• 한국강구조학회 논문집
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• 제28권1호
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• pp.35-42
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• 2016

본 연구는 기존의 시설물을 횡단하기 위한 목적으로 시공된 지간장이 다른 2경간 연속 구조물을 대한 압출공법을 적용에 관한 것이다. 압출구간이 비교적 짧은 구조물은 인접 경간의 길이가 다른 경우가 많고 압출시 후방 구조물이 연속되지 않는 경우가 많기 때문에 부재 단면력이 최대 내력에 도달하기 이전에 과도한 처짐과 전도가 발생하여 구조적 안정성이 확보되지 못하는 경우가 있다. 이러한 구조물의 시공단계별 구조물의 처짐과 전도에 대한 안정성을 예측하기 위해서 해석적 연구를 수행하였다. 해석에서의 매개변수는 압출추진코와 상부구조물의 길이비, 지간비, 중량비 등이다.해석결과로부터 매개변수의 영향을 분석하였고 압출추진코에서의 구조물의 처짐과 전도 발생 조건식을 제시하였다.

• Journal of Chest Surgery
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• 제51권3호
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• pp.180-186
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• 2018

Background: Endovascular aortic repair (EVAR) is widely performed to treat infrarenal abdominal aortic aneurysms (AAAs), and related techniques and devices continue to be developed. Although continuous attempts have been made to perform EVAR in patients with unfavorable aortic anatomy, the outcomes are still controversial. This study examined the short-term outcomes of EVAR for the treatment of infrarenal AAAs in patients with a 'hostile' neck and unfavorable iliac anatomy. Methods: Thirty-eight patients who underwent EVAR from January 2012 to December 2017 were enrolled in this study. A hostile neck was defined based on neck length, angulation, the presence of an associated thrombus, or a conical shape. Unfavorable iliac anatomy was considered to be present in patients with a short common iliac artery (<15 mm) or the presence of aneurysmal changes. Results: No perioperative mortality was recorded. No significant differences were found depending on the presence of a hostile neck, but aneurysmal sac shrinkage was significantly less common in the group with unfavorable iliac anatomy (p=0.04). A multivariate analysis performed to analyze the risk factors for aneurysmal progression revealed only unfavorable iliac anatomy to be a risk factor (p=0.02). Conclusion: Patients with unfavorable aortic anatomy showed relatively satisfactory short-term outcomes after EVAR. No difference in the surgical outcomes was observed in patients with a hostile neck. However, unfavorable iliac anatomy was found to inhibit the shrinkage of the aneurysmal sac.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권4호
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• pp.372-380
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• 2005

Condylar process of mandible, has the specialized anatomic structure compared with any other body structure, acts directly in connection with mastication and speech and so on. In general, mandibular condyle fractures have been managed by two methods as open and closed reduction. But, there are no reasonable consensus about the proper management of this injury. This study was designed for analysis of the prognosis of two methods of treatment, open and closed reduction, with positional change of fractured condyle and complications within 6 months post-intermaxillary fixation period. We conducted a retrospective analysis of 154 patients whose unilateral mandibular condyle fractures were treated by open or closed reduction in our department. The horizontal, sagittal, and coronal change of the condyle was examined using modified Towne's and panoramic radiographs before intermaxillary fixation(IMF), immediately after IMF, and at 6 months after IMF. Patients, whose mandibular condyle fractures were treated by closed reduction, had significantly shorter ramus height on the side of injury(P<0.05). But, fractured condylar fragments were displaced insignificantly with aspect to sagittal and coronal plane(P>0.05). The level of the fracture influenced the ramus length and the degree of coronal change in the closed reduction group(P<0.05). There was no significant correlation among the level of the fracture, treatment methods and complications(P>0.05). From the results obtained in this study, fractured mandibular condyles, were treated by closed reduction, had a tendency that continuous condylar displacement was occurred with aspect to horozontal and coronal plane in treatment period including intermaxillary fixation. And then there was a correlation between the level of the fracture and the position change in close reduction group statistically. These result suggested that care must be taken in basing treatment decisions on the degree of displacement of the condyle and in treating the mandibular condyle fractures for a long time.

