• Journal of Biomedical Engineering Research
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• v.29 no.3
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• pp.212-221
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• 2008

The total hip replacement (THR) has been used as the most effective way to restore the function of damaged hip joint. However, various factors have caused some side effects after the THR. Unfortunately, the success of the THR have been decided only by the proficiency of surgeons so far. Hence, It is necessary to find the way to minimize the side effect caused by those factors. The purpose of this study was to suggest the definite data, which can be used to design and choose the optimal hip implant. Using finite element analysis (FEA), the biomechanical condition of bone cement was evaluated. Stress patterns were analyzed in three conditions: cement mantle, procimal femur and stem-cement contact surface. Additionally, micro-motion was analyzed in the stem-cement contact surface. The 3-D femur model was reconstructed from 2-D computerized tomography (CT) images. Raw CT images were preprocessed by image processing technique (i.e. edge detection). In this study, automated edge detection system was created by MATLAB coding for effective and rapid image processing. The 3-D femur model was reconstructed based on anatomical parameters. The stem shape was designed using that parameters. The analysis of the finite element models was performed with the variation of parameters. The biomechanical influence of each parameter was analyzed and derived optimal parameters. Moreover, the results of FE A using commercial stem model (Zimmer's V erSys) were similar to the results of stem model that was used in this study. Through the study, the improved designs and optimal factors for clinical application were suggested. We expect that the results can suggest solutions to minimize various side effects.

• Computational Structural Engineering
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• v.9 no.3
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• pp.179-186
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• 1996

A simple nonlinear programming(NLP) formulation for the optimal topology problem of structures is developed and examined. The NLP formulation is general, and can handle arbitrary objective functions and arbitrary stress, displacement constraints under multiple loading conditions. The formulation is based on simultaneous analysis and design approach to avoid stiffness matrix singularity resulting from zero sizing variables. By embedding the equilibrium equations as equality constraints in the nonlinear programming problem, we avoid constructing and factoring a system stiffness matrix, and hence avoid its singularity. The examples demonstrate that the formulation is effective for finding an optimal solution, and shown to be robust under a variety of constraints.

• Journal of the Korea institute for structural maintenance and inspection
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• v.28 no.4
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• pp.1-12
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• 2024

In this study, a determination method of structural member section based on Nonlinear behaviors of steel cable-stayed bridges and the Harmony Search algorithm was presented. The Harmony Search algorithm determines the structural member section of cable-stayed bridges by repeating the process of setting the initial value, initializing the harmony memory, configuring the new harmony memory, and updating the harmony memory to search for the optimal value. The nonlinear initial shape analysis of a three-dimensional steel cable-stayed bridge was performed with the cross-section of the main member selected by the Harmony Search algorithm, and the optimal cross-section of the main members of the cable-stayed bridge, such as pylons, girders, cross-beams, and cables, reflecting the complex behavior characteristics and the nonlinearity of each member was determined in consideration of the initial tension and shape. The total weight was used as the objective function for determining the cross-section of the main member of the cable-stayed bridges, and the load resistance ability and serviceability based on the ultimate state design method were used as the restraint conditions. The width and height ratio of the girder and cross-section were considered additional restraint conditions. The optimal sections of the main members were made possible to be determined by considering the geometry and material nonlinearity of the pylons, girders, and cross-sections and the nonlinearity of the cable members. As a result of determining the optimal cross-section, it was confirmed that the proposed analysis method can determine the optimal cross-section according to the various constraint conditions of the cable-stayed bridge, and the structural member section of the cable-stayed bridge considering the nonlinearity can be determined through the Harmony Search algorithm.

• Journal of the Korean Society of Industry Convergence
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• v.13 no.1
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• pp.31-39
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• 2010

An exergy analysis is carried out for the regenerative gas turbine cycle which has a potential of enhanced thermal efficiency and specific power owing to the more possible water injection than that of inlet fogging under the ambient conditions. Using the analysis model in the view of the second law of thermodynamics, the effects of pressure ratio, water injection ratio and ambient temperature are investigated on the performance of the system such as exergetic efficiency, heat recovery ratio of recuperator, exergy destruction or loss ratios, and on the optimal conditions for maximum exergy efficiency. The results of computation for the typical cases show that the regenerative gas turbine system with afterfogging can make a notable enhancement of exergy efficiency.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.184-187
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• 2005

Forging process is one of the forming process and is used widely in automobile parts and manufacture industry. Especially the gears like spur gear, helical gear, bevel gear were produced by machine tool, but recently they have been manufactured by forging process. The goal of this study is to study forming process with data obtained by comparison between forward extrusion and upsetting simulation results and formability improvement by various heat treatment conditions. By analysis data of 3D FEM by upsetting and forward extrusion forming, the forming process of clutch gear develops using data based on 3D FEM analysis. Through tensile test using specimens by various heat treatment conditions, the optimal heat treatment condition is obtained by comparison the results of tensile test.

