• BMB Reports
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• v.43 no.12
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• pp.836-841
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• 2010

In the era of personal genomics, predicting the individual response to drug-treatment is a challenge of biomedical research. The aim of this study was to validate whether interaction information between genetic and transcriptional signatures are promising features to predict a drug response. Because drug resistance/susceptibilities result from the complex associations of genetic and transcriptional activities, we predicted the inter-relationships between genetic and transcriptional signatures. With this concept, captured genetic polymorphisms and transcriptional profiles were prepared in cancer samples. By splitting ninety-nine samples into a trial set (n = 30) and a test set (n = 69), the outperformance of relationship-focused model (0.84 of area under the curve in trial set, P = $2.90{\times}10^{-4}$) was presented in the trial set and validated in the test set, respectively. The prediction results of modeling show that considering the relationships between genetic and transcriptional features is an effective approach to determine outcome predictions of drug-treatment.

• Water for future
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• v.29 no.2
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• pp.143-151
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• 1996

The dynamic responses in the subsurface outflow, surface saturation area, soil moisture storage are established by numerical experiments with Richards equation. In addition to this, the dynamical relationship between surface saturation area and subsurface outflow, and between surface saturation area and soil moisture storage are also determined by varying the hillslope shape, soil type, and boundary condition. The simulation results indicate that the dynamical relationships between surface saturation area and subsurface outflow, and between surface saturation area and soil moisture storage are approximated by the steadystate relationships. And the dynamic responses of subsurface outflow and surface saturation area are characterized by the double peaks although the rainfall pattern is asimple pulse input. As a result of numerical simulation, the physical mechanism for the occurrence of the double peaks is explained using the concept of variable source area.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.391-396
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• 2013

As the construction environment has been changing all the times, the techniques for managing the construction projects have been improved accordingly. The schedule management technique, one of the construction management tools, has been evolved as well in order to be adaptable to new construction environment. Most of newly proposed scheduling techniques have been based on the Critical Path Method (CPM) that was proposed in 1956. The CPM is classified into two categories, Arrow Diagramming Method (ADM) and Precedence Diagramming Method (PDM). ADM is so good in the visual format but it cannot express the overlapping relationships between two consecutive activities. On the other hand, PDM can express the overlapping relationships but it is unsatisfactory in the visual format. Recently, as the construction environment becomes more complex and the role of schedule management becomes more and more important, the overlapping expression becomes one of critical factors for scheduling as well. Most of construction project participants prefer more comfortable visual format, however, the scheduling software based on the PDM cannot satisfy their basic requirement. Beeliner, new scheduling software based on the Beeline Diagramming Method (BDM) that was proposed in 2010, was developed in 2012, it can express more flexible overlapping relationships and has superior visual format as well. This paper presents major features and applications of Beeliner, and makes construction professionals understand new scheduling concept and its applications.

• Journal of the Korean School Mathematics Society
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• v.8 no.2
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• pp.203-222
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• 2005

The purpose of this study is to investigate students' understanding of functions based on concept image and concept definition suggested by Vinner, For the study a graphing calculator was provided as a tool for students to use for their exploration. Three students participated in the study using the qualitative research method to identify their processes of understanding functions. The student with previous experiences of the functions had various concept images about the functions and did not have many opportunities to modify their images because the student did not want to depend on the calculator. However, the student who did not have many chances to study about the functions before used the calculator effectively for developing the concept definition on the functions. The calculator played an important role in connecting different representations and finding relationships between these representations supported by dynamic exploration.