• Journal of Pharmaceutical Investigation
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• 제36권6호
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• pp.355-361
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• 2006

Intraarticular corticosteroid injections for therapy of rheumatic arthritis are administered with the aim of optimal local anti-inflammatory effect at the injection site. Since the side effects of corticosteroidal drug, dexamethasone(DEX), administered at hish dose limited the therapeutic efficacy, there was a need to design a new drug delivery system for controlled release of dexamethasone. As a prodrug for continuous therapeutic efficacy, dexamethasone-21-palmitate(DEX-PAL) was prepared via esterification of palmitoyl chloride and dexamethasone. DEX-PAL was identified by NMR and MASS analysis. DEX-PAL or DEX was entrapped in lipid nanosphere which could be prepared by using a self emulsification-solvent evaporation method. Physicochemical characteristics such as mean particle diameter, zeta potential and drug loading efficiency of the lipid nanospheres were investigated with variation of either the kind of lipid or the lipid composition. The lipid nanospheres had a mean diameter $83{\sim}95$ nm and DEX-PAL loading efficiency of up to 95%. The drug loading efficiency increased with the increase of aliphatic chain length attached to the phospholipid. The incorporation of cationic lipid was very efficient for both reducing particle size of lipid nanospheres and enhancing drug loading efficiency. The lipid nanospheres containing DEX-PAL may be a promising novel drug carrier for the controlled release of the poorly water-soluble drugs.

• 대한두개안면성형외과학회지
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• 제24권2호
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• pp.59-65
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• 2023

Background: Fibrous dysplasia (FD) is a localized bone disorder in which fibro-osseous tissue replaces the normal bone structure. Patients with craniofacial FD often present with gradual swelling, deformity, and compromised vision or hearing. We previously introduced "the core extirpation method," a novel surgical technique that is minimally invasive like traditional bone shaving but has longer-lasting effects. This study presents the long-term outcomes of our core extirpation method. Methods: We conducted a retrospective analysis of patients who underwent core extirpation for FD of the zygomaticomaxillary region from 2012 through 2021. Computed tomography (CT) scans were performed 6 to 12 months before the operation, immediately before and after the operation, and during follow-up visits. We performed all operations using the upper gingivobuccal approach, and we extirpated the core of the lesion while preserving the cortical structures of the zygoma and the maxilla to maintain symmetrical facial contour. Results: In 12 patients with lesions in the growth phase, anteroposterior/mediolateral (AP/ML) length discrepancies and the volume increased between preoperative and immediate postoperative CT scans. All patients' immediate postoperative AP/ML discrepancies were stable up to 12-17 months postoperatively. Postoperative volume showed continuous lesion growth; the median volume growth rate was 0.61 cc per month. Conclusion: In this article, we present our experiences managing FD using the minimally invasive core extirpation technique, which entails small expected blood loss and can be performed as day surgery. It provides similar cosmetic outcomes as traditional bone shaving but with longer-lasting results. Although there are some limitations with the study's retrospective nature and small sample size, our 4-year follow-up results show promising results of the core extirpation method in well-indicated patients.

• 대한치과교정학회지
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• 제33권6호
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• pp.453-463
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• 2003

본 연구는 MC3T3El 조골세포가 저산소증에 반응하여 유발될 수 있는 세포 고사조절 기전을 구명하고자 함에 목적이 있다. $2\%$ 저산소증의 조건하에서 MC3T3El 조골세포는 DNA 사다리 분절 헝성을 보였으며 형광성 염료인 Hoechst 33258로 염색된 핵 구조 형태 관찰시 시간이 지남에 따라 세포고사 현상을 관찰할 수 있었다 Pancaspase 억제제인 Z-VAD-FMK나 특정한 caspase-3 억제제인 Z-DEVD-CHO로 사전 처치하였을 경우에는 저산소증에 의한 DNA 사다리 분절형성이 농축에 비례하여 억제되었다. caspase-3류의 프로테아제(DEVDase) 활성 증가가 세포고사 중에 관찰되었으나 caspase-1 (YVADase)의 활성은 없었다. 어떤 caspase가 세포고사에 관여하는지를 확인하기 위하여 anti-caspase-3 또는 anti-caspase-6의 항체를 이용한 western blotting이 시행되었다. caspase-3의 활성산물에 해당하는 17-KDa단백질과 caspase-6의 활성산물인 20-KDa 단백질이 세포용해물에서 발생되었다. 또한 시간 경과와 더불어 caspase-6의 활동의 상징인 Lamin A의 분열을 일으켰으며, 사이토크롬 C를 cytosol로 방출하였다. 이로써 저산소증에 의한 조골세포의 고사 과정에 사이토크롬 C의 방출이 포함된 caspase의 활성이 관여한다는 것을 확인할 수 있었다.

