• Advances in Computational Design
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• 제8권4호
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• pp.327-351
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• 2023

This article explores how multi-objective optimization techniques can be used to design cost-effective and structurally optimal spatial steel structures, highlighting that optimizing performance can be as important as minimizing costs in real-world engineering problems. The study includes the minimization of maximum horizontal displacement, the maximization of the first natural frequency of vibration, the maximization of the critical load factor concerning the first global buckling mode of the structure, and weight minimization as the objectives. Additionally, it outlines a systematic approach to selecting the best design by employing four different evolutionary algorithms based on differential evolution and a multi-criteria decision-making methodology. The paper's contribution lies in its comprehensive consideration of multiple conflicting objectives and its novel approach to simultaneous consideration of bracing system, column orientation, and commercial profiles as design variables.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3699-3703
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• 2013

Background: This study aimed to show the localization of estrogen / progesterone receptors, human epidermal growth factor receptor 2 (Her-2) and protein 53 (p53) by immunohistochemistry in a series of consecutive breast cancer patients. Materials and Methods: The study covered invasive breast cancers from 299 patients presenting at the Oncogenetic Clinic and Pathology Centers of Ahwaz Jondishapour University of Medical Sciences Hospital in Iran during the time period from 2009 to 2011. The Scarff-Bloom Richardson scoring method was used. Results: Of the 299, 27% (80/299) were <40, 33% (100/299) were 41-50, and the remaining 40% (119/299) were>50 years old. The highest incidence of breast cancer in this study population was in the group of more than 50 year age, and the most common histological type of breast cancer was the invasive ductal carcinoma, which accounted for 68% (203/299) of the cases. Out of possible total of 207, 6% (13/207), 41% (85/207), and 53% (109/207) were scored as grade I, II, III, respectively. Conclusion: Our findings demonstrated a lack of association between labeling for the markers studied and tumor size and age of the patients. We confirmed an association between ER labeling and nuclear grade of breast cancer. The conflicting results obtained compared with the literature be because of differences in the immunohistochemical techniques applied in the various studies and to the scoring systems used.

• 대한암한의학회지
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• 제25권1호
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• pp.11-24
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• 2020

Objective : Radiodermatitis is a common sequelae in 95% of patients receiving radiation therapy, which is important to be well managed as it can affect the patient's quality of life as well as the cancer treatment schedule. The aim of this study is to review and summarize the interventions available for the treatment of acute radiodermatitis, including traditional Korean medicine, and to propose treatment algorithms for clinicians. Methods : To collect studies about managements for radiodermatitis, domestic and foreign database were used such as Korean journal of traditional knowledge portal (KTKP), Korean studies information service system (KISS), national discovery or science leaders (NDSL), and oriental medicine advance searching integrated system (OASIS), Pubmed, Google scholar and Scopus. Results : Thirty-two studies were selected. There were nine studies on usual care and dressing, eleven studies on chemical agents, two studies on biological preparations, and ten studies on herbal medicines. Conclusion : Hygienic options and dressings have proved to be useful in the management of radiodermatitis. Chemical agents such as corticosteroid, statin, and topical antibiotic agent have proved to alleviate symptoms and severity, regenerate damaged skin, and prevent secondary infection. In biological preparations, EGF (epidermal growth factor) and GM-CSF (granulocyte-macrophage colony-stimulating factor) could be used to protect skin and prevent radiodermatitis. For herbal medicines, Calendula, catechin, β-sitosterol, and Jaungo (紫雲膏) may be effective for symptoms including pain, itching, and burning sensation induced by radiation therapy. Because of some research with conflicting results, further studies are needed to propose an algorithm for more optimal treatments.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9687-9692
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• 2014

Background: Biliary tract cancers are rare, and surgical resection is the standard treatment at early stages. However, reports on the benefits of adjuvant treatment following surgical resection are conflicting. This study aimed to evaluate the factors affecting survival and adjuvant treatments in patients with surgically treated biliary tract cancers. Materials and Methods: Patient clinical features, adjuvant treatments, and efficacy and prognostic factor data were evaluated. Survival analyses were performed using SPSS 15.0. Results: The median overall survival was 30.7 months (95% confidence interval [CI], 18.4-42.9 months). Median survival was 19 months (95% CI, 6-33) for patients treated with fluorouracil based chemotherapy and 53 months (95% CI, 33.2-78.8) with gemcitabine based chemotherapy(p=0.033). On univariate analysis, poor prognostic factors for survival were galbladder localization, perineural invasion, hepatic invasion, a lack of adjuvant chemoradiotherapy treatment, and a lack of lymph node dissection. On multivariate analysis, perineural invasion was a poor prognostic factor (p=0.008). Conclusions: Biliary tract cancers generally have poor prognoses. The main factors affecting survival are tumour localization, perineural invasion, hepatic invasion, adjuvant chemoradiotherapy, and lymph node dissection. Gemcitabine-based adjuvant chemotherapy is more effective than 5-fluorouracil-based chemotherapy.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3331-3333
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• 2014