• Journal of the Korean Geographical Society
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• v.48 no.6
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• pp.929-943
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• 2013

This paper examines the evaluation and categorization of national heritage 'Myeongseung(scenic places)' from the viewpoint of world heritage concept and its criteria. This study focuses on Myeongseung because the author thinks it implies the unique human-nature relationships that have been evolved in Korean Peninsula, and then draws some pending problems with the evaluation of those heritage. Formerly, the paper discusses theoretically the outcome and point at issue on concept, criteria, evaluation of world heritage, and then proposes three issues on the evaluation and categorization of national heritage 'Myeongseung': first, the establishment of basic concept for evaluation of heritage; second, the building of unified criteria list to cover both natural and cultural heritage; and third, the reorganization of categories for the advanced registration and management. Especially, the author emphasizes that it is necessary rather to extend actively the world heritage concept than to regard it as a fixed framework.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2002.03a
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• pp.67-74
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• 2002

An experimental assessment on the dynamic behavior of saturated sand which can consider the irregular characteristics of earthquakes was proposed. The equivalent uniform stress concept presented by Seed and Idriss has been applied to evaluate the liquefaction resistance strength to simplify earthquake loading. However, it was known that the liquefaction resistance strength of soil based on the equivalent uniform stress concept can't exactly mirror the dynamic characteristics of the irregular earthquake motion. In this study, estimation of the criterion of the liquefaction resistance strength was determined by applying real earthquake loading to the cyclic triaxial test. From the test results, relationships between excess pore water pressure and the earthquake characteristics such as magnitude or duration were determined. Magnitude scaling factors to determine the soil liquefaction resistance strength in seismic design were also proposed.

• Journal of Information Technology Applications and Management
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• v.11 no.2
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• pp.125-148
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• 2004

It is quite sure that e-commerce through internet has significant impacts on consumer behavior and marketing activities as well. In this context, the concept of 'Internet Community' has been emerged and highlighted in consumer marketing. Internet community means social relationships and linkages which can be established through continuous and iterative internet-mediated communications among people with homogeneous interests and concerns. It has been a current trend to exchange product information among consumers by forming internet communities, which would affect sales performance directly or indirectly. It, therefore, is necessary to study the community's behavior and its impact on its marketing performance. This article focuses on the following points : ① the structural concept and factors of forming traditional consumer community and internet community : ② the role of trust and commitment as mediating variables between the internet community formation and marketing performance : ③ the performance and implications of the internet community on marketing.

• Journal of the Korean Home Economics Association
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• v.35 no.6
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• pp.41-53
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• 1997

The primary purpose of the present study was to investigate the pre-parents' motivations for parenthood, concept of marital role and demands for pre-parent education. the subjects were 179 women, who are planning to have a child and already are pregnant, and their husbands. 1. Among 7 motivations for parenthood presented, strong ties for couples and maturity demands were selected the most important. Economic and emotional dependency was valued the least. 2. The harmonious relationships between husband and wife chosen as the most important marital role concept. 3. For the contents of the pre-parent education program, the postnatal care, fathering, nutrition and exercise during pregnancy, and others were desired. 4. Over two-thirds of respondents preferred a joint participation (husband-wife together).

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.122-127
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• 1998

This paper suggests an integrated method for discovering knowledge from a large database. Our approach applies an attribute-oriented concept hierarchy ascension technique to extract generalized data from actural data in databases, induction of decision trees to measure the value of information, and knowledge reduction of rough set theory to remove dispensable attributes and attribute values. The integrated algorithm first reduce the size of database for the concept generalization, reduces the number of attributes by way of elimination condition attributes which have little influence on decision attribute, and finally induces simplified decision rules removing the dispensable attribute values by analyzing the dependency relationships among the attributes.

• Journal of the Korean Operations Research and Management Science Society
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• v.3 no.2
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• pp.47-74
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• 1978

This paper reviews the zero-base budgeting whose concept was developed in the late 1960's, and applied to the actual budgeting situations in the early 1970's. Since then, it has been expanded to become one of major tools in corporate planning and control system. The primary purpose of this review is to clarify the followings: 1) concept of zero-base budgeting and its history, 2) relationships among zero-base budgeting, planning and program evaluation, 3) comparison of zero-base budgeting with other budgeting techniques, and 4) implementation procedure. Some discussions are also provided with respect to the practical implications of zero-base budgeting, its advantages and disadvantages, and others. Finally, the possibility of actual application in a local setting is investigated.