• 한국의료질향상학회지
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• 제4권1호
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• pp.50-63
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• 1997

Background : A pressure sore was defined as any skin lesion caused by unrelieved pressure and resulting in damage to underlying tissue. The health care institutions in the United States were reported the incident rate of pressure sores ranging from 6 to 14 %. Intensive Care Unit needed highest quality of care has been found over 40% incidence rate of pressure sore. Also, Annual expenditures for the care of pressure sores in patients in the United States have been estimated to be $7.5 billion; furthermore, 50 percent more nursing time is required to care for patients with pressure sore in comparison to the time needed to implement preventive measures against pressure sore formation. However, In Korea, there were little reliable reports, or researches, about incidence rates of pressure sore in health care institution including intensive care unit and about the integrated approach like CQI action team for risk assessment, prevention and treatment of pressure ulcers. Therefore, this study was to develop pressure sore risk assessment tool and the protocol for prevention of pressure sore formation through CQI action team activities, to monitor incident rate of pressure sore and the length of sore formation for patients at high risk, and to approximately estimate nursing time for sore dressing during research period as the effect of CQI action team. Method : CQI action team in intensive care unit, launched since early 1996, reviewed the literature for the standardized risk assessment tool, developed the pressure sore assessment tool based on the Braden Scale, tested its validity, compared on statistics including incidence rate of pressure sore for patients at high risk. Throughout these activities, CQI action team was developed the protocol, called as St. Marys hospital Intensive Care Unit Pressure Sore Protocol, shifted the emphasis from wound treatment to wound prevention. After applied the protocol to patients at high risk, the incident rate and the period of prevention against pressure development were tested with those for patients who received care before implementation of protocol by Chi-square and Kaplan-Meier Method of Survival Analysis. Result : The CQI action team found that these was significant difference of in incidence rate of pressure sores between patients at high risk (control group) who received care before implementation of protocol and those (experimental group) who received it after implementation of protocol (p<.05). 25% possibility of pressure sore formation was shown for the patients with 6th hospital day in ICU in control group. In experimental group, the patients with 10th hospital day had 10% possibility of pressure sore. Therefore, there was significant difference(p<.05) in survival rate between two groups. Also, nursing time for dressing on pressure sore in experimental group was decreased as much as 50% of it in control group. Conclusion : The collaborative team effort led to reduced incidence, increased the length of prevention against pressure sore, and declined nursing care times for sore dressing. However, there have had several suggestions for future study. The preventive care system for pressure sore should be applied to patients at moderate, or low risk throughout continuous CQI team activities based on Bed Sore Indicator Fact Sheet. Hospital-wide supports, such as incentives, would be offered to participants for keeping strong commitment to CQI team. Also, Quality Information System monitoring incidents and estimating cost of poor quality, like workload (full time equivalence) or financial loss, regularly in a hospital has to be developed first for supporting CQI team activities as well as empowering hospital-wide QI implementation. Being several limitations, this study would be one of the report cards for the CQI team activities in intensive care unit of an acute hospital and a trial of quality improvement of health care in Korea.

• 한국작물학회지
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• 제37권3호
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• pp.264-273
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• 1992

White clover는 여러 가지 장점에도 불구하고 조기정착과 조성이 어렵고 단속방목에 대한 적응력 부족으로 초지내에서의 존속년한이 짧아 이용성이 제한되어 왔다. 따라서 본 시험은 white clover를 기존초지에 도입하는데 필요한 정보를 제공하기 위하여 최초예취시기(trifoliolate 1, 4, 8)의 조만과 예취간격 (7일, 28일)이 28일의 재생기간 동안 엽의 크기가 다른 white clover 품종들(Regal, La S.1, Huia 및 S184)의 수량과 재생에 미치는 영향을 조사하기 위하여 온실에서 pot 시험으로 실시한 바 그 결과를 요약하면 다음과 같다. 1. 28일 동안의 수확 건물중은 최초예취시기를 빨리하거나 예취간격을 줄임으로써 현저히 감소한 반면, 예취간격에 관계없이 최초예취시기를 늦춤으로써 지품종에 비하여 대업형 Regal이 높았다. 2. 지상부 및 뿌리의 건물중은 재생 초기 (7일)에는 최초예취시기를 늦추고 예취간격을 늘임으로써 증가하나 충분한 기간 동안 재생(28일)이 허용될 때 완화되는 경향을 보였고, 전재생기에 걸쳐 Regal이 지품종에 비하여 근중 및 전식물체중은 높았다. 3. 재생기간 동안 전식물체중의 증가는 주로 지상부 건물중의 증가에 기인하였고, 예취간격 28일에서는 예취시의 건물중으로 회복하는 데는 약 2주가 걸렸다. 4. 식물개체당 엽면적과 예취간격 7일에서 현저히 감소되었고, 재생 7일에서는 최초예취시기가 빠를수록 감소하나 재생 28일에서는 차이가 없었다. 5. 포복경장과 분지경수는 소엽형 S184에서 가장 길고 많았으며 재생기간 동안 급겹히 증가한 반면 대엽형 Regal은 포복경장과 분지경수가 가장 적었고 증가도 완만하였다. 또한 포복경장은 예취간격을 줄임으로써 감소하였다.