Background: The results of previous researches that analyzed the association between genetic polymorphisms of transcription factor-7-like 2 (TCF7L2, rs7903146) and polycystic ovary syndrome (PCOS) were conflicting. Current systematic analysis was conducted to re-explore this association using updated materials. Materials and Methods: The PubMed database was used for data collection and the final search was conducted on January 3, 2014. For TCF7L2 rs7903146, a non-signficiant slight increase in risk of PCOS development was observed under three genetic models (dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12, 95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05). In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated (allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05), the differences were again not statistically significant. Conclusions: The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.

• International Journal of Air-Conditioning and Refrigeration
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• 제13권1호
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• pp.51-60
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• 2005

This paper reviews the studies on the pressure drop and the heat transfer in microchannels. Although a lot of studies about the single-phase flow have been done until now, conflicting results are occasionally reported about flow transition from laminar flow to turbulent flow, friction factor, and Nusselt number. Some studies reported the early flow transition due to relatively greater wall effect like surface roughness, but the other studies showed that the flow transition occurred at the Reynolds number of about 2300 and the early flow transition might be due to less accurate measurement of the channel geometry. Also, there have been arguments whether the conventional relation based upon continuum theory can be applied to the fluid flow and the heat transfer in microchannels without modification or not. The studies about the two-phase flow in microchannels have been mostly about investigating the flow pattern and the pressure drop in rectangular channels using two-component, two-phase flow like air/water mixture. Some studies proposed correlations to predict two-phase flow pressure drop in microchannels. They were mostly based on Lockhart-Martinelli model with modification on C-coefficient, which was dependent on channel geometry, Reynolds number, surface tension, and so on. Others investigated the characteristics of flow boiling heat transfer in microchannels with respect to test parameters such as mass flux, heat flux, system pressure, and so on. The existing studies have not been fully satisfactory in providing consistent results about the pressure drop and the heat transfer in microchannels. Therefore, more in-depth studies should be done for understanding the fundamentals of the transport phenomena in the microchannels and giving the basic guidelines to design the micro devices.

• 한국전자통신학회논문지
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• 제1권1호
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• pp.56-62
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• 2006

현재 국내.외 기간 통신망은 급격히 증가하는 고속 대용량 트래픽을 효율적으로 멀리 전송하기 위해 광증폭기를 이용한 파장분할다중화방식 (DWDM : Dense Wavelength Division Multiplexing) 광전송 시스템 통신망을 구축하고 있다. DWDM광전송 시스템에서 고속, 대용량 및 장거리 전송을 하기 위해서는 기존 3R 광 중계기 시스템에서 크게 중요시 않았던 광 fiber의 비선형(non-linearity) 전송제약 요소를 고려하여 통신망을 설계하여야 한다. 광통신망에서 장거리 전송 시 신호펄스 파형의 왜곡을 최소화하기 위해 영분산(zero-dispersion)을 구현하여야 하지만, 영분산으로 인하여 파이버의 비선형 현상이 나타나 신호 스펙트럼 왜곡 현상이 발생하는 문제가 있다. 즉 영 분산과 파이버의 비선형 사이에 서로 상충관계를 해결하여야 고속 대용량 트랙픽을 장거리 전송할 수 있다. 본 논문에서는 DWDM 해저 광 통신망에서 고속 대용량 트래픽을 장거리 전송하기 위한 기술을 알아보고, 영분산과 파이버의 비선형 사이에 상충문제를 해결 위한 분산관리 기법을 소개하고, 실제 한국-홍콩간 해저 광통신 구간에서 분산 맵 (dispersion map)을 설계 구현하였다.