• Journal of Applied Biological Chemistry
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• v.64 no.2
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• pp.153-158
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• 2021

Cordyceps militaris (CM) is one of the most important medicinal mushrooms known to possess various biological activities. Cordycepin (CP) is a bioactive compound present in the fruiting bodies of CM and is known to have anti-tumor, anti-metastatic immunomodulatory and anti-inflammatory activities. In this study, we aim to analyze CP quantitatively under various CM extraction conditions. CP was measured using high-performance liquid chromatography, quantified using a reversed phase column using a gradient elution system of water and acetonitrile, and detected with a UV absorbance wavelength of 260 nm. The CP content of CM was the highest in 100% ethanol extract of the fruiting bodies and 60% ethanol extract of the mycelium. This study provides an efficient analysis method to determine the optimal extraction conditions for CP that can be used as a basis for developing functional foods and pharmaceutical products derived from CM.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.458-462
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• 2005

This paper deal with the optimal lamination condition of cylindrical shell applied new composite URN300 for a study of composite empirical formula. Finite element analyses for isotropic materials considered element numbers and boundary conditions are compared with existing empirical formulas to apply FE analysis for composite. And composite tensile test is done to know the composite material applied FE analysis for composite. The results of FE analyses for isotropic materials have indicated that Optimal element number and boundary condition were 1600 and both simple support. These conditions were applied in composite FE analyses. Ply orientations and lamination patterns in FE analyses for composite were considered. Ply orientations are $0^{\circ},\;15^{\circ},\;30^{\circ},\;45^{\circ},\;60^{\circ},\;75^{\circ},\;and\;90^{\circ}$. Lamination patterns are $[\pm\theta/0/90]_{14s]$ and $[\pm\theta_{14}/0_{14}/90_{14}]_s$ in FE analysis. Lamination pattern $[\pm\theta_{14}/0_{14}/90_{14}]_s$ is the equivalent model of $[\pm\theta/0/90]_{14s}$. At the result of this study, the FE analyses for composite have indicated that the optimized ply orientation $75^{\circ}$ is and real model must use in FE analysis for accurate results.

• Journal of the Korean housing association
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• v.16 no.1
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• pp.27-35
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• 2005

It has seen the significant increase of water consumption rate due to rapid industrialization, high-densities of city, and increasing the population; thereby leads further water resource required in near future. In order to solve this deficit there are one of solution that gray water method demonstrates advantages regarding the questions of optimal water utility and thereby master plan of water. The method of study is analysis of investigation data through interview and research of sewage treatment plants in Daegu City. Through these analysis, this paper examines the capacity of graywater and optimal graywater facility.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2002.10a
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• pp.487-492
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• 2002

In this study, designs of protection fences such as the concrete median barrier and the guardrail were performed. The foreign standard of concrete median barrier was introduced and implemented without modification fitting to domestic vehicles and highway conditions. In a car accident, median barrier doesn't protect vehicles effectively, especially for heavy vehicles such as bus and heavy truck. Guardrail doesn't protect vehicle effectively, either. The purpose of this study is to develop the optimal performance design of concrete median barrier and design of guardrail using the design of experiment as well as crashworthiness analysis which is done by Pam-Crash. As a result of this study, an optimal design of concrete median barrier was obtained considering von Mises stress, volume and COG acceleration of truck. And design of guardrail satisfying the domestic requirements was obtained.

• Journal of Food Hygiene and Safety
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• v.37 no.1
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• pp.21-28
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• 2022

In this study, a new lactic acid bacterium (LAB) that could produce gamma-aminobutyric acid (GABA) was isolated from Oenanthe javanica (water celery) and identified as an Enteroccoccus casseliflavus strain. Until recently, there have been many studies on the gamma-aminobutyric acid producing lactic acid bacterium, as well as on some lactic acid bacterium in Enteroococcs genus, but none on the species E. casseliflavus. Therefore, in the purpose of finding the optimal conditions for GABA production of E. casseliflavus PL05, the effects of several conditions including the type of mediums, growth temperatures, initial pH, growth time, L-mono sodium glutamate (MSG) concentration, and carbon source were tested. The study revealed that the PL05 strain grew better in the Brain Heart Infusion (BHI) medium than in the Man, Rogosa, and Sharpe (MRS) or Tryptic Soy Broth (TSB) medium. Also, similar results were obtained with GABA production conditions. As a result of analysis on the GABA production yield by concentration of MSG, a GABA substrate, the highest production was found at 7% of MSG concentration. However, since similar level of production was found at 5%, it is considered to be more efficient to use 5% MSG concentration. The analysis on the growth and GABA production yield by carbon sources showed the highest results when maltose was used. From the final test under the optimal conditions found, 140.06±0.71 mM of GABA was produced over 24 hours with the conversion rate of 78.95%. Lastly, from the sensitivity analysis on the 10 different antibiotics, including vancomycin, it was found that there were not confirmed cases of resistance.