The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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An Experimental Study on the Anticonvulsive Effects of Jisungbomuyngtan

지성보명단(至聖保命丹)의 항경련(抗痙攣) 작용에 관한 실험적 연구

  • Lee, Hee-Sung (Department of Pediatrics, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Deog-Kon (Department of Pediatrics, College of Oriental Medicine, Kyunghee University)
  • 이희성 (경희대학교 한의과대학 한방소아과학교실) ;
  • 김덕곤 (경희대학교 한의과대학 한방소아과학교실)
  • Published : 2008.04.30
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Abstract

Objectives In order to investigate the anticonvulsive effects of Jisungbomuyngtan, the experiments were done in mice. Methods After solid extracts of Jisungbomuyngtan was orally administered to mice, four types of convulsion were induced in mice by ECT, strychnine, picrotoxin, caffein. Each of the time to convulsion and death was measured. Results 1. The solid extracts of Jisungbomuyngtan showed a remarkable effect in delaying the onset of convulsion induced by ECT 2. In case of convulsion induced by strychnine, the solid extracts of Jisungbomuyngtan revealed a slight, but not statistically significant effect. 3. Considerable prolongation of time to death was observed in convulsion induced by picrotoxin due to the anticonvulsive effect of Jisungbomuyngtan. 4. The anticonvulsive effect of Jisungbomuyngtan was not found in convulsion induced by caffein. Conclusions Jisungbomuyngtan effect remarkably in delaying the onset of convulsion induced by ECT. But slightly effect by strychnine. And Jisungbomuyngtan effect in prolonging time to death in convulsion induced by picrotoxin, but not found in convulsion induced by caffein.

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