• International Journal of Industrial Entomology and Biomaterials
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• 제26권2호
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• pp.95-112
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• 2013

As a first step toward understanding the divergence and relationships of the Nymphalidae (Lepidoptera: Papilionoidea) occurring in South Korea, cytochrome oxidase subunit I (COI), 16S ribosomal RNA (16S rRNA), and elongation factor-$1{\alpha}$ (EF-$1{\alpha}$) that comprise 3,501-3,716 bp were either sequenced (55 species) or the sequences were obtained from GenBank (23 species). The concatenated sequence divergence of six nymphalid subfamilies ranked in the following order: Danainae (10.3%), Satyrinae (9.5%), Limenitidinae (8.0%), Apaturinae (7.0%), Nymphalinae (6.7%), and Heliconiinae (6.2%). As has been reported in previous large scale international studies, the subfamilial relationships of (((((Limenitidinae + Heliconiinae) + (Nymphalinae + Apaturinae)) + Satyrinae) + Libytheinae) + Danainae) were also confirmed, except for the switched positions between Danainae and Libytheinae, and supported all subfamilies and tribe monophylies. Unlikely consistent phylogenetic relationships among genera within the majority of tribes in Nymphalidae, a conflicting relationship within the subfamily Apaturinae was obvious, presenting Apatura as sister to either Mimathyma or (Mimathyma + (Sephisa + (Hestina + Sasakia))), and both of these relationships are unconventional. Within the subfamily Limenitidinae, the genus Neptis was consistently revealed as a paraphyletic with respect to the genus Aldania, requiring further taxonomic investigation of the genus. Although limited, current sequence information and phylogenetic relationships are expected to be helpful for further studies.

• 천문학회지
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• 제30권1호
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• pp.27-70
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• 1997

The brightest stars in galaxies have been used as distance indicators since Hubble. However, the accuracy of the brightest stars for distance estimates has been controversial. Recently, Rozanski & Rowan-Robinson [1994 : MNRAS, 271, 530] argued large errors of this method for the distance determination : 0.58 mag and 0.90 mag, respectively, for the brightest red stars and the brightest blue stars, while Karachentsev & Tikhonov [1994 : A&A, 286, 718] suggested much smaller errors in the distance determination than the former: 0.37 mag for the brightest red stars and 0.46 mag for the brightest blue stars. The reasons for these conflicting results are not yet known. In this study we have investigated the accuracy of this method using a sample of 17 galaxies for which Cepheid distances are known and reliable photometry of the brightest stars are available. We have obtained the calibrations of the relations between the mean luminosities of the three blue and red brightest supergiants (BSGs and RSGs, respectively) and the total luminosities of the parent galaxies: $= 0.21M_B^T- 3.84, \sigma(M_v) = 0.37 mag,\;and\;\delta_{\mu0}=0.47$ mag for the brightest red supergiants, and $= 0.30M_B^T -3.02, \sigma(M_B)\;=\;0.55 mag,\;and\; \delta_{\mu0}=0.79mag$ for the brightest blue supergiants. Also it is found that the errors in the distance determination are reduced by a factor of two, as the observing wavelengths increase from B-band to K-band. In conclusion, the brightest red supergiants are considered to be useful for determining the distances to resolved late-type galaxies.

• 품질경영학회지
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• 제42권3호
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• pp.425-444
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• 2014

Purpose: This study aims to overcome the problem of private education market environment which is polarized into commercialized large private education institutions and small and medium sized private education institutions in a poor business environment, and develop systematic performance measurement model applicable for small and medium sized private education institutions. Methods: To develop the BSC which measures financial and non-financial indicator in a balanced manner and introduce the BSC into private education institutions that contain conflicting goals "EDUCATION" and "PROFIT". In particular, Utilizing the methodology of AHP, the priority of strategies and execution assignments are derived. Results: BSC model was developed and introduced by cooperating with executives of the private education institution. Moreover, the study permits to achieve the strategy, enterprise-wide vision and mission by deriving strategy map and applying it to the private education institution. To measure the performance of BSC model instruction, KPI corresponding to the strategic objectives of each perspective was derived. Conclusion: BSC model generally introduces to large-sized companies and public institutions. In this study, BSC model is developed by focusing on small and medium sized private institution. Furthermore, this study is more than simple model development, it makes a connection with achievement of strategic objectives, enterprise-wide vision and mission through strategy map and strategy execution method. Through the developed BSC model and strategy execution method, utilization plan in practice and customized model for private education institutions coexisting profit and non-profit objectives were developed, and academic implications were presented.