conclusions : Podam-hwan can be prescribed for the treatment of convulsion by enhancement of brain GABA level and inhibition of GABA transaminase activity.