• 청정기술
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• 제11권1호
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• pp.41-50
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• 2005

본 연구는 환경친화적인 선형 비이온 계면활성제인 LE-형유화제를 사용하여 점착성분의 단량체로 노말부틸 아크릴레이트 (n-butyl acrylate, n-BA)와 응집성분의 단량체로 메틸메타 아크릴레이트 (methyl metacrylate, MMA)를 사용하여, 폴리머 시멘트용 아크릴계 에멀젼 수지를 제조하기 한 최적조건을 얻기 위해 수용액상에서 유화중합을 실시하였다. 실험결과, 사용한 계면활성제 (LE-형)의 친수성인 체인 길이(n)의 값이 증가할수록 응석의 발생이 줄어들어 안정한 폴리머 에멀젼을 얻을 수 있었다. 최종 폴리머 에멀젼의 농도는 이 계면활성제의 사용량을 증가시킴에 따라 증가하다가 어느 농도 이상에서 응석의 발생이 거의 없는 폴리머 에멀젼을 얻을 수 있었으며, 반면에 평균 입자크기도 사용량에 따라 작아지다가 250 nm로 일정한 크기를 나타내었다. 또한 기능성 폴리머로서 보조모노머의 첨가는 최종 폴리머 에멀젼의 응석과 입자크기에 크게 영향을 미쳤는데, 주 모노머에 보조 모노머인 아크릴산 (acrylic acid, AA)과 아크릴 아마이드 (acrylic amide, AM)의 혼합하여 첨가한 경우, 첨가하지 않은 경우에 비해 응석의 발생이 줄어들어 안정한 폴리머 에멀젼을 얻을 수 있었다. 최적조건에서 어진 아크릴 폴리머 에멀젼은 평균 입자크기 200-300 nm, 제타전위 (zeta potential)값 -50 mv 정도였으며, 단일 유리전이온도 (glass temperature, Tg)를 가진 고분자 나노 입자가 수용액상에 잘 분산되어 있음을 알 수 있었다. 따라서 중합조건을 최적화시켜 안정된 폴리머 에멀젼을 얻을 있었다.

• 한국작물학회지
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• 제39권3호
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• pp.245-255
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• 1994

White clover는 많은 장점에도 불구하고 계속방목에 대한 적응력이 낮아 존속연한이 짧은 것이 결점이다. 따라서 본 시험은 white clover 혼파초지관리에 필요한 정보를 제공하기 위하여 예취주기의 장단(7일, 14일, 28일)이 28일의 재생기간동안 잎의 크기가 다른 white clover 품종들(Osceola, Huia, S184)의 수량과 재생에 미치는 영향을 조사하기 위하여 온실에서 pot 시험으로 실시한 바 그 결과를 요약하면 다음과 같다. 1. 28일의 처리기간중 수확 건물중은 대엽종 Osceola가 타품종에 비하여 많았고, 예취주기를 28일에서 7일로 줄임으로써 현저히 감소하였다. 2. 재생기간중 개체당 건물중은 주로 잎과 엽병의 증가에 기인하였고 예취 후 14일부터 대엽종 Osceola가 타품종에 비하여 많았다. 3. 개체당 엽면적과 복엽당 엽면적은 28일의 재생 기간동안 꾸준히 증가하였으나 예취를 28일에서 7일로 줄임으로써 현저히 감소하였다. 대엽종 Osceola의 개체당 엽면적과 복엽당 엽면적은 타품종에 비하여 많았다고 하나, 예취 후 28일의 개체당 엽면적에는 품종간 차이가 없는 것으로 측정되었다. 4. 예취주기를 짧게 할수록 엽수와 엽병장이 감소하였으며 예취 후 14일부터 타품종에 비하여 소엽종 S184가 많은 엽수를, 대엽종 Osceola가 긴 엽병을 확보하고 있는 것으로 조사되었다. 5. 개체당 포복경장과 분지경수는 재생기간동안 급격히 증가한 반면 소엽형 S184에서 가장 길고 많았으며 예취주기를 28일에서 7일로 줄임으로써 현저히 감소하였다.